Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Abstract Cancer therapy-related cardiovascular toxicity (CTR-CVT) is now recognised as one of the leading causes of long-term morbidity and mortality in cancer patients. …”
Get full text

Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population by Guadalupe Flores Tomasino, Caroline Park, Kajetan Grodecki, Jolien Geers, Donghee Han, Andrew Lin, Keiichiro Kuronuma, Nipun Manral, Emily Xing, Heidi Gransar, Sebastien Cadet, Alan Rozanski, Piotr J. Slomka, Michelle Williams, Daniel S. Berman, Damini Dey

“…Quantitative plaque volumes—including total plaque, non-calcified plaque, low-attenuation non-calcified plaque (<30 Hounsfield Units [HU]), and calcified plaque—were measured using artificial intelligence-enabled software. …”
Get full text

Intraprosthetic Dislocation Following Dual Mobility Total Hip Arthroplasty: A Retrieval Analysis Study by Salar Sobhi, BSc, MD, Alan Kop, MSc, PhD, Moreica Pabbruwe, PhD, Christopher W. Jones, BCom, BEng(Hons), MBBS(Hons), PhD, FRACS, FAOrthA, Michael A. Finsterwald, MD, FMH, FRACS, FAOrthA

“…In older designs, IPD occurred due to a small head size and late PE wear with head-capture-mechanism failure. …”
Get full text

Alternative splicing expands the antiviral IFITM repertoire in Chinese rufous horseshoe bats. by Nelly S C Mak, Jingyan Liu, Dan Zhang, Jordan Taylor, Xiaomeng Li, Kazi Rahman, Feiyu Chen, Siddhartha A K Datta, Kin Kui Lai, Zhengli Shi, Nigel Temperton, Aaron T Irving, Alex A Compton, Richard D Sloan

Get full text

Cobertura LiDAR-Fotogramétrica, batimetría y levantamiento de infraestructuras como soporte al análisis de riesgos de inundación en la subcuenca del río Genil by J. J. Vales-Bravo, E. M. Méndez-Caballero, R. Prieto-Molina, L. Granado-Ruíz, I. Pino-Serrato, E. Sañudo-Costoya, G. García-Alén Lores, A. M. Pello-Rodríguez, A. Zabala-Ordóñez, E. Ortega-Díaz

Subjects: Get full text

Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…Introduction Artificial Intelligence Ready and Equitable for Diabetes Insights (AI-READI) is a data collection project on type 2 diabetes mellitus (T2DM) to facilitate the widespread use of artificial intelligence and machine learning (AI/ML) approaches to study salutogenesis (transitioning from T2DM to health resilience). …”
Get full text

Multidimensional library for the improved identification of per- and polyfluoroalkyl substances (PFAS) by Kara M. Joseph, Anna K. Boatman, James N. Dodds, Kaylie I. Kirkwood-Donelson, Jack P. Ryan, Jian Zhang, Paul A. Thiessen, Evan E. Bolton, Alan Valdiviezo, Yelena Sapozhnikova, Ivan Rusyn, Emma L. Schymanski, Erin S. Baker

“…This information will provide the scientific community with essential characteristics to expand analytical assessments of PFAS and augment machine learning training sets for discovering new PFAS.…”
Get full text

Development of a patient-reported outcomes tool to monitor changes in joint health and wellbeing for young people with haemophilia B by Bladen Melanie, McDonagh Janet, McLaughlin Paul, Gooding Richard, Holder Kerry-Ann, Thind Sharon, Klooster Brittany, Shields Alan, Turner-Bowker Diane M., Chatterton Kaitlin, Leso Allison, Volpi Connor, Sivasubramaniyam Sujan, Abulizi Jiawula, Khan Nisa

Get full text

Large exciton binding energy in a bulk van der Waals magnet from quasi-1D electronic localization by Shane Smolenski, Ming Wen, Qiuyang Li, Eoghan Downey, Adam Alfrey, Wenhao Liu, Aswin L. N. Kondusamy, Aaron Bostwick, Chris Jozwiak, Eli Rotenberg, Liuyan Zhao, Hui Deng, Bing Lv, Dominika Zgid, Emanuel Gull, Na Hyun Jo

“…Here, we report an exceptionally large exciton binding energy in single crystals of the bulk van der Waals antiferromagnet CrSBr. …”
Get full text

