Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Results of qRT-PCR analysis demonstrated remarkable dysregulation of apoptotic and mitochondrial genes, including a significant downregulation of apoptotic p53 and mitochondrial ND3 genes and marked upregulation of the anti-apoptotic gene Bcl2. …”
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ucumeropsis mannii seed oil protects against Bisphenol A- induced testicular mitochondrial damages by Patrick Maduabuchi, Aja, Hilary Akobi, Ogwoni, Peter Chinedu, Agu, Ejike Ugbala, Ekpono, Joshua Nonso, Awoke, Oliver Ugochukwu, Ukachi, Obasi Uche, Orji, Boniface Anthony, Ale, Chinonso Peter, Nweke, Esther Ugo, Alum, Darlington C., Chukwu, Christian E., Offor, Atamgba Agbor, Asuk, Ejike, Daniel Eze, Ojochenemi E., Yakubu, J. B., Akob, Onyedika Gabriel, Ani, Chinaza Godswill, Awuchi

“…CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, C. mannii seed oil and bi- sphenol A co-administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. …”
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A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats by Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado

“…Preclinical experiments have shown that MBRT leads to a remarkable widening of the therapeutic window for GBM and elicits an effective immune priming. …”
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Contamination profile of heavy metals in marine fish and shellfish by M.A. Salam, S.C. Paul, S.N.B.M. Noor, S.A. Siddiqua, T.D. Aka, R. Wahab, E.R. Aweng

“…</em>Although the concentrations of all the heavy metals in all fish, prawn and crab species were lower as per Malaysian Food Act, but the concentrations showed remarkable differences among the species and organs. …”
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Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy by Jie Mei, Zhiwen Luo, Yun Cai, Renwen Wan, Zhiwen Qian, Jiahui Chu, Yaying Sun, Yuxin Shi, Ying Jiang, Yan Zhang, Yongmei Yin, Shiyi Chen

“…Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. …”
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MnS/MnO heterostructures with dual ion defects for high-performance aqueous magnesium ion capacitors by Minghui Liu, Mudi Li, Siwen Zhang, Yaxi Ding, Ying Sun, Jiazhuo Li, Haixi Gu, Bosi Yin, Hui Li, Tianyi Ma

“…As anticipated, using a three-electrode system, the developed DID-MnS/MnO demonstrated a discharge specific capacity of 237.9 mAh/g at a current density of 0.1 A/g. Remarkably, the constructed AMIC maintained a capacity retention rate of 94.3% after 10000 cycles at a current density of 1.0 A/g, with a specific capacitance of 165.7 F/g. …”
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Assessing favipiravir impact on SARS-CoV-2 transmission within households: Insights from a multi-center study (FaviPrev) by Taweegrit Siripongboonsitti, Marisa Muadchimkaew, Kriangkrai Tawinprai, Ornisa Issaranon, Wichuda Meepholkij, Pureepat Arttawejkul, Apiradee Vararungzarit, Onwalee Dhissayakamol, Wilaiporn Preeyachit, Kamonwan Soonklang, Nithi Mahanonda

“…Index cases treated with favipiravir also demonstrated a relative risk reduction of 0.19 in transmission (95 % CI [0.11–0.27]). Remarkably, favipiravir effectiveness was most notable in unvaccinated index cases, those with symptomatic infections, individuals living in shared spaces like dormitories, flats, or apartments, and those not adhering to mask-wearing within their households. …”
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D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…Results We first found that topical supplementation of D-mannose remarkably improved skin wound healing in diabetes mice. …”
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Iron⁃calcium⁃biochar enhanced sludge deep dewatering and sludge⁃based biochar preparation by JIAO Hongming, FU Liang*, ZHOU Yingying, WANG Xurong, ZHANG Leilei, Gao Yonglin, ZHOU Dandan

“…Notably, it showed remarkable efficiency in removing Cr6+, with an impressive adsorption capacity of 26.51 mg / g. …”
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Trends and factors associated with skilled birth attendance in a post-Ebola context: DHS Guinea 2018 by Madeleine Toure, Fanta Barry, Tiany Sidibe, Sadan Camara, Ramata Diallo, Kaba Saran Keita, Maimouna Balde, Bienvenu Salim Camara, Karifa Kourouma, Mamadou Dioulde Balde

