A catechol-O-methyltransferase genetic variant impacts functional movement in tactical athletes. by Marcus K Taylor, Lisa M Hernández, Richard C Allsopp, John J Fraser

“…The effect of rs737865 on functional movement was evaluated using general linear models, while associations between trauma and functional movement were determined with regression models. An alpha level of 0.05 was set as the threshold for significance. …”
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Safety and immunogenicity of an mRNA-1273 vaccine booster in adolescents by Amparo L. Figueroa, Kashif Ali, Gary Berman, Wenqin Xu, Weiping Deng, Bethany Girard, Anne Yeakey, Karen Slobod, Jacqueline Miller, Rituparna Das, Frances Priddy

“…Further, the booster increased bAb levels relative to pre-booster baseline against SARS-CoV-2 variants (alpha [B.1.1.7], beta [B.1.351], gamma [P.1], and delta [B.1.617.2]), regardless of pre-booster SARS-CoV-2 status. …”
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Intimate partner violence help-seeking norms: scale reliability and cross-sectional multilevel associations with intimate partner violence among youth in Nairobi, Kenya by Peter Gichangi, Mary Thiongo, Anaise Williams, Bianca Devoto, Shannon N. Wood, G Wamue-Ngare, Kristin G. Bevilacqua, Michele R. Decker

“…Multilevel mixed-effects models assessed associations with IPV experience for young women.Setting and participants A youth cohort of 586 men and 591 women aged 15–24 years in Nairobi, Kenya.Primary outcome measure Past 6-month physical and/or sexual IPV among young women.Results The IPV Help-Seeking Attitudes Scale had acceptable internal reliability (Cronbach’s alpha >0.60). IPV prevalence was 17.5%, among whom 21.7% had sought any help for the past 6-month IPV. …”
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Biological significance of soluble IL-2 receptor by Calogero Caruso, Giuseppina Candore, Diego Cigna, Antonio Tobia Colucci, Maria Assunta Modica

“…Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. …”
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Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…No differences were observed between the fecal microbiome’s alpha and Shannon diversity indices; however, a distinct microbial composition was observed in COVID-19 patients (when compared to the controls). …”
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Competências de escrita manual e processamento sensorial em crianças dos 6 aos 7 anos e 11 meses by Ana Sofia Sousa Oliveira, Helena Silva Reis, Claúdia Sofia Góis Ribeiro Silva Reis

“…O questionário demonstrou excelente consistência interna, com valores de Alpha de Cronbach superiores a 0,80. Para avaliar a validade discriminativa por grupos conhecidos, foram realizadas comparações entre géneros e anos escolares. …”
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TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…The influence of TMEM147 on HCC prognosis was assessed using Kaplan–Meier analysis, Cox regression analysis, and a prognostic nomogram. …”
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Knowledge, attitude and practices associated with COVID-19 among undergraduate students from Malaysian public universities during the endemic phase: a cross-sectional study by Nur Umairah Mohd Hawary, Nor Malia Abd Warif, Ismarulyusda Ishak, Arimi Fitri Mat Ludin, Barathan Muttiah, Navindra Kumari P, Kumutha Malar Vellasamy, Vanitha Mariappan

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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…Test-retest reliability and internal consistency was confirmed with intraclass correlation coefficients and Cronbach alpha exceeding 0.70 across most QOL-E domains/summary scores. …”
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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…SSPR models were created for each protein using the MultiPASS software based on the Bayesian algorithm and different levels of MNA (Multilevel Neighborhoods of Atoms) descriptors for the representation of structural formulas of protein fragments including AAS.ResultsThe accuracy of prediction was assessed through a 5-fold cross-validation and compared to other bioinformatics tools, such as SIFT4G, Polyphen2 HDIV, FATHMM, MetaSVM, PROVEAN, ClinPred, and Alpha Missense. The best SSPR models demonstrated high accuracy, with an average ROC AUC of 0.831 ± 0.037, a Balanced accuracy of (0.763 ± 0.034), MCC (0.457 ± 0.06), and F-measure (0.623 ± 0.07) across all genes, outperforming the most popular bioinformatics tools.ConclusionsThe best created SSPR models for the prediction of pathogenicity of amino acid substitutions related with PIDs have been implemented in a freely available web application SAV-Pred (Single Amino acid Variants Predictor, http://www.way2drug.com/SAV-Pred/), which may be a useful tool for medical geneticists and clinicians. …”
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Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of <i>Mycobacterium bovis</i>-Infected Domestic Dogs (<i>Canis lupus familiaris</i>) by Conor O’Halloran, Paul Burr, Danielle A. Gunn-Moore, Jayne C. Hope

“…The production of antigen-specific tumour necrosis factor-alpha (TNF-α) by PBMC in response to a cocktail of ESAT-6 and CFP-10 peptides correlated very strongly with the overall IGRA results, suggesting future diagnostic potential. …”
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Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high... by Oluwatosin O. Omodara, Mohammed U. Kawu, Ibrahim G. Bako, Daniel H. Mhya, Theophilus T. Dawus

