Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…JiangFei Zhou,1,* SongSong Jiao,1,* Jian Huang,2,* TianMing Dai,3,* YangYang Xu,1,* Dong Xia,4,* ZhenCheng Feng,1 JunJie Chen,1 ZhiWu Li,5 LiQiong Hu,4 QingQi Meng1,3 1Department of Orthopedics, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 4Critical Care Medicine Department, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 5Department of Orthopedics, the 2nd People’s Hospital of Bijie, Guizhou, 551700, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiQiong Hu; QingQi Meng, Email 13929526981@163.com; mengqingqi@jnu.edu.cnBackground: Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. …”
Get full text

Long non-coding RNA Malat1 modulates CXCR4 expression to regulate the interaction between induced neural stem cells and microglia following closed head injury by Qin Dong, Pengyu Chen, Wenqiao Qiu, Zhijun Yang, Yanteng Li, Yuhui Zhou, Lili Guo, Dan Zou, Ruxiang Xu, Mou Gao

Get full text

Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment by Li G, He F, Feng J, Xu G, Wu C, Qiao Y, Liu Y, Chen H, Du P, Wang J

“…Guangjie Li,1,2,* Fei He,2,* Jianbao Feng,3 Ge Xu,1 Chengye Wu,1 Yufei Qiao,1 Yang Liu,3 Hanlin Chen,1 Pengcheng Du,4 Jizeng Wang2 1The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 3Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 4College of Chemistry and Chemical Engineering, Lanzhou University, Gansu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jizeng Wang, Email jzwang@lzu.edu.cnBackground: Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. …”
Get full text

Effects of virtual reality technology on early mobility in critically ill adult patients: a systematic review and meta-analysis by Yansha He, Yansha He, Qin Yang, Xiaoxia Dai, Tian Chen, Huan Wu, Kunjie Li, Shiqiong Zhu, Yanlin Liu, Hua Lei

Get full text

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic Opportunities by Liu C, Yin Q, Wu Z, Li W, Huang J, Chen B, Yang Y, Zheng X, Zeng L, Wang J

“…Chunyan Liu,1,* Qinan Yin,2,3,* Zhaoying Wu,1 Wenhui Li,1 Jun Huang,1 Bo Chen,1 Yanjun Yang,1 Xuewei Zheng,3 Li Zeng,3 Jingjing Wang3 1Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Radiation Oncology, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, People’s Republic of China; 3Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunyan Liu, Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, No. 2 Yinghua Dongjie, Chaoyang District, Beijing, 100029, People’s Republic of China, Email juneliu2022@126.comAbstract: Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to its late-stage diagnosis and high recurrence rates. …”
Get full text

Burden of alopecia areata in China, 1990–2021: Global Burden of Disease Study 2021 by Xiangqian Li, Huixin Liu, Wenhui Ren, Qijiong Zhu, Peng Yin, Lijun Wang, Jianzhong Zhang, Jinlei Qi, Cheng Zhou, Lishao Guo

Get full text

Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

Get full text

PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

Get full text

Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
Get full text

Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis by Kun Zhang, JunHong Fu, Liang Hua, Peijian Zhang, Yeqin Shao, Sheng Xu, Huiyu Zhou, Li Chen, Jing Wang

Get full text

Study on the Mechanism of Black Phosphorus Nanosheets Loading Sr2+ Used in Photothermal Antibacterial Treatment by Ma G, Li B, Diao J, Zhang Y, Zhang B, Wu D, Gui H, Zhong J, Zhu H, Zhang D

“…Gaoqiang Ma,1,* Binyang Li,1,* Jiayong Diao,1 Yongzhi Zhang,1 Bing Zhang,1 Dongni Wu,1 Houda Gui,1 Junhao Zhong,1 Hongguang Zhu,2 Dongjiao Zhang1 1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, People’s Republic of China; 2Department of Stomatology, Weifang People’s Hospital, Weifang, 261000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongjiao Zhang; Hongguang Zhu, Email djzhang1109@sdu.edu.cn; zhuhongguang9025@126.comPurpose: Bacterial infections seriously affect the health of patients and their incidence is very high. …”
Get full text

