miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

Get full text

Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 by Settimio Rossi, Michele D'Amico, Annalisa Capuano, Mary Romano, Pasquale Petronella, Clara Di Filippo

Get full text

Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

Get full text

Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis by Ryan McBain, Adeyemi Okunogbe, Rhoda K Wanyenze, Violet Gwokyalya, Glenn Wagner

“…Objective We conducted a cost-effectiveness analysis of an evidence-based collaborative care model for treatment of perinatal depression among women living with HIV in Uganda.Design Maternal Depression Treatment in HIV (M-DEPTH) is a cluster randomised controlled trial implemented from July 2019 to August 2023, during which 391 pregnant women with mild-to-severe depressive symptoms were randomised to receive stepped care for depression (M-DEPTH: behavioural and pharmacological treatments) or care as usual (CAU: hospital referral for severe cases), at one of eight public health facilities in Uganda.Methods We implemented time-driven, activity-based costing to determine the economic cost of M-DEPTH from a societal perspective, compared with CAU. …”
Get full text

A Special, Strict, Fat-Reduced, and Carbohydrate-Modified Diet Leads to Marked Weight Reduction even in Overweight Adolescents with Prader-Willi Syndrome (PWS) by Walter Bonfig, Kathi Dokoupil, Heinrich Schmidt

Get full text

The experience of living with human immunodeficiency virus among adolescents at Felege Hiwot Comprehensive Specialized Hospital Bahir-Dar, Northwest Ethiopia, A phenomenological study. by Bazezew Asfaw Guadie, Minyichil Birhanu Belete, Meseret Mekuriaw Beyene, Ayalew Kassie Melese, Tarik Yenew Tessema, Yinager Workineh

“…<h4>Background</h4>Adolescents who have the human immunodeficiency virus face difficulties in their lives not just from the physical consequences of the illness but also from social stigma and discrimination. …”
Get full text

Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

Get full text

A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

Get full text

Prenatal diagnosis of chromothripsis causing complex chromosomal rearrangement involving chromosomes 5, 7 and 11 leading to TWIST1 deletion and Saethre-Chotzen syndrome by Ivana Joksic, Mina Toljic, Nela Maksimovic, Dijana Perovic, Tatjana Damnjanovic, Aleksandar Jurisic

Get full text

Investigation of Genipin Cross-Linked Microcapsule for Oral Delivery of Live Bacterial Cells and Other Biotherapeutics: Preparation and In Vitro Analysis in Simulated Human Gastrointestinal Model by Hongmei Chen, Wei Ouyang, Christopher Martoni, Fatemeh Afkhami, Bisi Lawuyi, Trisna Lim, Satya Prakash

“…This study suggested the potential of the GCAC microcapsules for oral delivery of live microorganisms and other biotherapeutics.…”
Get full text

Sustainable Valorization of Rice Straw into Biochar and Carbon Dots Using a Novel One-Pot Approach for Dual Applications in Detection and Removal of Lead Ions by Jagpreet Singh, Monika Bhattu, Meenakshi Verma, Mikhael Bechelany, Satinder Kaur Brar, Rajendrasinh Jadeja

Subjects: Get full text

A Novel p.G141R Mutation in ILDR1 Leads to Recessive Nonsyndromic Deafness DFNB42 in Two Chinese Han Families by Xueling Wang, Longhao Wang, Hu Peng, Tao Yang, Hao Wu

Get full text

And the Oscar Goes to Peripheral Blood Film for the Detection of Lead Poisoning in a Complicated Toxic Patient: A Case Report with a Review of Laboratory Clues by Amir Zamani, Ehsan Sarraf Kazerooni, S. Saeed Kasaee, Mohammad Hossein Anbardar, Sahand Mohammadzadeh, Golsa Shekarkhar, Neda Soleimani

“…It provides rich morphological information, among which basophilic stippling is highly suggestive of lead poisoning.…”
Get full text

Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial by Fiona Jones, Nick Sevdalis, Adrian Edwards, Bernadette Sewell, Monica Busse, Philip Pallmann, Rachel Lowe, Shaun Harris, Aloysius Niroshan Siriwardena, Jessica Fish, Claire Potter, Muhammad Riaz, Fiona J Leggat, Andrea Jane Longman, Jackie McRae

