C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability by Santhosh Kumar Nagarajan, Joy Weber, Daniel Roderer, Jörg Piontek

“…While the mechanism of CPE-claudin interaction is well understood, the structure and assembly of the pore complex remain elusive. Here, we used AlphaFold2 complex prediction, structure alignment, and molecular dynamics simulations to generate models of prepore and pore states of the CPE/claudin-4 complex. …”
Get full text

The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2. Here we report results from phase 1a of PROTA, a single-arm, multicentre dose escalation trial with TILT-123 and pembrolizumab in female patients with platinum resistant or refractory ovarian cancer (NCT05271318). …”
Get full text

Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract by Megha B. Abbigeri, Bothe Thokchom, Sapam Riches Singh, Santosh Mallikarjun Bhavi, B.P. Harini, Ramesh Babu Yarajarla

“…They exhibited significant inhibition of alpha amylase, a pivotal enzyme in carbohydrate metabolism, suggesting their efficacy as anti-diabetic agents. …”
Get full text

Characteristics of functional constipation and analysis of intestinal microbiota in children aged 0–4 in Zunyi region by Shungang Gong, Zhengbo Yu, Yuan Ding, Yue Wang, Xi Li, Shengli Gu

“…The prevalence rates in boys and girls were 6.6% and 8.5%, respectively, with no significant gender difference (P > 0.05). Alpha diversity analysis revealed higher richness and diversity of intestinal flora in the FCG compared to the CG. …”
Get full text

Importance of Cheese Whey Processing: Supplements for Sports Activities – a Review by Patricia Fassina, Gabriela Quadros Nunes, Fernanda Scherer Adami, Márcia Inês Goettert, Claucia Fernanda Volken de Souza

“…Compared to WPC and WPI, WPH improved peak torque associated with strength training without reducing the creatine kinase (CK) and tumor necrosis factor alpha (TNF-α) levels in this type of physical activity, and the decreases in CK and lactate dehydrogenase (LDH) associated with aerobic exercise were significant. …”
Get full text

Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. …”
Get full text

Psychometric properties of the Arabic version of the Forgotten Joint Score usage in total hip arthroplasty by Waleed Albishi, Nasser M. AbuDujain, Orfan Arafah, Ibrahim S. Alshaygy, Abdulaziz Almaawi, Zyad A. Aldosari, Mohammed N. Alhuqbani, Omar A. Aldosari, Saad M. Alangari

“…To assess the test-retest reliability, 72 people took the Ar-FJS test twice. Results Cronbach’s alpha (Internal Consistency) of the Ar-FJS-12 was 0.957 and the intraclass correlation coefficient (ICC) was 0.931 indicating high reliability. …”
Get full text

The effect of forest gaps on the diversity and composition of bacterial communities in mixed-type forest soils across the Carpathian mountains by Nejc Suban, Oliver Maksimović, Nataša Šibanc, Tijana Martinović, Eva Darenova, Matjaž Čater, Tine Grebenc

“… Mixed forests of European beech (Fagus sylvatica L.) and silver fir (Abies alba Mill.) play a vital ecological role in Central and South-Eastern Europe. …”
Get full text

Spatial-geographical analysis of smart growth indices in urban areas (Case study: Bushehr Port) by Hajar Jahanshahi, Hamidreza Varesi, Masoud Taghavei

“…Reliability of the research instrument based on Cronbach's alpha coefficient of the research was 0.749 which is higher than 0.7 and is appropriate. …”
Get full text

Current Perspectives in Detection of Bioactive Compounds From Costus spicatus Through GC–MS and LC-MS/MS: Antioxidant Properties and In Silico Analysis for Industrial Applications... by Dharmar Manimaran, Ararsa Tessema, M. Govindarajulu Yadav, S. Parthasarathi, Vasan Palanisamy

“…In this study, we performed molecular docking and found that four compounds exhibited promising binding affinities with predicted binding sites on alpha-synuclein. Notably, Androsta [17-16-b] furan-5′-imine, 4′-methylene-3-methoxy-N-cyclohexyl- showed the highest docking interaction score of −7.4, indicating a strong binding affinity. …”
Get full text

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women by Emily Delgouffe, Samuel Madureira Silva, Frédéric Chalmel, Wilfried Cools, Camille Raets, Kelly Tilleman, Guy T'Sjoen, Yoni Baert, Ellen Goossens

“…Although most peritubular myoid cells expressed alpha-smooth muscle actin 2, the expression pattern was disturbed. …”
Get full text

