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VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment
Published 2025-01-01“…Mechanistically, VCP stabilizes the expression of glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L), leading to the accumulation of glycerol-3-phosphate (G3P), a downstream metabolite of GPD1L. …”
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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed...
Published 2025-01-01“…Upon exposure to low-intensity pulsed ultrasound (LIPUS) stimulation, the NPs underwent a phase transformation to form microbubbles with substantial molecular ultrasound diagnostic effects, and combined treatment resulted in a tumor growth inhibition rate of 88.91%. …”
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Exogenous Interleukin-37 Alleviates Hepatitis with Reduced Dendritic Cells and Induced Regulatory T Cells in Acute Murine Cytomegalovirus Infection
Published 2023-01-01“…The present study suggested that exogenous IL-37 can alleviate MCMV-infected hepatitis, likely through reduced DCs and induced Tregs with a weaker cytokine storm, demonstrating its potential value in clinical management for HCMV-infected hepatitis.…”
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Surgical Challenges in Multi-Vessel Minimally Invasive Coronary Artery Bypass Grafting
Published 2021-01-01“…Surgical challenges encountered during this procedure may increase the operative duration, intraoperative blood loss, ICU admission, and the duration of postoperative hospitalization. …”
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Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach
Published 2025-01-01“…Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS. …”
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Review—Recent Progress in Materials Development for Electrochemical Gas Sensors
Published 2025-01-01“…In addition to the materials aspect, we also cover many advanced electrochemical techniques, including electrode design enhancements, surface functionalization strategies, and innovative electrolytes like ionic liquids and polymer electrolytes. Overall, this comprehensive overview of state-of-the-art developments in electrochemical gas sensing highlights the potential for transformative applications across diverse fields and emphasizes the importance of interdisciplinary collaboration to drive future innovations.…”
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NUDT21 regulates lysyl oxidase-like 2(LOXL2) to influence ECM protein cross-linking in silica-induced pulmonary fibrosis
Published 2025-01-01Subjects: Get full text
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