Chaperones Utilization in Clinical Practice: Intimate and Sensitive Physical Examination Best Practice Strategies and Concepts in Modern Urological Medicine by Tarini Mitra, Nicolas K. Koerber, Harini Shah, Austin C. Kassels, Danyon J. Anderson, Brennen J. Cooper, Meghan B. Schaefer, Alan D. Kaye, Harish B. Bangalore Siddaiah, Jibin S. Mathew, Jeffrey R. Sterritt, Zachary S. Lee, Ivan Urits

Get full text

Decrease in platelet count in patients with AKI and its association with major adverse kidney events by Ramón Medina-González, Jose J. Zaragoza, Eduardo M. Hernández-Barajas, Juarez Correa-de Leon, Rolando Claure-Del Granado, Armando Vazquez-Rangel, Liliana M. Pineda-Segura, Martha K. Franco-Garcia, Gael Chávez-Alonso, Juan A. Gómez-Fregoso, Francisco G. Rodríguez-García, Guillermo Navarro-Blackaller, Luz Alcantar-Vallin, Alejandro Martínez Gallardo-González, Gabriela J. Abundis-Mora, Guillermo García-García, Jonathan S. Chávez-Iñiguez

Get full text

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

Subjects: Get full text

Accelerated symptom improvement in Parkinson’s disease via remote internet-based optimization of deep brain stimulation therapy: a randomized controlled multicenter trial by Alireza Gharabaghi, Sergiu Groppa, Marta Navas-Garcia, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, S. Elizabeth Zauber, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Ming-Hua Chung, Yagna Pathak, Bram Blomme, Binith Cheeran, Corneliu Luca, Daniel Weiss

“…After surgery and initial configuration of stimulation parameters, optimization of DBS settings occurred in the clinic alone (IC) or with additional access to RIBA. The primary outcome assessed differences in the average time to achieve a one-point improvement on the Patient Global Impression of Change score between groups. …”
Get full text

Efficacy and safety of combined low‐dose rituximab regimen for chronic inflammatory demyelinating polyradiculoneuropathy by Ying Du, Qi Yan, Chuan Li, Wenping Zhu, Chao Zhao, Yunfeng Hao, Lin Li, Dan Yao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Lin Han, Yuanyuan Wang, Tao Hou, Juan Li, Hailin Li, Panpan Jiang, Pei Wang, Fenying Chen, Tingge Zhu, Juntong Liu, Shuyu Liu, Lan Gao, Yingjun Zhao, Wei Zhang

“…Abstract Objective To determine the efficacy and safety of combined low‐dose rituximab with conventional therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) treatment. …”
Get full text

The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. by William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez

“…This indicates a conserved role for GlRac and GlActin in forming membrane protrusions, despite the absence of canonical actin binding proteins that link Rho GTPase signaling to lamellipodia formation. …”
Get full text

Rimegepant for the treatment of migraine by Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…The trigeminovascular system is now known to have a significant role in the initiation of migraines, including the release of pain mediators such as CGRP and substance P. Traditional treatment of migraine is usually divided into acute and preventive treatment. …”
Get full text

Response to: Comment on “New Alternatives for Autoimmune Disease Treatments: Physicochemical and Clinical Comparability of Biosimilar Etanercept” by Mariana P. Miranda-Hernández, Carlos A. López-Morales, Francisco C. Perdomo-Abúndez, Rodolfo D. Salazar-Flores, Nancy D. Ramírez-Ibanez, Nestor O. Pérez, Aaron Molina-Pérez, Jorge Revilla-Beltri, Emilio Medina-Rivero, Luis F. Flores-Ortiz

Get full text

Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature. by Dianna Wolfe, Kim Corace, Claire Butler, Danielle Rice, Becky Skidmore, Yashila Patel, Premika Thayaparan, Alan Michaud, Candyce Hamel, Andra Smith, Gary Garber, Amy Porath, David Conn, Melanie Willows, Hanan Abramovici, Kednapa Thavorn, Salmaan Kanji, Brian Hutton

“…<h4>Objective</h4>To perform a scoping review to map the evidence regarding the health effects of cannabis use for medical and non-medical purposes in older adults.<h4>Methods</h4>Electronic databases (MEDLINE, Embase, PsycINFO, Cochrane Library) were searched for systematic reviews (SRs), randomized controlled trials (RCTs) and non-randomized/observational studies (NRSs) assessing the health effects and associations of cannabis use (medical or non-medical) in adults ≥ 50 years of age. …”
Get full text