Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The three most active compounds: 4e (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-nitrobenzamide), 4f (N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)-4-chlorobenzamide) and 4g (4-bromo-N-(4-(3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)acryloyl)phenyl)benzamide), were evaluated for anticancer activity against human OS cancer cell line (MG-63), liver cancer cell line (HepG2), lung cancer cell line (A549) and cervical cancer (HeLa), using MTT assay. …”
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Evaluación de condiciones de proceso y conservación en la calidad de mandarina Satsuma by F. BELLO, M. PANOZZO, N. ALMIRON, D. VÁZQUEZ

“…Luego las mandarinas fueron procesadas en una línea de empaque y almacenadas a 5 ºC durante 25 días. …”
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Evaluation of Lyso-Gb1 as a biomarker for Gaucher disease treatment outcomes using data from the Gaucher Outcome Survey by Ari Zimran, Shoshana Revel-Vilk, Tama Dinur, Majdolen Istaiti, Jaco Botha, Elena Lukina, Pilar Giraldo, Patrick Deegan, Stephan vom Dahl

“…Assessments included change in lyso-Gb1 concentration, hemoglobin concentration, platelet counts, and spleen and liver volume from baseline to the last lyso-Gb1 assessment. …”
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Implementation of Accurate and Fast DNA Cytometry by Confocal Microscopy in 3D by Lennert S. Ploeger, André Huisman, Jurryt van der Gugten, Dionne M. van der Giezen, Jeroen A. M. Beliën, Abdelhadi Y. Abbaker, Hub F. J. Dullens, William Grizzle, Neal M. Poulin, Gerrit A. Meijer, Paul J. van Diest

“…Methods: Nuclear DNA was stained in 14 μm thick tissue sections of normal liver and adrenal stained with either YOYO-1 iodide or TO-PRO-3 iodide. …”
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In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways by Khalid Saad Alharbi, Muhammad Afzal, Fahad A. Al-Abbasi, Ehssan Moglad, Salwa D. Al-Qahtani, Naif A. R. Almalki, Faisal Imam, Nadeem Sayyed, Imran Kazmi

“…Biochemicals parameters including anti-diabetic (Glucose, HbA1c, serum insulin), cardiac markers (hs-CRP, CPK-MB), dyslipidaemia (lipid analysis), anti-inflammatory (IL6, TNF-α and IL-β), oxidative stress (MDA) and antioxidant (SOD, CAT and GSH), kidney function (creatinine), liver function (AST) and pancreatic function (lipase) along with apoptosis markers (Bcl-2, caspase-3) were evaluated. …”
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P<0.001), shock (P=0.002), acute kidney injury (AKI) (P<0.001), acute liver injury (ALI) (P=0.002), and gastrointestinal (GI) dysfunction (P=0.012), but not respiratory failure, brain injury, and pathogenic species (all P>0.05). …”
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Involvement of Pneumocystis jirovecii in infectious and other diseases in children and adults with immunosuppression of various origin by Rybalkina T.N., Karazhas N.V., Kornienko M.N., Avetisyan L.R., Boshyan R.E., Pulnova N.L., Kabikova O.F., Ivanova M.Yu., Chereshneva E.V.

“…The incidence of pneumocystosis infection was significantly higher in children with druginduced immunodeficiency after a related liver transplant (70.1%) than among children with HIV-related immunodeficiency (36.7%), t = 2.4. …”
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Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning by Shuxian Pan, Zibing Wang

“…The accuracy of the model is verified in the DCA curve.ResultsA total of 274 HBV-related liver cancer patients were enrolled in the study. …”
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Relation among zootechnical performance, biochemical indicators, water quality, and small invertebrates (zooplankton) abundance reared in biofloc-supplemented systems by Ahmed Said Al-Souti, Marwa M. Zaher, Amr M. Helal, Dina T. Meshhal, Mansour D. H., Afify D. G. Al-Afify, Mohamed M. Rafaey, Abeer El-Saharty, Ehab El-Haroun, Marian G. Nassif, Abdallah Tageldein Mansour, Abdallah Tageldein Mansour, Mohamed Ashour

“…L−1, respectively, which included four families (Rotifera, Copepoda, Cladocera, and free-living nematodes) with the domination of family Rotifera at 81.65% and 93.89%, respectively. …”
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Matching-Adjusted Indirect Comparison of the Efficacy and Safety of Erdafitinib vs Enfortumab Vedotin in Patients with Locally Advanced Metastatic Urothelial Carcinoma by Suzy Van Sanden, Ayman Youssef, Simona Baculea, Keith Stubbs, Spyros Triantos, Zijiao Yuan, Caitlin Daly

