TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…Background: Tubulin alpha 1b (TUBA1B) is a key microtubule protein essential for maintaining cellular structure and function. …”
Get full text

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition by Jingying Zhao, Xiuli Wang, Yubin Wu, Chengguang Zhao

“…This study tested the hypothesis that the Krüppel-like factor 4 (KLF4)/miR-101/Collagen alpha-1X (COL10A1) axis could inhibit epithelial-mesenchymal transition (EMT) and renal fibrosis after AKI in a mouse model of ischemia-reperfusion (I/R)-induced renal fibrosis and HK-2 cells by gene silencing, overexpression, immunofluorescence, immunohistochemistry, real-time quantitative PCR, Western blotting, dual-luciferase reporter assay, fluorescence in situ hybridization (FISH) and ELISA. …”
Get full text

Prognostic impact of primary versus secondary resistance to sorafenib in patients with HCC by Jin Lei, Hongyuan Dai, Ya Zhang, Guangling Ou, Zhi Peng Liang, Yinying Lu, Haiyang Li

“…The independent risk factors for primary resistance were alpha-fetoprotein (AFP) > 400 ng/mL and alanine aminotransferase (ALT) > 40 U/L. …”
Get full text

Development and validation of a questionnaire for table tennis teaching in physical education by Miguel Ángel Ortega-Zayas, Antonio José Cardona-Linares, Alberto Quílez, Alejandro García-Giménez, Miguel Lecina, Francisco Pradas

“…The last study was a confirmatory factor analysis (to establish the final number of items and their structure. The ordinal alpha values ranged from 0.65 to 0.72, obtaining an average value of 0.70, indicating coherence between the measurement of the items. …”
Get full text

A comparative study to determine the sport branches that the classroom pre-service teachers want to be engaged in the most in their leisure time by Osman Dalaman

“…First part is personal information form and the second part is a scale aiming to determine the sports that the participants want to perform the most in their leisure. The Cronbach Alpha reliability coefficient of the scale to determine the sports the participants want to perform the most in their leisure was found to be .628. …”
Get full text

Biochemical characteristics, genetic variants and treatment outcomes of 55 Chinese cases with neonatal intrahepatic cholestasis caused by citrin deficiency by Juan Li, Jintao Duan, Shuli He, Ying Li, Meifen Wang, Chengjun Deng

“…All NICCD patients were followed up until death or at least 1 year of age.ResultsCompared to INC group, significant increase was found in levels of total bilirubin, indirect bilirubin, total bile acid, gamma-glutamyl transpeptidase, alkaline phosphatase, prothrombin time, thrombin time, international normalized ratio, alpha-fetoprotein (AFP), Vitamin D, and Vitamin E of NICCD group, while alanine aminotransferase, albumin, fibrinogen, glucose, and Vitamin A levels showed significant decrease in the NICCD group (P < 0.05). …”
Get full text

Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children by Qun Huang, Hu Hua, Wei Li, Xi Chen, Lei Cheng

“…In TH group, elevated expression was observed in the innate immune mediators, including retinoic acid-inducible gene I (RIG-I), interferon alpha (IFN-α), mitochondrial antiviral-signaling protein (MAVS), NLR family pyrin domain containing 3 (NLRP3), toll-like receptor (TLR) 4 and TLR7. …”
Get full text

Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children’s motor performance in activities of daily livin... by Meihuan Huang, Yujun Zhan, Haishan Zhou, Ping Song, Yanping Fan, Yang Lu, Yijing Chen, Zhen Lv, Qing Liu, Guojun Yun, Jianguo Cao

“…The instrument demonstrated excellent internal consistency across the total and the three subscales (Cronbach’s alpha = 0.83–0.91). The confirmatory factor analysis showed a good fit for the original three-factor model (CFI = 0.936, RMSEA = 0.049). …”
Get full text

Retinal Protection of New Nutraceutical Formulation by Luca Rosario La Rosa, Veronica Pepe, Francesca Lazzara, Giovanni Luca Romano, Federica Conti, Erika Giuffrida, Claudio Bucolo, Santa Viola, Giuseppe De Pasquale, Maria Cristina Curatolo, Cristina Zappulla

“…Finally, Epicolin treatment on DBA/2J mice protected the RGCs from loss of function, as demonstrated by PERG analysis, and attenuated their death by enhancing brain-derived neurotrophic factor (<i>BDNF</i>) and reducing interleukin-1 beta (<i>IL-1β</i>) and tumor necrosis factor-alpha (<i>TNF-α</i>) expression. <b>Conclusions:</b> Epicolin, due to its neuroprotective, antioxidant, and anti-inflammatory properties, represents a promising potential treatment for glaucoma.…”
Get full text

The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis by Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

