Aggressive Recurrence of Primary Hepatic Epithelioid Haemangioendothelioma after Liver Transplantation by Qusay A. Abdoh, Asma M. Alnajjar, Faisal A. Abaalkhail, Mohammed Al Sebayel, Hussa F. Al-Hussaini, Waleed K. Al-Hamoudi, Hazem Helmy, Mohamad Almansour, Hussien A. Elsiesy

“…Viral hepatitis markers were negative and serum alpha fetoprotein was within reference range. Liver biopsy was consistent with HEHE, with positive endothelial markers (CD31, CD34, and factor VIII-related antigen). …”
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Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from <i>Taenia solium</i> Using Computational and Bioinformatics Tools by César Sánchez-Juárez, Roberto Flores-López, Lluvia de Carolina Sánchez-Pérez, Ponciano García-Gutiérrez, Lucía Jiménez, Abraham Landa, Rafael A. Zubillaga

“…The workflow involved modeling and refining the 3D structure from the sequence using the AlphaFold algorithm and all-atom molecular dynamics simulations with an explicit solvent. …”
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ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells by Lijing Qin, Geng Tang, Ruirui Gui, Yanming Yang, Li Wang, Weiqiang Xu, Hongyuan Tian, Lei Yu, Xiangshan Yang, Zhicheng Wang

“…Abstract Identifying novel targets for molecular radiosensitization is critical for improving the efficacy of colorectal cancer (CRC) radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member of the SWI/SNF-like chromatin remodeling protein family, functions in the maintenance of genomic integrity and the regulation of apoptosis and senescence. …”
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Psychometric Assessment of a Physician-Patient Communication Behaviors Scale: The Perspective of Adult HIV Patients in Kenya by Juddy Wachira, Susan Middlestadt, Michael Reece, Chao-Ying Joanne Peng, Paula Braitstein

“…Internal consistency (Cronbach’s alpha = .81) and one-week retest reliability scores (.82) supported the reliability of the 13-item scale. …”
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Matrix-free human 2D organoids recapitulate duodenal barrier and transport properties by Kopano Valerie Masete, Dorothee Günzel, Jörg-Dieter Schulzke, Hans-Jörg Epple, Nina A. Hering

“…Tumour necrosis factor-alpha induced paracellular transport of 4-kDa Dextran and transcytosis of 44-kDa horseradish peroxidase. …”
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Les qualités métriques des principales échelles qui mesurent l’engagement dans l’activité physique : revue de la littérature by Anthony KHAWAJA, Jaouad ALEM

“…La consistance interne du PES est la plus élevée, avec des coefficients alpha de Cronbach atteignant .90. La validité concomitante des trois premières échelles est relativement mitigée, avec des corrélations variant de .16 à .81. …”
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Drug-Induced Liver Injury Caused by Adalimumab: A Case Report and Review of the Bibliography by Bernardo Frider, Andres Bruno, Marcelo Ponte, Marcelo Amante

“…We describe a case of a 35-year-old man, with rheumatoid arthritis (RA) and hepatitis C virus genotype 1a with a liver biopsy in 2001 with a METAVIR score pattern A1 F0; he received interferon alpha 2b for six months, but treatment was suspended because of reactivation of RA. …”
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Spinal cord injury induces transient activation of hepatic stellate cells in rat liver by Inmaculada Fernandez-Canadas, Alejandro Badajoz, Jesús Jimenez-Gonzalez, Martin Wirenfeldt, Beatriz Paniagua-Torija, Clara Bravo-Jimenez, Mar Del Cerro, Angel Arevalo-Martin, Daniel Garcia-Ovejero

“…This is followed by a morphological and phenotypical transformation into alpha-smooth muscle actin (ACTA2/SMA) immunoreactive myofibroblast-like cells, peaking at 14 days post-injury and returning to control-like levels at later timepoints (45 days post-injury). …”
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Biosynthesis of the Essential Fatty Acid Oxidation Cofactor Carnitine Is Stimulated in Heart and Liver after a Single Bout of Exercise in Mice by Tom L. Broderick, Frank A. Cusimano, Chelsea Carlson, Jeganathan Ramesh Babu

“…Liver and heart were removed under the same conditions for measurement of carnitine biosynthesis enzymes (liver butyrobetaine hydroxylase, γ-BBH; heart trimethyllysine dioxygenase, TMLD), organic cation transporter-2 (OCTN2, carnitine transporter), and liver peroxisome proliferator-activated receptor-alpha (PPARα, transcription factor for γ-BBH and OCTN2 synthesis). …”
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Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…It is the first FDA-approved drug to target hypoxia-inducible factor 2 alpha (HIF-2α). By inhibiting the HIF-2α transcription factor, belzutifan prevents HIF-2α from dimerizing with HIF-1β, thereby preventing the transcription of downstream oncogenes. …”
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Chronic Kidney Disease Induced Intestinal Mucosal Barrier Damage Associated with Intestinal Oxidative Stress Injury by Chao Yu, Zhen Wang, Shanjun Tan, Qiang Wang, Chunyu Zhou, Xin Kang, Shuang Zhao, Shuai Liu, Huijun Fu, Zhen Yu, Ai Peng