“…Individual patient data from THOR were adjusted to match published key eligibility criteria and average baseline characteristics of EV-301, such as Bellmunt risk score, liver or visceral metastases, primary site, among others. …”
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An Unusual Presentation of Glandular Fever by Dominic Worku, Li Hui Chang, Ian Blyth

“…Serum vitamin B12 and folate were low with serum ferritin raised (1027 µg/L) suggesting a proinflammatory state. Admission liver function tests, coeliac serology, autoimmune panel (ANA, ANCA, and anti-dsDNA), hepatitic (hepatitis A, B, and E), human immunodeficiency virus (HIV), toxoplasmosis, parvovirus, and CMV serology were normal. …”
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Dietary Zinc Requirement of Young Giant Gouramy (Osphronemus gouramy, Lac.) by Mia Setiawati, N.R. Azwar, I. Mokoginta, R. Affandi

“…The highest accumulation of the zinc in the liver occurred in 50 mg Zn/kg diets. There was increase in zinc content of the tissues after increasing levels of dietary zinc. …”
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The Assessment of Different Dietary Selenium Resources on Reproductive Performance, Spawning Indicators, and Larval Production of Red Tilapia (Oreochromis mossambicus × O. niloticu... by Mohammed A. E. Naiel, El-Sayed H. Eissa, Yasmin M. Abd El-Aziz, Saadea Saadony, Heba E. Abd Elnabi, Salah El-Sayed Sakr

“…The findings showed that female fish fed NPSe-enriched diets had significantly higher viscera, liver, and gonad weight than other experimental groups. …”
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The pattern of genetic diversity of different breeds of pigs based on microsatellite analysis by V. R. Kharzinova, N. A. Zinovieva

“…We analysed the polymorphism of microsatellites and the information on the state of genetic diversity and the population structure of local breeds in Russia: the Kemerovo, the Berkshire, the Liven, the Mangalitsa, and the Civilian; in the Republic of Belarus: the Large White and the Black-and-White; and in Ukraine: the White Steppe, as well as commercial breeds of imported origin of domestic reproduction: the Large White, the Landrace, and the Duroc. …”
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Efficacy and safety of tripterygium glycosides combined with ACEI/ARB on diabetic nephropathy: a meta-analysis by Zhuan’E. Yao, Zhuan’E. Yao, Pengbo Wang, Qinjuan Fu, Qiong Song, Haojian Xu, Peng Zhang

“…However, the side effects of the combined treatment group were higher than those of the control group, especially liver function damage, which also suggested that its safety in the treatment of diabetic nephropathy was worth considering. …”
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Cerrando brechas: género y competencias digitales en la formación inicial del profesorado para una ciudadanía digital igualitaria by Alba de la Cruz Redondo, Antonia García Luque

“…Con este trabajo, y en línea con lo recogido en los Objetivos de Desarrollo Sostenible 2030, se pretende reflexionar cómo, a pesar de contar con dispositivos y competencias digitales similares, existe una relación diferencial de género con el mundo online, lo que provoca oportunidades y dificultades diferentes en función de si eres hombre o mujer. …”
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Effects of dietary selenium nanoparticles, selenomethionine and sodium selenite on growth performance, levels of thyroid hormones and antioxidant status of rainbow trout, Oncorhync... by Fardin Shaluei, Somayeh Hadadi, Shafigh Shafiei, Hossein Rahimi, Mehrdad Fattollahi

“…The level of malondialdehyde in the liver of fish fed the diet containing sodium selenite was significantly lower than the other experimental treatments (p<0.05). …”
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RELATIONSHIPS BETWEEN LIPID PROFILE AND COMPLETE BLOOD CELL COUNT PARAMETERS by Yevhen Dzis, Oleksandra Tomashevska, Andriy Petrukh

“…An increase in the level of HDL-C leads to a decrease in the intensity of innate and adaptive immune responses. …”
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Clinical Usefulness of Bioavailable Vitamin D and Impact of GC Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population by Hyun-Young Kim, Jin Hyun Kim, Myeong Hee Jung, In Ae Cho, Youngjin Kim, Min-Chul Cho

“…The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). The role of genotyping of GC, a gene encoding VDBP, in the determination of bioavailable 25(OH)D concentration in a Korean population was also evaluated. …”
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First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies by Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag

“…Five patients experienced a severe (≥ grade 3) TRAE; neutropenia (n=2), febrile neutropenia (n=1), chest pain (n=1), increased liver enzymes (n=1), and leukopenia and thrombocytopenia (n=1). …”
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