Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

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PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Application of information-based closed-loop management in optimizing surgical process (基于信息化的闭环管理优化手术流程的设计与实践) by ZHOU Liheng (周立恒), ZHU Xiaodong (朱小东), CHEN Qiannan (陈倩楠), LI Amin (李阿敏)

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Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis by Kun Zhang, JunHong Fu, Liang Hua, Peijian Zhang, Yeqin Shao, Sheng Xu, Huiyu Zhou, Li Chen, Jing Wang

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Multiscale attention network via topology learning for cerebral vessel segmentation in angiography images by Tao Han, Junchen Xiong, Tingyi Lin, Tao An, Cheng Wang, Jianjun Zhu, Zhongliang Li, Ligong Lu, Yi Zhang, Gao-Jun Teng

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Study on the Mechanism of Black Phosphorus Nanosheets Loading Sr2+ Used in Photothermal Antibacterial Treatment by Ma G, Li B, Diao J, Zhang Y, Zhang B, Wu D, Gui H, Zhong J, Zhu H, Zhang D

“…Gaoqiang Ma,1,* Binyang Li,1,* Jiayong Diao,1 Yongzhi Zhang,1 Bing Zhang,1 Dongni Wu,1 Houda Gui,1 Junhao Zhong,1 Hongguang Zhu,2 Dongjiao Zhang1 1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, People’s Republic of China; 2Department of Stomatology, Weifang People’s Hospital, Weifang, 261000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongjiao Zhang; Hongguang Zhu, Email djzhang1109@sdu.edu.cn; zhuhongguang9025@126.comPurpose: Bacterial infections seriously affect the health of patients and their incidence is very high. …”
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DRAFTS: A Deep-learning-based Radio Fast Transient Search Pipeline by Yong-Kun Zhang, Di Li, Yi Feng, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Hua-Xi Chen, Yu-Hao Zhu

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Predicting Time to First Rejection Episode in Lung Transplant Patients Using a Comprehensive Multi-Indicator Model by Chen Y, Li E, Yang Q, Chang Z, Yu B, Lu J, Wu H, Zheng P, Cheng ZJ, Sun B

“…Youpeng Chen,1,* Enzhong Li,2,* Qingqing Yang,1 Zhenglin Chang,1 Baodan Yu,1 Jiancai Lu,1 Haojie Wu,1 Peiyan Zheng,1 Zhangkai J Cheng,1,* Baoqing Sun1 1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhangkai J Cheng; Baoqing Sun, Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510140, People’s Republic of China, Email jasontable@gmail.com; sunbaoqing@vip.163.comBackground: Rejection hinders long-term survival in lung transplantation, and no widely accepted biomarkers exist to predict rejection risk. …”
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Kinematics of Young Stellar Objects under Various Stellar Feedback by Longhui Yang, Dejian Liu, Chaojie Hao, Zehao Lin, YingJie Li, Yiwei Dong, Zu-Jia Lu, En-Wei Liang, Y. Xu

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Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma by Zhecheng Li, Yaxin Zhao, Peng Huang, Zhaoyi Wu, Dengjie Ouyang, Adolphus Osei Nyarko, Lei Ai, Zhejia Zhang, Shi Chang

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PCT/ALB Ratio in Initial Three days for the Prediction of Secondary Infection in Septic Patients by Zhang C, Huang G, Li H, Zhang T, Jian M, Huang C, Zhang Y, Wang Z, Hou X, Xia Y, Jiang W

“…Chunmei Zhang,1,* Guoge Huang,2,* Haizhong Li,1,3,* Tiancao Zhang,1 Mengling Jian,1 Chunyang Huang,1 Yingqin Zhang,1,4 Zheng Wang,5 Xun Hou,1 Yuanyuan Xia,6 Wenqiang Jiang1,7 1Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, People’s Hospital of Longhua, Shenzhen, Guangdong, People’s Republic of China; 3Department of Emergency, Boai Hospital of Zhongshan, Zhongshan, Guangdong, People’s Republic of China; 4School of Medicine, South China University of Technology, Guangzhou University City, Guangzhou, Guangdong, People’s Republic of China; 5Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 6Medical Oncology Department, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 7Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang Jiang; Yuanyuan Xia, Email jiangwenqiang@gdph.org.cn; xiayuany1021@163.comBackground: Procalcitonin (PCT) to albumin (ALB) ratio (PAR) in initial three days is a rapidly available indicator to assess the prognosis of patients with sepsis. …”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Haiou Wang,1 Wenkang Huang,1 Xiaoya Pan,1 Meizi Tian,1 Jiahui Chen,1 Xiaotong Liu,1 Qin Li,1 Jianhua Qi,2 Yiping Ye,1 Lijuan Gao1 1School of Pharmacy, Hangzhou Medical College, Hangzhou, 310013, People’s Republic of China; 2College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Lijuan Gao; Yiping Ye, Hangzhou Medical College, 182 Tianmushan Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Email gaolijuan04141002@126.com; yeyiping2005@163.comPurpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). …”
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Correlation Between Gastroesophageal Reflux Disease and Small Intestinal Bacterial Overgrowth: Analysis of Intestinal Microbiome and Metabolic Characteristics by Wang ZT, Tan WT, Huang JL, Zhang PF, Li Q, Wang MM, Meng MM, Su H, Guo CM, Liu H

“…Zi-Teng Wang,1,2,* Wen-Tao Tan,1,* Jia-Li Huang,1 Peng-Fei Zhang,3 Qian Li,1 Miao-Miao Wang,1 Ming-Ming Meng,1 Hui Su,1 Chun-Mei Guo,1 Hong Liu1 1Gastroenterology Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Gastroenterology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Emergency Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Liu, Email liuhong_sjt@ccmu.edu.cnBackground: Our study examines the relationship between gastroesophageal reflux disease (GERD) and small intestinal bacterial overgrowth (SIBO), focusing on the potential impact of acid-suppressive drugs. …”
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Risk prediction models for stress urinary incontinence after pelvic organ prolapse (POP) surgery: a systematic review and meta-analysis by Bi Jun Yu, Hao Chong He, Li Wang, Han Mei Shao, Ying Min Liu, Xiao Ying Yan, Jian Liu

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Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

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Pressure-anisotropy-mediated Helical Dynamo in Turbulent Collisionless Plasmas by Z. H. Zhao, W. Q. Yuan, L. X. Li, X. W. Zhu, X. X. Jin, S. P. Zhu, X. T. He, B. Qiao

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Gut microbiota interacting with vitamin D but not anandamide might contribute to the pathogenesis of preeclampsia: a preliminary study by Xiao-Qiang Han, Xiao-Qiang Han, Hui-Hui Jiang, Meng-Ling Chen, Meng-Ling Chen, De-Yang Han, De-Yang Han, Su-Fen Zhou, Su-Fen Zhou, Jin-Wen Wang, Shu-Shen Ji, Ling-Yun Wang, Jing-Wei Lou, Ming-Qun Li, Ming-Qun Li

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How to monitor and discriminate the causes of lower limb swelling during home-based rehabilitation after total knee arthroplasty? A delphi study by Lin Yang, Hui-Wu Li, Zan-Jing Zhai, Cai-Feng Wang, Bei-Ying Wu, Jia Zhou, Wei-Wei Bian, Hong Ruan

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Identification of deep intronic variants in junctional epidermolysis bullosa using genome sequencing and splicing assays by Fuying Chen, Ruoqu Wei, Yumeng Wang, Qiaoyu Cao, Jianbo Wang, Chenfei Wang, Dingjin Yao, Zhirong Yao, Cheng Ni, Ming Li

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