“…UA significantly decreased serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) and increased adiponectin level compared to the HCHFD + DW-fed animals. …”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Results: Cadmium (Cd) exposure caused anemia and hepatorenal damage, as evidenced by increased serum levels of urea, creatinine, uric acid, total bilirubin (including its direct and indirect fractions), and elevated activities of liver enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP). However, total protein and albumin levels decreased. …”
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Novel Drug Delivery Particles Can Provide Dual Effects on Cancer “Theranostics” in Boron Neutron Capture Therapy by Abdul Basith Fithroni, Haruki Inoue, Shengli Zhou, Taufik Fatwa Nur Hakim, Takashi Tada, Minoru Suzuki, Yoshinori Sakurai, Manabu Ishimoto, Naoyuki Yamada, Rani Sauriasari, Wolfgang A. G. Sauerwein, Kazunori Watanabe, Takashi Ohtsuki, Eiji Matsuura

“…Boron (B) neutron capture therapy (BNCT) is a novel non-invasive targeted cancer therapy based on the nuclear capture reaction ¹⁰B (n, alpha) ⁷Li that enables the death of cancer cells without damaging neighboring normal cells. …”
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The validation and cross-cultural adaptation of the PainDETECT questionnaire in osteoarthritis-related pain by Xiaofeng Chang, Shuxin Yao, Jie Wei, Lei Shang, Chao Xu, Jianbing Ma

“…We assessed internal consistency using Cronbach’s alpha and test-retest reliability via intraclass correlation coefficient (ICC). …”
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Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis:... by Morten R. Blichfeldt-Eckhardt, Claus Varnum, Jørgen T. Lauridsen, Lasse E. Rasmussen, Winnie C. P. Mortensen, Hanne I. Jensen, Henrik B. Vaegter, Kate L. Lambertsen

“…Baseline pain was associated with blood concentrations of lymphotoxin alpha (LTα), TNFR1, TNFR2, and IL-6R (R2 = 0.37, p < 0.001) and CSF concentrations of TNFR1, TNFR2, IL-6, IL-6R, and IL-1Ra (R2 = 0.40, p = 0.001). …”
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Predictive factors for clinical cure in the treatment of HBeAg(−) chronic hepatitis B or compensated cirrhosis: a prospective observational study by Yan-Qing Lv, Ru-Hua Guo, Kun-Yu Liu, Jia-Jie Li, Hui-Fan Ji

“…BackgroundSequential or combined treatment with nucleos(t)ide analogs (NAs) and pegylated interferon alpha-2b (Peg-IFN-α-2b) can improve the clinical cure rate. …”
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Effect of Ashi Point Pricking and Cupping Combined with Quadriceps Femoris Function Exercise on the Clinical Curative Effect of Knee Osteoarthritis by Zhiqiang HUANG, Yu LIU, Zhaoyuan SU, Jiafu SU, Qiang WU

“…The changes of the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score, range of motion of joints, levels of inflammatory factors and clinical efficacy were compared between the two groups before and after treatment.Results:The clinical effect of the comprehensive group was better than the drug group(<italic>P</italic>&lt;0.05).WOMAC score(pain, daily activities, joint stiffness, comprehensive score)of the two groups after treatment was significantly lower than that before treatment(<italic>P</italic>&lt;0.05).After treatment, WOMAC score of the comprehensive group was significantly lower than that of the drug group(<italic>P</italic>&lt;0.05);joint range of motion of the two groups was larger than that before treatment(<italic>P</italic>&lt;0.05), and joint range of motion of the comprehensive group was larger than that of the drug group(<italic>P</italic>&lt;0.05);tumor necrosis factor alpha(TNF-α)and interleukin 1(IL-1)levels of the two groups were lower than those before treatment(<italic>P</italic>&lt;0.05), TNF-α and IL-1 of the comprehensive group were significantly lower than those of the drug group(<italic>P</italic>&lt;0.05).Conclusion:The method of Ashi point pricking and cupping combined with quadriceps femoris functional exercise can relieve joint pain, increase joint range of motion, reduce the inflammatory index of joint, and then improve the function of knee joint of KOA.…”
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Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…Results The jejunal microbiota showed a significant increase in alpha diversity in the third week post-FMT compared with the ileum and colon. …”
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Glycated hemoglobin and microalbuminuria in patients with type 2 diabetes mellitus by Afrim Zeqiraj, Dafina Zeqiraj, Teuta MullaGoga, Fidel Krasniqi, Agim Shabani, Sanije Berisha, Agim Berisha, Blerim Morina, Florjana Zogaj

“…All analyzes were performed with Roche-Integra 400 Plus equipment at the Polyclinic and Laboratory Alpha in Peja. This prospective study was conducted in the Dukagjin Plain in the Republic of Kosovo. …”
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