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24061
Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology
Published 2025-01-01“…It also exhibits diverse toxicological properties and poses specific toxic risks to the liver, heart, and kidney. Nonetheless, research is scarce regarding the toxicology of EF, especially on its cardiotoxicity and nephrotoxicity. …”
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24062
Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand
Published 2025-01-01“…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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24063
Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1
Published 2025-01-01“…Abstract Background Distant metastasis occurs in the majority of adrenocortical carcinoma (ACC), leading to an extremely poor prognosis. However, the key genes driving ACC metastasis remain unclear. …”
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24064
Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection
Published 2020-01-01“…In patients with chronic hepatitis C and liver cirrhosis, sustained virological response 12 weeks after the end of treatment (SVR12) was 97.4% and 96.7%, respectively, and rapid virological response (RVR) was 75.0% and 57.1%, respectively. …”
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24065
Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database
Published 2025-01-01“…Additionally, uncommon but notable ADE signals were observed, such as renal cyst rupture, renal cyst infection, polycystic liver disease, and renal cyst hemorrhage. These several ADEs have not been referred to in the previous literature. …”
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24066
Toxicity and antioxidant assessment of ethanol leaf extract of Hibiscus surattensis in Wistar rats: hepatotoxicity evaluation
Published 2025-02-01“…Behavioural changes, haematological and liver function parameters, in-vivo oxidative stress markers and histological changes were then evaluated. …”
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24067
Ontología del presente del ser maestro y ciberformación en docencia universitaria
Published 2025-01-01“…Los datos producidos y analizados en conversaciones en línea con veintinueve docentes que trabajan en educación superior en cursos de licenciatura en cuatro continentes, América, África, Europa y Asia, constituyeron tres Unidades Categóricas de Análisis de las prácticas discursivas docentes: virtualidad, intersubjetividad y ciberformacividad. …”
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24068
Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice
Published 2025-01-01“…Synthetic antidiabetic drugs are often associated with various adverse side effects, including hypoglycemia, nausea, gastrointestinal disturbances, headaches, and even liver damage. In contrast, plant-derived natural antidiabetic bioactive compounds typically exhibit lower toxicity and fewer side effects and have been reported to aid effectively in diabetes management. …”
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24069
Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden
Published 2020-01-01“…PHP-M for nonresectable LMUV provides a safe and locally efficient liver-directed procedure that offers patients a chance for long-term OS, especially for patients with a low hepatic tumor burden.…”
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24070
Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk
Published 2024-12-01“…Fasting blood samples were obtained to assess C-reactive protein (CRP), leukocytes, myeloperoxidase (MPO), adiponectin, monocyte chemoattractant protein-1, superoxide dismutase-1, I-TAC/CXCL11, and a comprehensive cardiometabolic profile, including glucose, lipid, renal, liver, and thyroid function markers. Adiposity indices were determined using bioelectrical impedance analysis (BIA) and anthropometric measures, including BMI, waist-to-hip and waist-to-height ratios, and visceral and subcutaneous fat thickness. …”
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24071
Gallbladder Carcinomas: An Immunoprognostic Evaluation of P53; Bcl-2; CEA and Alpha-Fetoprotein
Published 2000-01-01“…The p53 gene is the most frequently mutated gene in many human cancers, including those of the colon, breast, lung, esophagus, liver and brain. Such genetically mutated tumours are generally associated with progression of the disease and poor clinical outcome. …”
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24072
Hacia una Teoría de los modelos organizativos transcomplejos como aspiración socio-eco-planetaria