“…The serum levels of cytokines interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, tumour necrosis factor-α (TNF-α), and interferon-γ (INF-γ) were tested by flow cytometric bead array (CBA). Alpha and beta diversity of gut microbiome were explored by bioinformatics analysis. …”
Get full text

Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not appr... by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…-sitosterol (10.45%), alpha.-tocopherol-beta.-D-mannoside (7.50%) and 3-amino-4-piperonyl-5-pyrazolone (5.84%). …”
Get full text

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway by Yanqin Wu, Fusheng Sun, Yujin Guo, Yumao Zhang, Li Li, Ruili Dang, Pei Jiang

“…The expressions of PGC-1α, estrogen-related receptor alpha (ERRα), FNDC5, and BDNF were determined to investigate the regulatory effects of CUR on the PGC-1α/FNDC5/BDNF pathway. …”
Get full text

Effects of Manual Acupuncture Versus Sham Acupuncture in patients with Post-Stroke Depression: A Randomized Clinical Trial by Conghui Wei, Jinling Chen, Qu Yang, Jingjing Xu, Qingsong Li, Fulin Li, Yu Liu, Jun Luo

“…After 6 weeks of treatment, the alpha and beta bands power spectrum increased significantly, while the delta and theta bands power spectrum decreased significantly in the MA group compared to the SA group. …”
Get full text

EZH2 Might Affect Macrophage Chemotaxis and Anti-Inflammatory Factors by Regulating CCL2 in Dental Pulp Inflammation by Ziqi Hu, Yingyi Chen, Jie He, He Liu, Tianqian Hui

“…Immunohistochemistry staining was used to detect changes of the expression of EZH2 and tumor necrosis factor alpha (TNF-α) in dental pulp inflammation. The expression of EZH2, CCL2, and cluster of differentiation 68 (CD68: macrophage surface marker) was measured by immunofluorescence staining. …”
Get full text

Effect of Die Spacer Thickness on the Microshear Bond Strength of CAD/CAM Lithium Disilicate Veneers by Sherine Mohamed Farag, Mona Mohamed Ghoneim, Rania Reda Afifi

“…Statistical analyses included one-way ANOVA, Tukey’s post hoc test, and chi-square test with a 5% alpha error and 80% study power. Results. The mean microshear bond strength values were calculated in MPa for group A = 31.91 ± 12.41, group B = 29.58 ± 5.03, and group C = 13.85 ± 4.12. …”
Get full text

Psychometric Measurement of Fertility-related Quality of Life across Gender in Primary Infertile Couples by Amita Kumari, Afreen Begum H. Itagi, V. Bhargava Reddy Kanchi, Vijayan Sharmila, Satish Pundlik Dipankar

“…Descriptive statistics, Kolmogorov–Smirnov test, Cronbach’s alpha and Student’s independent t-tests were used. …”
Get full text

Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation path... by Nermin A Helmy, Elsayed A Abdel Aziz, Mustafa Abd El Raouf, Reda M S Korany, Doaa A Mansour, Sara M Baraka, Arwa A Hassan, Eman Gomaa, Mennatullah M Faisal, Walaa A A Basha, Esraa M Fahmy, Rashed A Alhotan, Anam Ayyoub, Shaimaa Selim

“…The TAD-loaded proniosomal gel successfully antagonized the impacts of DEX by dampening MDA production, and enhancing total antioxidant capacity, coupled with modulation of inflammatory-related genes, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1β, and matrix metalloproteinase 9, during all healing stages (p < 0.05). …”
Get full text

In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells by Annunziata Mauro, Hashimita Sanyal, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Nicola Bernabò, Luca Valbonetti, Barbara Barboni

“…The results indicated that EMT can be prevented exclusively in the presence of high doses of P4, while it occurred rapidly in cells exposed to E2 as denoted by protein (cytokeratin-8 and alpha-SMA) and gene expression (vimentin and snail) profiles. …”
Get full text

The impact of parental phubbing on social withdrawal in preschool children: the serial mediating roles of parent–child conflict and negative emotions by Pan Zhang, Xiaoying Wang

“…The parents completed measures of the Parental Phubbing Scale, Child–Parent Relationship Scale, Children’s Behavior Questionnaire, and Child Social Preference Scale. The Cronbach’s alpha coefficient of the four scales were 0.75, 0.84, 0.74, and 0.83, respectively. …”
Get full text

Use of approved cefazolin based intramammary dry goat treatment and its effects on the milk microbiota by Delower Hossain, Filippo Biscarini, Valentina Monistero, Paola Cremonesi, Bianca Castiglioni, Anoar Jamai Masroure, Alessandro Marinoni, Sara Fusar Poli, Matteo Mezzetti, Maria Filippa Addis, Valerio Bronzo, Erminio Trevisi, Paolo Moroni

“…Despite the reduction in SCC and infection rates, cefazolin-based treatment did not significantly affect the alpha- and beta-diversity between the TG and CG. …”
Get full text