Comparative analysis of EGFR mutations in circulating tumor DNA and primary tumor tissues from lung cancer patients using BEAMing PCR by Duhita Mirikar, Nandini Banerjee, Kumar Prabhash, Rajiv Kumar Kaushal, Vanita Naronha, C. S. Pramesh, George Karimundackal, Amit Joshi, Swapnil Rane, Ranjan Basak

“…For both comparisons, Cohen’s kappa agreement was significant. The advantage of BEAMing is its ability to identify mutated DNA sequences in cancer cells in the background of normal cell DNA contamination. …”
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Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu, Fei Xu, Fei Xu

“…ObjectivesTo explore the mechanism underlying the effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses of the gut microbiota.MethodsIn this study, we randomly divided mice into the control, model, FAE high-dose, FAE medium-dose, and FAE low-dose groups to analyze the pathological changes in the hepatic fibrosis and levels of the α-SMA, collagen 1, Nuclear Factor Kappa B (NF-κ B), Toll Like Receptor 4 (TLR4). The gut microbiota was analyzed through 16S rDNA sequencing analysis of liver metabolites using liquid chromatography-mass spectrometry. …”
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Chronic Stress Mediates Inflammatory Cytokines Alterations and Its Role in Tumorigenesis by Liu Z, Lei M, Bai Y

“…These hormones interact with receptors on inflammatory cells, leading to the activation of key signaling pathways, including the transcription factors signal transducer and activator of transcription 3 (STAT-3) and kappa-light-chain-enhancer of activated B cells (NF-κB). …”
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Can GastroPanel be used as a triage tool to select patients with advanced atrophic gastritis for gastroscopy? A prospective clinical validation study by Eleanor Wood, Marco Novelli, Laura Marelli, Roger Feakins, Cinzia Papadia, Ray Shidrawi, Kari Juhani Syrjänen

“…GastroPanel results were interpreted using the GastroSoft app (Biohit).Results Overall agreement between GastroPanel and the USS classification was 90% (95% CI=86.7 to 93.8%), with a weighted kappa (κw) of 0.828 (95% CI=0.781 to 0.865). In receiver operating characteristics (ROC) curve analysis, using moderate/severe atrophic gastritis of the corpus (AGC2+) as the endpoint, AUC=0.840 (95% CI 0.630 to 1.000) and 0.960 (95% CI 0.907 to 1.000) for PGI and the PGI/PGII ratio, respectively.Conclusion GastroPanel is a reliable dyspepsia triage test distinguishing patients who can be safely treated conservatively from those with moderate to severe corpus atrophic gastritis at high risk of developing GAC.…”
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Vegetation Classification in a Mountain–Plain Transition Zone in the Sichuan Basin, China by Wenqian Bai, Zhengwei He, Yan Tan, Guy M. Robinson, Tingyu Zhang, Xueman Wang, Li He, Linlong Li, Shuang Wu

“…The MLP algorithm achieved the best overall accuracy (OA: 81.65%, Kappa: 77.75%), demonstrating robustness and lower dependence on feature quantity. …”
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Konfor Alanı Yönelim Ölçeğinin (KAYÖ) Türkçe Uyarlaması: Geçerlik ve Güvenirlik Çalışması by Mehmet Uzun, Akif Köse

“…Her bir boyut altındaki madde içerikleri dikkate alınarak birinci boyut “Konfor Alanında Kalma”, ikinci boyut ise “Meydan Okuma” şeklinde adlandırılmıştır. …”
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Validez del índice demográfico integral como medidor del desarrollo socioeconómico y el estado de salud by Irlán Amaro Guerra, Nelsa sagaró del Campo, Jacno Erik Ferrer Castro

“…Existió una alta correlación y elevada concordancia entre el índice demográfico integral y el índice de desarrollo humano. …”
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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function by A. J. Theron, H. C. Steel, G. R. Tintinger, C. M. Gravett, R. Anderson, C. Feldman

“…Underlying mechanisms include interference with cyclic nucleotide phosphodiesterases, 5′-lipoxygenase, and the proinflammatory transcription factor, nuclear factor kappa B. These and other secondary anti-inflammatory mechanisms of the commonly used cysLTR1 antagonists are the major focus of the current review, which also includes a comparison of the anti-inflammatory effects of montelukast, pranlukast, and zafirlukast on human neutrophils in vitro, as well as an overview of both the current clinical applications of these agents and potential future applications based on preclinical and early clinical studies.…”
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The Effect of Glycerol Monolaurate on Intestinal Health and Disease Resistance in Cage-Farmed Juvenile Pompano Trachinotus ovatus by Huaxing Lin, Beiping Tan, Qihui Yang

