Natural Polymer Derivative-based pH responsive Nanoformulations Entrapped Diketo-tautomers of 5-fluorouracil for Enhanced Cancer Therapy by Anbazhagan Thirumalai, Koyeli Girigoswami, Karthick Harini, Venkatakrishnan Kiran, Pazhani Durgadevi, Agnishwar Girigoswami

“…However, its limited ability to penetrate cell membranes and its short half-life, caused by rapid metabolism, necessitate frequent administration of high doses to maintain effective therapeutic levels. …”
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Türk Sigorta Sektöründe Hayat/Emeklilik Branşında Faaliyet Gösteren Sigorta Şirketlerinin Çok Kriterli Karar Verme Yöntemleri ile Performans Analizi by Murat Akbalık, Mehmet Zafer Taşcı

“…Ayrıca Halk Hayat ve Emeklilik A.Ş. ile Ziraat Hayat ve Emeklilik A.Ş.’nin ele alınan yıllarda performans sıralamasında ilk sıralarda yer aldığı BNP Paribas Cardif Hayat A.Ş.’nin analize dahil edilen tüm yıllarda performans sıralamasında son sıralarda olduğu tespit edilmiştir.…”
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Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by N. B. Rudometova, D. N. Shcherbakov, A. P. Rudometov, A. A. Ilyichev, L. I. Karpenko

“…The classical method of virology, which makes it possible to evaluate the neutralizing activity of the sera of animals immunized with experimental vaccines and the eff icacy of chemotherapy agents is the method of neutralization using viral isolates and infectious molecular clones, i. e. infectious viral particles obtained via cell transfection with a plasmid vector including the full-length HIV-1 genome coding structural, regulatory, and accessory proteins of the virus required for the cultivation of replication-competent viral particles in cell culture. …”
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Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites by Surendra Kumar Patel, Guoxin Dai, Lu Liu, Zhen Sun, Lei Shi

“…The surface composites were successfully fabricated by friction stir processing method with a rotation speed of 800 rpm, travel speed of 80 mm/min and 2.5° tilt angle at multi-passes. The surface properties were characterized via optical, SEM, EDS, XRD and EBSD techniques. …”
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Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021-2024. by Andrew D Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Scott Sherrill-Mix, Carter Merenstein, Ronald G Collman, Roderick B Gagne, Frederic D Bushman

“…SARS-CoV-2 continues to transmit and evolve in humans and animals. White-tailed deer (Odocoileus virginianus) have been previously identified as a zoonotic reservoir for SARS-CoV-2 with high rates of infection and probable spillback into humans. …”
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Navigating the current landscape of ocean observations: an overview from platform infrastructures to networks related to ocean time series by Anabel von Jackowski

“…The marine biome can be observed and monitored using ocean observations with satellite-based platforms, tagging of animals, autonomous platforms and vehicles, and ship-based measurements. …”
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Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1 by Mardi M. Algandaby

“…AM guarded against Pb-induced enhanced the protein expression of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB). …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Extracellular vesicles (EVs) were isolated by ultracentrifugation and characterized. For the animal studies, enucleated BMSCs were labelled with Mitotracker and injected into ethane dimethanesulfone (EDS)-treated rats. …”
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Screening of <em>FecLL</em> prolific allele of the <em>B4GALNT2</em> gene in Algerian sheep populations by Assia Hadjazi, Fatima Zahra Belharfi, Fatima Zohra Mahammi, Stéphane Fabre, Semir Bechir Suheil Gaouar, Nacera Tabet-Aoul

“…Methods: A total of 338 animals from 12 breeds were genotyped using the PCR-RFLP technique. …”
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Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage by Ji Eon Kim, Hyun Su Kim, Wonsik Kim, Eun Hae Lee, Soyeon Kim, Taewoo Kim, Eun-Ae Shin, Kyung-hee Pyo, Haesong Lee, Seo Hee Jin, Jae-Ho Lee, Soo-Min Byeon, Dong Joo Kim, Jinwook Jeong, Jeongwon Lee, Minjae Ohn, Hyojung Lee, Su Jong Yu, Dongyun Shin, Semi Kim, Jun Yeob Yoo, Seung-Chul Lee, Young-Ger Suh, Jung Weon Lee

