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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity
Published 2012-01-01“…In this line, the paper presents new data indicating that iPLA2γ deficiencies accentuate AMPA receptor destabilization and tau phosphorylation, which suggests that this iPLA2 isoform should be considered as a potential target for the treatment of Tau-related disorders.…”
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1202
Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum
Published 2015-01-01“…Pharmacological activation of adenylyl cyclase by forskolin caused LTP at Purkinje neurons, but only transient potentiation at Bergmann glia, reinforcing the concept that ectopic sites lack the capacity to express sustained cAMP-dependent potentiation. …”
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1203
Effect of SiC Particle Incorporated Dielectric Medium on Electrical Discharge Machining Behavior of AA6061/B4Cp/SiCp AMCs
Published 2022-01-01“…Moreover, during machining, optimized parameters like pulse on time 36 seconds, current 4 Amps, and also a brass electrode.…”
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1204
Synthetic Computed Tomography generation using deep-learning for female pelvic radiotherapy planning
Published 2025-01-01Get full text
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1205
Latis: A Spatial Decision Support System to Assess Low-Impact Site Development Strategies
Published 2010-01-01“…Significant advances have been made in the use of spatial and hydrologic models to quantify the impact of Best Management Practices (BMPs) and Low-Impact Development (LID) practices on water quality. …”
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Exploring the Ability to Perform Activities of Daily Living and Cognitive Status after Hospitalization with COVID-19: A Multiple Case Study
Published 2022-01-01“…Data collection included Assessment of Motor and Process Skills (AMPS) and Montreal Cognitive Assessment (MoCA) at discharge and three-month follow-up. …”
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1208
Motor-Skill Learning Is Dependent on Astrocytic Activity
Published 2015-01-01“…The learning impairments are likely caused by impaired LTP as FC blocked LTP in slices and prevented motor-skill training-induced increases in synaptic AMPA-type glutamate receptor in vivo. …”
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1209
Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury
Published 2025-02-01“…Corresponding targeted medications such as Abatacept, chemokine receptor (CCR) inhibitors, CDDO-Im (2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide), adenosine monophosphate-activated protein kinase (AMPK) activators, and Adalimumab are currently under investigation. …”
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1210
Cognitive Aspects of Modern Philosophy of Historical Knowledge
Published 2014-06-01Get full text
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1211
Effect of UHT Thermal Treatment on the Secondary Structures of Milk Proteins: Insights From FTIR Analysis and Potential Allergenic Activity
Published 2024-01-01“…Therefore, investigating the possible alterations of cow’s milk proteins (CMPs) resulting from thermal treatments is necessary. …”
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1212
Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease
Published 2025-02-01“…We propose that FOXO3 plays a key role in the intersection of menopause and AD, given its dysregulation in both AD patients and postmenopausal women, modulating cellular metabolism through interactions with the AMPK/AKT/PI3K pathways. This relationship highlights the intersection between hormonal changes and increased AD susceptibility. …”
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1213
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
Published 2014-01-01“…In addition, TNF-α can potentiate glutamate-mediated cytotoxicity by two complementary mechanisms: indirectly, by inhibiting glutamate transport on astrocytes, and directly, by rapidly triggering the surface expression of Ca+2 permeable-AMPA receptors and NMDA receptors, while decreasing inhibitory GABAA receptors on neurons. …”
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1214
A new crustin-like gene from the redclaw crayfish Cherax quadricarinatus and its response to decapod iridescent virus 1 (DIV1) challenge
Published 2025-01-01“…Crustin, a widely-studied antimicrobial peptides (AMPs), has been proven to be involved in mediating innate immune responses against intruding pathogens. …”
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1215
Canadian Patterns of Antimicrobial Resistance: Overview of Current Trends Related to Hospital Pathogens
Published 2006-01-01“…There are very little data on the epidemiology of ampC cephalosporinases among Gram-negative organisms, although combined American and Canadian data suggest that ceftazidime resistance rates for Enterobacter species range from 17.1% to 24.8%. …”
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1216
The Effect of Sleep Disruption on Cardiometabolic Health
Published 2025-01-01“…Sleep loss affects key metabolic regulators, including AMPK signaling and disrupts the secretion of metabolic hormones such as leptin and ghrelin. …”
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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Published 2014-01-01“…There is accumulating evidence that activity-dependent immediate early gene Arc is an activity “sensor,” which acts upstream of Aβ production and triggers AMPA receptor endocytosis to homeostatically downregulate the strength of excitatory synaptic transmission. …”
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INTERPASSIVITY AS A SUBJECTIVE EFFECT OF MODERN MEDIA-CULTURE: TO THE STATEMENT OF PROBLEM
Published 2014-06-01Get full text
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1220
Myogenic differentiation markers in muscle tissue after aerobic training
Published 2025-01-01“…The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. …”
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