Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. …”
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Features of diagnosis and treatment of gastrointestinal stromal tumors by N. I. Bogomolov, T. V. Burdinskaya, M. A. Goncharova, A. G. Goncharov, N. N. Tomskikh

“…Retroperitoneal location of the GIST was revealed in 3 (2,5%) patients, pancreatic - in 2 (1,7%), liver - in 1 (0,8%) patient. The tumor was complicated by development of gastro-intestinal bleeding in 51 (44,8%) patients, in 3 cases (2,5%) it was lethal. …”
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Radiocobalt-Labeling of a Polypyridylamine Chelate Conjugated to GE11 for EGFR-Targeted Theranostics by Lorraine Gaenaelle Gé, Mathias Bogetoft Danielsen, Aaraby Yoheswaran Nielsen, Mathias Lander Skavenborg, Niels Langkjær, Helge Thisgaard, Christine J. McKenzie

“…Disappointingly, no tumor uptake was observed in EGFR-positive tumor-bearing mice, with most activity being accumulated predominantly in the liver, gall bladder, kidneys, and spleen. Some bone uptake was also observed, suggesting in vivo dissociation of ⁵⁷Co from the complex. …”
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HYPERTENSION THERAPY USING ACUPUNCTURE AND HERBALS OF LEDS AND CARROTS by Ulfa Nur Khasanah, Ario Imandiri, Myrna Adianti

“…Acupuncture therapy was carried out at Fengchi (GB20), Taichong (LR3), Hegu (LI4) points with the principle of liver fire sedation and Xuehai (SP10) and Chize (LU5) with the tonification principle. …”
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Prevalence of Hepatitis C Virus Infection in a Surgical Population of Southeast China: A Large-Scale Multicenter Study by Ping Chen, Yang Zheng, Yubo Cai, Pengfei Zou, Nan Li, Conggao Peng, Hainv Gao, Jimin Liu, Yongping Chen, Zhaowei Tong, Lanjuan Li

“…Chronic HCV infection affects 80 million people globally and may progress to advanced liver disease. The present study aims to investigate the present epidemiology of HCV infection in a southeastern Chinese surgical patient cohort. …”
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A Comparative Study of the Effect of Including Full-Fat <i>Tenebrio molitor</i> for Replacing Conventional Ingredients in Practical Diets for <i>Dicentrarchus labrax</i> Juveniles by Sara Flores-Moreno, Francisco Javier Alarcón-López, Antonio J. Coronel-Domínguez, Eugenia Zuasti, Ismael Hachero-Cruzado

“…In general, the diets containing TM modulated the lipid profile in fish tissues by reducing the liver lipid content and muscle triglycerides and increasing the n-3/n-6 ratio compared to the CT diet. …”
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Monitoring Guidelines for Home and Outpatient Parenteral Antibiotic Therapy by Alain Y Martel

“…Other considerations for HIVAT include renal impairment, liver failure and hematological toxicities. These factors have led the author and colleagues to develop specific monitoring recommendations and techniques.…”
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NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity by Rui Ma, Zhenlong Li, Hejun Tang, Xiaojin Wu, Lei Tian, Zahir Shah, Ningyuan Liu, Tasha Barr, Jianying Zhang, Sean Wang, Srividya Swaminathan, Guido Marcucci, Yong Peng, Michael A. Caligiuri, Jianhua Yu

“…Here, we show that NKp46 is indispensable for expressing IL-2 receptor-α (IL-2Rα) by non-NK liver-resident type-1 innate lymphoid cells (ILC1s). …”
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Outcomes of the toxic hepatites caused by alcohol surrogates by I. Yu. Pirogova, I. Yu. Ponomareva, S. P. Sinitsyn, Ye. P. Samokhina, A. S. Gorbunova, Ye. Yu. Startseva, V. S. Chulkov, T. F. Kondrat'yeva

“…Within the first month of disease 16 (20%) patients died of liver failure, during following period – 13 patients (19%). …”
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Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings by Se Jun Park, Kabsoo Shin, In-Ho Kim, MyungAh Lee, Tae Ho Hong, Hyunho Kim

“…Nearly all patients (97.9%) had extrahepatic metastasis and stable liver function, with three-quarters previously treated with sorafenib. …”
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Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). …”
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Alteration of Plasma Amino Acid Concentrations in Iranian Children with COVID-19 by Sedigheh Shams, Aileen Azari-Yam, Moeinadin Safavi, Zahra Zamani, Maryam Sotoudeh-Anvari, Meisam Sharifzadeh Ekbatani, Mohammad-Taghi Haghi-Ashtiani, Fatemeh Mozafari, Bahareh Yaghmaie, Leila Shafeghat

