大鼠放射性口腔黏膜炎病损组织细胞因子检测及意义

“…【目的】 检测大鼠放射性口腔黏膜炎形成过程中病损局部组织内细胞因子,探讨其动态变化规律及意义65377;【方法】 获取接受单次30 Gy X线照射后5 d65380;8 d65380;14 d的大鼠口腔黏膜组织,采用抗体芯片技术检测19种细胞因子;荧光定量PCR检测8种炎性相关因子的mRNA水平;ELISA定量检测IL-1α65380;IFN-γ65380;TIMP-165377;【结果】 抗体芯片技术检测到,照射后Frac65380;IL-465380;IL-665380;IL-1065380;TNF-α 5种细胞因子水平下降;IL-1β65380;LIX65380;VEGF65380;β-NGF 4种细胞因子照射前后水平无明显差异;照射后水平上升幅度 < 2倍的有CINC-265380;GM-CGF65380;Leptin65380;MCP-1和MIP-3α 5种细胞因子,上升幅度≥2倍的有CINC-365380;INF-γ65380;IL-1α和TIMP-1 4种细胞因子65377;Real-time PCR检测到抗凋亡相关基因Bcl-2,以及IL-665380;TNF-α65380;VEGF及IL-1β的mRNA表达水平下降;而促凋亡相关基因Bax65380;中性粒细胞局部募集相关基因CINC和TLR-9表达上升65377; IL-1α65380;IFN-γ65380;TIMP-1的ELISA检测结果与前两种检测结果一致65377;【结论】 大鼠抗体芯片和荧光定量PCR65380;ELISA检测结果互相佐证了病损组织内的细胞因子在口腔黏膜炎发生65380;发展65380;演进中呈现分泌受阻和表达增加的动态变化并发挥调控作用65377;…”
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早初潮及GnRHa治疗女孩初潮后代谢和性腺轴的改变 by 陈秋莉, 李燕虹, 马华梅, 杜敏联, 陈红珊, 古玉芬

“…测量身高、体重，B 超测量子宫、卵巢大小，抽血查性激素及胰岛素、血糖、血脂、leptin、adiponectin 等代谢指标。 【结果】早初潮女孩年龄别和骨龄别体质指数标准差分值（BMISDS）均较正常初潮女孩显著增高（P < 0.05），发生胰岛素抵 抗的比例（20.5%）亦较正常初潮女孩（0%）显著升高，而脂代谢和性腺轴各项指标均无差异。…”
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Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat by B. S. Muhlhausler, R. Cook-Johnson, M. James, D. Miljkovic, E. Duthoit, R. Gibson

“…Samples from distinct adipose depots (omental and retroperitoneal) were collected and mRNA expression of the pro-lipogenic transcription factors Sterol-Retinoid-Element-Binding-Protein1c (SREBP1c) and Peroxisome Proliferator Activated Receptor-γ (PPARγ), lipogenic enzymes Sterol-coenzyme Desaturase1 (SCD-1), Fatty Acid Synthase (FAS), lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (G3PDH) and adipokines leptin and adiponectin determined by qRT-PCR. Increasing dietary ALA content resulted in altered expression of SREBP1c, FAS and G3PDH mRNA in both adipose depots. …”
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Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction by Hernán Gonzalo Villagarcía, Vanesa Sabugo, María Cecilia Castro, Guillermo Schinella, Daniel Castrogiovanni, Eduardo Spinedi, María Laura Massa, Flavio Francini

“…MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). …”
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Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats by Opeyemi Christianah De Campos, Daniel Ikpomwosa Osaigbovo, Titilayo Ifeoluwa Bisi-Adeniyi, Franklyn Nonso Iheagwam, Solomon Oladapo Rotimi, Shalom Nwodo Chinedu

“…APN also significantly (P<0.05) upregulated the relative expression of glucokinase, carnitine palmitoyltransferase-1 (CPT-1), and leptin at 400 mg/kg body weight when compared to the group fed with an HFHF diet only. …”
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Geographically widespread and novel hemotropic mycoplasmas and bartonellae in Mexican free-tailed bats and sympatric North American bat species by Daniel J. Becker, Kristin E. Dyer, Lauren R. Lock, Beckett L. Olbrys, Shawn A. Pladas, Anushka A. Sukhadia, Bret Demory, Juliana Maria Nunes Batista, Micaela Pineda, Nancy B. Simmons, Amanda M. Adams, Winifred F. Frick, M. Teague O'Mara, Dmitriy V. Volokhov

