Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8 by Nadège Hertzog, Mert Duman, Maëlle Bochud, Valérie Brügger-Verdon, Maren Gerhards, Felicia Schön, Franka Dorndecker, Dies Meijer, Robert Fledrich, Ruth Stassart, Devanarayanan Siva Sankar, Jörn Dengjel, Sofía Raigón López, Claire Jacob

“…We found that HDAC8 is specifically expressed in sensory SCs and regulates the E3 ubiquitin ligase TRAF7, which destabilizes hypoxia-inducible factor 1-alpha (HIF1α) and counteracts the phosphorylation and upregulation of c-Jun, a major inducer of the repair SC phenotype. …”
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Enhancing dissolving pulp quality of mixed raw materials through pre-hydrolysis kraft-cooking: A study on Acacia crassicarpa and Terminalia catappa by Yusnimar Sahan, Sri Wahdini Rahmi, Evelyn, Syamsu Herman, Chairul, Khairat, Hiroshi Ohi, Amun Amri

“…The DP produced had ISO brightness > 88%, alpha-cellulose content > 94%, viscosity > 6.2 cP, and pentosan content of 2.54%. …”
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Studies on the Interleukin-10 Gene in Animal Models of Colitis by Hugh J Freeman

“…IL-10-deficient mice develop intestinal inflammation with increased tissue levels of other cytokines, including tumour necrosis factor-alpha. In patients with inflammatory bowel disease, impaired IL-10 production by lamina propria T cells occurs and human recombinant IL-10 improves clinical parameters in inflammatory bowel disease (eg, Crohn's disease). …”
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Insights into COVID-19 Delta variant (B.1.617.2) by Angel Yun-Kuan Thye, Ke-Yan Loo, Kyle Bond Chene Tan, Jenny May-Sim Lau, Vengadesh Letchumanan

“…It caught worldwide attention due to its greater transmissibility than the progenitor strain and the first variant of concern (VOC)- Alpha variant (B.1.1.7). B.1.617.2 spread rapidly across the globe and became a VOC due to its high transmissibility, clinical implications, and impact on vaccine efficacy. …”
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Specialized Bacteroidetes dominate the Arctic Ocean during marine spring blooms by Álvaro Redondo-Río, Christopher J. Mundy, Javier Tamames, Carlos Pedrós-Alió

“…These specialized taxa quickly displaced the microbial clades that dominate nutrient-poor waters during early spring, such as Archaea, Alpha-and Gammaproteobacteria. At the functional level, phyla Bacteroidetes, Planctomycetes, and Verrucomicrobia showed higher contents of polysaccharide-degradation functions. …”
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The compositional behavior of the human T cell receptor repertoire in ovarian cancer compared to healthy donors by Miriam Zuckerbrot-Schuldenfrei, Alona Zilberberg, Sol Efroni

“…In this study, we sampled the repertoire of 85 women: ovarian cancer patients (OC) and healthy donors (HD), generating a dataset of T cell clones and their abundance. For the alpha chain we obtained 6.4·106 reads, with an average of 75936 clones per sample, and an average of 30607 clonotypes per sample. …”
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An Investigation into the Critical Attitudes of Iranian EFL Students toward English Language Learning in Iran: An Introspective Longitudinal Study by Mojtaba Maghsoudi, Abolfazl Khodamoradi, Seyed Hassan Talebi

“…The reliability of this questionnaire through Cronbach’s alpha was .93. Then, statistical tests such as the Mann-Whitney test and one-way ANOVA indicated that the students’ critical pedagogy attitudes did not significantly grow in the process of education from the first to the last semester. …”
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The research of expectations and perceptions of Individuals towards service quality that are coming to sports center continually by Adnan Ersoy, Sihmehmet Yıgıt

“…The internal consistency of the scale is tested by Cronbach Alpha techniques. To define the differences between the groups, “independent sample t test” and “the analysis of one way variance” are used. …”
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Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease by Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Ambreen Fatima, Saba Khanam, Rahul, Fahad Ali, Syed Faiz Mujtaba, Mohammad Faisal

“…The role of Centella asiatica L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. The leaf extract was prepared in acetone and was subjected to GC-MS analysis. …”
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Current and future therapeutic options for chronic hepatitis D virus infection by Mariantonietta Pisaturo, Antonio Russo, Pierantonio Grimaldi, Salvatore Martini, Nicola Coppola

