Influence of urokinase gene-knockout in C57BL/6-PlautmI. IBugThisPlau6FDhu/GFDhu mice on growth factors in malignant melanoma by E. M. Frantsiyants, I. V. Kaplieva, I. V. Neskubina, V. A. Bandovkina, L. K. Trepitaki, E. I. Surikova, N. D. Cheryarina, L. A. Nemashkalova, N. S. Lesovaya

“…Lower levels of FGF‑21 in tumors (males – by 5.3 times, females – by 18.4 times), perifocal tissues (males – by 9.6 times, females – by 8,5 times) and skin (males – by 6.7 times, females – by 3.3 times) in uPA gene-knockout animals could be due to the IGF‑1 growth, as their reciprocal interaction is known. …”
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Probiotics Can Boost the Antitumor Immunity of CD8+T Cells in BALB/c Mice and Patients with Colorectal Carcinoma by Jie Mao, Shu-Ze Zhang, Peng Du, Zhi-Bin Cheng, Huan Hu, Shi-Yao Wang

“…To detect the tumor samples of 122 patients with colorectal carcinoma after surgery, analyze the effect of probiotics on enhancing tumor-infiltrating CD8+T cells to inhibit colorectal carcinoma, and further verify the mechanism of probiotics on enhancing the antitumor immune response of CD8+T cells through animal experiments. Results. The results of immunohistochemistry showed that the proportion of CD8+T cells in the patients treated with probiotics before surgery was increased significantly than that in other patients (P=0.033). …”
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The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Lastly, a co-culture system of RA patient-derived peripheral blood mononuclear cells (RA-PBMCs) and vascular endothelial cells (VECs) was established to mimic the in vivo microenvironment, and the anti-inflammatory and anticoagulant mechanisms of XFC were validated in vitro.ResultsData mining analysis revealed abnormally elevated levels of inflammatory and coagulation markers such as fibrinogen (FBG), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (Hs-CRP), and rheumatoid factor (RF) in RA patients (p < 0.001), and emphasized the close correlation between XFC treatment and the improvement of these markers including Hs-CRP, ESR, and RF (confidence >60% and lift >1). Animal experimental data indicated that XFC effectively reduced the levels of inflammatory and coagulant markers (IL-6, D-D, FBG, PAF, VEGF, and TF) in adjuvant-induced arthritis (AA) rats while enhancing the expression of anti-inflammatory factors (IL-10) (p < 0.05). …”
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A meta-analysis of MHC diversity in Pan troglodytes verus by Christelle Vangenot, Alicia Sanchez‑Mazas

“…We performed a meta-analysis of the Major Histocompatibility Complex (MHC) diversity for locus A, B, C, DQB1, DPB1 and DRB1 in Chimpanzees by selecting cohorts of animals for which MHC genotypes were available in publications and by extracting DNA sequences available on the IPD-MHC database. …”
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ANALISIS DESKRIPTIF BERBASIS MODEL MENTAL FISIKA TERHADAP PEMAHAMAN KOGNITIF MAHASISWA PADA KONSEP KINEMATIKA PARTIKEL DAN GERAK PARABOLA by Nyoman Rohadi, Iwan Setiawan

“…ABSTRAK   Artikel ini menguraikan hasil analisis deskriptif berbasis model mental fisika terhadap pemahaman kognitif mahasiswa semester pertama tahun ajaran 2019/2020 prodi pendidikan fisika JPMIPA FKIP UNIB Universitas Bengkulu pada konsep kinematika partikel dan gerak parabola. …”
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Disponibilidad de biomasa y contenido de proteína cruda de cuatro especies de pasto asociadas con Leucaena leucocephala cultivar Cunninghan en sistema de pasturas en callejones by Álvaro José González Martínez, Erick Alexander Gutiérrez Rosales

“…La disponibilidad de biomasa con alto contenido de proteína es esencial en la nutrición animal, la que puede ser obtenida combinando especies de pasto con leguminosas forrajeras. …”
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Quelques observations sur l’alimentation des bonobos en semi-liberté au sanctuaire « Tasok » de Kinshasa by Paul N ’ Lemvo Budiongo

“…Malgré son endémisme, cette espèce peut survivre dans un milieu autre que son habitat naturel à condition de lui fournir une alimentation de qualité et en quantité suffisante. Il importe d’approfondir des recherches sur les besoins nutritifs réels de cet animal et sur les effets de différents aliments et des compléments alimentaires sur sa santé pour donner de meilleures chances à sa survie en captivité.…”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Samples of dorsal skin from these animals were subjected to hematoxylin and eosin staining or Masson’s trichrome staining. …”
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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…Qing Wang,1,* Yishan Yin,2,* Wei Liu,3,* Lingyu Li,1 Zhen Wang,1 Yue Tian,1 Jing Fan1 1Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China; 2Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People’s Republic of China; 3Department of Emergency Critical Care Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Fan, Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China, Email sddzfanjing@163.comBackground: This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.Methods: We analyzed data from the 2011– 2012 and 2013– 2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). …”
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Effect of Muscle Energy Technique Combined with Conventional Rehabilitation Therapy on Elderly Patients with Knee Osteoarthritis by FAN Jingjing, HUANG Lihua, XU Yiming, LIU Kun, FANG Ping

