Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…Widely distributed α1-adrenergic receptors (ARs) are physiologically stimulated during exercise, were reported to associate with the activating energetic AMPK pathway, and are expected to have biological effects beyond their hemodynamic effects. …”
Get full text

Transformation of the Human Image in the Paradigm of Knowledge Evolution by V. H. Kremen, V. V. Ilin

Get full text

GENDER EQUALITY AS A MODERN PHENOMENON by S. V. Storozhuk, I. M. Hoyan

Get full text

ANTHROPOLOGICAL DIMENSIONS OF PRAGMATISM AND PERSPECTIVES OF SOCIO-HUMANITARIAN REDESCRIPTION OF ANALYTIC METHODOLOGY by A. S. Synytsia

Get full text

HUMAN AS A CARRIER OF THE WORLDVIEW: INDIVIDUAL AND COLLECTIVE DIMENSIONS by V. V. Havrylenko

Get full text

EGOISM AS A WAY OUT OF EXISTENTIAL CRISIS FOR A PERSON IN DISABILITY SITUATION by N. A. Mrinskaya

Get full text

COEVOLUTIONARY SEMANTICS OF TECHNOLOGICAL CIVILIZATION GENESIS AND EVOLUTIONARY RISK (BETWEEN THE BIOAESTHETICS AND BIOPOLITICS) by V. T. Cheshko, O. M. Kuz

Get full text

Somatic Transformations in the Context of Antropotechnogynesis at the Modern Stage by І. Р. Pecheranskyi

Get full text

RELIGIOUS FAITH: EXISTENTIAL-ANTHROPOLOGICAL MEANINGS by O. I. Predko

Get full text

Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice by Wenbin Zheng, Jing Zhou, Shasha Song, Wen Kong, Wenfang Xia, Lulu Chen, Tianshu Zeng

“…Moreover, sitagliptin increased the levels of phosphorylation of AMPK and decreased those of mTOR. This study indicates that sitagliptin significantly ameliorates the development of hepatic steatosis and insulin resistance in ob/ob mice by inhibiting inflammatory responses and activating autophagy via AMPK/mTOR signaling pathway.…”
Get full text

GODS OF TRANSHUMANISM by A. V. Halapsis

Get full text

ANTHROPOLOGIZATION OF SCIENCE: FROM THE SUBJECT OF COGNITION TO THE RESEARCHER’S PERSONALITY by N. V. Kryvtsova, I. A. Donnikova

Get full text

The Effect of Lipopolysaccharides from <i>Salmonella enterica</i> on the Size, Density, and Compressibility of Phospholipid Vesicles by Tamás Szabó, Zuzana Garaiová, Sopio Melikishvili, Marek Tatarko, Zsófia Keresztes, Tibor Hianik

“…The properties of the large unilamellar vesicles (LUVs) from 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC), modified by lipopolysaccharides (LPS) from <i>Salmonella enterica</i> sv. …”
Get full text

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation. …”
Get full text

“I LIGHT MY CANDLE FROM YOURS…”: ANTHROPOLOGICAL ASPECTS OF MODERN LIBRARY SERVICES FOR SCIENTISTS by T. О. Kolesnykova

Get full text

HISTORICAL-PHILOSOPHICAL COMPONENTS OF POLICY AND MO-RALITY RELATIONS by Dmytro V. Usov

Get full text

ANTHROPOLOGICAL SEARCH FOR VALUE ORIENTATIONS OF A NEW CULTURE BY AURELIUS AUGUSTINE by V. V. Kuzmenko, V. O. Boniak, I. A. Serdіuk

Get full text

EDUCATION LIKE BREACH BETWEEN PAST AND FUTURE by V. S. Voznyak, N. V. Lipin

Get full text

HEIDEGGER ABOUT THE ANTHROPOLOGICAL INTENTION OF DESCARTES` PHILOSOPHIZING by Anatolii M. Malivskyi

Get full text

EXISTENTIAL CHOICE. AN ESSAY ABOUT THREE AFRICANS (REFLECTION ON AUGUSTINE’S CONFESSIONS) by S. V. Sannіkov

Get full text