The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice by Vera F. Monteiro-Cardoso, Xin Yi Yeo, Han-Gyu Bae, David Castano Mayan, Mariam Wehbe, Sejin Lee, Kumar Krishna-K, Seung Hyun Baek, Leon F. Palomera, Lik Hang Wu, Leroy S. Pakkiri, Sangeetha Shanmugam, Kai Ping Sem, Mun Geok Yew, Matthew P. Parsons, Michael R. Hayden, Leonard L.L. Yeo, Vijay K. Sharma, Chester Drum, Elisa A. Liehn, Sreedharan Sajikumar, Svend Davanger, Dong-Gyu Jo, Mark Y.Y. Chan, Benjamin Y.Q. Tan, Sangyong Jung, Roshni R. Singaraja

“…Bile acids are liver-derived signaling molecules that can be found in the brain, but their role there remains largely unknown. …”
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Intensified monsoonal rainstorm events over westerly-dominated Asian interior during the warm mid-Holocene by Peixian Shu, Weijian Zhou, Aaron E. Putnam, Baosheng Li, Shugang Kang, Yingying Sha, Zhengguo Shi, Guodong Ming, Hong Wang, Youbin Sun, David K. Wright, Weiguo Liu, Xiaodong Liu, Peng Cheng, Yougui Song, Dongfeng Niu, John R. Dodson, Hua Du, Jiaju Zhao, Zeke Zhang, Yahui Qiu, Zhisheng An

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Improving community-based first response to out of hospital cardiac arrest (FirstCPR): protocol for a cluster randomised controlled trial by Sandra Ware, Blake Angell, Julie Redfern, Clara Chow, Cate Ferry, Lee Taylor, Christopher Semsarian, Adrian Bauman, Janet E Bray, Simone Marschner, Michael Nelson, Saurabh Kumar, Matthew Vukasovic, Kevin Lai, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Alan Robert Denniss, Sarah Khanlari, Ian Opperman

“…Introduction Out-of-hospital cardiac arrest (OHCA) is associated with poor survival outcomes, but prompt bystander action can more than double survival rates. Being trained, confident and willing-to-perform cardiopulmonary resuscitation (CPR) are known predictors of bystander action. …”
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Radiographic outcomes and subsidence rate in hyperlordotic versus standard lordotic interbody spacers in patients undergoing anterior cervical discectomy and fusion by Rajkishen Narayanan, Nicholas B. Pohl, Jonathan Dalton, Yunsoo Lee, Alexa Tomlak, Anthony Labarbiera, Meryem Guler, Emilie Sawicki, Sebastian I. Fras, Mark F. Kurd, John J. Mangan, Ian David Kaye, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder, Joseph K. Lee

“…Currently, there is a lack of literature comparing subsidence rates or long-term radiographic outcomes with hyperlordotic and standard lordotic spacers. …”
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Canadian Association of Gastroenterology Clinical Practice Guidelines: The Use of Infliximab in Crohn's Disease by Remo Panaccione, Richard N Fedorak, Guy Anmais, Charles N Bernstein, Alain Bitton, Ken Croitoru, Robert Enns, Brian Feagan, Marty Fishman, Gordon Greenberg, Anne Griffiths, John K Marshall, Imran Rasul, Daniel Sadowski, Ernest Seidman, Hillary Steinhart, Lloyd Sutherland, Eric Walli, Gary Wild, C Noel Williams, Mary Zachos

“…The current guidelines have been updated to reflect knowledge gained from two pivotal randomized clinical trails, with the use of infliximab in the maintenance of inflammatory Crohn's disease in remission (2) and in the maintenance of fistulous Crohn's disease in remission (3).…”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Polyunsaturated fatty acids (PUFA) are lipid mediators that have anti-inflammatory characteristics and can be found in animals and plants, with capybara oil (CO) being a promising source. …”
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Lessons for the COVID era and beyond: The impact of inactive lifestyle and mental health events on burnout syndrome in university professors working from home during the pandemic by Angelica Castilho Alonso, Alan Oliveira Máximo de Carvalho, Juliana Sanches Lira, Vitória Camargo Paixão, Rafael Diego Modenes, Rita de Cássia Ernandes, Vanderlei Carneiro da Silva, Gerson Scherrer Júnior, Kleyton Góes Passos, Matheus Henrique dos Santos Lino, Sofia Silva, Sónia Brito-Costa, Guilherme Eustáquio Furtado, Guilherme Carlos Brech

“…Results showed high levels of emotional exhaustion, low levels of depersonalization, and moderate levels of reduced personal accomplishment among professors. …”
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FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Conclusions These data validate FORCE as a drug delivery platform and support the notion that DM1 may be treatable with low and infrequent dosing of DYNE-101.…”
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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization. by Gowtham A Rao, Azza Shoaibi, Rupa Makadia, Jill Hardin, Joel Swerdel, James Weaver, Erica A Voss, Mitchell M Conover, Stephen Fortin, Anthony G Sena, Chris Knoll, Nigel Hughes, James P Gilbert, Clair Blacketer, Alan Andryc, Frank DeFalco, Anthony Molinaro, Jenna Reps, Martijn J Schuemie, Patrick B Ryan

“…<h4>Conclusion</h4>Diagnostics based on large-scale population-level characterization can offer insights into the misclassification errors of PAs.…”
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Refined methodology for quantifying Pseudomonas aeruginosa virulence using Galleria mellonella by Christopher M. R. Axline, Travis J. Kochan, Sophie Nozick, Timothy Ward, Tania Afzal, Issay Niki, Sumitra D. Mitra, Ethan VanGosen, Julia Nelson, Aliki Valdes, David Hynes, William Cheng, Joanne Lee, Prarthana Prashanth, Timothy L. Turner, Nathan B. Pincus, Marc H. Scheetz, Kelly E. R. Bachta, Alan R. Hauser

