Increased Incidence of Rhinovirus Pneumonia in Children During the COVID-19 Pandemic in Mexico by Fanny Yasmin Ortega-Vargas, Aldo Agustin Herrera-González, Ilen Adriana Díaz-Torres, Isamu Daniel Cabrera-Takane, Patricia Bautista-Carbajal, Miguel Leonardo García-León, Daniel E. Noyola, María Susana Juárez-Tobías, Verónica Tabla-Orozco, Pedro Antonio Martínez-Arce, María del Carmen Espinosa-Sotero, Gerardo Martínez-Aguilar, Fabian Rojas-Larios, Luis Alfonso Salazar-Soto, Rosa María Wong-Chew

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The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…Our results suggest that Lrp directly activates the transcription of both aroX and npsA genes by binding to the intergenic regulatory region in a leucine-dependent manner. Furthermore, the lack of Lrp significantly diminished the cytotoxicity of K. oxytoca on HeLa cells due to reduced production of TM and TV. …”
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…Testing a thyromimetic (LL-341070) compared to clemastine, we find it better enhances oligodendrocyte gain and hastens recovery of neuronal function. The therapeutic benefit of the thyromimetic is temporally restricted, and it acts exclusively following moderate to severe demyelination, eliminating the endogenous remyelination deficit. …”
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Management of childbearing with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: A scoping review and expert co-creation of evidence-based clinical guidelin... by Sally Pezaro, Isabelle Brock, Maggie Buckley, Sarahann Callaway, Serwet Demirdas, Alan Hakim, Cheryl Harris, Carole High Gross, Megan Karanfil, Isabelle Le Ray, Laura McGillis, Bonnie Nasar, Melissa Russo, Lorna Ryan, Natalie Blagowidow

“…The co-creation of guidelines was based on descriptive evidence synthesis along with practical and clinical experience supported by patient and public involvement activities.…”
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Detecting early cognitive deficits in preclinical Alzheimer’s disease using a remote digital multi-day learning paradigm by Roos J. Jutten, Daniel Soberanes, Cassidy P. Molinare, Stephanie Hsieh, Michelle E. Farrell, Aaron S. Schultz, Dorene M. Rentz, Gad A. Marshall, Keith A. Johnson, Reisa A. Sperling, Rebecca E. Amariglio, Kathryn V. Papp

“…Our results suggest that diminished MDLCs track with advanced AD pathophysiology, and demonstrate how a digital multi-day learning paradigm can provide novel insights about cognitive decline during preclinical AD.…”
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NONAN GaitPrint: An IMU gait database of healthy older adults by Tyler M. Wiles, Seung Kyeom Kim, Madhur Mangalam, Joel H. Sommerfeld, Kolby J. Brink, Alli Grunkemeyer, Marilena Kalaitzi Manifrenti, Anaelle E. Charles, Narges Shakerian, Mehrnoush Haghighatnejad, Spyridon Mastorakis, Nick Stergiou, Aaron D. Likens

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Evaluation of Handheld Assays for the Detection of Ricin and Staphylococcal Enterotoxin B in Disinfected Waters by Mary Margaret Wade, Tracey D. Biggs, Joseph M. Insalaco, Lisa K. Neuendorff, Vicky L. H. Bevilacqua, Amanda M. Schenning, Lisa M. Reilly, Saumil S. Shah, Edward K. Conley, Peter A. Emanuel, Alan W. Zulich

“…Limits of detection (LOD) were determined for all HHAs in each water type. …”
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Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer by Kelly Gaudian, Min Jung Koh, Min Ji Koh, Ryan R. Collins, Shaine Eden, Zoya Zwart, Malika Danner, Alan Zwart, Mark Fallick, Deepak Kumar, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Poor drug adherence was delineated as failure to reach castration or non-adherence per the SMAQ (any non-adherence answer, missed > 2 doses in last week or since last visit). …”
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Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort by Bryan F. Vaca-Cartagena, Ana S. Ferrigno Guajardo, Hatem A. Azim Jr, Federico Rotolo, Antonio Olivas-Martinez, Alejandra Platas, Alan Fonseca, Fernanda Mesa-Chavez, Marlid Cruz-Ramos, Ana Rodriguez, Alejandro Mohar, Cynthia Villarreal-Garza

“…Regular alcohol consumption at diagnosis (aOR [adjusted odds ratio] 1.64; 95 % CI [confidence interval] 1.02–2.65) and HER2-positive BC (aOR 2.53; 95 % CI 1.35–4.73) were independent factors associated with classification to the poor and good groups, respectively. …”
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Eficacia y seguridad de la desensibilización a hongos alergénicos en sujetos con enfermedad respiratoria alérgica. Revisión narrativa. by Alain Raimundo Rodríguez-Orozco, Karla Katia Prado-Quezada, Jorge Gonzales-Jaramillo, Ignacio López- Sánchez, Karla Katia Prado-Quezada, Daniel Calderón-Loeza, Martha Estrella García-Pérez, Christian Cortés-Rojo, Rocío del Carmen Montoya-Pérez

