GLP‐1 Receptor Agonists Alleviate Diabetic Kidney Injury via β‐Klotho‐Mediated Ferroptosis Inhibition by Shasha Tian, Saijun Zhou, Weixi Wu, Yao lin, Tongdan Wang, Haizhen Sun, A‐Shan‐Jiang A‐Ni‐Wan, Yaru Li, Chongyang Wang, Xiaogang Li, Pei Yu, Yanjun Zhao

“…Notably, Smg treatment significantly increases the mRNA expression of KLB through the activation of the cyclic adenosine monophosphate (cAMP) signaling pathway, specifically through the phosphorylation of protein kinase A (PKA) and cAMP‐response element‐binding protein (CREB). …”
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Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9 by Xuemei Zhang, Meiyu Qiu, Bing Han, Li Liao, Xinrong Peng, Jiapeng Lin, Ning Zhang, Lati Hai, Long Liang, Yila Ma, Wenrong Li, Mingjun Liu

“…Our results also indicated that the parity signification, our data demonstrate that highly efficient introduction of the intended base mutation into the sheep genome can be achieved by combining the CRISPR/Cas9 system with ssODN and SCR7. The offspring of BMPR/B edited sheep with the defined mutation exhibited high fecundity performance. …”
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Screening of <em>FecLL</em> prolific allele of the <em>B4GALNT2</em> gene in Algerian sheep populations by Assia Hadjazi, Fatima Zahra Belharfi, Fatima Zohra Mahammi, Stéphane Fabre, Semir Bechir Suheil Gaouar, Nacera Tabet-Aoul

“…However, their action differs from that of other major genes discovered previously, such as: FecX/BMP15 (bone morphogenetic protein 15); FecG/GDF9 (growth differentiation factor 9); and FecB/BMPR1B (bone morphogenetic protein receptor type 1B). …”
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Characteristics and spatiotemporal changes in phenotypes and genotypes of extended-spectrum β-lactamases in Escherichia coli isolated from bloodstream infections in China from 2014... by Sayyed Salman, Hao Xu, Yunbo Chen, Jinru Ji, Zhiying Liu, Yonghong Xiao

“…Among 983 phenotypically confirmed ESBL-positive E. coli, 763 (77.6%) were confirmed to carry ESBL genes, with the majority being of the CTX-M type, which is further divided into 23 subtypes and dominated by the CTX-M-9 and CTX-M-1 groups, with 457/763 and 333/763, respectively. Other ESBLs and ampC genes, such as bla OXA−1, bla CMY, and bla DHA−1, often coexisted with either the CTX-M-9 or CTX-M-1 groups. bla CTX−M−14 (34.3%, 157/457) and bla CTX−M−55 (45.9%, 153/333) were the dominant subtypes in the CTX-M-9 and CTX-M-1 groups, respectively. …”
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Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum by Ana Gabriela de Oliveira do Rêgo, Francesca D'Amico, Vincenza D’Angelo, Silvia Cardarelli, Debora Cutuli, Davide Decandia, Eugenia Landolfo, Laura Petrosini, Manuela Pellegrini, Marcello D’Amelio, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario

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Semen quality and fertility effectiveness of cloned buffalo (Bubalus bubalis) bulls by Manoj Kumar Singh, Smiriti Gupta, Kanika Gandhi, S.S. Lathwal, Naresh L. Selokar

“…KEGG analysis revealed that the Up- and down-regulated transcripts affect excision repair, autophagy, lipolysis, AMPK, and insulin signaling pathways. A total of 278 miRNAs were found in both cloned and parent bull spermatozoa, of which 239 were common and 28 were unique to cloned bulls spermatozoa. …”
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Human Periodontal Ligament Stem Cell-Derived Exosomes Promote Bone Regeneration by Altering MicroRNA Profiles by Ting Liu, Wenyun Hu, Xue Zou, Jingchen Xu, Shushu He, Le Chang, Xinyi Li, Yuanyuan Yin, Mi Tian, Ziyu Li, Jialiang Zhou, Xiaoge Jiang, Song Chen

