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Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species
Published 2025-02-01“…Jinqing Zhang,1,* Gaolian Li,2,* Jing Hu,3,* Jingwen Tan,4 Heng Zhang,5 Yizheng Zhou5 1Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Gynaecology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People’s Republic of China; 3Department of Clinical Medicine, Xiangyang Polytechnic, Xiangyang, Hubei Province, People’s Republic of China; 4Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 5Department of Clinical Laboratory, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yizheng Zhou, Email zhou_yizheng@163.comIntroduction: Treating infections caused by azole-resistant Candida spp. poses a significant challenge. …”
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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
Published 2025-01-01“…Ying Gao,1 Lu Li,1 Fang Zhao,1 Yi Cheng,1 Mu Jin,2 Fu-Shan Xue1,3 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 An-Zhen Road, Chao-Yang District, Beijing, 100029, People’s Republic of China, Tel +86-13366600987, Email jinmu0119@hotmail.com Fu-Shan Xue, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Tel +86-13911177655, Fax +86-591-88217841, Email xuefushan@aliyun.com; xuefushan@mail.ccmu.edu.cnPurpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. …”
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Prediction of tuberculosis-specific mortality for older adult patients with pulmonary tuberculosis
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The role of teledentistry in promoting oral health and preventing disease among the elderly
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The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier
Published 2025-01-01“…Miao Yu,1,2,* Wen-Jun Jiang,3,4,* Meng Yu,1 Zan Zhou,1,2 Min Wang,1 Li Li1 1Department of Physiology, Medical College of Jiaxing University, Jiaxing, Zhejiang, 314000, People’s Republic of China; 2Department of Physiology, Medical College of Shihezi University, Shihezi, Xinjiang, 832000, People’s Republic of China; 3The Second People’s Hospital of Li Shui, Li Shui, Zhejiang, 323000, People’s Republic of China; 4Department of Physiology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310051, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min Wang, Email wangmin3826@zjxu.edu.cn Li Li, Email lily7588@163.comBackground: Blood–labyrinth barrier (BLB) damage has been recognized as a key mechanism underlying cisplatin (CDDP)-induced hearing loss. …”
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