“…The uremia group presented an increase trend over time in the serum tumor necrosis factor-alpha, interleukin-6 (IL-6) and IL-10, serum D-lactate and diamine oxidase, and intestinal permeability, and these biomarkers were significantly higher than those in control group in POW 8 and/or 10. …”
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Analysis of Fungal Diversity and Isolation and Identification of Yeast in High-temperature and Medium-high-temperature Daqu Using Three Generation Sequencing Technology by Mengjun CUI, Yurong WANG, Qiangchuan HOU, Haibo ZHANG, Longxin TIAN, Mingbo YE, Zhuang GUO

“…Additionally, traditional microbial pure culture methods and molecular biology techniques were utilized to investigate the yeast resources within Daqu. Alpha diversity analysis revealed significant differences (P<0.05) in the richness and diversity of fungal communities between the two types of Daqu. …”
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The Frequency and the Significance of TNF-&#945;+CD19+ B-cell Population in Lymph Nodes of Patients with Squamous Cell Carcinoma of Head and Neck by Marzieh Norouzian, Fereshteh Mehdipour, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi

“…Materials and Methods: Thirty-six draining lymph nodes from untreated patients with tongue and larynx SCC were stimulated with CpG, recombinant CD40L and phorbol-12-myristate-13-acetate/ionomycin and analyzed by flow cytometry for the frequency of B-cell subsets based on interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-&#945;) cytokine production. Results: It was indicated that patients with uninvolved lymph nodes and low stage of the disease had an increased percentage of TNF-&#945;+CD19+ B-cells (p=0.006 and p=0.041, respectively), whereas the frequency of IL-10+CD19+ B-cells showed an increasing trend in tumor-draining lymph nodes (TDLNs) of patients with grade 2+3 compared to grade 1 (p=0.054). …”
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A Cocktail Method for Promoting Cardiomyocyte Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells by Qing Gao, Maojuan Guo, Xijuan Jiang, Xiantong Hu, Yijing Wang, Yingchang Fan

“…Real-time qPCR and Western blotting analyses showed that cTnT, alpha-cardiac actin, mef-2c, Cx43, and GSK-3beta expression increased while beta-catenin expression decreased. …”
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Accurate Prediction of Advanced Liver Fibrosis Using the Decision Tree Learning Algorithm in Chronic Hepatitis C Egyptian Patients by Somaya Hashem, Gamal Esmat, Wafaa Elakel, Shahira Habashy, Safaa Abdel Raouf, Samar Darweesh, Mohamad Soliman, Mohamed Elhefnawi, Mohamed El-Adawy, Mahmoud ElHefnawi

“…Model 1 uses six parameters, while model 2 uses four, which are similar to FIB-4 features except alpha-fetoprotein instead of alanine aminotransferase. …”
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Taxonomic and functional diversity of protists in saline and hypersaline lakes in southern Western Siberia, a region strongly affected by climate change by Elena A. Gerasimova, Alexander S. Balkin, Vladimir Y. Kataev, Ekaterina S. Filonchikova, Yulia V. Mindolina, Denis V. Tikhonenkov

“…Phototrophs dominated the delta-hypersaline waters, and free-living heterotrophs dominated the alpha- and beta-hypersaline lakes. The parasite amplicon sequence variants (ASVs) were affiliated mainly with mixohaline and beta-hypersaline lakes.…”
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Development and Validation of the Patient Experience Assessment Scale (PXAS) in Tertiary Care Hospital - Oman by Naima Khamis Al-Bulushi MD, FFR RCSI, Zainab Ali Al-Mukhaini MD, DCH, DTM&H, MSc, PhD, Jehan Al Fannah BSc, MSc, MBA, Afaf Ali Al Zadjali BSN, MBA, Huda Al Zidi BSc, Zubaida Mahmood Al-Balushi NNP BSN, MBA, Aida Khalfan Al-Hadidi IBCLC, Samir Al-Adawi BSc, MSc, PhD

“…PXAS showed good reliability (Cronbach's alpha = 0.88) and test-retest (r = 0.72). The content validity (I-CVI: 0.83-1.0; S-CVI = 0.93) and the validity of the face (98.3% agreement) were excellent. …”
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Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis by Jieyang Yu, Hongping Li, Jingjie Zhao, Yanhua Huang, Chunlei Liu, Pengfei Yang, Dinggui Lu, Jian Song, Lingzhang Meng

“…Additionally, significantly lower microbial alpha diversity was observed in patients with sepsis than in healthy individuals. …”
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Investigating the security consequences of climate change on Iran with a Good Governance approach by Parisa ghorbani sepehr, Zaki Yashar, Seyed abbas ahmadi

“…The results of the studies according to the obtained P-value which is equal to 0.000 and is less than 0.05 alpha, indicate the difference between the natural and human consequences of climate change in Iran. …”
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Circulating Dynamics of SARS-CoV-2 Variants between April 2021 and February 2022 in Turkey by Murat Sayan, Ayse Arikan, Murat Isbilen

“…We revealed that the lineages Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2), Eta (B.1.525), variant of interest (VOI), lota (B.1.526), Zeta (P.2), Omicron (B.1.1.529), and Omicron BA.1 (B.1.1.529.1) were in the circulation in Turkey during the given period. …”
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