Cancer-associated fibroblasts and their role in tumor progression by M. S. Ermakov, A. A. Nushtaeva, V. A. Richter, O. A. Koval

“…The molecular phenotype of activated CAFs is similar to fibroblasts activated during inflammation. In activated CAFs, alpha-smooth muscle actin (α-SMA) is synthetized de novo and various proteases and fibronectin are produced. …”
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Pilot study to understand and compare challenges being faced in reporting of transfusion reactions in various types of blood banks enrolled under Haemovigilance Programme of India by Rayaz Ahmad Bhat, Vishal Tiwari, Satyajeet Singh, Ruchi Rao, Akash Chaudhary, Akanksha Bisht

“…STATISTICAL ANALYSIS USED: MS Excel Ver. 2007 was used for compilation and descriptive analysis of collected data, and SPSS Ver. 25.0 was used for determining the Cronbach’s alpha for the questionnaire which was statistically significant (α > 0.7). …”
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Comparative assessment of a virtual performance measure with self-report and performance-based outcomes in patients with hip osteoarthritis by Helen Razmjou, Suzanne Denis, Susan Robarts, Amy Wainwright, Patricia Dickson, Ania Roszkowski, John Murnaghan

“…Results Data of 100 patients, 64 (64%) females, mean age: 67 ±10 were examined. The Cronbach’s alpha coefficient that examined internal consistency of the VPM total score was 0.88. …”
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Study protocol for a randomised controlled trial on the use of intraoperative ultrasound-guided laparoscopic ovarian cystectomy (UGLOC) as a method of fertility preservation in the... by Srdjan Saso, Sadaf Ghaem-Maghami, Jan Yvan Jos Verbakel, Benjamin P Jones, Joseph Yazbek, Mona El-Bahrawy, Lorraine S Kasaven

“…We aim to randomise 94 patients over 3 years to achieve power of 80% at an alpha level of 0.05.Ethics and dissemination Findings will be published in peer-reviewed journals and presented at national and international conferences and scientific meetings. …”
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Workflow for detecting biomedical articles with underlying open and restricted-access datasets. by Anastasiia Iarkaeva, Vladislav Nachev, Evgeny Bobrov

“…The screening results were highly reliable, as witnessed by inter-rater reliability values of ≥0.8 (Krippendorff's alpha) in two different validation samples. We also report the results of the screening, both for our institution and an independent sample from a meta-research study. …”
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Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis by Tao Jiang, Jinhong Xu, Yang Lu, Xiaojin Chen, Yongxia Li

“…The inflammatory factor tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) in a dose-dependent manner were decreased. …”
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Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells by K. S. Young, G. R. Hancock, E. C. Fink, A. Zigrossi, B. Flowers, D. A. Cooper, V. T. Nguyen, M. C. Martinez, K. S. Mon, M. Bosland, D. R. Zak, A. P. Runde, M. N. Sharifi, I. Kastrati, D. D. L. Minh, S. Kregel, Sean W. Fanning

“…Mutations to estrogen receptor alpha (ERα) arise after continued therapeutic pressure. …”
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Isolation and Characterization of Gram-Negative Bacterial Species from Pasteurized Dairy Products: Potential Risk to Consumer Health by Solomon H. Mariam

“…None tested positive for phenotypic gelatin hydrolysis but exhibited alpha- or beta-hemolysis. Sequence alignments of 16S rRNA gene partial sequences suggested up to 99% sequence similarities to subspecies of Salmonella enterica. …”
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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…Therefore, we analyzed serum interleukin-6 (IL-6) and transforming growth factor-beta 1 (TGF-β1) levels and mRNA expressions of IL-6 and tumor necrosis factor-alpha (TNF-α) in peripheral blood mononuclear cells of AD patients and controls. …”
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Comparative Study of Different Irrigation Protocols in Endodontic Treatment by Midhun Paul, Rekha V. Ravi, Chintu Sundaresan, Dinesh G. Kamath, Gargi Yumnam, Nada M. Ibrahim

“…In this study, the analysis of variance and post hoc tests were used with a predetermined alpha level of (0.05). Results: Comparing all the groups, Group A exhibited the best performance with Group B being the second best as seen with the mean log reduction of the bacterial load being 5. …”
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Agro-Morphological Characterization and Estimation of Genetic Parameters of Spring Maize Hybrids in the Inner Plains of Far-West Nepal by Prachi Bista, Sandesh Thapa, Sara Rawal, Deependra Dhakal, Darbin Joshi

