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  1. 24061

    Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology by Yule Hao, Jiawen Qi, Xinggui Huang, Chenhao Liu, Yi Liu

    Published 2025-01-01
    “…It also exhibits diverse toxicological properties and poses specific toxic risks to the liver, heart, and kidney. Nonetheless, research is scarce regarding the toxicology of EF, especially on its cardiotoxicity and nephrotoxicity. …”
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  2. 24062

    Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

    Published 2025-01-01
    “…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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  3. 24063

    Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1 by Cunru Zou, Yu Zhang, Chengyue Liu, Yaxin Li, Congjie Lin, Hao Chen, Jiangping Hou, Guojun Gao, Zheng Liu, Qiupeng Yan, Wenxia Su

    Published 2025-01-01
    “…Abstract Background Distant metastasis occurs in the majority of adrenocortical carcinoma (ACC), leading to an extremely poor prognosis. However, the key genes driving ACC metastasis remain unclear. …”
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  4. 24064

    Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection by Yong-yu Mei, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, Wen-xiong Xu

    Published 2020-01-01
    “…In patients with chronic hepatitis C and liver cirrhosis, sustained virological response 12 weeks after the end of treatment (SVR12) was 97.4% and 96.7%, respectively, and rapid virological response (RVR) was 75.0% and 57.1%, respectively. …”
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  5. 24065

    Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database by Peiyang Cao, Qian Wang, Yan Wang, Qing Qiao, Liyuan Yan

    Published 2025-01-01
    “…Additionally, uncommon but notable ADE signals were observed, such as renal cyst rupture, renal cyst infection, polycystic liver disease, and renal cyst hemorrhage. These several ADEs have not been referred to in the previous literature. …”
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  6. 24066

    Toxicity and antioxidant assessment of ethanol leaf extract of Hibiscus surattensis in Wistar rats: hepatotoxicity evaluation by Israel Kevin Umana, Tobechukwu Anthony Tochukwu, Enoluomen Ehigiator, Chinedu Joseph Ikem, Godswill James Udom, Akinyele Olubiyi Akinsola

    Published 2025-02-01
    “…Behavioural changes, haematological and liver function parameters, in-vivo oxidative stress markers and histological changes were then evaluated. …”
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  7. 24067

    Ontología del presente del ser maestro y ciberformación en docencia universitaria by Octavio Silvério de Souza Vieira Neto, Adriana Rocha Bruno

    Published 2025-01-01
    “…Los datos producidos y analizados en conversaciones en línea con veintinueve docentes que trabajan en educación superior en cursos de licenciatura en cuatro continentes, América, África, Europa y Asia, constituyeron tres Unidades Categóricas de Análisis de las prácticas discursivas docentes: virtualidad, intersubjetividad y ciberformacividad. …”
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  8. 24068

    Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice by Md Fahim Ahmed, Khalid Hasan Raby, Nishat Tasnim, Md Tariful Islam, Mahbub Chowdhury, Zarin Tasnim Juthi, Md Ashik Mia, Lubna Jahan, A.K.M. Zakir Hossain, Shoeb Ahmed

    Published 2025-01-01
    “…Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. In contrast, plant-derived natural antidiabetic bioactive compounds typically exhibit lower toxicity and fewer side effects and have been reported to aid effectively in diabetes management. …”
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  9. 24069

    Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden by R. Brüning, M. Tiede, M. Schneider, P. Wohlmuth, H. Weilert, K. Oldhafer, A. Stang

    Published 2020-01-01
    “…PHP-M for nonresectable LMUV provides a safe and locally efficient liver-directed procedure that offers patients a chance for long-term OS, especially for patients with a low hepatic tumor burden.…”
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  10. 24070

    Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk by Tjaša Hertiš Petek, Evgenija Homšak, Mateja Svetej, Nataša Marčun Varda

    Published 2024-12-01
    “…Fasting blood samples were obtained to assess C-reactive protein (CRP), leukocytes, myeloperoxidase (MPO), adiponectin, monocyte chemoattractant protein-1, superoxide dismutase-1, I-TAC/CXCL11, and a comprehensive cardiometabolic profile, including glucose, lipid, renal, liver, and thyroid function markers. Adiposity indices were determined using bioelectrical impedance analysis (BIA) and anthropometric measures, including BMI, waist-to-hip and waist-to-height ratios, and visceral and subcutaneous fat thickness. …”
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  11. 24071

    Gallbladder Carcinomas: An Immunoprognostic Evaluation of P53; Bcl-2; CEA and Alpha-Fetoprotein by R Kanthan, JM Radhi, SC Kanthan

    Published 2000-01-01
    “…The p53 gene is the most frequently mutated gene in many human cancers, including those of the colon, breast, lung, esophagus, liver and brain. Such genetically mutated tumours are generally associated with progression of the disease and poor clinical outcome. …”
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  12. 24072

    Hacia una Teoría de los modelos organizativos transcomplejos como aspiración socio-eco-planetaria by Ricardo Gil Otaiza, Consuelo Toba Igualada

