NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…Specifically, NeuTox 2.0 exhibits remarkable performance in three of the four datasets. …”
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Novel role of FTO in regulation of gut–brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure by Ruonan Chen, Xiaoqin Chai, Yunxiao Zhang, Tianxiu Zhou, Yinyin Xia, Xuejun Jiang, Bo Lv, Jun Zhang, Lixiao Zhou, Xin Tian, Ruonan Wang, Lejiao Mao, Feng Zhao, Hongyang Zhang, Jun Hu, Jingfu Qiu, Zhen Zou, Chengzhi Chen

“…By using both CRISPR/Cas9-based FTO knock-in strategy and adeno-associated virus (AAV)-mediated overexpression of FTO in the intestine, we established for the first time that up-regulation of FTO remarkably ameliorated arsenic-induced disruption of intestinal barriers and altered microenvironment of mice. …”
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Real world study on combining local interventions with systemic therapy in unresectable hepatocellular carcinoma by Zhaosong Xue, Ming Yao, Kang Chen, Taiyun Huang, Jianjun Li, Jian Chen, Fei Huang, Yubin Huang, Xiaoyong Cai, Yihe Yan

“…Abstract  Combining local interventions with tyrosine kinase inhibitors (TKIs) plus anti-PD-1 antibodies in a triple therapy has demonstrated remarkable anti-tumor efficacy and facilitated conversion resection in patients with initially unresectable hepatocellular carcinoma (HCC). …”
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Thermal radiation effects of ternary hybrid nanofluid flow in the activation energy: Numerical computational approach by Hakeem Ullah, Syed Arshad Abas, Mehreen Fiza, Aasim Ullah Jan, Ali Akgul, Magda Abd El-Rahman, Seham M. Al-Mekhlafi

“…Significance: The remarkable thermal conductivity and heat transfer characteristics of nanofluids make them extremely valuable in thermal engineering and other areas. …”
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A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition by Jiawen Li, Guanyuan Feng, Chen Ling, Ximing Ren, Xin Liu, Shuang Zhang, Leijun Wang, Yanmei Chen, Xianxian Zeng, Rongjun Chen

“…Such performances are remarkable when considering limited data resources as a concern, which opens possibilities for an innovative entropy fusion method that can help to design portable EEG-based emotion-aware devices for daily usage.…”
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora by Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang

“…In particular, spore yield, spore germination rate, traps, and nematode predation efficiency were remarkably decreased in the mutants. Phenotypic and transcriptomic analyses revealed that AoMsn2 is essential for fatty acid metabolism and autophagic pathways. …”
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Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…Results: After RT, the mean counts of white blood cells (WBCs), lymphocytes, and platelets significantly decreased, while the red blood cells (RBCs) and hemoglobin notably increased (P ​< ​0.001), while the dic frequency was elevated remarkably, significantly higher in patients with higher-grade (>1) acute skin toxicities compared to those with lower-grade (=1) acute skin toxicities (Z ​= ​−1.985, P ​= ​0.047). …”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…By adopting this model, we were able to unveil a remarkable increase in lactate concentration and monocarboxylate transporter 1 (MCT1) expression in the site of hematopoiesis, associated with a strong downregulation of lactate export channel MCT4. …”
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Isolation of competent actinomycetes strains from soil planted with three species of mint irrigated with olive mill wastewater by Oumaima Beroigui, Lahsen El Ghadraoui, Faouzi Errachidi

“…Optimizing OMWW dosage can positively influence soil microflora, where actinomycetes exhibiting remarkable resilience at higher doses. These results contribute to understanding the use of microorganisms for olive oil industry waste management, in order to offer practical solutions to mitigate OMWW environmental impact. …”
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Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil by Xin Pan, Shaoping Kuang, Xiao Wang, Habib Ullah, Zepeng Rao, Esmat F. Ali, Qumber Abbas, Sang Soo Lee, Sabry M. Shaheen

“…Abstract The increased contamination of potentially toxic element (PTE) has posed remarkable ecological risks to environment. Application of functionalized biochar for the remediation of PTE contaminated water and soils are of great concern, and effective strategies are urgently needed to enhance the removal capacity of biochar for PTE. …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. …”
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The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review by V. Ribeiro, J-L. Teillaud, J-L. Teillaud, J-L. Teillaud, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort

“…The impact of tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) on OSCC prognosis remains debated. Remarkably, Tertiary Lymphoid Structures (TLS) identified in solid tumors have shown associations with favorable outcomes, yet their prognostic significance in OSCC remains understudied.ObjectiveThus, this systematic review aims to explore the value of TLS in OSCC reported in the literature.MethodA scoping review was conducted and six retrospective cohort studies involving 1,203 patients met the inclusion criteria.ResultsPredominantly male patients, with an average age of 49.3 years were included. …”
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MCPA: multi-scale cross perceptron attention network for 2D medical image segmentation by Liang Xu, Mingxiao Chen, Yi Cheng, Pengwu Song, Pengfei Shao, Shuwei Shen, Peng Yao, Ronald X. Xu

“…Abstract The UNet architecture, based on convolutional neural networks (CNN), has demonstrated its remarkable performance in medical image analysis. However, it faces challenges in capturing long-range dependencies due to the limited receptive fields and inherent bias of convolutional operations. …”
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Effectiveness of a pharmacist-led tele-psychiatric clinic in managing drug-related problems by Majed Al Shakhori, Savera Arain, Suhaj Abdulsalim, Mohammed Salim Karattuthodi, Marwa Al Dhamen, Shoruq Almutairi, Shabeer Ali Thorakkattil, Dina Alahmdi, Vijayanarayana Kunhikatta, Abdul Sammad AlJishi

“…The Krska classification was utilised to classify and analyse the identified DRPs, ensuring a structured and systematic approach to the study's findings.Results: A total of 259 pharmacist interventions were made, and the results revealed a remarkably high acceptance rate of 98.5% among physicians. …”
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Association between Virulence Factors and TRAF1/4-1BB/Bcl-xL Expression in Gastric Mucosa Infected with Helicobacter pylori by Fen Wang, Xiang Wu, Zhiying Liu, Guangkui Bu, Xiayu Li, Nanfang Qu, Jin Peng, Canxia Xu, Shourong Shen, Yi Yuan

“…Additionally, there were a remarkably large number of samples with upregulated TRAF1/4-1BB/Bcl-xL expression in cases of cagA+/vacAs1+/vacAm1+ H. pylori infection (44 cases, 67.7%; P<0.05). …”
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Screening Southeast Asian medicinal plants: Clausena lansium, Leea indica, Strobilanthes crispa, Vitex trifolia for anti-platelet aggregation and blood coagulation effects by Sogand Zareisedehizadeh, Fu-Xun Heng, Chay-Hoon Tan, Paul Chi-Lui Ho, Hwee-Ling Koh

“…Leea indica demonstrated remarkable antiplatelet and anticoagulant activities, highlighting its potential in preventing pathological thrombus formation and related cardiovascular disorders.…”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…Importantly, the multitarget compounds 6d, 8c, and 8d exhibited remarkable efficacy in simultaneously mitigating Aβ-induced toxicity in SH−SY5Y cells while demonstrating minimal cytotoxicity. …”
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT... by Huizhen Xing, Xinwei Bai, Xiaoying Pei, Yuqi Zhang, Xueying Zhang, Shujun Chen, Dan Li, Bin Lv, Xiaoying Wang, Xiaoli Wu

“…Additionally, with excellent biosafety, CHSe NPs exhibited superior therapeutic effects in ALI mice models in vivo, surpassing the performance of the clinic drug dexamethasone. They remarkably reduced ROS levels, and elevated the SOD and GPX enzyme activities in lung tissue to exert antioxidant effects. …”
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LoCS-Net: Localizing convolutional spiking neural network for fast visual place recognition by Ugur Akcal, Ugur Akcal, Ugur Akcal, Ivan Georgiev Raikov, Ekaterina Dmitrievna Gribkova, Ekaterina Dmitrievna Gribkova, Anwesa Choudhuri, Anwesa Choudhuri, Seung Hyun Kim, Mattia Gazzola, Rhanor Gillette, Rhanor Gillette, Ivan Soltesz, Girish Chowdhary, Girish Chowdhary, Girish Chowdhary

“…However, spiking neural networks (SNNs) implemented on neuromorphic hardware are reported to have remarkable potential for more efficient solutions computationally. …”
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Signatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9 by Tao Fan, Chu Xiao, Ziqin Deng, Shuofeng Li, He Tian, Yujia Zheng, Bo Zheng, Chunxiang Li, Jie He

“…The mice melanoma model showed Slamf9 knockdown remarkably restrained cancer progression and enhanced the efficacy of anti-CTLA-4 and anti-PD-L1 therapies by elevating CD8 + T cell infiltration. …”
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