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Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors by Matthew P. Johnson, Ryan Keyho, Nicholas B. Blackburn, Sandra Laston, Satish Kumar, Juan Peralta, Suman S. Thapa, Bradford Towne, Janardan Subedi, John Blangero, Sarah Williams-Blangero

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<i>‘Changing the Focus’</i>: Co-Design of a Novel Approach for Engaging People with Dementia in Physical Activity by Claudia Meyer, Den-Ching A. Lee, Michele Callisaya, Morag E. Taylor, Katherine Lawler, Pazit Levinger, Susan Hunter, Dawn C. Mackey, Elissa Burton, Natasha Brusco, Terry Haines, Christina L. Ekegren, Amelia Crabtree, Keith D. Hill

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Surveillance of Mycoplasma agassizii in Texas tortoises (Gopherus berlandieri) for translocation with emphasis on treatment and recovery by Christin A. Moeller, Saren Perales, Wraith Rodriguez, Alynn M. Martin, Cord B. Eversole, Sandra Rideout-Hanzak, Paul Crump, Clayton D. Hilton, Scott E. Henke

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Management of CAR-T cell therapy in patients with multiple myeloma: a systematic review and expert consensus in Australia by P. Joy Ho, Hang Quach, M. Hasib Sidiqi, M. Hasib Sidiqi, Cindy H. Lee, Jason Butler, Andrew Spencer, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Kenneth Micklethwaite, Jingya Li, Elissa Cusson, Robert Bagnall, Simon J. Harrison

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τ̃ searches at future e+e− colliders by Berggren Mikael, Núñez Pardo de Vera Maria Teresa, List Jenny

“…The direct pair-production of the superpartner of the τ-lepton, the τ̃, is one of the most interesting channels to search for SUSY in: the τ̃ is likely to be the lightest of the scalar leptons, and is one of the most experimentally chalanging ones. …”
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Pobreza y subdesarrollo rural en Colombia. Análisis desde la Teoría del Sesgo Urbano by Laura Vanessa López Muñoz

“…Con el propósito de profundizar el entendimiento de las dinámicas que favorecen la perdurabilidad de esta situación, en este artículo se realiza un análisis del subdesarrollo rural en Colombia desde la perspectiva que ofrece la Teoría del Sesgo Urbano, propuesta por Michael Lipton en 1977. A partir de una revisión histórica, se ha encontrado que el detrimento de las zonas rurales del país se explica en gran medida por los procesos políticos y económicos que han sido impulsados por las élites urbanas para su beneficio y el desarrollo de las ciudades. …”
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Extracting the dependence of directed flow differences on conserved charges by Lin Zi-Wei, Nayak Kishora, Shi Shusu

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Fermion masses, neutrino mixing and Higgs-mediated flavor violation in 3HDM with S 3 permutation symmetry by K. S. Babu, Yongcheng Wu, Shiyuan Xu

“…Global fits to the quark/lepton masses and CKM/PMNS matrices are performed. …”
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Previable Preeclampsia Diagnosed by Renal Biopsy in Setting of Novel Diagnosis of C4 Glomerulopathy by Jessica Parrott, Timothy A. Fields, Marc Parrish

“…She developed posterior reversible encephalopathic syndrome and pregnancy termination was recommended. Conclusion. The lectin complement pathway may play a role in the pathophysiology of severe, early onset preeclampsia. …”
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Un/Seeing Campus Carry: Experiencing Gun Culture in Texas by Benita Heiskanen

“…In particular, it considers the ways in which members of The University of Texas at Austin community delineate their visual-spatial surroundings and sensory perceptions on campus before and after the implementation of the Campus Carry law. …”
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Notes from Field Work on the Ijemo in Abeokuta by Damilola Osunlakin, Toyin Falola

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Warm Dark Matter Sterile Neutrinos in Electron Capture and Beta Decay Spectra by O. Moreno, E. Moya de Guerra, M. Ramón Medrano

“…We study the deexcitation spectrum in the considered cases of electron capture and the charged lepton spectrum in the case of Tritium beta decay. …”
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NLO QCD predictions for t t ¯ γ $$ t\overline{t}\gamma $$ with realistic photon isolation by Daniel Stremmer, Malgorzata Worek

“…Abstract We present a complete description of top quark pair production in association with a hard photon in the di-lepton decay channel. The calculation is performed at NLO QCD and includes all resonant and non-resonant Feynman diagrams, interferences, and finite-width effects of the top quarks and W ±/Z gauge bosons. …”
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A Modified Strain‐Wedge Model for Small Strain Rigid Piles in Sand by Yisheng Yin, Dongyuan Wang, Kai Cui

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