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3821
Immunogenetics of longevity and its association with human endogenous retrovirus K
Published 2025-02-01“…Furthermore, we identified 13 HLA alleles (9 HLA-I and 4 HLA-II) that occurred at greater frequency in very old individuals (age ≥90 years) as compared to younger individuals. Remarkably, for those 13 alleles, the predicted binding affinities were significantly higher for HERVK than for the other viruses (P < 0.001). …”
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3822
Synthesis, Characterization, and DNA-Binding Kinetics of New Pd(II) and Pt(II) Thiosemicarbazone Complexes: Spectral, Structural, and Anticancer Evaluation
Published 2020-01-01“…Structure-activity profiles were evident especially between C1 and C2 differing by the presence of a Br in position 5 of thiophene ring, which caused a remarkable increase in IC50 values, from 14.71 ± 0.016 (C1) to 43.08 ± 0.001(C2) in Caco-2 cells, 1.973 ± 0.048 (C1) to 59.56 ± 0.010 (C2) in MCF-7 cells, 16.65 ± 0.051 (C1) to 72.25 ± 0.003 (C2) in HeLa cells, 14.64 ± 0.037 (C1) to 94.34 ± 0.003 (C2) in HepG2, and 14.05 ± 0.042 (C1) to >100(C2) in PC-3 cells.…”
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3823
Prevalence and Determinants of Diarrheal Diseases among Under-Five Children in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia: A Community-Based Cross-Sectional Study
Published 2021-01-01“…Diarrhea was significantly associated with poor knowledge of mothers/caretakers on diarrhea prevention methods (AOR: 2.05, 95% CI (1.14, 3.69), being in the age group of 6–11(AOR = 1.546 (1.68, 3.52), and 12–23 months (AOR = 1.485 (1.84, 2.63)), families with poor wealth index (AOR: 2.41, 95% CI (1.29, 4.51)), children who were not vaccinated against measles (AOR: 4.73, 95% CI (2.43, 9.20)), unsafe child feces disposal (AOR = 3.75; 95% CI (1.91, 7.39)), inappropriate liquid waste disposal (AOR = 3.73 (1.94, 7.42)), and having two or more siblings (AOR: 3.11, 95% CI (1.81, 5.35)). Conclusion and Remarks. The prevalence of diarrhea among under-five children was high. …”
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3824
Phytochemical and Bioactivity Evaluation of Bee Pollen and Androecia of <i>Castanea</i>, <i>Salix</i>, and <i>Quercus</i> Species
Published 2024-12-01“…HPTLC-EDA combined with image analyses was used for comparing the activities of bee pollen, androecia, <i>N</i><sup>1</sup>,<i>N</i><sup>5</sup>,<i>N</i><sup>10</sup>-tricaffeoylspermidine, and also other marker compounds (quercetin, myricitrin, hyperoside, quercitrin, isoquercitrin, and rutin). The remarkable bioactivity of <i>N</i><sup>1</sup>,<i>N</i><sup>5</sup>,<i>N</i><sup>10</sup>-tricaffeoylspermidine was for the first time evaluated by HPTLC-EDA and <i>in vitro</i> tests. …”
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3825
Fabrication of tin nanoparticles with functionalized platinum nanodendrites on ITO electrode for simultaneous detection of Cd2+, Pb2+, and Cu2+ ions
Published 2025-01-01“…The modified electrode exhibited remarkable sensitivity to these ions: 1.09 µA/ppb for Cd(II), 2.5 µA/ppb for Pb(II), and 0.96 µA/ppb for Cu(II). …”
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3826
Exploring anticancer, antioxidant, and antimicrobial potential of Aspergillus flavus, a fungal endophyte isolated from Dillenia indica leaf callus
Published 2025-02-01“…As, endophytes are remarkable source of active constituents, there is a great need to explore such endophytes. …”
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3827
Anemia and Contributing Factors in Severely Malnourished Infants and Children Aged between 0 and 59 Months Admitted to the Treatment Centers of the Amhara Region, Ethiopia: A Multi...
Published 2021-01-01“…Furthermore, being exclusively breastfed (AOR = 0.57; 95% CI 0.39–0.83) remarkably reduced the likelihood of anemia. Conclusions. …”
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3828
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Published 2025-01-01“…Results Here, we found that the level of histone deacetylase 7 (HDAC7) was remarkably increased in the astrocytes of AD patients and P301S tau transgenic (PS19) mice. …”
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3829
Research progress on characteristics of secondary aluminum dross and its detoxification and utilization
Published 2025-03-01“…However, it contains not only a large amount of aluminum nitride (AlN), chlorine salts, fluoride, and other hazardous substances but also about 40% (mass fraction) of aluminum, making it a potential aluminum resource with remarkable utilization value. The annual output of secondary aluminum dross in China has estimated to be over 3 million tons based on the aluminum production in 2023. …”
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3830
The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired p...
