CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases by Arthur I. Cederbaum, Lili Yang, Xiaodong Wang, Defeng Wu

“…Considerable attention has been given to alcohol elevated production of lipopolysaccharide (LPS) and TNFα and to alcohol induction of CYP2E1. …”
Get full text

Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

Subjects: Get full text

The antiarthritic effect of CBR‐470‐1 in hypoxic environment is to increase the level of NOD‐like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity by Ao Duan, Zemeng Ma, Xiaolong Shao, Zhencheng Xiong, Chaoyi Zhang, Wenzheng Liu, Guanglin Wang, Shouye Hu, Wei Lin

“…Results In hypoxic conditions, CBR‐470‐1 significantly inhibited the progression of OA in the DMM‐induced OA mouse model, but that effect disappeared in the DMM‐induced OA phosphoglycerate kinase 1 (PGK1)fl/flLyz2‐Cre mouse model. Not only that, CBR‐470‐1 can also improve the proliferation and migration of chondrocytes, reduce the apoptosis rate of chondrocytes, and regulate the expression of chondrocyte‐related proteins in the co‐culture system of THP‐1 and chondrocytes. …”
Get full text

Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

Get full text

Timing evolution and prediction of Internet transmission behavior by He TIAN, Hai ZHAO, Jinfa WANG, Chuan LIN

“…The transmission behavior of Internet plays an importance role in the research on the relationship between network topology structure and dynamic behavior.Selecting effective path samples in four monitoring points which from different regions authorized by CAIDA_Ark project and statistics network traveling time and traveling diameter,their correlation is very weak,network traveling time is presented on multi-peak and heavy tail distribution.Using nonlinear time sequences analysis method to identify the Chaos characteristics of network traveling time evolution sequences.The results show that their timing evolution has Chaos characteristics.Based on this,the Logistic equation was lead to establish network transmission behavior prediction model,and particle swarm optimization (PSO) was used to optimize model parameters.The model by the network traveling time sequences of four monitoring points was experimented,evaluated it from accuracy and availability,the results show that the model can predict network transmission behavior accurately in the short term.It can be used as a tool for predicting the network behaviors’ evolution in a period of time.…”
Get full text

WORKING PRINCIPLE AND PERFORMANCE EVOLUTION OF CAMERA-BASED INTELLIGENT SIGNALIZED INTERSECTIONS: SAMSUN CITY, TÜRKIYE EXAMPLE by Metin Mutlu AYDIN, Dimitris POTOGLOU, Liana CIPCIGAN

Get full text

Real Time Face-mask Detection with Arduino to Prevent COVID-19 Spreading by Saman M. Almufti, Ridwan B. Marqas, Zakiya A. Nayef, Tamara S. Mohamed

“… The rise of COVID-19 pandemic has had a lasting impact in many countries worldwide since 2019. …”
Get full text

Editorial: Dietary protein for human health by Paul J. Moughan, Wouter H. Hendriks, Suzanne M. Hodgkinson, Sylvia M. S. Chungchunlam, Wen Xin Janice Lim, Marco Mensink, Natascha Stroebinger, Nikkie van der Wielen

Get full text

Chaotic Motion of the Underactuation Planar Five-bar Mechanism with Variable Parameter by Ren Bichun, Xie Jin, He Shanghong

Get full text

The Term ‘Ebda’ in the Comparative View of Fakhr Razi and Allameh Tabatabai by Mohammad Bahrami

Subjects: Get full text

Nonlinear Dynamics Numerical Analysis of Rolling Bearing-rotor System based on Finite Element Modeling by Yunlong Li

Get full text

Nonlinear Dynamics of Helicopter Planetary Gear-rotor System Caused by Stiffness Variation by Lanlan Hou, Mingqiang Li, Guosheng Wang, Lingyun Lai, Hao Chen, Yuping Huang

Get full text

The Effect of Tumor Angiogenesis Agents on Tumor Growth Dynamics: A Mathematical Model by Ali Mohseni, Mohammad Pooyan, Somayeh Raiesdana, Mohammad Bagher Menhaj

“… Purpose: Tumor-induced angiogenesis is a dangerous state of the tumor growth process in which solid tumors have a blood supply. Modeling has been a very important tool in studying tumor growth and angiogenesis. …”
Get full text

THE IMPACTS OF STOCK LIQUIDITY ON DIVIDEND POLICY: EVIDENCE FROM LISTED FIRMS ON HOCHIMINH STOCK EXCHANGE by Phùng Đức Nam, Hoàng Thị Phương Anh, Lê Thị Thanh Vương

Subjects: Get full text

Chaotic evolutionary multi-objective optimization for multivariate pair trading in tehran stock exchange: the distance approach by Hossein Nikoo, Jamal Barzgari khanagha, Hamid Reza Mirzaei

“…Purpose: Pair formation is an important step in pair trading that has only been examined manually or through numerical instructions. …”
Get full text

Energy-space random walk in a driven disordered Bose gas by Zhang, Yansheng, Martirosyan, Gevorg, Ho, Christopher Junhong, Etrych, Jiří, Eigen, Christoph, Hadzibabic, Zoran

Get full text

CS-based data collection method for airborne clustering WSN by HOUWei Z, INGBo J, UANGYi-feng H, IAOXiao-xuan J, UJia-xing H, IANGWei L

Get full text

Dynamic Modeling and Nonlinear Vibration Research of the Rotary Cutting Mechanism Based on Bond Graphs by Zhao Jiayi, Gao Yiyang, Zhao Changzhen, Rao Xiaobo, Ding Shunliang, Gao Jianshe

Get full text

Effect of Boundary Layer Evolution on Nitrogen Dioxide (NO2) and Formaldehyde (HCHO) Concentrations at a High-altitude Observatory in Western India by Mriganka Sekhar Biswas, G. Pandithurai, M. Y. Aslam, Rohit D. Patil, V. Anilkumar, Shrikant D. Dudhambe, Christophe Lerot, Isebelle De Smedt, Michel Van Roozendael, Anoop S. Mahajan

Get full text

Long-term Measurements of Carbonaceous Aerosol at Cape Hedo, Okinawa, Japan: Effects of Changes in Emissions in East Asia by Kojiro Shimada, Akinori Takami, Takatsugu Ishida, Yuta Taniguchi, Shuichi Hasegawa, Chak K. Chan, Yong Pyo Kim, Neng-Huei Lin, Shiro Hatakeyama

Subjects: Get full text