The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

“…Additionally, mycolactone depleted many secreted basement membrane components and microvascular basement membranes were disrupted in vivo during M. ulcerans infection in the mouse model. Remarkably, exogenous addition of laminin-511 reduced endothelial cell rounding, restored cell attachment and reversed the defective migration caused by mycolactone. …”
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Ammonia electrosynthesis from nitrate using a stable amorphous/crystalline dual-phase Cu catalyst by Yi Wang, Shuo Wang, Yunfan Fu, Jiaqi Sang, Pengfei Wei, Rongtan Li, Dunfeng Gao, Guoxiong Wang, Xinhe Bao

“…The ammonia partial current density and formation rate reach 3.33 ± 0.005 A cm−2 and 15.5 ± 0.02 mmol h−1 cm−2 at a low cell voltage of 2.6 ± 0.01 V, respectively. Remarkably, the dual-phase Cu catalyst can maintain stable ammonia production with a Faradaic efficiency of around 90% at a high current density of 1.5 A cm−2 for up to 300 h. …”
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Optimizing the synergy of strength and ductility in a Fe–18Mn–8Al–1C–5Ni lightweight steel by adjusting the distribution, volume fraction and size of B2 phases and κ-carbides... by P. Li, H.L. Sun, N. Xiao, H. Ding, X.F. Guo

“…As a result, the aged steel exhibited a remarkable ultra-high strength (yield strength of 1220 MPa, tensile strength of 1423 MPa) and a total elongation of 35.8%. …”
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Ferromagnetic Nickel as a Sustainable Reducing Agent for Tin–Lead Mixed Perovskite in Single‐Junction and Tandem Solar Cells by Doyun Im, Passarut Boonmongkolras, Yeonghun Yun, Sung Woong Yang, Sunwoo Kim, Jungchul Yun, Rajendra Kumar Gunasekaran, You‐Hyun Seo, Nam Joong Jeon, Gill Sang Han, Sangwook Lee

“…Furthermore, Ni‐based all‐perovskite tandem solar cells combining 1.77 eV WBG top cells with 1.25 eV NBG bottom cells achieve a remarkable PCE of 28.13%. Thus, the proposed strategy can facilitate the commercialization of all‐perovskite tandem devices.…”
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The MIL-125(Ti)/Co3O4 towards efficiently removing tetracycline by synergistic adsorption-photocatalysis roles by Qiuyang Dai, Guicheng Gao, Jijun Tang, Rongfei Jiang, Shijiao Sun, Yonglin Ye, Shiyun Li, Rong Xie, Jiaoxia Zhang

“…Furthermore, the photocatalytic degradation rate of tetracycline increased from 41.1 % for MIL-125(Ti) to 57.6 % for MIL-125(Ti)/Co3O4, resulting in a remarkable overall tetracycline removal efficiency of 91.9 % due to the combined effects of adsorption and photocatalysis. …”
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Effects of Biogas Slurry Drip Irrigation on Growth Performance of Brassica chinensis L. and Soil Nutrient Dynamics by DongXue Yin, Jiajun Qin, Dongdong Chen, Baozhong Wang, Wei Liu, Yingxian Wang, Weijuan Lan, Zhihao Wang, Jiachen Wang

“…The soil available potassium content was highest under the BS-3 treatment and had increased 20.4% compared with that before drip irrigation treatment. The most remarkable influence on the yield and quality of BL was observed when the drip irrigation amount was 24 L. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…While assessed in neurons, astrocytes, and microglia, its role is far less investigated in myelinating glia, including Schwann cells (SCs), responsible for peripheral nerve myelination. Remarkably, the dysregulation in endosomal trafficking is emerging as a pathophysiological mechanism underlying peripheral neuropathies, such as demyelinating Charcot‐Marie‐Tooth (CMT) diseases. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Here, we show that the single point mutation of Pro173 in the IsdB domain responsible for Hb binding, which weakens the IsdB:Hb interaction without hampering heme extraction, totally abolishes the previously observed behavior. Remarkably, Pro173 does not directly interact with Hb, but undergoes cis–trans isomerization upon IsdB:Hb complex formation, coupled to folding-upon binding of the corresponding protein loop. …”
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Lemongrass (Cymbopogon citratus) Essential Oil: Extraction, Composition, Bioactivity and Uses for Food Preservation – a Review by Ewa Majewska, Mariola Kozłowska, Eliza Gruczyńska-Sękowska, Dorota Kowalska, Katarzyna Tarnowska

