AI-assisted diagnosis of vulvovaginal candidiasis using cascaded neural networks by Zhongxiao Wang, Ruliang Wang, Haichun Guo, Qiannan Zhao, Huijun Ren, Jumin Niu, Ying Wang, Wei Wu, Bingbing Liang, Xin Yi, Xiaolei Zhang, Shiqi Xu, Xianling Dong, Liqun Wang, Qinping Liao

“…The consistency rates and Cohen’s kappa coefficients between experts’ interpretations of microscopic digital images and microscopic examination under eyepiece exceeded 93% and 0.83 for the three different morphologic states of yeast. …”
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Regional climatic changes and their impact on the level of avalanche hazard in East Kazakhstan by Olga Petrova, Natalya Denissova, Gulzhan Daumova, Yelena Ivashchenko, Evgeny Sergazinov

“…The mountainous regions of East Kazakhstan are represented by the Kalba, Altai and Saur-Tarbagatay ranges, they are surrounded by rolling plains. …”
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Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

“…This consequently improved weaning-induced colon and liver injury and dysfunction through the DCA-secondary bile acid (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. …”
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Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…KEGG pathway analysis indicated significant modifications in genes associated with influenza A, mitogen-activated protein kinase signaling, nuclear factor kappa-B signaling, and apoptosis following XYP injection. …”
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Antimicrobial resistance profile of Pseudomonas aeruginosa clinical isolates from healthcare-associated infections in Ethiopia: A systematic review and meta-analysis. by Zelalem Asmare, Melese Abate Reta, Yalewayker Gashaw, Ermias Getachew, Assefa Sisay, Muluken Gashaw, Ephrem Tamrat, Atitegeb Abera Kidie, Wagaw Abebe, Tadesse Misganaw, Agenagnew Ashagre, Zelalem Dejazmach, Getinet Kumie, Marye Nigatie, Sisay Ayana, Abdu Jemal, Solomon Gedfie, Woldeteklehaymanot Kassahun, Mulat Awoke Kassa, Selamyhun Tadesse, Biruk Beletew Abate

“…AMR of P. aeruginosa to 10 different antibiotics were extracted separately into Microsoft Excel and analyzed using STATA 17.0. Cohen's kappa was computed to determine the agreement between reviewers, the Inverse of variance (I2) was used to evaluate heterogeneity across studies, and Egger's test to identify publication bias. …”
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Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats by Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares

“…At the end of the training protocol, we evaluated the following: glycosuria, body weight gain, plasma, renal and urinary levels of nitric oxide and thiobarbituric acid reactive substances, renal glutathione, and immunolocalization of lymphocytes, macrophages, and nuclear factor-kappa B (NF-κB/p65) in the renal cortex. The results showed that exercise training reduced glycosuria, renal TBARS levels, and the number of immune cells in the renal tissue of the TD and PTD groups. …”
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Effects of Electroacupuncture at Fengchi Acupoint on Myosatellite Cells and TLR4/MyD88/NF-κB Signaling Pathway in Chronic Cervical Muscle Injury Rats by HUANG Yuting, CHEN Jiayan, KAN Yu, FANG Yanping, WANG Jinwei, ZHENG Linyao, JING Xianghong, LIAO Jun

“…ObjectiveTo observe effects of electroacupuncture at Fengchi acupoint on expression of myosatellite cells, myogenic determining factor (MyoD), proliferating cell nuclear antigen (PCNA), Toll-like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88) and nuclear factor-kappa B p65 (NF-κBp65) protein in rat with chronic cervical muscle injury, so as to explore possible mechanism of electroacupuncture in promoting the repair of chronic cervical muscle injury.MethodsTen Wistar rats were selected from 45 Wistar rats as blank group, and the remaining rats were divided into model group, electroacupuncture group (EA group) and meloxicam group according to random number table method, with 10 rats in each group (5 rats were unsuccessful in modeling). …”
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Alcohol abuse in gastroenterological patients by M. V. Mayevskaya, I. G. Bakulin, A. A. Chirkov, Ye. O. Lyusina, V. D. Lun’Kov