Published 2009-01-01“…Las organizaciones han estado ancladas a la concepción newtoniana-cartesiana del mundo: sus estructuras y el pensamiento de quienes las conforman han buscado sólo dar respuesta a los objetivos organizacionales desde el ángulo de lo establecido, sin preguntarse qué habrá más allá de esa línea divisoria de un mundo empresarial que se ha hecho endogámico, egoísta y filosóficamente inaceptable; en ese proceso se ha ido perdiendo la necesidad de establecer entre sus miembros y la comunidad una relación dialógica, que anhele la bidireccionalidad, el enriquecimiento de su talento humano; que permita dar el salto cualitativo a mayores cimas de humanismo y de productividad empresarial; para ello es perentorio el establecimiento de la denominada transcomplejidad, que permita levantar las bases de organizaciones efectivas, sólidas, proactivas y pertinentes; es por ello que para alcanzar la meta se planteó una investigación cualitativa, bajo la modalidad teórico-hermenéutica, que sirvió de base para la reflexión filosófica, epistemológica y para la interpretación de los fenómenos estudiados, de ello resultó la Teoría de los modelos organizativos transcomplejos como aspiración socio-eco-planetaria, que podría abrir la posibilidad de nuevos espacios para la reflexión y la comprensión del hecho organizacional, así como para el cambio paradigmático en el pensamiento del talento humano, porque sólo así se erigirá el ámbito ideal en donde lo humano no esté en discrepancia con lo meramente maquinal, sino que produzca la sinergia, la sumatoria exponencial de los esfuerzos, así como organizaciones verdaderamente interrelacionadas en la búsqueda del crecimiento compartido.…”
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24073
Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer
Published 2023-01-01“…After a median follow-up time of 29.7 months, patients with higher burden of skin, endocrine and musculoskeletal irAEs (the latter two’s effect was confirmed at multivariable analysis) had longer overall survival (OS), as opposed to gastrointestinal, pneumonitis, neurological, liver, renal and other irAEs, which showed an harmful effect. …”
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24074
Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy
Published 2025-01-01“…Further analysis of this repurposed drug showed that norfluoxetine, a long-lasting metabolite of fluoxetine which is produced in the liver and accumulates in the brain, was more effective than fluoxetine itself in selectively inhibiting the dominant pathogenic channel activity of the pathogenic allele. …”
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24075
Appropriate dietary phosphorus levels promote growth performance, mineral retention, and hepatic lipid metabolism in juvenile American eels (Anguilla rostrata)
Published 2025-04-01“…Lipidomic analysis indicated that, compared to eels fed diets containing 0.52 % Pi, autophagy, glycerophospholipid metabolism, glycosylphosphatidylinositol metabolism, α-linolenic acid metabolism, and arachidonic acid metabolism were enhanced in the liver of those fed diets with 1.31 % Pi. The quadratic regression analysis of weight gain rate, feed efficiency, and Pi retention against the dietary Pi levels indicated optimal dietary Pi levels for American eels range from 1.31 % to 1.40 %. …”
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24076
Eficacia de un programa grupal, online sincrónico de salud y bienestar para personas que trabajan con jóvenes y adultos con discapacidad intelectual
Published 2021-12-01“…Los hallazgos permiten concluir que participar en un programa de promoción de la salud en formato grupal en línea sincrónico resultó eficaz para incrementar el bienestar y la salud de los trabajadores. …”
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24077
In vivo imaging and pharmacokinetics of percutaneously injected ultrasound and X-ray imageable thermosensitive hydrogel loaded with doxorubicin versus free drug in swine.
Published 2024-01-01“…Intratumoral injections often lack visibility, leading to unpredictable outcomes such as incomplete tumor coverage, off-target drug delivery and systemic toxicities. …”
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24078
Effects of lifetime feeding of hydrolyzed yeast to broiler breeders on egg production, quality, and hatchling attributes
Published 2025-02-01“…Two hens per pen were necropsied at 44 and 64 woa for breast, abdominal fat and liver weights. There were no (P>0.05) interactions between diet and BB age or the diet effects on response criteria. …”
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24079
Construction of nomogram model based on contrast-enhanced ultrasound parameters to predict the degree of pathological differentiation of hepatocellular carcinoma
Published 2025-01-01“…ObjectiveTo predict the degree of pathological differentiation of hepatocellular carcinoma (HCC) by quantitative analysis the correlation between the perfusion parameters of contrast-enhanced ultrasound (CEUS) and the pathological grades of HCC using VueBox® software.MethodsWe enrolled 189 patients who underwent CEUS and liver biopsy at our hospital from July 2019 to September 2024 and were pathologically confirmed with primary HCC. …”
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24080
Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach
Published 2025-01-01“…The VHA Corporate Data Warehouse was queried to identify Veterans with possible undiagnosed cirrhosis using Fibrosis-4 (FIB-4) ≥ 3.25 and at least one risk factor for liver disease (e.g., obesity), and generate an age-stratified sample. …”
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