Clinical Holistic Medicine: Chronic Infections and Autoimmune Diseases by Søren Ventegodt, Joav Merrick

“…We invite the medical community to cooperate on this important challenge.…”
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Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery by Carolin Sophie Dombrowsky, Felix Klaus Geyer, Diana Zakharchuk, Harald Kolmar

“…In this context, we have developed a modular approach for cytosolic penetration of tumor cells based on bispecific antibodies containing a masked cytosol-penetrating Fab on one arm and a tumor-targeting scFv linked via an endosomal cleavable linker on the other arm. The relevance of the antigen-specific binding, internalization, and cytosolic cargo delivery was demonstrated in several in vitro assays using different cell lines with anti-B7-H3 scFv, the well-characterized trastuzumab (HER2), and inotuzumab (CD22) as examples. …”
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Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis by Rong Zhu, Jing Yang, Ling Xu, Weiqi Dai, Fan Wang, Miao Shen, Yan Zhang, Huawei Zhang, Kan Chen, Ping Cheng, Chengfen Wang, Yuanyuan Zheng, Jingjing Li, Jie Lu, Yingqun Zhou, Dong Wu, Chuanyong Guo

“…Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future.…”
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Challenges and possible improvements for healthcare teams at outreach clinics in Nepal – a qualitative study by Ingrid Eriksen, Eirin Helene Rasmussen, Biraj Karmacharya, Seema Das, Elisabeth Darj, Maria Lisa Odland

“…The rural population´s health awareness needs to be increased, and the work environment for rural healthcare workers needs to be improved. These issues need to be prioritised by the government and policymakers.…”
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Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells by Li-Chun Zhao, Mei Tang, Qian-Hua Zhang, Zhi-Yi Hu, Hong-Wei Gao, Xia-Yun Liao, Gang Wang, Jing Leng

“…In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. …”
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The Model and Practices of Human Potential Development by P. D. Rabinovich, K. E. Zavedenskiy, E. A. Lopatina, G. D. Emelin, D. N. Dolganov

“…By human potential is meant the subject’s capabilities in cooperation with Significant Others to open prospects for self-development and self-realization in the described contexts. …”
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The Dilution Dependency of Multigroup Uncertainties by M. R. Ball, C. McEwan, D. R. Novog, J. C. Luxat

“…The propagation of nuclear data uncertainties through reactor physics calculation has received attention through the Organization for Economic Cooperation and Development—Nuclear Energy Agency’s Uncertainty Analysis in Modelling (UAM) benchmark. …”
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Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation by Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou

“…Collectively, this study suggests that Kv1.3 is essential for macrophage M2 polarization and highlights the potential of Kv1.3 blockers as therapeutic agents for renal fibrosis and other M2 polarization-related diseases.…”
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Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease by Bingjie Wu, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Shanshan Wang, Xiaojing Liu, Yan Ling, Xin Gao

“…Multiple logistic regression analysis demonstrated an independent association of FT4 levels with PH after adjustment of gender, age, body mass index, systolic blood pressure, left ventricular ejection fraction, hypertension, and medication use of calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists, and nitrates. …”
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Enhancing Software Distribution and Collaboration in Manufacturing: Developing the IMOS Platform by Antonio Monte Pegado, Andre Dionisio Rocha, Jose Barata

“…IMOS is designed to address recent industry challenges, with a focus on building a solid framework that highlights modularity, facilitates distribution, and promotes cooperation. This system facilitates the distribution of industry-oriented tools by offering containerized software solutions through a unified marketplace. …”
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Evaluation of the Environmental Performance of Seasonal Spaces in the Vernacular Architecture of the Regions With Cold Climate: A Case Study in Ardabil by Marjaneh Kharrat Sadeghi, Mahsa Javadi Nodeh, Mehrdad Sarabi

“…Methods: To this end, two traditional houses in Ardabil were studied using a data logger. Data collection was carried out through field observations and logical reasoning, followed by numerical analyses to evaluate the environmental performance of the structures. …”
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Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population by Incheol Seo, Seong-Il Suh, Min-Ho Suh, Won-Ki Baek