“…Sensitivity and specificity of questionnaires of AUDIT-C and CAGE was 66 and 91,4%, respectively, diagnostic accuracy - 86,2%, coherence coefficient (Kappa) - 0,567 (medium correlation). Of all patients with alcohol abuse, only 16,5% would refer to attending physician and 10,4% - to narcologist, 8,5% did not consider alcohol consumption as a problem, and 64,4% of them believe that they can cope with the problem on their own. …”
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Dietary supplementation of Lycium barbarum polysaccharides alleviates soybean meal-induced enteritis in spotted sea bass Lateolabrax maculatus by Longhui Liu, Yanbo Zhao, Zhangfan Huang, Zhongying Long, Huihui Qin, Hao Lin, Sishun Zhou, Lumin Kong, Jianrong Ma, Yi Lin, Zhongbao Li

“…Through transcriptomic and metabolomic analysis, it was found that the expression of proinflammatory factors such as interleukin-1β (IL-1β), interleukin-12 (IL-12), nuclear factor kappa B subunit 2 (NF-κB2), and Toll-like receptor 2 (TLR2) were significantly down-regulated in the mitogen-activated protein kinase (MAPK) and Toll-like receptor signaling pathways (P < 0.05), and the important tight junction protein gene Occludin was up-regulated (P < 0.05). …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Specifically, tumor-associated macrophages (TAMs) create an immunosuppressive milieu through the production of a plethora of paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting the acquisition by CSCs of a stem-like, invasive and metastatic phenotype. …”
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Pink1/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia by Zirong Li, Yi Shu, Deguo Liu, Sheng Xie, Liangbo Xian, Jiaqi Luo, Xiuwen Huang, Haixing Jiang

“…The results showed that the levels of reactive oxygen species (ROS) in cerebrospinal fluid of CUMS+SD rats significantly increased along with the inflammatory factors Interleukin-1β (IL-1β) and nuclear factor kappa-B (NF-κB) in cerebrospinal fluid. In addition, the number of pineal gland cells significantly decreased, cell boundaries became blurred, cell volume shrank, and apoptotic bodies appeared in the pineal gland tissue under HE staining, indicating pineal gland inflammation. …”
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Mudanças percebidas no estilo de vida no distanciamento social: validade preliminar do questionário by Sueyla Ferreira da Silva dos Santos, Thiago Ferreira de Sousa, Silvio Aparecido Fonseca, Ana Maria Alvarenga, Karine Moraes Pereira, Gildeene Silva Farias, Luiz Rodrigo Augustemak de Lima, Fernanda Carneiro Mussi

“…Em seguida, realizou-se a análise da reprodutibilidade com a aplicação do teste e reteste com intervalo de 15 a 30 dias e utilizou-se o coeficiente Kappa (K) para a concordância dos dados. O nível de significância estatística adotado foi de 5%. …”
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How Uremic Toxins Alter Atorvastatin Disposition: Molecular Mechanisms of Inhibition of the Enzyme CYP3A4 by Ashna Asim, Fen Wang, Dong Pu, Sisi Wang, Dian Wang, Wenwen Li, Feng Yu, Li Ji

“…The influence of UTs on pregnane X receptor (PXR)/nuclear factor kappa B (NF-κB) mRNA and the protein expression was also detected. …”
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Frailty index, frailty phenotype and 6-year mortality trends in the FRASNET cohort by Sarah Damanti, Sarah Damanti, Rebecca De Lorenzo, Rebecca De Lorenzo, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Maria Pia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Francesca Farina, Costanza Festorazzi, Giordano Vitali, Paolo Manunta, Paolo Manunta, Angelo Andrea Manfredi, Chiara Lanzani, Chiara Lanzani, Patrizia Rovere-Querini, Patrizia Rovere-Querini