“…The results of Gene Ontology analysis and pathway analysis demonstrated that the target genes of differentially expressed exosomal miRNAs participate in the regulation of a variety of biological processes, such as catalytic activity, protein binding, metabolic processes, cell development, and differentiation, and are enriched in osteogenic differentiation-related pathways, such as MAPK signaling, AMPK signaling, and insulin signaling pathways. Our results reveal for the first time that the exosomal miRNAs derived from osteogenic differentiated PDLSCs may promote the osteogenic differentiation of BMSCs, which provides a basis for further research on the regulatory function of exosomal miRNA of PDLSCs during osteogenesis.…”
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Impact of protein intake from a caloric-restricted diet on liver lipid metabolism in overweight and obese rats of different sexes by Ying Tian, Jiawei Gong, Zhiyan He, Suwen Peng, Yuping Huan, Hongpeng Cao

“…Moreover, the trend of expression in the signaling pathways of adiponectin/phosphorylated AMP-activated protein kinase (p-AMPK) and adiponectin/peroxisome proliferators-activated receptor alpha (PPARα) in the liver was consistent with that of the liver fat content, and leptin acted in the same way as adiponectin. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10‐fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC‐1α axis to regulate the mitochondrial function, providing a multi‐dimensional PD therapy. …”
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Oral-Delivery Lactococcus lactis expressing cherry fusion lactoferrin peptides against infection of avian pathogenic Escherichia coli in chickens by Zhuoran Li, Xueying Wang, Dianzhong Zheng, Fuzhen Han, Yue Li, Han Zhou, Jiaxuan Li, Wen Cui, Yanping Jiang, Xiaona Wang, Weichun Xie, Lijie Tang

“…Probiotics and antimicrobial peptides (AMPs) are potential alternatives to antibiotics and represent promising strategies to combat APEC. …”
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Transcriptome Analysis Reveals the Molecular Mechanism of PLIN1 in Goose Hierarchical and Pre-Hierarchical Follicle Granulosa Cells by Hua He, Yueyue Lin, Xi Zhang, Hengli Xie, Zhujun Wang, Shenqiang Hu, Liang Li, Hehe Liu, Chunchun Han, Lu Xia, Jiwei Hu, Jiwen Wang, Lin Liao, Xin Yuan

“…Additionally, nine potential candidate genes were identified: <i>PPARγ</i>, <i>MGLL</i>, <i>PTEN</i>, <i>BAMBI</i>, <i>BMPR2</i>, <i>JUN</i>, <i>FST</i>, <i>ACSF3</i>, and <i>ACSL4</i>. …”
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Applicazione del Workload Indicators of Staffing Need (WISN) per la stima del fabbisogno di Tecnici Sanitari di Radiologia Medica in una Struttura di Diagnostica per Immagini itali... by Domenico Riccardo Cammisa, Francesca Fortunato, Antonio Alemanno, Rosetta D'Andria, Federica Guglielmi

“…Nel dicembre 2022, la Conferenza Stato-Regioni ha ratificato un nuovo “Metodo per la determinazione del fabbisogno di personale del SSN”, ma anch'esso fornisce indicazioni troppo vaghe e range operativi troppo ampi. Il presente studio mira a sperimentare l’applicazione del metodo Workload Indicators of Staffing Need (WISN), già utilizzato in ambito industriale e nelle professioni sanitarie assistenziali, per la stima del fabbisogno dei Tecnici Sanitari di Radiologia Medica (TSRM). …”
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Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…Results of gene ontology analysis identified two biological pathways namely skeletal system development and calcium channel complex with two important KEGG pathways including glucagon signaling pathway and AMPK signaling pathway which play an important role in glucose metabolism and homeostasis and skeletal system development. …”
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L’approccio multidisciplinare al trattamento del dolore cronico pediatrico: analisi qualitativa mediante focus group by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…Studi futuri con campioni più ampi potrebbero validare le conclusioni e perfezionare le raccomandazioni per un'efficace gestione del dolore cronico nei pazienti pediatrici. …”
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Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy by Guillermo Paz-López, Teresa M. Linares-Pineda, Andrés González-Jiménez, Raquel Sancho-Marín, Luis Ocaña-Wilhelmi, Francisco J. Tinahones, Sonsoles Morcillo, Carolina Gutiérrez-Repiso