Risk prediction models for stress urinary incontinence after pelvic organ prolapse (POP) surgery: a systematic review and meta-analysis by Bi Jun Yu, Hao Chong He, Li Wang, Han Mei Shao, Ying Min Liu, Xiao Ying Yan, Jian Liu

Get full text

Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

Get full text

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Haiou Wang,1 Wenkang Huang,1 Xiaoya Pan,1 Meizi Tian,1 Jiahui Chen,1 Xiaotong Liu,1 Qin Li,1 Jianhua Qi,2 Yiping Ye,1 Lijuan Gao1 1School of Pharmacy, Hangzhou Medical College, Hangzhou, 310013, People’s Republic of China; 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lijuan Gao; Yiping Ye, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Email gaolijuan04141002@126.com; yeyiping2005@163.comPurpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). …”
Get full text

PCT/ALB Ratio in Initial Three days for the Prediction of Secondary Infection in Septic Patients by Zhang C, Huang G, Li H, Zhang T, Jian M, Huang C, Zhang Y, Wang Z, Hou X, Xia Y, Jiang W

“…Chunmei Zhang,1,* Guoge Huang,2,* Haizhong Li,1,3,* Tiancao Zhang,1 Mengling Jian,1 Chunyang Huang,1 Yingqin Zhang,1,4 Zheng Wang,5 Xun Hou,1 Yuanyuan Xia,6 Wenqiang Jiang1,7 1Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, People’s Hospital of Longhua, Shenzhen, Guangdong, People’s Republic of China; 3Department of Emergency, Boai Hospital of Zhongshan, Zhongshan, Guangdong, People’s Republic of China; 4School of Medicine, South China University of Technology, Guangzhou University City, Guangzhou, Guangdong, People’s Republic of China; 5Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 6Medical Oncology Department, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 7Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang Jiang; Yuanyuan Xia, Email jiangwenqiang@gdph.org.cn; xiayuany1021@163.comBackground: Procalcitonin (PCT) to albumin (ALB) ratio (PAR) in initial three days is a rapidly available indicator to assess the prognosis of patients with sepsis. …”
Get full text

Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study by Xiao-Qiang Han, Xiao-Qiang Han, Hui-Hui Jiang, Meng-Ling Chen, Meng-Ling Chen, De-Yang Han, De-Yang Han, Su-Fen Zhou, Su-Fen Zhou, Jin-Wen Wang, Shu-Shen Ji, Ling-Yun Wang, Jing-Wei Lou, Ming-Qun Li, Ming-Qun Li

Get full text

Pressure-anisotropy-mediated Helical Dynamo in Turbulent Collisionless Plasmas by Z. H. Zhao, W. Q. Yuan, L. X. Li, X. W. Zhu, X. X. Jin, S. P. Zhu, X. T. He, B. Qiao

Get full text

Identification of deep intronic variants in junctional epidermolysis bullosa using genome sequencing and splicing assays by Fuying Chen, Ruoqu Wei, Yumeng Wang, Qiaoyu Cao, Jianbo Wang, Chenfei Wang, Dingjin Yao, Zhirong Yao, Cheng Ni, Ming Li

Get full text

Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children by Yang Zhuo, Yalan Yang, Mingjun Zhang, Ying Xu, Zhongping Chen, Lihong Mu, Xiaojun Tang, Zhaohui Zhong, Juan Chen, Li Zhou

Get full text

Altered brain functional network connectivity and topology in type 2 diabetes mellitus by Weiwei Ni, Weiyin Vivian Liu, Mingrui Li, Shouchao Wei, Xuanzi Xu, Shutong Huang, Lanhui Zhu, Jieru Wang, Fengling Wen, Hailing Zhou

Get full text