“…Concordance was assessed using Cohen’s Kappa coefficients. Age-and sex-adjusted Cox regression analyses were conducted to evaluate the association with mortality.ResultsOut of 1,114 participants (median age 72 years, IQR 69–77), 186 were classified as frail by the FI, 13 by the FP and 48 by both definitions. …”
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Çocuklarda Dental Anksiyete: Başarılı Dental Tedavinin Önündeki Engel by Aysun Avşar, Büşra Mutlu

“…Dental kaygıya sahip çocuklarda diş tedavisi esnasında kalp hızında artış, nefes almada değişiklik, terleme, karın ağrısı, titreme, mide bulantısı, ağız kuruluğu, ağlama, huzursuzluk, dikkat dağınıklığı sıklıkla görülmektedir. …”
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THE ROLE OF N. I. VAVILOV AND VIR’S SCIENTISTS IN DESERT RECLAMATION by N. I. Dzyubenko, A. A. Kochegina

“…The research on this topic was conducted by the Repetek Sand Desert Station (run by VIR from 1925 to 1941) with a supporting site in the Kara-Bogaz-Gol, the Aral Experimental Station (organized in 1933), the Turkmen Research Station of VIR in Kara-Kala (established in 1927), the Azerbaij ani branch VIR on the Apsheron Peninsula (organized in 1926). …”
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Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study by Yaqin Peng, Ruijie Xie, Yifeng Luo, Yifeng Luo, Yifeng Luo, Penghao Guo, Zhongwen Wu, Yili Chen, Pingjuan Liu, Jiankai Deng, Bin Huang, Kang Liao

“…Taking BC as the gold standard, receiver operating characteristic curve and Cohen’s kappa agreement were used to investigate whether the pathogen load could predict a corresponding culture-proven BSI for the top five microorganisms detected by ddPCR.ResultsOf the 173 blood samples collected, BC and ddPCR were positive in 48 (27.7%) and 92 (53.2%) cases, respectively. …”
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(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms by Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Júnior, Catarina Alves de Lima Serafim, Matheus Marley Bezerra Pessoa, Michelle Liz de Souza Pessôa, Vitória Pereira Alves, Marianna Vieira Sobral, Marcelo Sobral da Silva, Adriano Francisco Alves, Maria Carolina de Paiva Sousa, Aurigena Antunes Araújo, Leônia Maria Batista

“…At a dose of 150 mg/kg, the acute and chronic phase decreased malondialdehyde (MDA) and myeloperoxidase (MPO) (<i>p</i> < 0.001), restored glutathione (GSH) levels and superoxide dismutase (SOD) (<i>p</i> < 0.001), decreased immunomarking for factor nuclear kappa B (NF-κB) and levels of interleukin (IL)-1 and tumor necrosis factor α (TNF-α), and maintained IL-10 and TGF-β basal levels. …”
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Potential Mechanisms and Effects of Dai Bai Jie Ethanol Extract in Preventing Acute Alcoholic Liver Injury by Niantong Xia, Hongwei Xue, Yihang Li, Jia Liu, Yang Lou, Shuyang Li, Yutian Wang, Juan Lu, Xi Chen

“…Furthermore, DBJ-3 significantly increased alcohol dehydrogenase 1b (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) expression at the gene and protein levels within alcohol metabolism pathways and reduced the nuclear factor kappa-B (NF-κB) gene and protein levels. These findings suggest that DBJ-3 can prevent AALI by enhancing alcohol metabolism via the regulation of ADH1B and ALDH2 and the modulation of the NF-κB pathway to improve antioxidant and anti-inflammatory effects.…”
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In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA by Zhaoxing Ou, Rui Zeng, Yifan Lin, Si Zhang, Mohammad Alzogool, Peng Zeng, Yuqing Lan

“…To seek for a small interfering RNA (siRNA) sequence targeting a cynomolgus monkey inhibitor of nuclear factor kappa B α (IκBα) that can specifically and effectively suppress IκBα gene expression of cynomolgus monkey ciliary muscle (CM) cells and trabecular meshwork (TM) cells in vitro and screen for optimal siRNA transfection concentration. …”
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