“…Of them, 59,308 DMPs were annotated to genes. KEGG enrichment analysis showed that pathways involved in the signalling of MAPK, Wnt, mTor, FoxO and AMPK, among others, were involved in weight loss trajectory.A stepwise logistic regression using the DMPs with an absolute Δβ >0.2 showed that higher methylation levels in the CpG sites cg02405213 (mapping to JAK2) (OR: 1.20098, [0.9586, 1.5044]) and cg01702330 (OR: 2.4426, [0.5761, 10.3567]), were shown to be associated with a higher probability of achieving >60 %EWL after sleeve gastrectomy, whereas higher methylation levels in the CpG site cg04863892 (mapping to HOXA5) were associated with lower probability of achieving >60 %EWL after sleeve gastrectomy (OR: 0.7966, [0.5637, 1.1259]). …”
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Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring by Xiu Cheng, Yue Xue, Houpeng Wang, Zhangqiang Ma, Na Hu, Chenchen Zhang, Yu Gao, Ruihong Fan, Liaoliao Hu, Jia Li, Dalei Zhang, Jian Huang, Sitian Fang, Runting Xiao, Yuanqiao He, Tao Luo, Liping Zheng

“…The impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…However, enhancing autophagy by activating the PI3K/AKT, AMPK, and mTOR pathways, improves podocyte injury and renal pathological changes, and ameliorates renal function. …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…Finally, we established that the suppression of NET formation by S100A8/A9 inhibition is primarily mediated through the AMPK/Nrf2/HO-1 signaling pathway. These findings underscore the critical pathological role of S100A8/A9 in TBI and emphasize the need for further exploration of S100A8/A9 inhibitor Paquinimod as a potential therapeutic strategy for TBI.…”
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Corrigendum to “Search for a common baryon source in high-multiplicity pp collisions at the LHC” [Phys. Lett. B 811 (2020) 135849] by S. Acharya, D. Adamová, A. Adler, J. Adolfsson, M.M. Aggarwal, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S.U. Ahn, Z. Akbar, A. Akindinov, M. Al-Turany, S.N. Alam, D.S.D. Albuquerque, D. Aleksandrov, B. Alessandro, H.M. Alfanda, R. Alfaro Molina, B. Ali, Y. Ali, A. Alici, A. Alkin, J. Alme, T. Alt, L. Altenkamper, I. Altsybeev, M.N. Anaam, C. Andrei, D. Andreou, H.A. Andrews, A. Andronic, M. Angeletti, V. Anguelov, C. Anson, T. Antičić, F. Antinori, P. Antonioli, N. Apadula, L. Aphecetche, H. Appelshäuser, S. Arcelli, R. Arnaldi, M. Arratia, I.C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, S. Aziz, M.D. Azmi, A. Badalà, Y.W. Baek, S. Bagnasco, X. Bai, R. Bailhache, R. Bala, A. Balbino, A. Baldisseri, M. Ball, S. Balouza, D. Banerjee, R. Barbera, L. Barioglio, G.G. Barnaföldi, L.S. Barnby, V. Barret, P. Bartalini, K. Barth, E. Bartsch, F. Baruffaldi, N. Bastid, S. Basu, G. Batigne, B. Batyunya, D. Bauri, J.L. Bazo Alba, I.G. Bearden, C. Beattie, C. Bedda, N.K. Behera, I. Belikov, A.D.C. Bell