Subjects: “…knee osteoarthritis…”
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Collagenolytic activity of conjunctival fluid in healthy people and patients with aseptic ulcer of the cornea of various etiologies by Brzheskaya I.V., Somov E.E

“…Group 1 included patients (16) with systemic diseases: with Sjögren, Stevens-Johnson syndromes and rosacea; group 2 — patients (10) after herpetic keratitis; group 3 — patients (5) with a paralytic lagophthalmos after removal of cerebellopontile angle schwannoma.<br> An integral evaluation of the collagenolytic activity of the conjunctival fluid was made by estimating the drying rate of its mixture with collagen gel in a ratio of 1:1, directly dependent on the activity of the proteolytic enzymes contained in it.…”
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Respuesta de una comunidad de pajonal (Amelichloa brachychaeta) al pastoreo frecuente y de altas cargas en la región semiárida central de Argentina by Priscilia Lamela Arteaga, Carla Suárez, Daniel Estelrich

“…En un potrero con bosque de Neltuma caldenia con pajonal, se definieron 4 tratamientos de carga animal para el seguimiento del pajonal durante un año. …”
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Effect of Processed Coffee Husk on Feed Intake, Nutrient Digestibility, Body Weight Changes and Economic Feasibility of Bonga Sheep Fed on Natural Pasture Hay as a Basal Diet by Lidya Marew, Fentahun Meheret, Bimrew Asmare

“…The material can be used for ruminant diets to improve the nutrient utilisation of animals. However, coffee husk has toxic compounds, which can be minimised through different processing methods. …”
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Designing and modeling an intelligent system for managing the distribution and scheduling of farmed fish feed using the Arduino Uno microcontroller by Shayesteh Tabatabaei

“…Funding: This study has received no funding from any organizations.…”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

“…These criteria filtered out most of the commonly used approaches, leaving only two clustering methods, k-means and Gaussian mixture model (GMM), for further analyses. …”
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Integrated microbiome, transcriptome and metabolome insight into the alleviating mechanisms of sheep milk in a DSS-induced colitis mouse model by Wenna Yao, Ruilin Du, Shuo Yan, Teligun Bao, Huimin Zhang, Fang Yang, Yue Xue, Yulong Zhao, Siqin Bao, Xihe Li, Yongli Song

“…ELISA and qPCR analysis showed that relative mRNA expression levels of TNF-α, IL-1β, IL-6, and IL-17 were decreased in SM treatment compared to DSS-induced colitis mice. …”
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Dialing the glenosphere eccentricity posteriorly to optimize range of motion in reverse shoulder arthroplasty by Stefan Bauer, MD, Arnaud Meylan, MD, Jaad Mahlouly, MD, Wei Shao, MD, William G. Blakeney, MBBS, MSc, MS, FRACS

“…A 0° insert, 135° neck shaft angle (NSA), was tested with a 25-mm standard/or +3-mm BP for 3 configurations (30° posterior; neutral; 39 mm; +6 models). …”
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Rock breaking regularity of layered rock mass blasting under the influence of different resistance lines by Jianxin YU, Pengzhan MENG, Xin ZHANG, Zhenzhen LI

“…Resistance line is a key parameter affecting the effect of blasting, this study takes the minimum resistance line as a control index to study the blasting and rock breaking law of layered rock body under the influence of initial stress and joint angle. Taking the Class III surrounding rock as the geological background, the concrete specimens with different nodal parameters were prepared as the simulation material of layered rock body by layered casting method, and a series of blasting experiments under different blasting conditions were carried out, and the test process was monitored by the combination of high-speed camera, dynamic signal analysis system, and intelligent five-segment bursting tachymeter and other equipment; and the damage of layered rock body under the coupling of static geostatic load and dynamic blast load and the law of stress wave propagation were analysed by using the three-dimensional numerical simulation model of LS-DYNA. …”
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THE CHARACTERISTICS OF MIRNA BINDING SITES IN MRNA OF ZFHX3 GENE AND ITS ORTHOLOGS by A. М. Kondybayeva, A. N. Akimniyazova, S. U. Kamenova, A. Т. Ivashchenko

“…In the orthologous proteins of 36 animal species the length of polyGlu varied from 27 Glu to 33 Glu. …”
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TIESA IR TIKRUMAS WITTGENSTEINO FILOSOFIJOJE by Albinas Plėšnys

“… Vitgenšteiniška tiesos ir tikrumo sampratos analizė reikalauja bent paviršutiniškai išmanyti tradicinę tiesos interpretaciją. …”
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