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An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice
Published 2020-01-01Get full text
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14383
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Published 2022-03-01“…The second-generation CAR-T cells engineered from 2D2 specifically recognized and eliminated A2+/NY-ESO-1+tumor cells in vitro, inhibited tumor growth, and prolonged the overall survival of mice in TNBC and primary melanoma tumor model in vivo.Conclusions This study showed the specificity of the antibody identified from human scFv phage library and demonstrated the potential antitumor activity by TCR-like CAR-T cells both in vitro and in vivo, warranting further preclinical and clinical evaluation of the TCR-like antibody in patients. …”
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Prognostic prediction for inflammatory breast cancer patients using random survival forest modeling
Published 2025-02-01“…Background: Inflammatory breast cancer (IBC) is an aggressive and rare phenotype of breast cancer, which has a poor prognosis. …”
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Tear glucose is associated with the presence and severity of diabetic retinopathy
Published 2025-02-01Get full text
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14391
Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells
Published 2021-01-01Get full text
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Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications
Published 2025-01-01Get full text
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia
Published 2025-01-01“…Compared with healthy controls (HC; n = 59), voxel-based and brain-wide volumetric changes and their associations with stressful life events (SLE) were tested. These stratified associations were validated using two large population-based cohorts (the ABCD study; n = 1680, 11.92 ± 0.62 years; and UK Biobank, n = 20547, 55.38 ± 7.43 years). …”
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Joint effect of modifiable risk factors on Parkinson’s disease: a large-scale longitudinal study
Published 2025-01-01“…A broad exposure association study was conducted across seven domains: socioeconomic status, medical history, psychosocial factors, physical measures, early life, local environment, and lifestyle. Risk scores of each domain for each participant were generated. …”
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NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation
Published 2025-02-01“…The sensitivity is elevated to attomolar levels through the action of Pyrococcus furiosus Argonaute (PfAgo), which intensifies probe cleavage, thereby boosting both sensitivity and specificity within an innovative in-situ cascade circuit. This technology not only streamlines rapid, onsite diagnostics without pre-amplification but also demonstrates exceptional accuracy in identifying a broad spectrum of nucleic acids and crucial cancer-related protein biomarkers directly from clinical samples. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model
Published 2023-01-01“…We here show that exposure to HDM and CDE elicits asthma-like histopathology in guinea pigs with infiltration of inflammatory cells, airway remodelling, and accumulation of primarily mucosal mast cells. …”
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