Published 2025-01-01“…Adding AST/ALT to CURB-65 slightly increased the AUC, but remarkably enhanced NRI and IDI (AUC, 0.756 vs. 0.782, p = 0.017; continuous NRI, 0.635, 95% CI, 0.304–0.966, p < 0.001; categorical NRI, 0.175, 95% CI, 0.044–0.307, p = 0.009; IDI, 0.043, 95% CI, 0.006–0.080, p = 0.021). …”
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3831
Anti-Methanogenic Potential of Seaweeds and Impact on Feed Fermentation and Rumen Microbiome In Vitro
Published 2025-01-01“…The ranking of seaweeds in terms of CH<sub>4</sub> production (mL/g OM) is as follows: <i>Sargassum wightii</i> < <i>Kappaphycus alvarezii</i> < <i>Acanthophora specifera</i> < <i>Padina gymnospora</i> < <i>Spyridia filamentosa</i>. A remarkable decrease of 31–42% in CH<sub>4</sub> production was recorded with the incremental inclusion of <i>Kappaphycus alvarezii</i> at levels of 3–5% of the dry matter in the diet. …”
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3832
A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE
Published 2025-01-01“…This model also demonstrated remarkable discrimination in the external validation cohort, achieving AUCs of 0.862, 0.815, and 0.798 in the 1-, 2-, and 3-year survival groups, respectively. …”
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3833
Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica...
Published 2025-03-01“…However, markedly downregulation of the mRNA level of pro-inflammatory cytokine il-1β (p < 0.05) was observed in 0.05 and 0.3T23 groups, compared with the control. 16S rRNA sequencing analysis data on gut microbiota indicated that supplementation of T23 at lower levels (0.05, 0.1 and 0.2) resulted in a remarkable elevation of the abundance of phylum Firmicutes and reduced the abundance of Proteobacteria, and the ratio of (Firmicutes +Bacteroidota +Fusobacteria) /Proteobacteria. …”
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3834
HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand. (Niu jiao gua) stem bark and it...
Published 2025-02-01“…Our previous reports demonstrated the remarkable anti-liver and anti-colon cancer activities both in vitro and in vivo of the dichloromethane fraction from the stem barks of C. gigantea (CGD). …”
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3835
Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation
Published 2025-02-01“…KEGG pathway analysis implied that PI3K-AKT signaling pathway maight be involved in the protective effect of SGD agianst PICI Animal experiments displayed that SGD significantly alleviated cognitive impairment induced by paclitaxel, and decreased neuronal apoptosis. Furthermore, SGD remarkably reduced IL-1β, TNF-α and microglia activation, while enhanced SOD activity in hippocampus. …”
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3836
β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease
Published 2025-02-01“…The CSF β-syn values in the cohorts of sCJD, T188K-gCJD, E200K-gCJD and P102L-GSS were remarkably higher than that of the group of AD + PD, but similar as that of the group of VE + AE. …”
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3837
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer
Published 2025-01-01“…This model combined with various clinical features and critical breast cancer facets, demonstrated remarkable efficacy in predicting patient outcomes. …”
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3838
New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells
Published 2024-11-01“…Notably, C. perfringens sialidase remarkably increased MHC-I levels compared to other sialidases having different specificities, supporting the idea that higher MHC-I is due to the cleavage of specific sialoglycans on cell surface proteins. …”
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3839
Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus...
Published 2023-01-01“…The SJ-607 virus administration elicited neutralizing antibody formation in two immunocompetent mouse strains like the control JX-594 virus. Remarkably, we found that the SJ-607 virus evades neutralization by vaccinia virus-specific antibodies.Conclusion Our new oncolytic vaccinia virus platform, which expresses human CD55 protein on its membrane, prolonged viral survival by protecting against complement-mediated lysis and by evading neutralization by vaccinia virus-specific antibodies; this may provide a continuous antitumor efficacy until a complete remission has been achieved. …”
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3840
Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry
Published 2025-01-01“…The diagnostic model constructed with URGs exhibited remarkable accuracy, with area under the curve (AUC) values consistently exceeding 0.9. …”
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