“…Recently, new molecular targets have been identified, both in monotherapy and in combination with peginterferon alpha (PegIFNα). Evaluating this review of the literature of the last ten years, HDV-related chronic hepatitis seems to have become a potentially curable disease, a statement that was unthinkable a few years ago. …”
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The effect of academic enthusiasm on academic hope through the mediating role of academic optimism in students by Gholamhasan Panahi, Tayebeh Ordouni, Sajad Kazemi

“…The content validity and reliability of the questionnaires were estimated using Cronbach's alpha coefficient of 0.79, academic optimism 0.81 and academic hope 0.84.The results showed that academic enthusiasm had a direct and significant effect on academic hope and academic enthusiasm on students' academic optimism.…”
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Laser Photobiomodulation for a Complex Patient with Severe Hydroxyurea-Induced Oral Ulcerations by Marco Cabras, Adriana Cafaro, Alessio Gambino, Roberto Broccoletti, Ercole Romagnoli, Davide Marina, Paolo G. Arduino

“…Conventional therapeutic options aim at reducing vascular and thrombotic risk; low-dose aspirin and phlebotomy are first-line recommendations, for patients at low risk of thrombotic events, whereas cytoreductive therapy, usually hydroxyurea (HU) or interferon alpha, is recommended for high-risk patients. In the present study, we report the case of a patient with persistent oral ulcerations, possibly related to long-lasting HU treatment, firstly treated with topic and systemic corticosteroids and then more effectively with the addition of low-level laser therapy. …”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes. Unlike PPAR-alpha and PPAR-gamma, PPAR-delta is ubiquitously expressed, and its activity is key to maintaining proper metabolic homeostasis within the liver. …”
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Acute Portal Vein Thrombosis Treated with Recombinant Human Soluble Thrombomodulin Combined with Antithrombin III by Satoshi Nakayama, Naoya Murashima

“…Herein, we report a case of acute portal thrombosis associated with liver cirrhosis and treated with a recombinant form of soluble thrombomodulin (thrombomodulin alpha, TM-α) in combination with antithrombin III. …”
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Captivity Reduces Diversity and Shifts Composition of the Great Bustard (Otis tarda dybowskii) Microbiome by Zhiyuan Lu, Zhucheng Wang, Hexue Jia, Derong Meng, Dayong Wu

“…The results revealed a significant decline in alpha diversity and notable changes in microbial community structure in captive environments. …”
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Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice by Lia J. Zallar, Jean K. Rivera-Irizarry, Peter U. Hamor, Irena Pigulevskiy, Ana-Sofia Rico Rozo, Hajar Mehanna, Dezhi Liu, Jacqueline P. Welday, Rebecca Bender, Joseph J. Asfouri, Olivia B. Levine, Mary Jane Skelly, Colleen K. Hadley, Kristopher M. Fecteau, Scottie Nelson, John Miller, Pasha Ghazal, Peter Bellotti, Ashna Singh, Lauren V. Hollmer, David W. Erikson, Jacob Geri, Kristen E. Pleil

“…The pro-drinking, but not anxiolytic, effect of high endogenous estrogen occurred via rapid signaling at membrane-associated estrogen receptor alpha in the bed nucleus of the stria terminalis, which promoted synaptic excitation of corticotropin-releasing factor neurons and facilitated their activity during alcohol drinking. …”
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The complexity of caffeine's effects on regular coffee consumers by Mateja Lesar, Jakob Sajovic, Dušanka Novaković, Maša Primožič, Eva Vetrih, Martin Sajovic, Anja Žnidaršič, Peter Rogelj, Andreas Daffertshofer, Zoran Levnajić, Gorazd Drevenšek

“…However, except for the resting-state alpha power, changes due to ingestion in physiological responses and in cognitive functioning were not significantly different between the two groups. …”
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Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma: A Case Presentation by Francesco Fiorica, Carlo Greco, Sergio Boccia, Sergio Sartori, Antonio Stefanelli, Francesco Cartei, Stefano Ursino

“…A dramatic reduction in alpha-fetoprotein was observed. Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas. …”
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Detection and classification of single-circuit and intra-circuit faults based on analysis of current signals of near-end terminal in double-circuit transmission lines by Mahyar Abasi, Pirooz Gorjian

“…In the first step, by investigating the alpha component of the modal transform, it can be recognized that the fault is single-circuit or double-circuit. …”
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Assembly of oleosin during efficient extraction: Altering the sequence of defatting solvents by Yu Li, Yuqian Qiao, Yuxuan Zhu, Wangyang Shen, Weiping Jin, Dengfeng Peng, Qingrong Huang

“…The 3D spatial structure of oleosin was predicted using AlphaFold 2, revealing that the secondary structure of oleosin was dominated by α-helices (>60 %). …”
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