Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner by Dan-dan Xiong, Zhen-dong Chen, Jian-di Li, Yu-long Deng, Rong-quan He, Zhi-guang Huang, San-qi An, Yi-wu Dang, Gang Chen

“…Results In this study, utilizing HCC cell and zebrafish xenograft models, we validated NC’s ability to inhibit the growth, metastasis, and angiogenesis of HCC. …”
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Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading by Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO

“…The results show that: ① low strain rate dynamic loading still has a weakening effect on the strength of mudstone, the ability of mudstone to resist the disturbance of dynamic loading decreases with the increase of water content, dynamic loading rate, and strength, and the strength damage reaches the maximum of 28.47%, 59.76%, and 31.56%, respectively. ② The acoustic emission characteristic parameter law shows that during the loading process, the mudstone has gone through four fracture evolution stages: initial damage, damage intensification, damage quiescence (exacerbation), and damage development, and the Kaiser effect is more obvious at the lower level of each factor in the dynamic loading perturbation stage, and the Felicity effect is more significant at the higher level of each factor. ③ The loading strain and plastic strain of the mudstone under the initial dynamic load disturbance are the largest, and the time of the second significant damage of the mudstone is advanced at higher levels of each factor. …”
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Kombinasi Intent Classification dan Named Entity Recognition pada Data Berbahasa Indonesia dengan Metode Dual Intent and Entity Transformer by Zahra Asma Annisa, Rizal Setya Perdana, Putra Pandu Adikara

“…Atas kebutuhan pelayanan dengan kualitas tinggi ini, perusahaan dapat mengaplikasikan konsep pelayanan prima. …”
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Clinical Efficacy of Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training on Patients with Post Stroke Cognitive Impairment： A Meta-Analysis by LIU Changxing, GUO Xinyi, CHANG Xiang

“…If <italic>P</italic>≥0.10 and <italic>I</italic>²≤50%, a fixed effects model would be used, and if <italic>P</italic>&lt;0.10 and <italic>I</italic>²&gt;50%, a random effects model would be used.ResultsA total of 23 RCTs with 1 788 patients were included, 895 patients in the control group and 893 patients in the experimental group. (1) MoCA scores: subgroup analyses by different treatments in the control group showed that MoCA scores in the experimental group were significantly higher than those in the control group [<italic>MD</italic>=1.78, 95% <italic>CI </italic>(1.18, 2.38), <italic>P</italic>&lt;0.000 1; <italic>MD</italic>=3.30, 95% <italic>CI </italic>(3.01,3.58), <italic>P</italic>&lt;0.000 01]; subgroup analyses by stimulation frequency showed that MoCA scores in the experimental group were significantly higher than those in the control group [<italic>MD</italic>=3.49, 95% <italic>CI</italic> (3.40, 3.57), <italic>P</italic>&lt;0.000 01; <italic>MD</italic>=3.16, 95% <italic>CI</italic> (2.79, 3.53), <italic>P</italic>&lt;0.000 01]. (2) MMSE score: compared with the control group, MMSE score in the experimental group was higher [<italic>MD</italic>=2.14, 95% <italic>CI</italic> (1.14, 3.15), <italic>P</italic>&lt;0.000 1; <italic>MD</italic>=3.16, 95% <italic>CI</italic> (2.71, 3.60), <italic>P</italic>&lt;0.000 01]. (3) ADL score: compared with the control group, ADL score in the experimental group was higher [<italic>MD</italic>=10.78, 95% <italic>CI</italic> (9.18, 12.38), <italic>P</italic>&lt;0.000 01; <italic>MD</italic>=8.23, 95% <italic>CI</italic> (7.04, 9.41), <italic>P</italic>&lt;0.000 01]. (4) RBMT score: compared with the control group, RBMT score in the experimental group was higher [<italic>MD</italic>=2.00, 95% <italic>CI</italic> (1.37, 2.63), <italic>P</italic>&lt;0.000 01].ConclusionrTMS combined with cognitive training can improve cognitive function, intelligence state, behavioral memory ability and activities of daily living of stroke patients, which is recommended for clinical application.…”
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Screening and Identification of Cold-Tolerant Phosphorus and Potassium Solubilizing Bacteria and Their Growth-Promoting Effects on Soybean in Cold Regions by Hao Yan, Tianyi Wang, Haocheng Wang, Nan Sun, Xuebing Wang, Xingbo Zhao, Zhongbao Yao, Hao Tian, Shengjie Chen, Songyan Tang, Chenyang Li

“…In this study, we collected soybean inter-root soil (clay soil) from the cold region of Heilongjiang Province, China, screening for cold-tolerant phosphorus- and potassium-solubilizing bacteria by the gradient-cooling-directed screening and design of mixed bacterial agents. …”
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Microplastic contamination in the gut and gills of commercial marine fish by . Nurhasanah, . Hasrianti, L. Hakim, E. Riani, M.Y. Iswari, M.R. Cordova

“…The advancement has been predominantly influenced by the detection of microplastics, which have the ability to permeate food webs via both direct and indirect pathways. …”
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Effect of different photoperiods on growth indices of female sterlet sturgeon, Acipenser ruthenus by Bahman Meknatkhah, Masoud Sattari, Bahram Falahatkar, Samaneh Poursaeid

“…The condition factor also did not exhibit any significant difference among different treatments throughout the experiment. …”
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A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity by Wen Wang, Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu, Conggang Wang, Jie Pei, Xiaodan Li, Dongting Zhangsun, Dongting Zhangsun

