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2501
Nucleus-translocated GCLM promotes chemoresistance in colorectal cancer through a moonlighting function
Published 2025-01-01“…Mechanistically, we unveil a noncanonical mechanism through which nuclear GCLM competitively interacts with NF-kappa-B (NF-κB)-repressing factor (NKRF), to promote NF-κB activity and facilitate chemoresistance. …”
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2502
Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization
Published 2025-01-01“…It inhibited the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway by activating the CB2 receptor, reducing expression of interleukin-6, tumor necrosis factor-alpha, and cyclooxygenase-2 (COX2) (p<0.01). …”
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2503
Evaluating CNN Architectures for the Automated Detection and Grading of Modic Changes in MRI: A Comparative Study
Published 2025-01-01“…In the AI‐assisted experiment, agreement between the junior doctor and the senior spine surgeon significantly improved from Cohen's kappa of 0.368–0.681. Conclusions YOLOv8 in detecting and grading MCs was significantly superior to that of YOLOv5. …”
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2504
Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease
Published 2025-02-01“…Monocyte‐activated platelets initiate transforming growth factor (TGF)β1 release, which results in nuclear localization of nuclear factor kappaB in monocytes, therefore, driving the phenotypic conversion of classical monocytes (CD14+CD16−) into proinflammatory monocytes (CD14+CD16+). …”
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2505
The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction
Published 2025-01-01“…Abstract Receptor activator of nuclear factor kappa-B ligand (RANKL) initiates a complex signaling cascade that is crucial for inducing osteoclast differentiation and activation. …”
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2506
Dynamic EIT technology for real-time non-invasive monitoring of acute pulmonary embolism: a porcine model experiment
Published 2025-01-01“…Subsequently, a control verification was conducted utilising the hypertonic saline method, which revealed a high degree of consistency between the two methods in the detection of acute pulmonary embolism (Kappa = 0.75, P < 0.05). Conclusions The EIT imaging method, which is based on the analysis of blood flow pulsation, has the potential to reflect in real time the changes in pulmonary blood flow that occur before and after an embolism. …”
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2507
Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway
Published 2025-02-01“…It was also found that PRE-084 increased phosphorylation of serine/threonine protein kinase B (AKT) and glycogen synthase kinase 3β (GSK-3β) at Ser9, inhibiting nuclear factor kappa B (NF-κB)-mediated neuroinflammation in the dorsal root ganglion, thus reducing DNP. …”
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2508
Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement
Published 2019-01-01“…Osteocytes express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation. …”
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2509
Twin to Twin Transfusion Syndrom
Published 2014-05-01“…Kasus 2: Seorang pasien usia 31 tahun dengan diagnosa MP5 parturient aterm kala II dengan gemelli. Pasien melahirkan spontan. …”
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2510
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2511
Beyin, Bilinç ve Nedensel Güçler
Published 2024-07-01“…Örneğin yapay kalpler kas dokusundan üretilmez. Yapay kalp hangi malzemeden yapılmış olursa olsun önemli olan kalbin kan pompalamak için sahip olduğu nedensel güçlerin en azından eşik değerinde nedensel güçlere sahip olmasıdır. …”
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2512
‘İbrâhim Yaşasaydı Sıddîk Bir Nebî Olurdu’ Rivayetinin Hatmü’n-Nübüvve Bağlamında Sened ve Metin Tahlili
Published 2024-12-01“…Rivayete göre o (s.a.v.), hicri 10 yılında İbrâhim’in ahirete irtihali akabinde, “Göz yaşarır, yaş boşalır, kalp sızlar ve hüzünlenir. Ey İbrâhim! Biz senin ölümünle gerçekten çok üzgünüz. …”