“…The research was conducted in the Dhangadhi district from April 2020 to August 2020 in an alpha-lattice design with 26 genotypes and two replications. …”
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MicroRNA-155 Participates in the Expression of LSD1 and Proinflammatory Cytokines in Rheumatoid Synovial Cells by Ziliang Yu, Hao Liu, Jianbo Fan, Feihu Chen, Wei Liu

“…Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 are key proinflammatory cytokines implicated in the pathogenesis of RA. …”
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Mechanical analysis of 3D printed dental restorations manufactured using different resins and validation with FEM analysis by Buse Cebi Gul, Fatih Demirci, Nagehan Baki, Erkan Bahce, Mutlu Özcan

“…Data were analyzed using ANOVA, paired-t tests and Tukey’s HSD test (alpha = 0.05). Results As a result of thermomechanical aging, significant difference was found between the groups in wear and fracture resistance (P < .05). …”
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Prevalence of nasopharyngeal bacteria during naturally occurring bovine respiratory disease in commercial stocker cattle by Afroza Akter, Hannah Teddleton, Marc Caldwell, Gina Pighetti, Phillip R. Myer, Madison T. Henniger, Liesel Schneider, Elizabeth Shepherd

“…No differences were observed in the alpha diversity matrices based on day or NumTrt (P > 0.05). …”
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Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation by Qian-Lu Wang, Lei Yang, Yue Peng, Min Gao, Ming-Shi Yang, Wei Xing, Xian-Zhong Xiao

“…In both A549 cells and mouse lung tissues, further study showed that Rg1 perfusion significantly suppressed the secretion of inflammatory cytokines including tumor necrosis factor- (TNF-) alpha and interleukin- (IL-) 6 and relieved cells from ER stress as supported by decreased expression of marker proteins via upregulating sirtuin 1 (SIRT1). …”
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Inhibitory Effect of Flavonoid Extract of Lotus Leaf on Alcohol-Induced Gastric Injury by Antioxidant Capacity in Mice by Yi Chen, Qin Li, Zhiping Kuang, Xin Zhao, Ruokun Yi, Xiaowei He, Guangjing Feng

“…Besides, FELL significantly reduced the levels of interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ). The quantitative polymerase chain reaction (qPCR) and Western blot results proved that FELL upregulated the mRNA and protein expressions of SOD1, SOD2, CAT, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), neuronal nitric oxide synthase (nNOS), and endothelial nitric oxide synthase (eNOS) and downregulated the expression of inducible nitric oxide synthase (iNOS) in the gastric tissue of mice with gastric injury. …”
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Corporate genome screening India (CoGsI) identified genetic variants association with T2D in young Indian professionals by Shah Fahad Husami, Tavleen Kaur, Love Gupta, Garima Rastogi, Lakhvinder Singh, Pooja Meena, Indu Sharma, Hemender Singh, Varun Sharma

“…Out of 42, three missense variants (rs1402467, rs6050, and rs713598) in Sulfotransferase family 1 C member 4 (SULT1C4), Fibrinogen Alpha Chain (FGA), and Taste 2 Receptor Member 38 (TAS2R38) and two untranslated region (UTR) variants (rs1063320 and rs6296) in Major Histocompatibility Complex, Class I, G (HLA-G) and 5-Hydroxytryptamine Receptor 1B (HTR1B) were associated with the T2D risk. …”
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6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Hong Seog Seo

“…The lipid accumulation in differentiated 3T3-L1 cells was evaluated by using Oil Red O staining. 6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFα) in HUVECs. In HEK293 cells, the expression of the epithelial sodium channel (ENaC) protein was reduced by 6-gingerol. …”
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Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease by L. M. O. Caram, R. A. F. Amaral, R. Ferrari, S. E. Tanni, C. R. Correa, S. A. R. Paiva, I. Godoy

“…We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). …”
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Staphylococcus aureus host cell invasion and virulence in sepsis is facilitated by the multiple repeats within FnBPA. by Andrew M Edwards, Jennifer R Potts, Elisabet Josefsson, Ruth C Massey

“…In vivo and in vitro studies have shown that the staphylococcal invasin FnBPA triggers bacterial invasion of endothelial cells via a process that involves fibronectin (Fn) bridging to alpha(5)beta(1) integrins. The Fn-binding region of FnBPA usually contains 11 non-identical repeats (FnBRs) with differing affinities for Fn, which facilitate the binding of multiple Fn molecules and may promote integrin clustering. …”
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