“…Objective To evaluate the effectiveness of Listen, a self-management support intervention, for people living with long covid who were not in hospital.Design Pragmatic, multicentre, parallel group, randomised controlled trial.Setting Twenty four sites in England and Wales.Participants Identified from long covid clinic waiting lists, word of mouth, and adverts/social media self-referred to the trial, 554 adults with long covid were randomised to receive either the Listen trial intervention or NHS usual care.Interventions The Listen intervention involved up to six one-to-one personalised sessions with trained healthcare practitioners and an accompanying handbook co-designed by people with lived experience and health professionals. …”
Get full text

The Living-Related Kidney Transplant Program in Brunei Darussalam: Lessons Learnt from a Nascent National Program in a Small, Muslim, and Asian Country by Jackson Tan, Muhammad Abdul Mabood Khalil, Dalinatul Ahmed, Jayakrishnan Pisharam, Chiao Yuen Lim, Hock Beng Chua, William Chong, Kim Khee Tan

“…Brunei Darussalam commenced its living-related renal transplant program in 2013, with subsequent attainment of independent local capacity and proficiency in 2019. …”
Get full text

Grassland Alterations Do Not Affect Breeding Success, But Lead to Dietary Shifts of Eastern Imperial Eagle, a Top Predator: a Case of Successful Adaptation by Dimitar A. Demerdzhiev, Dobromir D. Dobrev, Zlatozar N. Boev, Nedko P. Nedyalkov, Atanas G. Delchev, Stoycho A. Stoychev, Tseno H. Petrov

Get full text

A clinical study of the immunogenicity and protective potency of a live recombinant GamLPV vaccine for intranasal use for the prevention of whooping cough in adult volunteers by Alevtina A. Lidzhieva, Alisa Yu. Medkova, Sergey V. Kulikov, Ludmila N. Sinyashina, Rezida A. Sioundioukova, Andrey P. Markov, Aleksey B. Verveda, Natalia E. Abaeva, Irina N. Chernyshova, Marina V. Gavrilova, Kristina K. Bushkova, Ilya N. Dyakov, Gennady I. Karataev

“…The increase in incidence rate of pertussis worldwide, short-term insufficient immunity induced by acellular pertussis vaccines (TDaP) and their failure to provide antibacterial protection and to prevent transmission of infection in human population dictate the development of new pertussis vaccines. A new live recombinant pertussis vaccine for intranasal use (GamLPV) has completed preclinical studies in experiments on nonhuman primates and 2 phases of clinical trials involving adult healthy volunteers, in which the safety, immunogenicity and protective activity of the GamLPV were proven. …”
Get full text

The Anti-Inflammatory Cytokine, Interleukin-10, Inhibits Inflammatory Mediators in Human Epithelial Cells and Mouse Macrophages Exposed to Live and UV-Inactivated Chlamydia trachomatis by Abebayehu N. Yilma, Shree R. Singh, Stacie J. Fairley, Murtada A. Taha, Vida A. Dennis

“…We used human epithelial (HeLa) cells and mouse J774 macrophages as target cells along with live and UV-inactivated C. trachomatis mouse pneumonitis (MoPn) as stimulants. …”
Get full text

Resilience Project Interventions and its Effect on Vulnerable Household’s Standards of Living in Uganda: An Empirical Evidence from USAID ICAN Project in Kigezi Sub-Region. by Sunday, Dismus

Subjects: Get full text

Adherence to Viral Load Testing Guidelines, Barriers, and Associated Factors Among Persons Living with HIV on ART in Southwestern Uganda: a Mixed-Methods Study. by Lubega, Polly, Nalugya, Sylivia Juliet, Kimuli, Angella Namyalo, Twinokusiima, Majoreen, Khasalamwa, Mercy, Kyomugisa, Richard, Kabami, Jane, Owaraganise, Asiphas

“…This study determined the adherence to national guidelines on VL testing, barriers, and associated factors in persons living with HIV (PLHIV) on ART in southwestern Uganda. …”
Get full text