Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…IntroductionRheumatoid arthritis (RA) primarily affects the joints but can also affect multiple organs and profoundly impacts patients’ ability to carry out daily activities, mental health, and life expectancy. …”
Get full text

The authority of the printed word in the Lithuanian village of the XIX century by Džiuljeta Maskoliūnienė

“…They could read only "their own" prayer book, that is, the book they were taught to read (A. …”
Get full text

Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…Our findings reveal significant correlations between the chosen training window size – a factor not commonly examined – and the CNNs' ability to assimilate observations effectively. We also establish a clear link between the CNNs' architecture and complexity and their overall performance.…”
Get full text

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…Methods: In vitro antidiabetic activity was tested with α-amylase enzyme inhibition method and antioxidant activity was evaluated. Furthermore, their ability to quench free radicals was investigated using the 2,2-diphenyl-1-picryhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical scavenging method and the superoxide dismutase (SOD) enzyme scavenging method was investigated. …”
Get full text

Comprehensive evaluation of physico-chemical, antioxidant, and antimicrobial properties in commercial soaps: A study on bar soaps and liquid hand wash by Jannatul Ferdous Nova, Susmita Zaman Smrity, Mahadi Hasan, Md. Tariquzzaman, Md Al Amin Hossain, Md. Tanvirul Islam, Md. Raysul Islam, Selina Akter, Md. Sifat Rahi, Md. Tuhinur R. Joy, Zannatul Kowser

“…Combining all the parameters, SN 3 has good results among bar soaps with mild moisturizing and cleansing properties (MC-8.30 ± 0.035 %, FH-22.33 ± 0.29 cm), is safe for the skin (pH-9.83 ± 0.02, TAC-0.99 ± 0.03), has good TFM values (72.89 %), has proficient bacteria growth-inhibiting properties (ZI-18.67 ± 0.29 mm/100 % conc.) and has the ability to remove free radicals (357.41 ± 2.07 μg/mL). …”
Get full text

Effects of flame retardant tributyl phosphate on early development of zebrafish by Yao LI, Jingying ZHU, Yao LI, Limei CHEN, Pengfei ZHU, Xinliang DING, Weijie ZHOU

“…The exposure time was from 2 hpf to 120 hpf and the hatching rate, malformation rate, heart rate and body length of zebrafish embryos at 72 hpf, the frequency of tail curling at 24-29 hpf, the locomotor ability at 96 hpf and the survival rate at 120 hpf were evaluated, respectively. …”
Get full text

Application of problem-based learning combined with responsibility-based teaching model in the clinical teaching of nursing students (PBL教学法结合责任制教学在实习护生带教中的应用研究)... by REN Huijuan (任慧娟), YUAN Xuemei (袁雪梅), QU Yue (曲悦)

“…Conclusion The combination of PBL teaching and responsibility-based teaching can improve the comprehensive nursing ability of the nursing students during the internship. …”
Get full text

Selection of lactic acid bacteria as a probiotic and evaluated its performance on gnotobiotic catfish Clarias sp. by Enita Romasni Turnip, Widanarni, Widanarni, Anja Meryandini

“…The selected isolate was tested in vivo to observe their ability to improve growth performances of catfish. …”
Get full text

A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…QuestionCan previously reported, largely anecdotal associations between exposure to any of a comprehensive list of putative trigger drugs and the development of pemphigus be reproduced using population level data?…”
Get full text

ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…Subsequently, a series of experimental procedures were performed, including sequential silencing of APJ or Exo70, overexpression of miR-299a-5p, inhibition of ERK1/2 phosphorylation, assessment of BMSCs migration through transwell and scratch assays, detection of F-actin polymerization via immunofluorescence, and evaluation of the expression levels of each factor using qPCR and Western blotting.ResultsIn vitro, the migration ability of ELA-pretreated BMSCs was significantly augmented in the H/R environment. …”
Get full text

Adsorption, in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides by Fangming Zhang, Hui Zheng, Tao Zheng, Pan Xu, Yao Xu, Yuxin Cao, Fan Jia, Yiqiong Zeng, Yubing Fan, Kai He, Xinwen Dai, Fengfei Hou, Yong Yang

“…Compared to WSP, little attention has been paid to ASP and ASP modified product carboxymethyl poria polysaccharide (CMP) which has been used as an antitumor adjuvant drug. In this study, the oil, cholesterol, metal ions and polyphenols adsorption ability, in vitro simulated digestive and the gut microbiota fermentation characteristics of WSP, ASP and CMP were studied to evaluate the functional values of three P. cocos polysaccharides (PCPs). …”
Get full text

Identification and validation of occupational stress factors for employees of the electricity distribution company of Ilam province by Ardeshir Shiri

“…The statistical population in the qualitative section consists of the organization's experts, which was conducted with a targeted sampling of 16 in-depth interviews until reaching theoretical saturation. The statistical population in the quantitative part consists of the managers and employees of the electricity distribution company of Ilam province; using Morgan's table, 212 people were selected as a sample in a simple random way. …”
Get full text

Estimation and evaluation of iron reserves in the eastern area of Eileh1 mine, Razavi Khorasan province by Hamid Esmati Daroneh, Maryam Gholamzadeh

“…This is attributed to Kriging’s ability to account for the spatial structure of the deposit, its unbiased nature, and its lower estimation variance. …”
Get full text

Analysis of the focal relationship of level five leadership with school organizational excellence by Hosein Majooni, Siroos Ghanbari

“…The level five leader is in the highest hierarchy of executive abilities and has all the conditions of the competency pyramid and creates lasting greatness by combining humility and professional will. …”
Get full text

Design and validation of consumer behavior model based on user-generated content in the banking industry by Sepahdar Rahnama, Marzieh ZendehDel, Mir Hadi Moazen Jamshidi

“…In fact, in order for marketing strategies to have the ability to persuade customers to buy a product or service, a correct understanding of consumer behavior must first be created. …”
Get full text

OVERCOMING THE ANTINOMIES OF HUMAN EXISTENCE: ONTOLOGY OF TRICKSTER by T. V. Danylova

“…Two poles, two extreme points are unambiguous; ambiguity “occurs” at an intermediate stage only. Shift from one point to another is impossible directly – for this we need a mediator. …”
Get full text

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease by Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

“…Similar effects were observed with the daily FENM or MEM treatments. Animals infused with 0.1 mg/kg/day FENM showed prevention of Aβ25–35-induced neuroinflammation, oxidative stress and apoptosis. …”
Get full text

Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats by Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge, Bodil Bjørndal

“…PPARγ effects were not only confined to adipose tissue, but specific effects were also seen in liver, heart, and plasma. …”
Get full text

hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…They demonstrate the ability to inhibit protein degradation mediated by UPS and autophagy lysosome pathway, along with the suppression of oxidative stress and inflammatory responses. …”
Get full text

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…For healthy volunteers, only HAMD-17 scale scores, RBANS scale scores, and serum samples were taken at baseline. …”
Get full text