Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

“…Zhaoming Guo,1,2,* Guqing Li,2,* Lanjun Shen,2 Jiawei Pan,2 Danni Dou,2 Yuwei Gong,2 Wanwan Shi,2 Yuhua Sun,2 Yi Zhang,2 Kun Ma,2 Changhao Cui,2 Wenxin Li,3,4 Qiang Liu,5 Xudong Zhu1,4,6 1Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 2School of Chemical Engineering, Marine and Life Sciences, Dalian University of Technology, Panjin, Liaoning, 124221, People’s Republic of China; 3The second Department of Hepatopancreatobiliary Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 4Liaoning Provincial Key Laboratory of Precision Medicine for Malignant Tumors, Shenyang, Liaoning, 110042, People’s Republic of China; 5Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, 116024, People’s Republic of China; 6Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Zhu, Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China, Tel +86 13354204706, Email xdzhu@cmu.edu.cn; XudongZhu@uky.edu Qiang Liu, Faculty of Medicine, Dalian University of Technology, Dalian, Liaoning, 116024, People’s Republic of China, Email andyliu_1844@dlut.edu.cnPurpose: Phototherapy has remarkable advantages in cancer treatment, owing to its high efficiency and minimal invasiveness. …”
Get full text

Patterns and wavelet coherence analysis of tidal dynamics and chlorophyll a concentration by M.N. Hidayat, R. Wafdan, M. Ramli, Z.A. Muchlisin, S. Rizal

“…Furthermore, the wavelet transform coherence analysis examines the rate of change in chlorophyll a in relation to tidal currents over 6, 12, and 24 hour.CONCLUSION: Tides remarkably affect chlorophyll a concentrations. There are strong links between chlorophyll a concentrations and key tidal aspects, such as sea level and current magnitude. …”
Get full text

Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Efficacy correlated with FcγR-mediated intratumoral Treg depletion. Remarkably, in a clinically relevant mouse model resistant to systemic ICB, intratumoral VVGM-αCTLA-4 synergized with αPD-1 to reject cold tumors.Conclusion Our findings demonstrate in vivo proof of concept for spatial restriction of Treg depletion-optimized immune checkpoint blocking, vectorized αCTLA-4 as a highly effective and safe strategy to target CTLA-4. …”
Get full text

A pulsed carbon dioxide laser-induced breakdown analysis for chemical profile of tsunami-affected soil by R. Mitaphonna, N. Idris, M. Ramli, N. Ismail, K. Kurihara, K. Lahna

“…Potassium concentration rose from 0.11 percent to 5.50 - 6.96 percent, alongside magnesium, which increased from 0.36 percent to 7.62 - 8.67 percent.CONCLUSION: The utilization of a pulsed carbon dioxide laser-induced breakdown spectroscopy has demonstrated remarkable proficiency in the identification of a diverse range of elements. …”
Get full text

FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

“…For the macrophage-depleted mouse tumor model, no remarkable change was observed in the tumor weight between the OE-FDFT1 group and the OE-NC group as well as the sh-FDFT1 group and the sh-NC group. …”
Get full text

Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species by Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello

“…Notably, dipeptide <b>7a</b> showed slightly enhanced antifungal efficacy compared to fluconazole also in <i>Aspergillus flavus</i> (IC₅₀ 176.69 µM vs. 184.64 µM), suggesting that this dipeptide might be more potent even against this strain. Remarkably, <b>3a</b> and <b>7a</b> are also more potent than fluconazole against <i>A. candidus</i> 10711. …”
Get full text

Green Tea Extract (<i>Theaceae</i>; <i>Camellia sinensis</i> L.): A Promising Antimicrobial, Anti-Quorum Sensing and Antibiofilm Candidate Against Multidrug-Resistant <i>Campylobac... by Mona S. Emara, Ahmed M. Ammar, Ashraf M.O. Abdelwahab, Attia A. Elgdawy, Adel Abdelkhalek, Elena Pet, Gabi Dumitrescu, Mirela Ahmadi, Norhan K. Abd El-Aziz

“…Regarding <i>C. jejuni</i>, the highest resistance rate was observed for amoxicillin–clavulanic acid and colistin (85.25% each), followed by cefotaxime (83.61%) and tetracycline (81.97%), whereas <i>C. coli</i> isolates showed absolute resistance to cefotaxime followed by erythromycin (92%) and colistin (88%). Remarkably, all <i>Campylobacter</i> isolates were MDR with elevated multiple antimicrobial resistance (MAR) indices (0.54–1). …”
Get full text

Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…City officials undertook the construction of attributes worthy of a Roman provincial capital: a powerful city wall, remarkable monumental decorations, large public spaces devoted to civic and economic life, circulation routes, water supply and drainage networks, etc. …”
Get full text

Aides à la navigation, pratique de la navigation et construction des paysages maritimes en Atlantique du Nord-Est : quelques éléments de réflexion by Pascal Arnaud

“…The construction of higher and more complex monuments has to take other factors into account. Their “remarkable construction” reflects the importance of the sponsor. …”
Get full text

Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…According to the composite reference standards, the accuracy of tNGS in the detection of responsible pathogens was 0.852 (95% confidence interval 0.786– 0.918), which resembled that of mNGS and remarkably exceeded that of CMTs. In addition, 81 AMR genes associated with responsible pathogens were reported, and 75.8% (25/33) priority drug-resistant pathogens could be directly identified. …”
Get full text

Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…<p>Deep learning models have demonstrated remarkable success in fields such as language processing and computer vision, routinely employed for tasks like language translation, image classification, and anomaly detection. …”
Get full text

Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP by Liyan Jiao, Hanping Li, Lin Li, Daomin Zhuang, Yongjian Liu, Zuoyi Bao, Siyang Liu, Jingyun Li

“…On the bases of various NNRTIs mutation profiles, Y181C remarkably improved the IC50 to NVP, although H221Ymutation alone just increases 2.1 ∼ 3.6-fold resistance to NVP, the mutation could improve 100.6 ∼ 3444.6-fold resistance to NVP when it copresent with Y181C, the phenotypic drug resistance fold was improved extremely. …”
Get full text

L’aqueduc du Gier : nouvelles données sur le pont-siphon de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by David Baldassari, François Blondel, Stéphane Gaillot

“…In 2018, an archaeological excavation was undertaken to study three piers (17, 18 and 19) of the Yzeron aqueduct at Beaunant (Sainte-Foy-lès-Lyon, France) which supported the conduits of a siphon that carried water from the Gier aqueduct to Lugdunum in Antiquity.The Yzeron siphon, which covered a length of 2,660 m and was located less than 20 km from the source of the Gier aqueduct on Fourvière hill in Lyon, made it possible to cross the Yzeron Valley which, at this point, was almost 1.50 km wide and 125 m deep. The remarkably well-preserved aqueduct first featured in the inventory of Historical Monuments in 1875. …”
Get full text

The History of Miss Jane Pittman by Christopher Mulvey

“…Gaines returned African American fiction to its roots, and he did so with a didactic purpose remarkably like that of William Wells Brown. For all that he had been a slave there, Brown seems to have loved the South more than he loved the North. …”
Get full text

Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…AI-2 perception by the AsrK-AsrR system remarkably reduces intracellular c-di-GMP levels and enhances tolerance of V. furnissii to oxidative stress and DNA damage by upregulating the transcription of universal stress proteins including UspA1, UspA2, and UspE. …”
Get full text

Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…There were 5 phyla and 20genera of remarkable bacteria found among mice groups including genera of Escherichia, Pseudomonas_E, Mailhella, Paramuribaculum, NM07-P-09, Odoribacter, Nanosyncoccus, SFM01, Onthenecus, Clostridium_Q, UBA6985, Ructibacterium, UBA946, Lachnoclostridium_B, Evtepia, CAG-269, Limivicinus, Formimonas, Dehalobacterium, Dwaynesavagella, and UBA6985. …”
Get full text

L’aqueduc de Fontanières : un cinquième aqueduc romain à Lyon ? by Jean-Yves Barbier

“…Facing east, this steep slope is known as the Balme de Fontanières and, thanks to the complex history of its geological formation, it offers abundant water resources, as evidenced by the resurgences and catchments from various periods in the vicinity of the eponymous road.The Romans could neither have ignored nor neglected the availability of these nearby resources, especially as to the north and west of the town, they had been forced to develop the remarkable network of four aqueducts spanning over 200 km long –including those of the Gier, Mont d’Or, Yzeron and Brévenne rivers– which captured the attention of renowned researchers such as G. …”
Get full text

Exemples d’habitats aristocratiques sur les sites des rues Eugène-Desteuque et Ponsardin à Reims/Durocortorum by Magalie Cavé, Stéphane Sindonino, Sabine Groetembril

“…These rooms are organized around a cryptoporticus composed of several wings, punctuated with aeration openings on the lower portions of its walls and endowed with a remarkable painted decoration bearing celadon green panels and delicate motifs. …”
Get full text

Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats by Xing Wei, Yaping Lin, Dongfeng Zhao, Xiaojuan Xiao, Qiao Chen, Siyi Chen, Yan Peng

“…Results. (1) After intervention, compared with blood glucose of rats in the NC group, all of the DGP, EA, and MP groups were remarkably increased (P<0.01); compared with the DGP group, the blood glucose of the EA and MP groups was decreased greatly (P<0.01). (2) Compared with gastrointestinal propulsive rate of rats in the NC group, no matter gastric emptying rate or intestinal propulsive rate, the EA and MP groups were significantly reduced (P<0.01); compared with the NC group, gastric emptying rate and intestinal propulsive rate in the EA group were obviously decreased (P<0.05, P<0.01); compared with the DGP group, the EA and MP groups were increased significantly (P<0.01). (3) Compared with the NC group, intensity of RFP and GFP in the DGP group was obviously increased (P<0.05, P<0.01), in other words, the DGP group accompanying suppression of autophagy; compared with the DGP group, intensity of RFP and GFP in the EA group was decreased significantly (P<0.05, P<0.01). (4) There was no autophagosome in the NC group, and an autophagosome existed in the DGP group. …”
Get full text

Preindustrial-to-present-day changes in atmospheric carbon monoxide: agreement and gaps between ice archives and global model reconstructions by X. Faïn, S. Szopa, V. Naïk, P. Martinerie, D. M. Etheridge, D. M. Etheridge, R. H. Rhodes, C. M. Trudinger, C. M. Trudinger, V. V. Petrenko, K. Fourteau, P. Place, P. Place

“…Over the 1980–2010 CE period (common era; all subsequent years in the paper are reported in CE), trends in ice archive and firn air observations and AerChemMIP outputs align remarkably well at northern and southern high latitudes, indicating improved quantification of anthropogenic CO emissions and the main CO sink (OH oxidation) compared to ACCMIP. …”
Get full text