“…., Vibrio, Pseudomonas, and Cetobacterium), downregulating nuclear factor kappa b (nf-κb) and interleukin 8 (il-8), and decreasing harmful bacteria abundances (e.g., Brevinema and Acinetobacter) (P<0.05). …”
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Immunomodulatory effects of fucoidan extracted from Sargassum fusiforme in RAW 264.7 macrophages by Serim Park, Yunjin Choi, Seonmi Ji, Seonghui Kim, Seon Yeong Ji, Yung Hyun Choi, You-Jin Jeon, Bomi Ryu, Jun-Geon Je, Suengmok Cho

“…Sargassum fusiforme, a brown alga, has been traditionally used as an herbal remedy. …”
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A Landscape-Clustering Zoning Strategy to Map Multi-Crops in Fragmented Cropland Regions Using Sentinel-2 and Sentinel-1 Imagery with Feature Selection by Guanru Fang, Chen Wang, Taifeng Dong, Ziming Wang, Cheng Cai, Jiaqi Chen, Mengyu Liu, Huanxue Zhang

“…The results demonstrate that the landscape-clustering zoning strategy achieves an overall accuracy of 93.52% and a kappa coefficient of 92.67%, outperforming the no-zoning method by 2.9% and 3.82%, respectively. …”
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Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. …”
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DC/TMD Examiner Protocol: Longitudinal Evaluation on Interexaminer Reliability by Marit Slåttelid Skeie, Paula Frid, Manal Mustafa, Jörg Aßmus, Annika Rosén

“…The interexaminer agreements in 2013 and 2014 between the “reference” and each examiner were analysed using Bland–Altman plots, intraclass correlation coefficient, Cohen’s kappa, and consistency values. Results. For the majority of the gathered data, no clear change of agreement between 2013 and 2014 could be observed, and only one muscle zone in 2014 could show any clear difference in agreement between the examiners. …”
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tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination by Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu

“…This stabilization activates the toll-like receptor 4/MyD88/nuclear factor kappa B pathway, further driving phenotypic switching and inflammation. …”
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The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes by Anjun Guo, Xueying Li, Lihua Pan, Qiangming Li, Jianping Luo, Xueqiang Zha

“…However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. …”
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Assessment of Groundwater Potential Zones of Upper Blue Nile River Basin Using Multi-Influencing Factors under GIS and RS Environment: A Case Study on Guder Watersheds, Abay Basin,... by Timketa Adula Duguma, Gemechis Adula Duguma

“…The results of this study were also verified by correlation and kappa statistics values of 0.73and 77%, respectively. …”
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Feasibility of an artificial intelligence phone call for postoperative care following cataract surgery in a diverse population: two phase prospective study protocol by Sarah Khavandi, Ernest Lim, Aisling Higham, Nick de Pennington, Amin Hatamnejad, Sohel Somani, Eric S Tam, Hannah H Chiu

“…The primary outcome of agreement between Dora and the supervisor will be assessed using the kappa statistic. Qualitative data from the interviews will further gauge patient opinions about Dora’s usability, appropriateness and level of satisfaction.Ethics and dissemination Research Ethics Board William Osler Health System (ID: 22–0044) has approved this study and will be conducted by guidelines of Declaration of Helsinki. …”
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Multiplex one-step RT‒qPCR assays for simultaneous detection of AMDV, MEV and CDV by Zhi Cao, Hang Xu, Xinru Zhao, Ke Zhang, Dehua Yin, Shuai Ma, Wenling Li, Siyu Li, Jianwei Ren, Jianxin Wen

“…Furthermore, two hundred clinical samples of mink with diarrhoea were simultaneously analysed using multiplex RT‒qPCR and single RT‒qPCR, the Kappa values were all greater than 0.921, indicating that there was a high degree of coincidence between the two detection methods. …”
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The effects of educational status and comorbidity on routine assessment of patient index data 3 and its correlation with disease activity score 28 and clinical disease activity ind... by Kubilay Sahin, Cem Ozisler, Nesibe Karahan Yesil, Fulya Dortbas, Ahmet Omma, Zeynep Ozbalkan Aslar, Yasar Karaaslan

“…Similarly, educational status and the presence of comorbidity did not affect this correlation (P < 0.001). The kappa analysis showing compliance of RAPID3 with DAS28 and CDAI scores was also significant (P < 0.001). …”
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Testing General Relativity Using Large-scale Structure Photometric Redshift Surveys and the Cosmic Microwave Background Lensing Effect by Shang Li, Jun-Qing Xia

“…After obtaining the angular power spectra ${C}_{\ell }^{gg}$ (galaxy–galaxy) and ${C}_{\ell }^{g\kappa }$ (galaxy–CMB lensing) from the combination of DES photometric data and Planck lensing, we derive new measurements of the E _G statistic: E _G  = 0.354 ± 0.146, 0.452 ± 0.092, 0.414 ± 0.069, and 0.296 ± 0.069 (68% confidence limit) across four redshift bins z = 0.30, 0.47, 0.63, and 0.80, respectively, which are consistent with the predictions of the standard Lambda cold dark matter model. …”
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