“…Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-Conotoxins, which are peptides derived from the venom of marine cone snails, target different subtypes of nAChRs. Specifically, α-Conotoxins [D1G, ΔQ14] LvIC, identified from Conus lividus, have demonstrated strong activity on α6β4* nAChRs in vitro. …”
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Effect of Floating Needle Perfusion Therapy combined with Joint Mobilization on Shoulder Pain of Hemiplegia after Stroke by Xin WANG, Hu LI, Xiuyan LU

“…Methods: A total of 90 hemiplegia patients with shoulder pain after stroke in the department of rehabilitation medicine of Shandong Provincial Third Hospital from February to December 2019, which were divided into the control group, the floating needle group and the comprehensive group according to the random number table, with 30 cases in each group. The control group only received routine rehabilitation training, including normal limb position, prevention of secondary injury, active or auxiliary functional exercise, low-frequency electrical stimulation, and daily living ability simulation training of upper limb, etc., 25 minutes a time, once a day, five days per week, continuous treatment for four weeks. …”
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Construction and management of echelon talent of Integrated Chinese and Western Medicine nursing in general hospitals (综合性医院中西医结合护理人才梯队建设管理实践)... by TAN Lei (谭蕾), CUI Yuqian (崔玉倩), ZHANG Zhenyu (张振宇)

“…Results After the training, The scientific research ability of nurses had been significantly improved. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…In vivo studies revealed that DSS-Exo enhanced the ability of Exo to improve peritoneal function,such as the peritoneal filtration rate and urea nitrogen, glucose clearance, while reducing peritoneal thickness and protein leakage, and cell morphology, reduce collagen deposition, and decrease the degree of fibrosis. …”
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Correlation between aboveground vegetation composition and soil seed bank of Raudhat desert habitat: a case study of Raudhat Alkhafs, Saudi Arabia by Asma A. Al-Huqail, Hanan F. Al-Harbi, Abdullah M. Alowaifeer, Mohamed A. El-Sheikh, Abdulaziz M. Assaeed, Turki S. Alsaleem, Hazem S. Kassem, Omar M. Azab, Basharat A. Dar, Jahangir A. Malik, Ahmed M. Abd-ElGawad

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Effect of Repetitive Transcranial Magnetic Stimulation on Patients with Post-Stroke Cognitive Impairment by Zheyi YU, Weiming ZHANG

“…ELISA method was used to observe the changes of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), interleukin-6(IL-6) and high-sensitivity C-reactive protein (hs-CRP) in the two groups after treatment.Results:There were no significant differences in the scores of MoCA, including orientation (ORT), visual space and executive function (EF), naming (NAM), memory (MEM), attention (ATT), language (LANG) and abstract ability (ABS) before treatment between the two groups (<italic>P</italic>&gt; 0.05). …”
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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…<b>Conclusions</b>: These findings highlight the potential of using ²²⁵Ac-DOTA-RGD₂ in the treatment of intractable pancreatic cancers, as its ability to induce G2/M cell cycle arrest enhances radiosensitization, resulting in notable growth inhibition.…”
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Pharmacogenomic profiling of variants affecting efficacy and toxicity of anti-infective medicines in a south Asian population from Sri Lanka by Priyanga Ranasinghe, Hajanthy Jeyapragasam, Nirmala Sirisena, D. P. Bhagya Hendalage, Vajira H. W. Dissanayake

“…However, the nature of the study limits the ability to explore clinical correlations with the genotypes, therefore further research focusing on clinical correlation and functional validation is required.…”
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Mutant Prevention Concentrations of Doripenem and Meropenem Alone and in Combination with Colistin (Polymyxin E), Levofloxacin and Tobramycin in Pseudomonas aeruginosa by George G Zhanel, Vibhu Vishisht, Ed Tam, Daryl J Hoban, James A Karlowsky

“…In the present study, the mutant prevention concentration (MPC) of doripenem was examined and compared with meropenem for its ability to prevent resistant mutant selection for P aeruginosa when used alone and in combination with the other antipseudomonal agents colistin (polymyxin E), levofloxacin and tobramycin. …”
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MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction by Teng Ma, Yueqiu Chen, Yihuan Chen, Qingyou Meng, Jiacheng Sun, Lianbo Shao, Yunsheng Yu, Haoyue Huang, Yanqiu Hu, Ziying Yang, Junjie Yang, Zhenya Shen

“…The effects of miR-132 exosomes on the angiogenic ability of endothelial cells were evaluated by tube formation assay. …”
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Designing a Model for Implementing Digital Banking Policy Based on Using Big Data in Iranian Banking Industry by Rahmatollah Gholipour Souteh, Hamed Esmaeili Rad

“…The study involved 15 accessible experts from the banking industry, selected through purposive judgment sampling. Interviews continued until theoretical saturation was reached, ensuring that the data collected was comprehensive and insightful. …”
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A qualitative study on health education knowledge demands of patients after gastric cancer surgery before discharge (胃癌术后患者出院前健康教育知识需求的质性研究)... by LAI Shurong (赖淑蓉), LAI Xiaoning (赖小令), YU Xiaoqing (喻小青), HUANG Xiaoyi (黄小恬)

“…In terms of self-actualization, they were concerned about their ability to return to work or normal life. Conclusion The physiological and safety needs of patients after gastric cancer surgery were prominent, and more than half of the patients had psychological needs (such as the needs for respect and self-actualization). …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…The study then develops a frequency response model of the optical pumping system’s power utilizing the state space method to predict how power fluctuations affect the system output. …”
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