Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

“…Unadjusted 5- and 10-year survival rates were 84% and 75%, respectively, among patients who received ACT and 70% and 50% among patients who did not (log-rank P < 0.01). Inadequate LNY was independently associated with both receipt of ACT (odds ratios, 1.50; P < 0.01) and decreased overall survival [hazard ratio (HR), 1.56; P < 0.01]. …”
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Collaboration entre chercheurs et praticiens dans le cadre du projet Saines habitudes de vie – éducation physique et à la santé by Cecília Borges, Enrique García Bengoechea, Shirley Gray, Paula Bush, Suzanne Guay, Alain Lefebvre, Katherine Baker et Sandy Farr, Thierry Mélinge, Margaret Amos, Anne Sophie-Aubin et Joli-Anne Mercier

“…This article addresses some issues emerging from the collaboration between researchers and practitioners within the framework of a Healthy Lifstyles Promotion- Physical Education and Health project aimed at the consolidation of the role of physical educators as promoters of a healthy active lifestyles towards their students. We present the main themes and findings of this project inspired by continuum training, action-research and collaboration, that involved both beginner and experienced teacher participants from one French and one English School Board on the island of Montreal.Based on data stemming from the evaluation of eight workshops involving twelve teachers, we present four fundamentals pillars of this project : the respective role of the practitioners and the researchers, their collaboration, the knowledge that they constructed together and the temporality in this process.…”
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Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals by Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane

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Red Blood Cell Transfusions and Iron Therapy for Patients Presenting with Acute Upper Gastrointestinal Bleeding: A Survey of Canadian Gastroenterologists and Hepatologists by Kyle J. Fortinsky, Myriam Martel, Roshan Razik, Gillian Spiegle, Zane R. Gallinger, Samir C. Grover, Katerina Pavenski, Adam V. Weizman, Lukasz Kwapisz, Sangeeta Mehta, Sarah Gray, Alan N. Barkun

“…Fewer than 15% would prescribe iron to patients with UGIB who are anemic upon discharge. …”
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Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs by Jennifer Mumaw, Erin T. Jordan, Corinne Sonnet, Ronke M. Olabisi, Elizabeth A. Olmsted-Davis, Alan R. Davis, John F. Peroni, Jennifer L. West, Franklin West, Yangqing Lu, Steven L. Stice

“…Autologous bone grafting is the most effective treatment for long-bone nonunions, but it poses considerable risks to donors, necessitating the development of alternative therapeutics. …”
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Brivaracetam to Treat Partial Onset Seizures in Adults by Dustin Latimer, David Le, Evan Falgoust, Patrick Ingraffia, Alaa Abd-Elsayed, Elyse M. Cornett, Rupin Singh, JooHee Choi, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Further studies are necessary to conclude long term efficacy and safety profile of brivaracetam…”
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MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing by Robinson Vidva, Mir Abbas Raza, Jaswant Prabhakaran, Ayesha Sheikh, Alaina Sharp, Hayden Ott, Amelia Moore, Christopher Fleisher, Hailey Netherton, Evan Goldstein, Pothitos M. Pitychoutis, Tam V. Nguyen, Aaron Sathyanesan

“…Using MyVivarium, lab members can collaboratively track individual animals within a database. …”
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Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic... by Partha Ray, Tomoko Hayashi, Karen Messer, Stephen Schoenberger, Aaron Miller, Dennis Carson, Sara McArdle, Zbigniew Mikulski, Jayanth S Shankara Narayanan, Suna Erdem, Herve Tiriac, Minya Pu, Rebekah R White

“…Mice were randomized to treatment with either sham laparotomy, IRE alone, CD40Ab alone, or IRE followed immediately by CD40Ab injection. …”
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Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

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Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer by Luyao Zhang, Shunfang Liu, Jingliang He, Zhongke Hu, Lan Zhu, Hongyi Huang, Qi Gao, Dan Wang, Lu Chen, Xingyu Zhang, Ruotong Liu, Jiayun Wang, Yizhuo Song, Kaile Zeng, Xiuming Li, Yulu Chen, Xun Zou, Shaojie Ma, Xiujun Wang, Guofeng Xu, Wei Liu, Bin Liu

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Effects of Low-Level Autonomic Stimulation on Prevention of Atrial Fibrillation Induced by Acute Electrical Remodeling by Yubi Lin, Ning Bian, Hairui Li, Jia Chen, Huijie Xing, Hong Li, Dandan Huang, Xianwu Lan, Bojun Gong, Li Zhou, Ruijie Liu, Min Guan, Dongdong Zhang, Gang Du, Zhengyi Huang, Xiaoming Chen, Tao Zhang, Jianyi Feng, Shaorong Wu, Liwei Wang, Aidong Zhang, Zicheng Li

“…Recent reports showed that low-level vagosympathetic nerve stimulation (LLVNS) can suppress AF, as an antiarrhythmic effect. …”
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CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