Hechavarria, F. Bellini, R. Bellwied, V. Belyaev, G. Bencedi, S. Beole, A. Bercuci, Y. Berdnikov, D. Berenyi, R.A. Bertens, D. Berzano, M.G. Besoiu, L. Betev, A. Bhasin, I.R. Bhat, M.A. Bhat, H. Bhatt, B. Bhattacharjee, A. Bianchi, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, A. Bilandzic, G. Biro, R. Biswas, S. Biswas, J.T. Blair, D. Blau, C. Blume, G. Boca, F. Bock, A. Bogdanov, S. Boi, J. Bok, L. Boldizsár, A. Bolozdynya, M. Bombara, G. Bonomi, H. Borel, A. Borissov, H. Bossi, E. Botta, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, E. Bruna, G.E. Bruno, M.D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, O. Bugnon, P. Buhler, P. Buncic, Z. Buthelezi, J.B. Butt, S.A. Bysiak, D. Caffarri, A. Caliva, E. Calvo Villar, R.S. Camacho, P. Camerini, A.A. Capon, F. Carnesecchi, R. Caron, J. Castillo Castellanos, A.J. Castro, E.A.R. Casula, F. Catalano, C. Ceballos Sanchez, P. Chakraborty, S. Chandra, W. Chang, S. Chapeland, M. Chartier, S. Chattopadhyay, S. Chattopadhyay, A. Chauvin, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D.D. Chinellato, S. Cho, P. Chochula, T. Chowdhury, P. Christakoglou, C.H. Christensen, P. Christiansen, T. Chujo, C. Cicalo, L. Cifarelli, F. Cindolo, G. Clai, J. Cleymans, F. Colamaria, D. Colella, A. Collu, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J.G. Contreras, T.M. Cormier, Y. Corrales Morales, P. Cortese, M.R. Cosentino, F. Costa, S. Costanza, P. Crochet, E. Cuautle, P. Cui, L. Cunqueiro, D. Dabrowski, T. Dahms, A. Dainese, F.P.A. Damas, M.C. Danisch, A. Danu, D. Das, I. Das, P. Das, P. Das, S. Das, A. Dash, S. Dash, S. De, A. De Caro, G. de Cataldo, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, S. De Pasquale, S. Deb, H.F. Degenhardt, K.R. Deja, A. Deloff, S. Delsanto, W. Deng, D. Devetak, P. Dhankher, D. Di Bari, A. Di Mauro, R.A. Diaz, T. Dietel, P. Dillenseger, Y. Ding, R. Divià, D.U. Dixit, Ø. Djuvsland, U. Dmitrieva, A. Dobrin, B. Dönigus, O. Dordic, A.K. Dubey, A. Dubla, S. Dudi, M. Dukhishyam, P. Dupieux, R.J. Ehlers, V.N. Eikeland, D. Elia, E. Epple, B. Erazmus, F. Erhardt, A. Erokhin, M.R. Ersdal, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, A. Fantoni, M. Fasel, P. Fecchio, A. Feliciello, G. Feofilov, A. Fernández Téllez, A. Ferrero, A. Ferretti, A. Festanti, V.J.G. Feuillard, J. Figiel, S. Filchagin, D. Finogeev, F.M. Fionda, G. Fiorenza, F. Flor, A.N. Flores, S. Foertsch, P. Foka, S. Fokin, E. Fragiacomo, U. Frankenfeld, U. Fuchs, C. Furget, A. Furs, M. Fusco Girard, J.J. Gaardhøje, M. Gagliardi, A.M. Gago, A. Gal, C.D. Galvan, P. Ganoti, C. Garabatos, E. Garcia-Solis, K. Garg, C. Gargiulo, A. Garibli, K. Garner, P. Gasik, E.F. Gauger, M.B. Gay Ducati, M. Germain, J. Ghosh, P. Ghosh, S.K. Ghosh, M. Giacalone, P. Gianotti, P. Giubellino, P. Giubilato, P. Glässel, A. Gomez