Toxicity assessment of DMSO extracts of environmental aged beached plastics using human cell lines by Florane Le Bihanic, Bettie Cormier, Emilie Dassié, Sophie Lecomte, Justine Receveur, Stéphane Le Floch, Jérôme Cachot, Bénédicte Morin

“…Human colorectal adenocarcinoma Caco-2 and human hepatocyte carcinoma HepG2 cells were selected as model of the colon and liver cells respectively. They are known for their high capacity to metabolize organic contaminants. …”
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Digital Twin Technology in Resolving Polycystic Ovary Syndrome and Improving Metabolic Health: A Comprehensive Case Study by Paramesh Shamanna, MD, Anuj Maheshwari, MD, Ashok Keshavamurthy, MD, Sanjay Bhat, DM, Abhijit Kulkarni, DM, Shivakumar R, MD, Kumar K, MD, Mukulesh Gupta, MD, Mohamed Thajudeen, MD, Ranjita Kulkarni, MD, Shashikiran Patil, MD, Shashank Joshi, DM

“…Ultrasound showed reduced ovarian volume and improved fatty liver infiltration, while computed tomography scan revealed significant reductions in epicardial (21.8%), pericardial (69.9%), and visceral fat (44.4%). …”
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Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study by Keiji Fujimoto, Takatoshi Haraguchi, Sho Kumano, Keita Yamazaki, Nobuhiko Miyatake, Kanae Nomura, Kiyotaka Mukai, Kazuaki Okino, Norifumi Hayashi, Hiroki Adachi, Hitoshi Yokoyama, Yasuo Iida, Kengo Furuichi

“…Significant predictors for time to 40% reduction in the eGFR were as follows: an increase in the serum soluble urokinase plasminogen activator receptor (s-suPAR) 2 months after initiating IST (Δs-suPAR (2M); hazard ratio (HR) for every 500 pg/mL increase: 1.36, P=0.006), s-suPAR at 2 months after initiating IST (s-suPAR (2M); HR for every 500 pg/mL increase: 1.13, P=0.015), urinary protein-to-creatinine ratio (u-PCR) (u-PCR (2M); HR for every 1.0 g/gCr increase: 2.94, P=0.003), and urinary liver-type fatty acid-binding protein (u-L-FABP) (u-L-FABP (2M); HR for every 1.0 μg/gCr increase: 1.14, P=0.006). …”
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Beyond BRAFV600E: Investigating the Clinical and Genetic Spectrum of Langerhans Cell Histiocytosis in Children by Xue Tang, Ju Gao, Xia Guo, Zhi Wan, Jing‐jing Sun

“…Patients carrying the BRAF mutation in exon 15 had higher rates of liver involvement compared with patients carrying the exon 12 (p = 0.042). …”
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The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a... by Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Chaoyue Zheng, Yutian Cai, Yutian Cai, Xiang Xu, Xiang Xu, Conglu Zhao, Conglu Zhao, Hongting Liu, Hongting Liu, Yao Sun, Yao Sun, Zhilin Luo, Zhilin Luo, Shuwen Zhu, Shuwen Zhu, Honggang Zhou, Honggang Zhou, Xiaoyu Ai, Cheng Yang, Cheng Yang

“…Caco-2 cells was used to investigate the permeability of Deg-AZM and whether it is a potential substrate of the efflux transporter P-glycoprotein. Human liver microsome phenotyping assays with chemical inhibition and recombinant CYPs phenotyping assays were used to investigate the CYP450 enzyme phenotype involved in Deg-AZM metabolism in vitro. …”
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Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin by Bayazit Yunusbayev, Anna Bogdanova, Nadezhda Nadyrchenko, Lavrentii Danilov, Viktor Bogdanov, Grigory Sergeev, Radick Altinbaev, Fanil Bilalov, Milyausha Yunusbaeva

“…We next showed that these enriched species were correlated with elevated biomarkers of intestinal and systemic inflammation and liver function. Functionally, one of the top species, Megasphaera elsdenii, is a potent lactate utilizer in the context of intestinal lactic acidosis and inflammation. …”
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The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…To eliminate this pathogen, the development of novel vaccines targeting SE is imperative. Attenuated live vaccines are capable of eliciting robust immune protection against SE.MethodsIn this study, an mcpC gene deletion strain (ΔmcpC) was constructed by the wild strain C50336, to evaluate its potential as a genetically engineered attenuated live vaccine. …”
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Profil Ekspresi MikroRNA Kanker Payudara di Purwokerto by Ari Dwi Nurasih, Indah Sulistiyawati, Muhammad Falah

“…Kemudian dilakukan penghitungan dengan metode Livak untuk mengetahui mikroRNA yang mengalami peningkatan dan penurunan ekspresi yang signifikan. …”
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Los entornos sociodigitales como espacios para interpelar los discursos androcéntricos del patrimonio y construir aprendizajes coeducativos en la formación inicial del profesorado... by Laura Lucas Palacios, Ainhoa Resa Ocio

“…A modo de conclusión, se considera que el uso de las redes sociales para la formación inicial docente puede suponer una línea de investigación relevante para contribuir al diseño de un marco competencial coeducativo.…”
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Effects of Dietary Fish Meal Replaced by Fish Steak Meal on Growth Performance, Antioxidant Capacity, Intestinal Health and Microflora, Inflammatory Response, and Protein Metabolis... by Dianguang Zhang, Yunzong Zheng, Xuexi Wang, Dejuan Wang, Hongjie Luo, Wenbo Zhu, Weini Zhang, Zhengbang Chen, Jianchun Shao