“…This proportion showed a remarkable variation with a trend in assisted deliveries from 61% in 2016 to 59% in 2017 and then to 50% (p = 0.003) in 2018. …”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…Animals exhibit remarkable behavioral and molecular adaptations to cope with thermal stressors, which are crucial for survival in variable environments that are exacerbated by climate change. …”
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Probe – Integrated electrochemical sensing platform for detection of trace levels of Dapoxetine hydrochloride drug residue in water and drug formulations by H. Alwael, N.A. Asiri, B.G. Alhogbi, A.S. Alharthi, E.A. Bahaidarah, T.N. Abduljabbar, D.F. Baamer, M. Madkour, F.A. Zainy, M.S. El-Shahawi

“…The sensor also revealed remarkable reproducibility, stability, and resistance towards interference. …”
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End of Pandemic Parental Hesitancy Towards Pediatric COVID-19 Vaccination: A Cross-sectional Survey at Two Lebanese Tertiary Hospitals by Sabine Shehab, Lina Anouti, Celina F. Boutros, Christelle Radi, Silma El Baasiri, Arabia Badih, Rawan Korman, Marwa El Masri, Joudie Alwan, Maha Monzer, Yara Bitar, Mona Kassem, Mayse Naser, Yara Salameh, Sarah Khafaja, Murielle Bou Ghosn, Dany Al Hamod, Sarah Ghadban, Soha Ghanem, Ghassan S. Dbaibo

“…Although routine childhood vaccinations received remarkable acceptance (98.3%), there was considerable hesitancy towards pediatric COVID-19 (56.4%). …”
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Cobalt (II) phthalocyanine derived Co3O4@HCNFs as highly effective bifunctional electrocatalysts for iodide redox couple reduction (IRR) and oxygen reduction reaction (ORR) by Ziyu Guo, Wenyu Gong, Jianing Guo, Mingxing Wu

“…In contrast, the E1/2 and Jlim of the pristine HCNFs are 0.630 V and 3.99 mA·cm−2, respectively, much lower than those of Co3O4@HCNFs. The remarkable catalytic activity of Co3O4@HCNFs can be ascribed the introduced Co3O4, resulting in additional active sites of Co-N-C, and the synergistic effects between metals and carbon also accounts for the enhanced catalytic activity. …”
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Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

“…Results: Male and female patients were remarkably similar across multiple plaque characteristics, including degree of stenosis, calcification severity and localization, and atherosclerotic patterns. …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…Our findings highlight the remarkable neuroprotective potential of EuEO and encourage further research of this very promising therapeutic alternative.…”
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CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors by Chiara Giordano, Simona Carlomagno, Simona Carlomagno, Michela Falco, Claudia Cantoni, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Franco Locatelli, Cristina Bottino, Cristina Bottino, Simona Sivori, Simona Sivori, Mariella Della Chiesa, Mariella Della Chiesa

“…They are characterized by CD94/NKG2C expression, a mature CD57+KIR+NKG2A– phenotype, a prolonged lifespan, and remarkable antitumor functions. In light of these features, adaptive NK cells represent suitable candidate to design next-generation therapies, based on their enhanced effector function which could be further boosted by Chimeric Antigen Receptors-engineering, or the combination with cell engagers. …”
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Effect of a bimetal Mn/Zn catalyst supported on activated carbon for selective oxidation of ethyl lactate to ethyl pyruvate by G. Madhanagopal, K. Premalatha, P.N. Poovizhi, V. Sumithra, S. Mahalingam, L. Guganathan, S. Sivakumar, A. Subramani, P. Tamizhdurai

“…The AC/Mn/Zn catalyst exhibited exceptional performance, achieving a remarkable 91 % conversion and 90 % selectivity for ethyl pyruvate, surpassing other investigated catalysts. …”
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MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis by Huifang Bai, Qianqian Dang, Guoliang Chen, Lingfeng Xie, Saining Wang, Ning Jiang, Xiaoxia Wu, Shuyan Zhang, Xuelin Wang

“…TJ-M2010-5 is a novel MyD88 inhibitor with remarkable protective effects against several diseases. …”
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Near Peer Learning in Neurology Residency Training on Electromyography by TAN Ying, HONG Yuehui, LI Jia, SHEN Dongchao, SHI Jiayu, YIN Hexiang, ZHOU Lixin, NI Jun, ZHU Yicheng

“…The results showed that the post-course test scores were significantly improved compared with pre-course test scores (74.33±2.43 vs. 70.11±2.49, P=0.005), with the most remarkable improvements seen for "tutees" (73.84±20.53 vs. 70.29±21.46, P=0.020), postgraduates (74.04±22.51 vs. 68.97±21.40, P=0.009), first-year residents (70.19±4.02 vs. 63.59±3.59, P=0.040) and first-time participating residents (65.23±3.24 vs. 60.97±3.21, P=0.030). …”
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