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Le travail des peaux et du cuir durant le Haut-Empire à Bordeaux/Burdigala (Gironde), d’après les vestiges mis au jour sur le site de la rue Jean-Fleuret by Vanessa Elizagoyen, Christophe Sireix, Gisèle Allenet de Ribemont, Laurence Benquet, Philippe Borgard, Emilie Claud, Katleen Couchez, Marie-France Dietsch-Sellami, Stéphan Dubernet, Véronique Guitton, Jérôme Hénique, Yannick Le Digol, Martine Leguilloux, Sébastien Lepetz, Fabrice Leroy, Hélène Martin, Alain Queffelec, Stéphanie Raux, Nima Saedlou, Farid Sellami, Laure Simon, Serge Vigier

“…From the 1st century BC onwards, it is particularly indicative of the establishment of iron and non-ferrous metalworking crafts, as well as workshops dedicated to the working of hides, leather, animal bones and possibly textiles. …”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

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Assessing the effects of a mixed Eimeria spp. challenge on performance, intestinal integrity, and the gut microbiome of broiler chickens by Danielle Graham, Victor M. Petrone-Garcia, Xochitl Hernandez-Velasco, Makenly E. Coles, Marco A. Juarez-Estrada, Juan D. Latorre, Jianmin Chai, Stephanie Shouse, Jiangchao Zhao, Aaron J. Forga, Roberto Senas-Cuesta, Lauren Laverty, Kristen Martin, Carolina Trujillo-Peralta, Ileana Loeza, Latasha S. Gray, Billy M. Hargis, Guillermo Tellez-Isaias

“…The treatment groups included: (1) Non-challenged (NC, n = 5 replicate pens); and (2) challenged control (PC, n = 7 replicate pens) with 20 chickens/pen. …”
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Review and Clinical Perspectives for the Use of Infliximab in Ulcerative Colitis by Remo Panaccione, Richard N Fedorak, Guy Aumais, Edmond-Jean Bernard, Charles N Bernstein, Alain Bitton, Ken Croitoru, Levinus A Dieleman, Robert Enns, Brian G Feagan, Denis Franchimont, Gordon R Greenberg, Anne-Marie Griffiths, John K Marshall, Pierre Pare, Sunil Patel, Robert Penner, Craig Render, Ernest Seidman, A Hillary Steinhart

“…A review of the literature is followed by practical recommendations regarding infliximab that address the needs of clinicians and UC patients. Where there is a lack of evidence-based information, the expert panel provides its combined opinion derived from the members’ clinical experiences.…”
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Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania by Gervas A. Chacha, Filbert Francis, Salehe S. Mandai, Misago D. Seth, Rashid A. Madebe, Daniel P. Challe, Daniel A. Petro, Dativa Pereus, Ramadhani Moshi, Rule Budodo, Angelina J. Kisambale, Ruth B. Mbwambo, Catherine Bakari, Sijenunu Aaron, Daniel Mbwambo, Stella Kajange, Samuel Lazaro, Ntuli Kapologwe, Celine I. Mandara, Deus S. Ishengoma

“…Individuals from households with low SES (aOR = 1.40, 95% CI 1.16–1.69, P < 0.001), or living in houses with open windows (aOR = 1.24, 95% CI 1.06–1.45, P < 0.001) and/or holes on the walls (aOR = 1.43, 95% CI 1.14–1.81, P < 0.001) also had higher odds. …”
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Liquid-based encapsulation for implantable bioelectronics across broad pH environments by He Sun, Xiaoting Xue, Gabriella L. Robilotto, Xincheng Zhang, ChangHee Son, Xingchi Chen, Yue Cao, Kewang Nan, Yiyuan Yang, Gavin Fennell, Jaewook Jung, Yang Song, Huijie Li, Shao-Hao Lu, Yizhou Liu, Yi Li, Weiyi Zhang, Jie He, Xueju Wang, Yan Li, Aaron D. Mickle, Yi Zhang

“…Abstract Wearable and implantable bioelectronics that can interface for extended periods with highly mobile organs and tissues across a broad pH range would be useful for various applications in basic biomedical research and clinical medicine. …”
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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization by Gowtham A. Rao, Azza Shoaibi, Rupa Makadia, Jill Hardin, Joel Swerdel, James Weaver, Erica A. Voss, Mitchell M. Conover, Stephen Fortin, Anthony G. Sena, Chris Knoll, Nigel Hughes, James P. Gilbert, Clair Blacketer, Alan Andryc, Frank DeFalco, Anthony Molinaro, Jenna Reps, Martijn J. Schuemie, Patrick B. Ryan

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Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem CellsSummary by Kentaro Tominaga, Daniel O. Kechele, J. Guillermo Sanchez, Simon Vales, Ingrid Jurickova, Lizza Roman, Akihiro Asai, Jacob R. Enriquez, Heather A. McCauley, Keishi Kishimoto, Kentaro Iwasawa, Akaljot Singh, Yuko Horio, Jorge O. Múnera, Takanori Takebe, Aaron M. Zorn, Michael A. Helmrath, Lee A. Denson, James M. Wells

“…However, most published human organoid model systems lack resident immune cells, thus limiting their potential as disease avatars. …”
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