“…Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. …”
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CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…Here, we demonstrate that mutating the CHD6 chromatin remodeler sensitizes cells to PARP1/2 inhibitors in a manner distinct from BRCA1, and that CHD6 recruitment to DNA damage requires cooperation between PAR- and DNA-binding domains essential for nucleosome sliding activity. …”
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Didactic Strategies for Autonomous Learning and their Impact on the Health of Students from a University in Lambayeque by Gioconda del Socorro Sotomayor Nunura, Doris Díaz de Angulo, Nelly Dioses Lescano, Humberto Iván Morales Huamán, Roberth Manuel Rivas Manay, José Alberto Silva Siesquén, Antenor Vásquez Muñoz

“…<strong>Foundation:</strong> teaching strategies to promote autonomous learning are cognitive and affective strategies that facilitate: learning to learn, learning to do and learning cooperatively, to establish relationships with peers and achieve health well-being. …”
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Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features by Krittapat Onthuam, Norrawee Charnpinyo, Kornrapee Suthicharoenpanich, Supphaset Engphaiboon, Punnarai Siricharoen, Ronnapee Chaichaowarat, Chanakarn Suebthawinkul

“…In addition, a custom weight was trained using a self-supervised learning framework known as the Simple Framework for Contrastive Learning of Visual Representations (SimCLR) in cooperation with generated images using generative adversarial networks (GANs). …”
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Disorders in brassinosteroids signal transduction triggers the profound molecular alterations in the crown tissue of barley under drought. by Anetta Kuczyńska, Martyna Michałek, Piotr Ogrodowicz, Michał Kempa, Paweł Krajewski, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Marina Pérez-Llorca, Sergi Munné-Bosch, Krzysztof Mikołajczak

“…This study also uncovered the candidate genes to be linkers of phytohormones crosstalk. Importantly, we detected the converging upregulation of several proteins and encoding genes under drought, including late embryogenesis abundant proteins and chaperones; they represent a promising target for cereals' improvement. …”
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Quasi one-dimensional organic conductors: from Fröhlich conductivity and Peierls insulating state to magnetically-mediated superconductivity, a retrospective by Jerome, Denis, Bourbonnais, Claude

“…In addition, the simple structures of these materials have allowed the development of theoretical models in close cooperation with almost all experimental findings.Even though these materials have not yet given rise to true high-temperature superconductivity, the wealth of their physical properties makes them systems of choice in the field of condensed matter physics due to their original properties and their educational qualities. …”
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Integrating Pull Request Comment Analysis and Developer Profiles for Expertise-Based Recommendations in Global Software Development by Sara Zamir, Abdul Rehman, Hufsa Mohsin, Elif Zamir, Assad Abbas, Fuad A. M. Al-Yarimi

“…Typical developer recommendation systems do not consider the dynamics of expertise and cooperative nature of the tasks for assessing their correctness, often restricting themselves to extracting review comments only to measure their usefulness and suggest reviewers. …”
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Orthogonal frequency‐division multiplexing‐based signal design for a dual‐function radar‐communications system using circulating code array by Yu Zhou, Wen Ren, Qiuyue Zhang, Sisi Chen, Linrang Zhang

“…A significant property of the circulating code array, which provides a relationship between the baseband frequency of the base signal and the spatial angles, implements a basis for safe telecommunication transmission towards the cooperative receiver and demodulation. Moreover, the circulating code array transmits the same signal and introduces the same time interval between adjacent array elements. …”
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Redefining Freedom. Digital Capitalism and Private Property by N. B. Afanasov

“…The author proposes his interpretation of most obvious and simultaneously less arguable transformations that take place in digital economy. Economy of cooperative use (sharing), precarious employment (gig economy), networkisation, as well as rapid growth of inequality determine digital capitalism in opposition to previous stages of capitalist production and consumption. …”
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