Historical-Philosophical Components of Policy and Mo-Rality Relations by Dmytro V. Usov

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Role of Ketamine in the Treatment of Psychiatric Disorders by Sahar Derakhshanian, Maxine Zhou, Alexander Rath, Rachel Barlow, Sarah Bertrand, Caroline DeGraw, Christopher Lee, Jamal Hasoon, Alan D. Kaye

“…Esketamine (Spravato) is an NMDA-receptor antagonist with additional AMPA-receptor agonist properties, which the FDA approved in 2019 to treat adult TRD in conjunction with an oral antidepressant. …”
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SPIRITUALITY AS PHILOSOPHICAL, SOCIAL AND CULTURAL DE-VELOPMENT PROBLEM by V. E. Gromov

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Mutant Prevention Concentration of Ciprofloxacin against Klebsiella pneumoniae Clinical Isolates: An Ideal Prognosticator in Treating Multidrug-Resistant Strains by B. Aditi Priyadarshini, Krishnan Mahalakshmi, Venkatesan Naveen Kumar

“…The MPCs were determined for 24 selected strains using an inoculum of 1010 CFU/ml in Müller–Hinton agar plates with serial/various concentrations (0.003–100 μg) of ciprofloxacin. In addition to the MPC, phenotypic screening for ESBL, AmpC, and carbapenemase was performed. …”
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Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats by Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu

“…In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.…”
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Interface Study of ITO/ZnO and ITO/SnO2 Complex Transparent Conductive Layers and Their Effect on CdTe Solar Cells by Tingliang Liu, Xing Zhang, Jingquan Zhang, Wenwu Wang, Lianghuan Feng, Lili Wu, Wei Li, Guanggen Zeng, Bing Li

“…The effects of their use in CdTe solar cells were studied by AMPS-1D software simulation using experiment values obtained from ZnO, ITO, and SnO2. …”
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Comparison of Gene Expression in Human Embryonic Stem Cells, hESC-Derived Mesenchymal Stem Cells and Human Mesenchymal Stem Cells by Romain Barbet, Isabelle Peiffer, Antoinette Hatzfeld, Pierre Charbord, Jacques A. Hatzfeld

“…Transcript analysis of membrane antigens suggests that IL1R1low, BMPR1Blow, FLT4low, LRRC32low, and CD34 may be good candidates for the detection and isolation of the most primitive hMSCs. …”
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From Integer Programming to Machine Learning: A Technical Review on Solving University Timetabling Problems by Xin Gu, Muralee Krish, Shaleeza Sohail, Sweta Thakur, Fariza Sabrina, Zongwen Fan

“…For three types of timetabling problems including course timetabling, class timetabling, and exam timetabling, we dive deeper into the commercial solvers CPLEX (47), Gurobi (11), Lingo (5), Open Solver (4), C++ GLPK (4), AIMMS (2), GAMS (2), XPRESS (2), CELCAT (1), AMPL (1), and Google OR-Tools CP-SAT (1) and identify that CPLEX is the most frequently used integer programming solver. …”
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Design of Interface ASIC with Power-Saving Switches for Capacitive Accelerometers by Juncheng Cai, Yongbin Cai, Xiangyu Li, Shanshan Wang, Xiaowei Zhang, Xinpeng Di, Pengjun Wang

“…To minimize average power consumption, a switched operational amplifier (op-amp) technique is adopted, which temporarily disconnects idle op-amps from the power supply. …”
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Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…TNFα contributes to excitotoxicity by increasing GluA2-lacking AMPA receptor (AMPAR) trafficking to the neuronal plasma membrane. …”
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Heme Oxygenase 1/Peroxisome Proliferator-Activated Receptor Gamma Pathway Protects Intimal Hyperplasia and Mitigates Arteriovenous Fistula Dysfunction by Regulating Oxidative Stres... by Tingfei Xie, Yunpeng Xu, Lecai Ji, Xiaolu Sui, Aisha Zhang, Yanzi Zhang, Jihong Chen

“…These DEmRNAs were significantly enriched in the PPAR signaling pathway, AMPK signaling pathway, glucagon signaling pathway, IL-17 signaling pathway, and Toll-like receptor signaling pathway. …”
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Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels by Indra Pal, Atri Bhattacharyya, Babak V-Ghaffari, Essence Devine Williams, Maolei Xiao, Mark Allen Rutherford, María Eulalia Rubio

“…Summary: AMPA-type glutamate receptors (AMPARs) mediate excitatory cochlear transmission. …”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…This is a review of recent advances in the development of innovative therapeutic strategies for PAH.The first section of this paper explores approaches targeting TGF-β signalling, both acting directly on receptors through drugs like Sotatercept and exogenous BMP9, and indirectly, inhibiting the degradation of key receptors, such as BMPR2. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Special attention was given to the various pathways involved, pointing out the ability of the phytoagents to hinder the deleterious ones (especially those leading to, driven by, or associated with TGF-β activation, SREBP, Smad, MAPK, PKC, NF-κB, NLRP3 inflammasome, and caspase), to promote the protective ones (PPAR-α, PPAR-γ, EP4/Gs/AC/cAMP, Nrf2, AMPK, and SIRT1), and to favorably modulate those with potentially dual effect (PI3K/Akt). …”
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Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy by Yuyang Wang, Hailing Zhao, Qian Wang, Xuefeng Zhou, Xiaoguang Lu, Tongtong Liu, Yongli Zhan, Ping Li

“…In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. …”
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THE PHENOMENON OF AESTHETICAL ANTROPLOGY IN KONTEST OF DEVELOPMENT OF THE UKRAINIAN POETIC CINEMA ФЕНОМЕН ЭСТЕТИЧЕСКОЙ АНТРОПОЛОГИИ В КОНТЕКСТЕ РАЗВИТИЯ УКРАИНСКОГО ПОЭТИЧЕСКОГО КИ... by S. G. Pichenikova

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Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin by Xiaoyu Chen, Hongyuan Zhao, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu

“…Furthermore, surfactin also improved hepatic glucose metabolism by activating the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, increasing glycogen synthesis and glucose transporter 2 (GLUT2) protein expression while reducing glucose-6-phosphatase (G6Pase) protein expression. …”
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Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition by Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan, Bin Tang

“…The overlapping DEGs were implicated in various biological processes, including protein metabolism, fatty acid metabolism, AMPK signaling, mTOR signaling, insulin/insulin-like growth factor signaling (IIS), the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the cellular process of meiosis in oocytes. …”
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Isolation of Escherichia coli and Klebsiella pneumoniae strains producing extended-spectrum ß-lactamases from dog urine of the Metropolitan Area of the Aburrá Valley (Antioquia, Co... by A. M. Ochoa, M. I. García, A.V. Cienfuegos, L. Vásquez-Jaramillo

“…Se utilizó PCR múltiple para la detección de betalactamasas tipo CTX-M (grupo 1, 2, 9 y 8/25), SHV, TEM y AmpC de origen plasmídico en aislados positivos a BLEE. …”
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Stevenleaf from Gynostemma Pentaphyllum inhibits human hepatoma cell (HepG2) through cell cycle arrest and apoptotic induction by Sayed Sajid Hussain, Fan Zhang, Yuanyuan Zhang, Kiran Thakur, Mahrukh Naudhani, Carlos L. Cespedes-Acuña, Zhaojun Wei

“…SV induced the mTOR-mediated cell apoptosis in HepG2 cells via activation of Akt and AMPK. The mechanistic explanation for the anticancer activity of SV as functional food can be derived from above results.…”
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