Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer by Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker

“…We find cCTCs represent between 5–30% of all CTC capture events, and 10-80% of the CTCs are clustered; remarkably, in 10 patients, most CTCs are circulating not as scCTCs, but as cCTCs. …”
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Plasma mediated water splitting for hydrogen production by M J Cook, T Nott, W J Trompetter, J Futter, C W Bumby, J V Kennedy

“…The integration of steam in plasma reactors in place of room temperature liquid water contributes a remarkable 20%–50% increase to the overall energy efficiency while the additional energy required in converting water to steam only incurs a 16.4% energy cost to the overall process. …”
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Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation by Qian-Lu Wang, Lei Yang, Yue Peng, Min Gao, Ming-Shi Yang, Wei Xing, Xian-Zhong Xiao

“…Ginsenoside Rg1 treatment remarkably suppressed apoptosis rate of LPS-induced A549 cells, relieved mouse lung tissue damage, and elevated survival rate. …”
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A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
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Design and Performance Analysis of ISFET Using Various Oxide Materials for Biosensing Applications by Sankararao Majji, Asisa Kumar Panigrahy, Depuru Shobha Rani, Muralidhar Nayak Bhukya, Chandra Sekhar Dash

“…The resulting 2D-ISFET exhibits remarkable blood electrolyte sensitivity and holds potential as a quick detection tool for blood cancer. …”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…Through the application of a structure-based drug design (SBDD) approach, we discover a series of novel potent non-covalent PLpro inhibitors with remarkable in vitro potency and in vivo PK properties. …”
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Hydrothermal Pre-Carbonization Triggers Structural Reforming Enabling Pore-Tunable Hierarchical Porous Carbon for High-Performance Supercapacitors by Cuihua Kang, Mingyuan Zuo, Chang Qiu, Fanda Zeng, Yuehui Wang, Zhuo Chen, Tingting Liang, Daping Qiu

“…Owing to the large ion-accessible, remarkable supermesoporous and macroporous pore volume, HJPC-4 exhibited ultra-high specific capacitance (6 M KOH: 316 F g⁻¹ at 1 A g⁻¹; EMIMBF₄: 204 F g⁻¹ at 1 A g⁻¹), excellent rate performance (6 M KOH: 231 F g⁻¹ at 100 A g⁻¹; EMIMBF₄: 154 F g⁻¹ at 30 A g⁻¹), outstanding cycling stability (6 M KOH: the retention rate is 92.11% after 60,000 cycles at 10 A g⁻¹; EMIMBF₄: the retention rate is 80% after 10,000 cycles at 5 A g⁻¹), and ultimate energy/power density up to 91.09 Wh kg⁻¹/24.25 kW kg⁻¹ in EMIMBF₄ two-electrode systems. …”
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The influence of Federal Regulations and community health indicators on community benefit spending by private nonprofit hospital in some States of the US: A retrospective longitudi... by Wael ELRAYES, David PALM, Fernando WILSON, Hongmei WANG, Jane MEZA, Robin HIGH, Valerie PACINO

“…States with the highest health needs spent the least, while those with lowest health needs spent the most. The remarkable fluctuation in spending over the three years of the study could not be explained by a matching variability in the community health needs. …”
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Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome by Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu, Ke Zen

“…Further examination of the single-cell dataset and cell binding assays suggest that monocytes likely bind to Stx2-B through the Toll-like receptor 4. Remarkably, Stx-laden monocytes demonstrate their ability to transport Stx2 to human renal glomerular endothelial cells (HRGEC), subsequently inducing apoptosis in HRGEC. …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…It was observed that AKT and phosphorylated AKT were remarkably reduced in CES4A overexpressing NPC cells, indicating that PI3K/AKT signaling pathway is hindered by CES4A. …”
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Antibacterial, Antibiofilm, and Efflux Pump Inhibitory Properties of the Crude Extract and Fractions from Acacia macrostachya Stem Bark by Akua Frema Barfour, Abraham Yeboah Mensah, Evelyn Asante-Kwatia, Cynthia Amaning Danquah, Daniel Anokwah, Silas Adjei, Michael Kwesi Baah, Merlin L. K. Mensah