    Published 2009-01-01
    “…Las organizaciones han estado ancladas a la concepción newtoniana-cartesiana del mundo: sus estructuras y el pensamiento de quienes las conforman han buscado sólo dar respuesta a los objetivos organizacionales desde el ángulo de lo establecido, sin preguntarse qué habrá más allá de esa línea divisoria de un mundo empresarial que se ha hecho endogámico, egoísta y filosóficamente inaceptable; en ese proceso se ha ido perdiendo la necesidad de establecer entre sus miembros y la comunidad una relación dialógica, que anhele la bidireccionalidad, el enriquecimiento de su talento humano; que permita dar el salto cualitativo a mayores cimas de humanismo y de productividad empresarial; para ello es perentorio el establecimiento de la denominada transcomplejidad, que permita levantar las bases de organizaciones efectivas, sólidas, proactivas y pertinentes; es por ello que para alcanzar la meta se planteó una investigación cualitativa, bajo la modalidad teórico-hermenéutica, que sirvió de base para la reflexión filosófica, epistemológica y para la interpretación de los fenómenos estudiados, de ello resultó la Teoría de los modelos organizativos transcomplejos como aspiración socio-eco-planetaria, que podría abrir la posibilidad de nuevos espacios para la reflexión y la comprensión del hecho organizacional, así como para el cambio paradigmático en el pensamiento del talento humano, porque sólo así se erigirá el ámbito ideal en donde lo humano no esté en discrepancia con lo meramente maquinal, sino que produzca la sinergia, la sumatoria exponencial de los esfuerzos, así como organizaciones verdaderamente interrelacionadas en la búsqueda del crecimiento compartido.…”
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  13. 24073

    Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

    Published 2023-01-01
    “…After a median follow-up time of 29.7 months, patients with higher burden of skin, endocrine and musculoskeletal irAEs (the latter two’s effect was confirmed at multivariable analysis) had longer overall survival (OS), as opposed to gastrointestinal, pneumonitis, neurological, liver, renal and other irAEs, which showed an harmful effect. …”
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  14. 24074

    Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

    Published 2025-01-01
    “…Further analysis of this repurposed drug showed that norfluoxetine, a long-lasting metabolite of fluoxetine which is produced in the liver and accumulates in the brain, was more effective than fluoxetine itself in selectively inhibiting the dominant pathogenic channel activity of the pathogenic allele. …”
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  15. 24075

    Appropriate dietary phosphorus levels promote growth performance, mineral retention, and hepatic lipid metabolism in juvenile American eels (Anguilla rostrata) by Yichuang Xu, Shuo Wang, Xinyu Hu, Pan Wang, Xiaozhao Han, Jinyue Yang, Ying Liang, Shaowei Zhai

    Published 2025-04-01
    “…Lipidomic analysis indicated that, compared to eels fed diets containing 0.52 % Pi, autophagy, glycerophospholipid metabolism, glycosylphosphatidylinositol metabolism, α-linolenic acid metabolism, and arachidonic acid metabolism were enhanced in the liver of those fed diets with 1.31 % Pi. The quadratic regression analysis of weight gain rate, feed efficiency, and Pi retention against the dietary Pi levels indicated optimal dietary Pi levels for American eels range from 1.31 % to 1.40 %. …”
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  16. 24076

    Eficacia de un programa grupal, online sincrónico de salud y bienestar para personas que trabajan con jóvenes y adultos con discapacidad intelectual by Flavia Arrigoni, Mara Abraham, Ivana Polo

    Published 2021-12-01
    “…Los hallazgos permiten concluir que participar en un programa de promoción de la salud en formato grupal en línea sincrónico resultó eficaz para incrementar el bienestar y la salud de los trabajadores. …”
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  17. 24077
  18. 24078

    Effects of lifetime feeding of hydrolyzed yeast to broiler breeders on egg production, quality, and hatchling attributes by Anderson N. Maina, Hagen Schulze, Elijah G. Kiarie

    Published 2025-02-01
    “…Two hens per pen were necropsied at 44 and 64 woa for breast, abdominal fat and liver weights. There were no (P>0.05) interactions between diet and BB age or the diet effects on response criteria. …”
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  19. 24079

    Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma by Shu-Min Lian, Hong-Jing Cheng, Hong-Jing Li, Hui Wang

    Published 2025-01-01
    “…ObjectiveTo predict the degree of pathological differentiation of hepatocellular carcinoma (HCC) by quantitative analysis the correlation between the perfusion parameters of contrast-enhanced ultrasound (CEUS) and the pathological grades of HCC using VueBox® software.MethodsWe enrolled 189 patients who underwent CEUS and liver biopsy at our hospital from July 2019 to September 2024 and were pathologically confirmed with primary HCC. …”
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  20. 24080

    Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

    Published 2025-01-01
    “…The VHA Corporate Data Warehouse was queried to identify Veterans with possible undiagnosed cirrhosis using Fibrosis-4 (FIB-4) ≥ 3.25 and at least one risk factor for liver disease (e.g., obesity), and generate an age-stratified sample. …”
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