“…La información sobre eficacia y seguridad de la desensibilización de pacientes con alergias respiratorias (asma y rinoconjuntivitis) y con pruebas de alergia positiva a hongos alergénicos es escasa respecto a aquella dirigida al resto de los aeroalergenos. …”
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Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

“…Introduction Forced anal examinations are used to prosecute sexual and gender minorities (SGM) in multiple countries under the presumption that decreased sphincter tone, assessed by a finger inserted into the anal canal, can detect persons practising receptive anal intercourse. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…Secondary outcomes will include device-based (activPAL3TM) and self-reported (Global Physical Activity Questionnaire and Workforce Sitting Questionnaire) physical activity and sedentary behaviour; self-reported musculoskeletal disorders (Standardised Nordic Questionnaire) and pain (Numeric Rating Scale); self-reported presenteeism and absenteeism (Health and Work Performance Questionnaire), job satisfaction (Need for Recovery scale) and fatigue (single-item 5-point Likert scale). …”
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Development and external validation of a nomogram for the early prediction of acute kidney injury in septic patients: a multicenter retrospective clinical study by Qin-Yue Su, Wen-Jie Chen, Yan-Jun Zheng, Wen Shi, Fang-Chen Gong, Shun-Wei Huang, Zhi-tao Yang, Hong-Ping Qu, En-Qiang Mao, Rui-Lan Wang, Du-Ming Zhu, Gang Zhao, Wei Chen, Sheng Wang, Qian Wang, Chang-Qing Zhu, Gao Yuan, Er-Zhen Chen, Ying Chen

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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to improve patient care and management; however, clinical trial evidence to support their use is lacking. This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice.Methods and analysis A community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. …”
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Prevalence and determinants of HIV testing-seeking behaviors among women of reproductive age in Tanzania: analysis of the 2022 Demographic and health survey by Jackson Micheal Asingwire, Isaac isiko, Kuli Faith Rombe, Aaron Mwesigwa, Emmanuel Asher Ikwara, Haron Olot, Lenz Nwachinemere Okoro, Manankong Jane Precious Izunwanne, Blessing Onyinyechi Agunwa, Abdul Aziiz Bwana, William Yiga Kalemba, Ebuka Louis Anyamene

“…Those able to ask their partner to use a condom are more likely to have been tested with increased odds [AOR: 3.52, CI (2.31–5.37)]. Participants with a history of genital discharge [AOR:4.30, CI (1.28–14.46)] and those who don’t know their genital discharge history have [AOR: 0.20, CI (0.07–0.55)] are significant for HIV testing. …”
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Vascular Complications and Bleeding After Transfemoral TAVR With Surgical Versus Percutaneous Approach: A Contemporary Prospective Study by Annick Astié Dardaillon, Mariama Akodad, Fabien Huet, Pierre Alain Meunier, Thomas Gandet, Jean-Christophe Macia, Laurent Schmutz, Frederic Targosz, François Roubille, Matthieu Steinecker, Benoit Lattuca, Pierre Robert, Jean-Michel Berdeu, Guillaume Cayla, Florence Leclercq

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Eagle Syndrome: Pathophysiology, Differential Diagnosis and Treatment Options by Daniel Swanson, Cole H. Evensky, Shadman Yusuf, Hannah Long, Jamal Hasoon, Mustafa Mohamed, Bruce M. Dixon, Tomasina Parker-Actlis, Michael A. Alvarado, Jaehong Song, Adam M. Kaye, Giustino Varrassi, Alan D. Kaye, Latha Ganti

“…This report aims to update providers on the important diagnostic criteria of Eagle Syndrome and how physicians can develop a treatment plan that addresses all the symptoms of patients with Eagle Syndrome because it can be treated safely and appropriately.…”
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A New Unsaturated Aliphatic Anhydride from Aspergillus candidus T1219W1, an Endophytic Fungus, from Pittosporum mannii Hook f. by Gaëlle Talle Juidzou, Elodie Gisèle Mouafo Anoumedem, Denis Kehdinga Sema, Virginie Flaure Tsague Tankeu, Peron Bosco Leutcha, Larissa Yetendje Chimi, Jean Paul Dzoyem, Simeon Kouam Fogue, Norbert Sewald, M. Iqbal Choudhary, Alain Meli Lannang

“…The tested sample showed good antibiofilm activity with the lowest MBEC50 obtained at 64 μg/mL. Compounds showed low anti-inflammatory activity even at high concentration (250 μg·mL−1 with an IC50 of 59.6 ± 0.1 μg·mL−1) with moderate cytotoxicity on brine shrimps at high concentration (1000 μg·mL−1, with 46.67% mortality). …”
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Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

Subjects: “…Locally advanced pancreatic ductal adenocarcinoma (laPDAC)…”
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