“…Abstract Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. However, the function of CDK14 during organ development and regeneration has not been investigated in genetically-modified animals. …”
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Gaps in Capacity in Primary Care in Low-Resource Settings for Implementation of Essential Noncommunicable Disease Interventions by S. Mendis, Igbal Al Bashir, Lanka Dissanayake, Cherian Varghese, Ibtihal Fadhil, Esha Marhe, Boureima Sambo, Firdosi Mehta, Hind Elsayad, Idrisa Sow, Maltie Algoe, Herbert Tennakoon, Lai Die Truong, Le Thi Tuyet Lan, Dismond Huiuinato, Neelamni Hewageegana, Naiema A. W. Fahal, Goitom Mebrhatu, Gado Tshering, Oleg Chestnov

“…A cross-sectional survey was done in eight low- and middle-income countries (Benin, Bhutan, Eritrea, Sri Lanka, Sudan, Suriname, Syria, and Vietnam) in 90 PC facilities randomly selected. …”
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Ethanolic Extract of <i>Averrhoa carambola</i> Leaf Has an Anticancer Activity on Triple-Negative Breast Cancer Cells: An In Vitro Study by Oscar F. Beas-Guzmán, Ariana Cabrera-Licona, Gustavo A. Hernández-Fuentes, Silvia G. Ceballos-Magaña, José Guzmán-Esquivel, Luis De-León-Zaragoza, Mario Ramírez-Flores, Janet Diaz-Martinez, Idalia Garza-Veloz, Margarita L. Martínez-Fierro, Iram P. Rodríguez-Sanchez, Gabriel Ceja-Espíritu, Carmen Meza-Robles, Víctor H. Cervantes-Kardasch, Iván Delgado-Enciso

“…This study aimed to assess the effects of ethanolic extract from <i>A. carambola</i> leaves on triple-negative breast cancer (TNBC), an aggressive subtype lacking specific therapy. <b>Methods</b>: Phytochemical analysis and HPLC profile and additional cell line evaluation employing MDA-MB-231 were carried out. …”
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The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

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Advances and Challenges in Antiviral Development for Respiratory Viruses by Luis Adrián De Jesús-González, Moisés León-Juárez, Flor Itzel Lira-Hernández, Bruno Rivas-Santiago, Manuel Adrián Velázquez-Cervantes, Iridiana Monserrat Méndez-Delgado, Daniela Itzel Macías-Guerrero, Jonathan Hernández-Castillo, Ximena Hernández-Rodríguez, Daniela Nahomi Calderón-Sandate, Willy Salvador Mata-Martínez, José Manuel Reyes-Ruíz, Juan Fidel Osuna-Ramos, Ana Cristina García-Herrera

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Meeting Report on “10th Anniversary Symposium on Inflammatory Skin Disease” by Shirin Emtenani, John F. Baines, Katja Bieber, Evelyn Gaffal, Stephanie Goletz, Gema Hernández, Misa Hirose, Markus Hoffmann, Pascal Joly, Henriette Kirchner, Jörg Köhl, Sripriya Murthy, Sabrina Patzelt, Frank Petersen, Manuela Pigors, Gabriela Riemekasten, Leon F. Schmidt-Jiménez, Tanya Sezin, Malte Spielmann, Diamant Thaçi, Nina van Beek, Jens Waschke, Ralf J. Ludwig, Enno Schmidt

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Brain atrophy in heart failure patients following left ventricular assist device implantation or heart transplantation by D.Alan Herbst, MD, Banafsheh Shakibajahromi, MD, Michael V. Genuardi, MD, Amit Iyengar, MD, Dawn Mechanic-Hamilton, PhD, H. Branch Coslett, MD, Pavan Atluri, MD, Christopher G. Favilla, MD

“…Advanced heart failure is associated with accelerated brain atrophy, largely related to chronic cerebral malperfusion. …”
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HIV-Infected Individuals Do Not Present Significant Differences regarding Periodontal Status: A Systematic Review and Meta-Analysis by Lucas Ribeiro Teixeira, Diana Estefania Ramos Peña, Leticia Rodrigues de Castro, Márcia dos Santos, Maria da Conceição Pereira Saraiva, Fernando Chahud, Bruno Pozzetto, Alan Grupioni Lourenço, Ana Carolina Fragoso Motta

“…To evaluate, through a systematic literature review, whether periodontal status in HIV-infected individuals is different from those non-HIV-infected. Materials and Methods. A systematic search for published observational studies within six electronic databases and grey literature was conducted, PROSPERO database number CRD42020160062. …”
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The Role of Dopamine in Impulsivity and Substance Abuse: A Narrative Review by Connor J Plaisance, Lloyd F Ledet III, Nicholas J Slusher, Charles P Daniel, Zachary Lee, Bradley Dorius, Sonnah Barrie, Tomasina Q Parker-Actlis, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye

“…Impulsive decision making is commonly defined as a reduced ability to choose a delayed large reward instead of a small immediate reward. …”
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