“…High antibacterial and remarkable antifungal activities make the lemongrass oil a potential food preservative. …”
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Low-Intensity Pulsed Ultrasound Modulates RhoA/ROCK Signaling of Rat Mandibular Bone Marrow Mesenchymal Stem Cells to Rescue Their Damaged Cytoskeletal Organization and Cell Biolog... by Rong Zhang, Zhaoling Wang, Guoxiong Zhu, Gaoyi Wu, Qingyuan Guo, Hongchen Liu, Lei Chen

“…Inhibition of RhoA/ROCK signaling remarkably aggravated the inhibitory effect of radiation and attenuated the therapeutic effect of LIPUS. …”
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Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique andof probabilities of measurable concentrations of interleukins IL-2, IL-4, IL-5,... by Klabusay Martin, Kohutova Viera, Coupek Petr, Nenickova Marie, Tesarova Eva

“…The cytokine network remarkably influences homeostasis. There is not a complex analysis describing physiological values of soluble cytokines in healthy individuals. …”
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Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes by Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus

“…These enzymes have demonstrated remarkable protective and antidotal value against some different organophosphorus compounds in vivo in animal models. …”
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Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis by Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia

“…An analysis of patient tumor burden before and after the niraparib challenge showed a remarkable vulnerability of OC intraperitoneal metastases to niraparib exposure. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Recently, bozitinib, a highly selective c-Met kinase inhibitor, has shown remarkable potency in selectively inhibiting MET-altered non-small cell lung cancer and secondary glioblastoma. …”
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Cultivating clean skies: unveiling the tapestry of air quality in Gujarat through innovative machine learning analysis by Gaddam Advitha, Allada Nagasai Varaprasad, Koti Vennela Khushi, Pullabhotla Vijay, Sukanta Nayak

“…Four pivotal parameters, PM2.5, PM10, SO2, and NOX, are scrutinized due to their substantial impact on air quality and inclusion in publicly available datasets. Remarkably, both RF and XGBoost models exhibit outstanding performance, surpassing 99% accuracy. …”
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Photocatalytic removal of textile wastewater-originated methylene blue and malachite green dyes using spent black tea extract-coated silver nanoparticles by Sikander Ali, Huma Ijaz, Muhammad Usman Ahmad, Rukhma, Najeeb Ullah, Abid Sarwar, Muhammad Jalal Khan, Tariq Aziz, Ashwag shami, Fahad Al-Asmari

“…The malachite green was also reduced by 33.3% and 60%, which was remarkably significant owing to the presence of the complex factor in the natural environment. …”
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Hydrogen Generation from the Hydrolysis of Diamond-Wire Sawing Silicon Waste Powder Vibration-Ground with KCl by Zhicheng Li, Tao Zhou, Jiangfan Liao, Xiufeng Li, Wenhui Ma, Guoqiang Lv, Shimin Zhao

“…The grinding duration and addition amount remarkably affect the final hydrogen yield and initial hydrogen generation rate (IHGR). …”
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Synthesis and Characterization of Silver and Gold Nanoparticles Using Aqueous Extract of Seaweed, Turbinaria conoides, and Their Antimicrofouling Activity by Sri Ramkumar Vijayan, Prakash Santhiyagu, Muthukkumarasamy Singamuthu, Natarajan Kumari Ahila, Ravindran Jayaraman, Kannapiran Ethiraj

“…The synthesized Ag NPs are efficient in controlling the bacterial biofilm formation; however, Au NPs did not show any remarkable antibiofilm activity. The maximum zone of inhibition was recorded against E. coli (17.6±0.42 mm), followed by Salmonella sp., S. liquefaciens, and A. hydrophila. …”
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PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice by Ying Sun, Zhanjun Jia, Gang Liu, Li Zhou, Mi Liu, Baoxue Yang, Tianxin Yang

“…Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1. …”
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Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration by Huihui Du, Dongdong Zhang, Kui Xue, Limin Ma, Ru Xu, Ji Tan, Feng Peng, Xuanyong Liu

“…Moreover, Cur-Fe coating exhibits remarkable narrow gap semiconductor characteristics, which can generate reactive oxygen species (ROS) and demonstrated excellent antibacterial effect under simulated sunlight (SSL) irradiation. …”
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