“…The FSM75 and FSM100 diets significantly decreased enzyme activities of amylase (AMS), lipase (LPS), trypsin, catalase (CAT), and total superoxide dismutase (T-SOD) and the total antioxidant capacity (T-AOC), and increased the malondialdehyde (MDA) content in the liver of large yellow croaker. The mRNA expression levels of intestinal barrier and inflammatory response-related genes suggested that the FSM50, FSM75, and FSM100 diets significantly decreased the mRNA abundances of intestinal barrier-related genes and anti-inflammatory response-related genes, and increased the mRNA abundances of proinflammatory gene il-6 in the anterior intestine. …”
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Artrosis: ¿cambios degenerativos o cambios adaptativos? Consejos educativos breves en la consulta de atención primaria by Gema Izquierdo Enríquez, María Victoria García Espinosa, Isabel Prieto Checa, María Fernández de Paúl, Patricia Moreno Carrero, Silvia Fernanda García Vila

“…Además, no existen fármacos modificadores de la enfermedad ni un tratamiento curativo en el momento actual; siendo el tratamiento base o de primera línea el no farmacológico, basado en educación y ejercicio físico.La presencia de cambios degenerativos en las pruebas de imagen está presente en un porcentaje elevado de la población general asintomática, es decir, en aquellos que no tienen dolor ni limitación funcional; y que dicho porcentaje aumenta progresivamente con la edad. …”
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Association between dietary betaine intake and overweight or obesity by Maierheba Kuerbanjiang, Wenzhuo Yu, Ting Shang, Yuchen Liu, Dina Muheyati, Mei-Xia Lv, Muhairemu Jielili, Jia Han

“…Abstract Betaine exhibits significant physiological functions in organisms and has positive impacts on obesity, alcohol-induced and metabolic-associated liver disease, diabetes, cardiovascular diseases, and certain cancers. …”
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ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism by Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu

“…Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) have been implicated in the metabolism of fatty acids in the liver and skeletal muscles. However, their role in the heart in diabetes remains unclear. …”
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The role of partial splenic artery embolization in the management of refractory esophageal variceal bleeding due to portal vein thrombosis by Büşra Tetik Dinçer, Nafiye Urgancı, Aylin Hasanefendioğlu Bayrak, Özlem Durmaz, İlgin Özden

“…The general condition was moderate, and the skin appeared pale. The liver was palpable 2 cm, and the spleen was palpable 6 cm below the costal margin. …”
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Effectiveness of Oral Semaglutide in Management of Type 2 Diabetes: A Real-World Study from India by Aditya Dutta, Shama Mahendru, Rutuja Sharma, Ambrish Mithal

“…Reductions in BMI, glucose (fasting/post-prandial), lipids, liver enzymes and body composition parameters were significant. …”
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Association between triglyceride-glucose index and clinical outcomes among patients with chronic kidney disease: a meta-analysis by Jinli Tuo, Zhong Li, Linshen Xie

“…Secondary outcomes included the coronary artery disease (CAD) mortality, CKD progression, risk of severe coronary artery stenosis (SCAS), major adverse cardiovascular event (MACE), coronary artery calcification (CAC) progression, end-stage renal disease (ESRD), and nonalcoholic fatty liver disease (NAFLD). The hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were combined to assess the predictive role of TyG index for above clinical outcomes among CKD patients. …”
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The Association of Polycystic Ovary Syndrome and Gestational Hypertensive Disorders in a Diverse Community-Based Cohort by Diane Schneider, Joel R. Gonzalez, Miya Yamamoto, Jingrong Yang, Joan C. Lo

“…The development of PIH, including gestational hypertension, preeclampsia/eclampsia, or HELLP (hemolysis, elevated liver enzymes, and low platelet count), was ascertained by chart review. …”
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Nutritional and General Awareness of Vitamin D Status among Adult Population in Sulaymaniyah Governorate, Kurdistan Region, Iraq: A Cross-Sectional Study by Reder Rafiq Mohammed Salih, Fadhluddin Nasruddin Shakor, Dalia Ardal Ali, Rafiq Mohammed Salih Rashid

“…In addition, less than 10% of individuals attributed vitamin D shortage to kidney and liver problems, fat malabsorption, obesity, and bariatric surgery. …”
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PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…Gene expression changes were evaluated using RNA sequencing, and inflammatory responses in bone marrow-derived macrophages (BMDMs) were analyzed in vitro.ResultsPCSK9 was expressed in murine heart tissue at levels comparable to the liver, despite minimal heart RNA expression. PCSK9 KO mice had lower plasma cholesterol levels and showed reduced cardiac functions in the working heart model compared to WT mice. …”
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Effects of Algal-Derived β-Glucan on the Growth Performance, Intestinal Health, and Aeromonas veronii Resistance of Ricefield Eel (Monopterus albus) by Yu Guo, Zijing Yuan, Yueyun Han, Daiqin Yang, Hanwen Yuan, Fuxian Zhang

“…Moreover, the addition of 0.05%–0.2% β-glucan significantly improved the relative survival rate (SR) of A. veronii-infected eels and significantly decreased the bacterial load of the liver, spleen, and kidney (p<0.05). In comparison to eels that did not receive β-glucan supplementation, eels supplemented with 0.2% β-glucan exhibited decreased intestinal structural damage. …”
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