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2513
The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters
Published 2025-06-01“…In the present study, CgCaspase-3 was demonstrated to regulate the expressions of proinflammatory cytokines through nuclear factor kappa B (NF-κB) signaling pathway. In haemocytes of Ac-DEVD-CHO-treated and CgCaspase-3-RNAi oysters, the nuclear translocation of NF-κB/Rel was inhibited at 24 h after Vibrio splendidus stimulation. …”
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2514
Ağ Toplumunda Dini Nefret Söylemi: Dijital Kürsü Şeyhliği
Published 2024-12-01“…X’ın etkileşim, dolaşımda kalma ve görüntüleme üzerine kurulmuş olan algoritmik yapısının dini içerikli nefret söylemlerinin slagonik bir yapıda ve manşet halde sunulmasına neden olduğu, tekfir ve reddiye geleneğinin dijital ortamlarda ötekileştirme, kalıp yargı oluşturma ve hedef gösterme olgusunu pekiştirdiği, nefret üretiminde rol oynadığı tespit edilmiştir. …”
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2515
Differentiation of Early Sacroiliitis Using Machine-Learning- Supported Texture Analysis
Published 2025-01-01“…The diagnostic efficacies of the two readers were judged and compared using an assigned Likert score, conducting a Kappa consistency test of the diagnostic results between two readers. …”
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2516
0-10 Yaş Grubu Çocuklara Yönelik Çocuk Şiir Kitaplarına İlişkin Fiziksel ve İçerik Özelliklerin İncelenmesi
Published 2022-06-01“…Kitapların resimlendirme özellikleri açısından; %88,8’inde kapak resmi içerikle uyumlu, %73,5’inde resimlerde duygu ifadelerine yer verildiği, %44,9’unda resimlerin renkli olduğu, %74,5’inde her sayfada resim olmadığı ve %60,2’sinde aynı sayfadaki resimlerle metinlerin birbirini tamamladığı tespit edilmiştir. …”
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2517
Àgbéyẹ̀wò Ipa àti Ipò Àwọn Ọmọdé Nínú Ìpohùn Òrìṣà Ẹgbẹ́ Ọ̀gbà ní Agbègbè Yewa-Awórì, Ẹ̀gbá, àti Ìjẹ̀bú
Published 2021-12-01“…A tún ṣe ìfò ̣ rọ̀ -wáni-lé ̣ nu-wò fún ̣ àwọn akópa tí wón jé ̣ àgbààgbà olùsìn Òrìṣà Ẹgbé ̣ náà ló ̣ lọ́ kan-ò-jò ̣ kan, a sì ká ̣ a sílẹ̀ nínú fọ́nrán àti fídíò. …”
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2518
Rükneddin es-Semerkandî’nin (ö. 701/1301) Risâle fî ḥaḳîḳati’l-ʿâlemi’l-kebîr ve’s-ṣağîr Adlı Eseri: İnceleme ve Tahkîk
Published 2024-12-01“…Bu çalışmanın önemi, söz konusu risâlenin ilk kez tahkîk ve incelenmesi yapılıp, risâlenin hâlâ kütüphanelerde el yazması olarak bulunmasında yatmaktadır. …”
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2519
Erken Dönem Sûfî Dilinin Bağlarını Birleştirmek: Ebu Tâlib el-Mekkî’de Havâtır
Published 2024-12-01“…Teklifin illeti ve temyizin mahalli olan akıl ise işlevini, kalbe gelen ilkânın bilgiye dönüştürülmesinden önce yerine getirir. …”
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2520
Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway
Published 2023-08-01“…Modified neurological severity score (mNSS) was used to evaluate neurological deficit; novel object recognition test (NORT) and Morris water maze (MWM) were used to evaluate the cognitive function; immunofluorescence was used to detect the expression of CD31 in cortex; Western blot was used to detect zonula occludens-1 (ZO-1), Occludin, Claudin-5, phosphorylated nuclear factor kappa-B (p-NF-κB), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), transient receptor potential melastatin-2 (TRPM2), phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthetase kinase-3β (p-GSK3β) protein expression levels.Results(1) Neurological function: compared with the sham surgery group, mNSS in the model group significantly increased at the 1st, 3rd, 5th and 7th day (<italic>P</italic><0.05); compared with the model group, mNSS in the 24A group significantly decreased at the 3rd and 7th day (<italic>P</italic><0.05). (2) Cognitive function: compared with the sham surgery group, the NORT recognition index at 1st and 24th hour in the model group was significantly lower (<italic>P</italic><0.05); compared with the model group, the 1-hour and 24-hour NORT recognition index in the 24A group significantly increased (<italic>P</italic><0.05). …”
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