Ramirez, V. Gonzalez, L.H. González-Trueba, S. Gorbunov, L. Görlich, A. Goswami, S. Gotovac, V. Grabski, L.K. Graczykowski, K.L. Graham, L. Greiner, A. Grelli, C. Grigoras, V. Grigoriev, A. Grigoryan, S. Grigoryan, O.S. Groettvik, F. Grosa, J.F. Grosse-Oetringhaus, R. Grosso, R. Guernane, M. Guittiere, K. Gulbrandsen, T. Gunji, A. Gupta, R. Gupta, I.B. Guzman, R. Haake, M.K. Habib, C. Hadjidakis, H. Hamagaki, G. Hamar, M. Hamid, R. Hannigan, M.R. Haque, A. Harlenderova, J.W. Harris, A. Harton, J.A. Hasenbichler, H. Hassan, D. Hatzifotiadou, P. Hauer, L.B. Havener, S. Hayashi, S.T. Heckel, E. Hellbär, H. Helstrup, A. Herghelegiu, T. Herman, E.G. Hernandez, G. Herrera Corral, F. Herrmann, K.F. Hetland, H. Hillemanns, C. Hills, B. Hippolyte, B. Hohlweger, J. Honermann, D. Horak, A. Hornung, S. Hornung, R. Hosokawa, P. Hristov, C. Huang, C. Hughes, P. Huhn, T.J. Humanic, H. Hushnud, L.A. Husova, N. Hussain, S.A. Hussain, D. Hutter, J.P. Iddon, R. Ilkaev, H. Ilyas, M. Inaba, G.M. Innocenti, M. Ippolitov, A. Isakov, M.S. Islam, M. Ivanov, V. Ivanov, V. Izucheev, B. Jacak, N. Jacazio, P.M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M.J. Jakubowska, M.A. Janik, T. Janson, M. Jercic, O. Jevons, M. Jin, F. Jonas, P.G. Jones, J. Jung, M. Jung, A. Jusko, P. Kalinak, A. Kalweit, V. Kaplin, S. Kar, A. Karasu Uysal, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, U. Kebschull, R. Keidel, M. Keil, B. Ketzer, Z. Khabanova, A.M. Khan, S. Khan, S.A. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, B. Kileng, B. Kim, B. Kim, D. Kim, D.J. Kim, E.J. Kim, H. Kim, J. Kim, J.S. Kim, J. Kim, J. Kim, J. Kim, M. Kim, S. Kim, T. Kim, T. Kim, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J.L. Klay, C. Klein, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, A. Kluge, M.L. Knichel, A.G. Knospe, C. Kobdaj, M.K. Köhler, T. Kollegger, A. Kondratyev, N. Kondratyeva, E. Kondratyuk, J. Konig, S.A. Konigstorfer, P.J. Konopka, G. Kornakov, L. Koska, O. Kovalenko, V. Kovalenko, M. Kowalski, I. Králik, A. Kravčáková, L. Kreis, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Krüger, E. Kryshen, M. Krzewicki, A.M. Kubera, V. Kučera, C. Kuhn, P.G. Kuijer, L. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A.B. Kurepin, A. Kuryakin, S. Kushpil, J. Kvapil, M.J. Kweon, J.Y. Kwon, Y. Kwon, S.L. La Pointe, P. La Rocca, Y.S. Lai, R. Langoy, K. Lapidus, A. Lardeux, P. Larionov, E. Laudi, R. Lavicka, T. Lazareva, R. Lea, L. Leardini, J. Lee, S. Lee, F. Lehas, S. Lehner, J. Lehrbach, R.C. Lemmon, I. León Monzón, E.D. Lesser, M. Lettrich, P. Lévai, X. Li, X.L. Li, J. Lien, R. Lietava, B. Lim, V. Lindenstruth, A. Lindner, S.W. Lindsay, C. Lippmann, M.A. Lisa, A. Liu, J. Liu, S. Liu, W.J. Llope, I.M. Lofnes, V. Loginov, C. Loizides, P. Loncar, J.A. Lopez, X. Lopez, E. López Torres, J.R. Luhder, M. Lunardon, G. Luparello, Y.G. Ma, A. Maevskaya, M. Mager, S.M. Mahmood, T. Mahmoud, A. Maire, R.D. 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