An insulator target detection algorithm based on improved YOLOv5 by Bing Zeng, Zhihao Zhou, Yu Zhou, Dilin He, Zhanpeng Liao, Zihan Jin, Yulu Zhou, Kexin Yi, Yunmin Xie, Wenhua Zhang

“…Finally, to flexibly improve the accuracy of bounding boxes of different sizes and enhance the robustness of the model, an $$\alpha CIOU$$ loss function is utilized to replace the original Complete Intersection Over Union (CIOU) loss function. …”
Get full text

THE RELATIONSHIP BETWEEN GADGET ADDICTION AND INTEREST IN STUDYING AND SLEEP QUALITY IN SCHOOL CHILDREN by Aries Chandra Ananditha, Diah Priyantini, Ranty Dwi Novelia

“…Gadget addiction was measured with a modified questionnaire consisting of 30 favorable items, which were then altered and tried out into 21 questions, consisting of 14 favorable items and 7 unfavorable items with a Cronbach's alpha reliability test result of 0.880. Interest in learning is measured with a questionnaire consisting of 4 answer items and sleep quality is measured with a sleep quality questionnaire (SQQ). …”
Get full text

Is <i>Punica granatum</i> Efficient Against Sepsis? A Comparative Study of Amifostine Versus Pomegranate by Kazim Sahin, Sena Sahin Aktura, Ilkay Bahceci, Tolga Mercantepe, Levent Tumkaya, Atilla Topcu, Filiz Mercantepe, Omer Faruk Duran, Huseyin Avni Uydu, Zihni Acar Yazici

“…Thiobarbituric acid reactive substances (TBARS), total thiol (TT), tumor necrosis factor-alpha (TNF-α) levels, and metalloproteinases 2 and 9 (MMP-2 and MMP-9) were assessed in the lung tissue. …”
Get full text

Artificial intelligence driven innovations in biochemistry: A review of emerging research frontiers by Mohammed Abdul Lateef Junaid

“…The methodology involves an extensive analysis of existing literature, particularly peer-reviewed studies on AI applications in biochemistry. AI-driven tools like AlphaFold, which have significantly advanced protein structure prediction, are evaluated alongside AI’s role in expediting drug discovery. …”
Get full text

Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines by Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle

“…A reduction in interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) by Epac1 could potentially restore normal insulin signal transduction. …”
Get full text

A novel approach to Lyapunov stability of Caputo fractional dynamic equations on time scale using a new generalized derivative by Michael Precious Ineh, Edet Peter Akpan, Hossam A. Nabwey

“…In this work, we introduced a generalized concept of Caputo fractional derivatives, specifically the Caputo fractional delta derivative (Fr$ \Delta $D) and Caputo fractional delta Dini derivative (Fr$ \Delta $DiD) of order $ \alpha \in (0, 1) $, on an arbitrary time domain $ \mathbb{T} $, which was a closed subset of $ \mathbb{R} $. …”
Get full text

Romanian validation study of the Boston questionare in patients with carpal tunnel syndrome by Lenuța Bîrsanu, Roxana Covali, Emanuel Matei Roman, Ioan Alexandru Chirap-Mitulschi, Alin Ciubotaru, Mihaela-Dana Turliuc

“…Our results showed a very good construct validity and excellent reliability (Cronbach's alpha = 0.79) for Boston Carpal Tunnel Questionnaire -Romanian version and the Kaiser-Meyer-Olkin of 0.732, which is considered acceptable (a value above 0.70 is usually statistically significant for factor analysis). …”
Get full text

Investigating the role of urban furniture in improving the quality of urban environment (Case study: Bandar Abbas city) by Sepideh Raeisi Qanavati, Marzieh Moghli, Mohammad Ebrahim Afifi

“…And its reliability was confirmed using Cronbach's alpha coefficient. In order to achieve the objectives of the research, single-sample T-test and simple linear regression were used in SPSS25 software environment. …”
Get full text

Two sexually compatible monokaryons from a heterokaryotic Lentinula edodes strain respond differently to heat stress by Yuan Guo, Wenyu Jiao, Yajie Zhang, Meiting Tan, Qi Gao, Yu Liu, Shouxian Wang

“…The differentially accumulated metabolites (DAMs) of both strains were enriched in the glycerophospholipid metabolism, alpha-linolenic acid metabolism, biosynthesis of cofactors, etc, but were regulated differently in each strain. …”
Get full text