“…Among the test samples, the crude extract, methanol, and ethyl acetate fractions showed remarkable efflux pump inhibition in S. aureus, E. coli, and P. aeruginosa. …”
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A UV to X-Ray View of Soft Excess in Type 1 Active Galactic Nuclei. I. Sample Selection and Spectral Profile by Shi-Jiang Chen, Jun-Xian Wang, Jia-Lai Kang, Wen-Yong Kang, Hao Sou, Teng Liu, Zhen-Yi Cai, Zhen-Bo Su

“…This correlation cannot be explained by ionized disk reflection alone, which produces mostly bb-like soft excess ( E _cut ~ 0.1 keV) as revealed by relxilllp simulation. Remarkably, we show with simulations that a toy hybrid scenario, where both ionized disk reflection ( relxilllp , with all reflection parameters fixed at default values except for ionization of the disk) and warm corona ( compTT , with temperature fixed at 1 keV) contribute to the observed soft excess, can successfully reproduce the observed correlation. …”
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Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients by Umberto Basile, Mariapaola Marino, Cecilia Napodano, Krizia Pocino, Paolo Emilio Alboini, Francesca Gulli, Amelia Evoli, Carlo Provenzano, Emanuela Bartoccioni

“…As MG course may be remarkably variable, we evaluated the possible use of FLCs as biomarkers of disease activity. …”
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Investigation of the Feasibility and Safety of a Highly Intensive Penetration Technique for Recanalization in Severe Calcified Femoropopliteal Occlusive Lesions: A Retrospective Ob... by Shinsuke Mori, Keisuke Hirano, Yusuke Setonaga, Toshihiko Kishida, Tomoya Fukagawa, Kohei Yamaguchi, Masafumi Mizusawa, Masakazu Tsutsumi, Norihiro Kobayashi, Yoshiaki Ito

“…Conclusion The HIP technique demonstrates remarkable effectiveness in navigating through highly calcified lesions, offering a reliable method for successful recanalization in challenging cases.…”
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Study of the Interplay Among Melt Morphology, Rheology and 3D Printability of Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends by Marco Costantini, Flavio Cognini, Roberta Angelini, Sara Alfano, Marianna Villano, Andrea Martinelli, David Bolzonella, Marco Rossi, Andrea Barbetta

“…Such a conclusion was validated by replicating with remarkable fidelity high-complexity objects, such as a patient’s cancer-affected iliac crest model.…”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…The normal inflammatory response to acute infection displays remarkable circadian rhythmicity in humans with increased inflammatory activity during the normal night or rest period. …”
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Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours by Gazanfer Belge, Markus Klemke, Bendix Hansen, Cansu Dumlupinar, Aylin Igde, Dirk Arnold, Hans Salwender, Christian Wülfing, Armin Soave, Klaus-Peter Dieckmann

“…Thus, the specificity of the M371-Test for GCT is 94.90% (95% CI 90.21–97.77%) when all NTMs and tumour-free controls are considered. Remarkably, three out of 5 patients with multiple myeloma had elevated M371 levels. …”
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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

“…Mechanistically, total crotonylation levels and H3K27cr were remarkably elevated in the skin and keratinocytes of diabetic rats; blocking high glucose-induced H3K27cr with MB-3 can enhance SQSTM1 transcription and expression while promoting autophagy and reducing ACSL4-induced ferroptosis in keratinocytes. …”
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Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Our experiments identified the regimen when complete resorption of the primary Krebs-2 ascites occurs in all of the treated animals, followed by a remarkable remission period lasting 7-9 days. Yet, this regimen does not prevent secondary site metastases (either solid or ascites form) from developing, which is likely caused by the migration of ascites cells into adjacent tissues or by incomplete eradication of cancer stem cells. …”
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Short-term evolution and dispersal patterns of fluconazole-resistance in Candida auris clade III by Irving Cancino-Muñoz, Juan Vicente Mulet-Bayona, Carme Salvador-García, Nuria Tormo-Palop, Remedios Guna, Concepción Gimeno-Cardona, Fernando González-Candelas

“…These results highlight the remarkable ability of the pathogen to adapt to its environment and its rapid global spread, underscoring the urgent need to address this epidemiological challenge effectively.IMPORTANCEThe number of cases affected by Candida auris has increased worryingly worldwide. …”
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