“…There was a positive and significant relationship between some amino acids levels, serum liver enzymes, and sodium concentrations. There was also a significant but negative correlation between histidine levels, ESR, and ferritin. …”
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Egg quality evaluation of japanese quail (Coturnix coturnix japonica) supplemented with powdered leaves of jute mallow (Corchorus olitorius) and siam weed (Chromolaena odorata) by Gemma M Guigue, Alejandro Jr B Dianon, Decem Mary Joice D Tolero

“…Additionally, the supplementation stimulates the digestive system, enhancing digestive enzyme production and feed utilization efficiency by improving liver function, as supported by [7]. Using such natural feed additives aligns with sustainable agricultural practices, offering a practical and environmentally friendly solution for improving specific aspects of egg quality, particularly yolk pigmentation, in laying quails.…”
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New insights into the effects of Aspergillus oryzae administration during the transition period in Bubalus bubalis by Sameh A. Abdelnour, Walaa M. Essawi, Nasser Ghanem, Ibrahim T. El-Ratel, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Ahmed N. F. Neamat-Allah, Shimaa A. Amer, Simon J. Davies, Ali Ali El-Raghi

“…ASG treatment significantly improved liver and kidney functions. The concentration of haptoglobin, tumour necrosis factor-alpha (TNF-α), and Malondialdehyde (MDA) was significantly lower in the treated group (4.42 mg/dl, 68.89 pg/ml, 3.46 nmol, respectively) than in the control group (8.29 mg/dl, 83 pg/ml, 6.23 nmol, respectively). …”
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Evaluation of Tissue Tropism and Horizontal Transmission of a Duck Enteritis Virus Vectored Vaccine in One-Day-Old Chicken by Yassin Abdulrahim, Yingying You, Linggou Wang, Zhixiang Bi, Lihua Xie, Saisai Chen, Benedikt B. Kaufer, Armando Mario Damiani, Kehe Huang, Jichun Wang

“…Gross and/or histological lesions were recorded in the kidney, heart, intestine, liver, lung, and spleen. Moreover, DEV-H5 replication in intestinal cells caused an increment in interferon-α expression, while occluding junction proteins and ZO-1 expression were significantly upregulated. …”
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An Injectable Oil-Based Depot Formulation of <i>N</i>-Acyloxymethyl Prodrug of Ropivacaine for Long-Acting Local Analgesia: Formulation Development and In Vitro/In Vivo Evaluation by Xiaowei Liu, Ruihan Zhao, Peijie Xu, Jianqiang Qian, Peiyan Zhang, Xudong Xie, Yong Ling, Qimin Ge, Yong Chen

“…The high Log P value of ROP-ST (9.16) demonstrated extremely low aqueous solubility, but the prodrug is biolabile when in contact with plasma or liver esterase. Intramuscular injection of ROP-ST oil solution in rats provided a significantly higher mean residence time without a very clear plasma peak of ROP. …”
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Entrevista a Marina Garzón by Johan Nicolás Molina Córdoba

“…Docente investigadora del Departamento de Física de la Universidad Pedagógica Nacional, en el cual coordina la línea de profundización: La Actividad Experimental para la Enseñanza de la Física. …”
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PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first‐pass metabolism? by Justine Henriot, André Dallmann, François Dupuis, Jérémy Perrier, Sebastian Frechen

“…To this end, a systematic review of the absolute CYP3A expression in the human gastrointestinal tract and liver was conducted. The resulting CYP3A4 expression profile and two previously published profiles were applied to PBPK models of seven CYP3A4 substrates (alfentanil, alprazolam, felodipine, midazolam, sildenafil, triazolam, and verapamil) built‐in PK‐Sim®. …”
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Diagnóstico y tratamiento de los feocromocitomas y paragangliomas by Jorge Luis Soriano Lorenzo

“…El 70 % son esporádicos y un 30 % están asociados a síndromes genéticos familiares con mutaciones en la línea germinal de genes como: NF1, VHL, RET y SDHx. …”
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The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism by Yu Hu, Hongyan Zai, Wei Jiang, Zhenglin Ou, Yuanbing Yao, Qin Zhu

“…Hepatoblastoma (HB) is the most common liver malignancy in pediatrics, but the treatment for this disease is minimal. …”
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