A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…Here, we propose a covalent chimeric peptide-based targeted degradation platform (Pep-TACs) by introducing a long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking upon binding with the protein of interest. …”
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The Dominant Role of the Water Column in Nitrogen Removal and N2O Emissions in Large Rivers by Junfeng Wang, Xinghui Xia, Shaoda Liu, Sibo Zhang, Ling Zhang, Chenrun Jiang, Zhenrui Zhang, Yuan Xin, Xin Chen, Jing Huang, Jiaao Bao, William H. McDowell, Greg Michalski, Zhifeng Yang, Jun Xia

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Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma by Yuxuan Zhang, Jie Liu, Yunzhao Mo, Zetao Chen, Taoliang Chen, Yan Li, Yaofeng Zheng, Shaokang Deng, Xiangdong Xu, Huajian Chen, Haoqi He, Jiansheng Chen, Tao Jin, Xinlin Sun, Yiquan Ke, Jihui Wang

“…The cell membranes of im-MSCs were taken up by glioma cells and targeted in situ gliomas in vivo, suggesting that im-MSCs and their plasma membranes can be used as natural drug carriers for targeting gliomas, and providing a safe, adequate, quality-controlled, and continuous source for the treatment of gliomas based on whole-cell or cell membrane carriers.…”
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Protocol for a nested case-control study: identifying neuroimaging biomarkers for the progression of subclinical depression and qi-stagnation constitution to major depressive disor... by Jing Wang, Chengfeng Zhang, Yueqi Zhang, Yuanyuan Liu, Jingli Zhang, Xingwei Fang, Wangyang Xia, Yanzhao Xie, Zhongli Lan, Jinhui Wang, Jinhui Wang, Jinhui Wang, Jinhui Wang, Min Lu, Jun Chen, Jun Chen

“…Specifically, MDD in adolescents is linked to an elevated suicide risk. Thus, early identification and intervention is crucial for adolescents at high risk for developing MDD. …”
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Cross-sectional association between plasma aldosterone concentration and cognitive performance by mini-mental state examination in community dwellers by Aketilieke Nusufujiang, Mulalibieke Heizhati, Nanfang Li, Ling Yao, Wenbo Yang, Hui Wang, Mei Li, Lin Gan, Adalaiti Maitituersun, Miaomiao Liu, Qiaolifanayi Nuermaimaiti, Li Cai, Xiayire Aierken, Xiufang Li, Qin Luo, Jing Hong

“…Subgroup analyses also were performed by age, gender, BMI, living region, ethnicity and education attainment status.Results27,707 subjects were included, of whom, 12,862 were apparently healthy and 14,845 had disease. …”
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Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…Patients who achieved a partial response were significantly more likely to have an abscopal effect( P = 0.025). The group with a lower baseline neutrophil–lymphocyte ratio had a significantly lower risks of distant metastasis and death( P = 0.024). …”
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Three-dimensional quantitative temporomandibular joint changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed o... by Majedh Abdo Ali Al-Somairi, Bowen Zheng, Xaiofeng Yang, Yongxin Zhang, Maged S. Alhammadi, Hao xu, Najah Alhashimi, Bushra Sufyan Almaqrami, Naseem Ali Al –Worafi, Enas Senan Alyafrusee, Barakat Al-Tayar, Yi Liu

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Study on improving yield and antioxidant enzyme activities in millet by rationing molybdenum and nitrogen by Yuan Zhao, Guoliang Wang, Min Liu, HongTao Xue, PeiYue Zhao, BaiShu Han, HuiPing Fan, Rui Wang, LiXia Wang, ErHu Guo, AiYing Zhang, AiYing Zhang

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Longitudinal analysis of lifestyle risk factors, nutrition status and drivers of food choice among urban migrants in Ulaanbaatar, Mongolia, and Almaty, Kazakhstan: a formative stud... by Sabri Bromage, Shamil Tazhibayev, Xin Zhou, Chang Liu, Enkhtsetseg Tserenkhuu, Oksana Dolmatova, Munkhbat Khishignemekh, Leyla Musurepova, Wusigale, Soninkhishig Tsolmon, Enkhjargal Tsendjav, Davaasambuu Enkhmaa, Rajesh Kumar Rai, Bayarmaa Enkhbat, Bilige Menghe, Davaasambuu Ganmaa

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Fire-driven disruptions of global soil biochemical relationships by Guiyao Zhou, Nico Eisenhauer, Zhenggang Du, Manuel Esteban Lucas-Borja, Kaiyan Zhai, Miguel Berdugo, Huimin Duan, Han Wu, Shengen Liu, Daniel Revillini, Tadeo Sáez-Sandino, Hua Chai, Xuhui Zhou, Manuel Delgado-Baquerizo

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Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. …”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

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Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites by Yexun Zhou, Yexun Zhou, Liang Chen, Hui Han, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao, Hongfu Zhang

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Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

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Nonviral targeted mRNA delivery: principles, progresses, and challenges by Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song

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Traditional Chinese Medicine nursing of a patient with type 2 diabetes complicated with hypertension (1例2型糖尿病合并高血压患者的中医特色护理体会) by ZHANG Ji (张继), LIU Ai (刘爱), ZHANG Min (张敏), ZHAO Lina (赵丽娜), MING Yue (明月), ZUO Lin (左琳), FENG Ying (冯莹), ZHAO Zitong (赵紫彤)

“…On the basis of western medicine treatment, the intervention was carried out in combination with Traditional Chinese Medicine nursing techniques such as auricular acupoint pressing pills, acupoint application, and Traditional Chinese medicine cream and rubbing, which fully played the characteristics and advantages of Traditional Chinese Medicine technology, effectively controlled the patient's blood pressure and blood glucose, and improve the patient's quality of life. (本文总结1例2型糖尿病合并高血压患者的中医特色护理经验。基于护理评估和中医辨证, 在病情监测、饮食指导、药物管理等常规干预基础上, 配合耳穴压丸、穴位贴敷、中药膏摩等中医护理技术进行干预, 有效控制患者血压、血糖, 提高患者生活质量。)…”
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Higher Serum Uric Acid Is Associated with Higher Bone Mineral Density in Chinese Men with Type 2 Diabetes Mellitus by Dian-dian Zhao, Pei-lin Jiao, Jing-jia Yu, Xiao-jing Wang, Lin Zhao, Yan Xuan, Li-hao Sun, Bei Tao, Wei-qing Wang, Guang Ning, Jian-min Liu, Hong-yan Zhao

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Gender differences in early posttraumatic stress disorder symptoms: a network analysis by Line Rønning, Rachel L. Zelkowitz, Marilyn L. Piccirillo, Jianlin Liu, Jordan L. Thomas, Jessy Guler, J. Joana Kyei, Chris M. Hoeboer, Jeanet F. Karchoud, Miranda Olff, Anke B. Witteveen, Mirjam van Zuiden

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Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…This study investigated the tissue-specific expression patterns of the heat shock protein genes hsp70, hsp90, and hsp90b in L. vannamei under low-temperature stress, and their correlation with cold tolerance. Fluorescence in situ hybridization revealed widespread expression of hsp70, hsp90, and hsp90b in the nucleus and cytoplasm of hepatopancreatic tubular cells. …”
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Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization by Hang Xian, Huan Guo, Yuan-Ying Liu, Sui-Bin Ma, Rui Zhao, Jian-Lei Zhang, Hang Zhang, Rou-Gang Xie, Xu-Cheng Guo, Jie Ren, Sheng-Xi Wu, Ceng Luo, Rui Cong

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