“…TSI treatments in cell lines and animal models of HCC blocked this binding, intracellular trafficking, and downregulation, resulting in higher levels of stimulatory NK cell ligands. …”
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Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…This phenomenon aligns with the animals' increasing exposure to the chemicals, showing no significant difference in the changes due to dosage across both sexes. …”
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Inhibitory effects of limonin on the proliferation of non-small cell lung cancer cells via targeting S-phase kinase-associated protein 2 by Zhu Jiaxian, Zhang Mengting, Li Shengqing, Liu Yongqiang

“…Then, flow cytometry was used to detect the cell cycle and apoptosis, while colony formation assay assessed the low-density proliferation ability of NSCLC cells. The matrigel 3D pelletization assay was performed to evaluate stem cell properties. …”
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Genome-wide quantification of polycistronic transcription in Leishmania major by Janne Grünebast, Stephan Lorenzen, Joachim Clos

“…We map transcription initiation sites at divergent strand switch regions and head-tail regions within the chromosomes and correlate them with known sites of chromatin modifications. …”
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Proximate, Mineral Contents and Physicochemical Properties of <i>Chrysophyllum Albidum</i> (African Star Apple) Kernel Flour and Oil by S.S. Audu, C.I. Beetseh, D.U. Edward-Ekpu, A.A. Ewuga

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The BLUP method in evaluation of breeding values of Russian spring wheat lines using micro- and macroelements in seeds by N. A. Potapova, A. S. Zlobin, I. N. Leonova, E. A. Salina, Y. A. Tsepilov

“…Genomic selection is a technology that allows for the determination of the genetic value of varieties of agricultural plants and animal breeds, based on information about genotypes and phenotypes. …”
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Dynamic physiology and transcriptomics revealed the alleviation effect of melatonin on Reaumuria trigyna under continuous alkaline salt stress by Xuebo Li, Lei Wang, Heyi Wang, Rui Hao, Lunkai Gao, Hongbo Cui, Hai Wu, Xiaodong Wu, Tong Qiao, Weijie Bai, Liming Zhang

“…The key mechanism identified involves melatonin’s ability to increase antioxidant enzyme activity, reduce reactive oxygen species and hydrogen peroxide levels, and alter gene expression patterns.DiscussionTranscriptomic analysis revealed significant changes in gene expression, particularly in photosynthetic signal transduction, phytohormone signaling, MAPK signaling, and the peroxisome pathway, which are crucial for the plant’s response to alkaline salt stress. …”
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Effect of Allium mongolicum Regel Powder Addition to the Diet and Aging Time on Physicochemical Properties and Antioxidant Capacity of Angus Beef by XIE Yaodi, GAO Huixia, HE Jianjian, SUN Chenxu, YU Aihuan, YAO Haibo, XU Lei, HU Jinsheng, WANG He, DUAN Yueyan, TANG Defu, LEI Zhaomin, LIU Wangjing

“…The control group was fed a basal diet, and the experimental groups, LAMR, MAMR and HAMR, were fed a basal diet supplemented daily with 10, 15 and 20 g of AMRP per animal, respectively. The experimental period lasted for 135 days. …”
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A Survey Study on Management Practices Associated With Voluntary Waiting Period and Its Effects on Reproductive Performance of dairy cows in Iranian Dairy Farms by Behnaz Mirzaie, Ali Sadeghi‐Sefidmazgi, Mahdi Zhandi

“…This model considered animals and herds as random factors and management practices as fixed factors in the analysis. …”
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Statistical analyzes and anomalies of precipitation in cold period in order to understand the effect of climate change on different regions of Iran (1951-2010) by elham yarahmadi, mostafa karampoor, hooshang ghaemi, mohammad moradi, behrouz nasiri

“…Investigating of rainfall behavior in the spatial-temporal dimension and determining the tolerance thresholds of different geographical areas with respect to vegetation, animal life and human activities, is essential for any decision in the environment. …”
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Safety and efficacy of omaveloxolone v/s placebo for the treatment of Friedreich's ataxia in patients aged more than 16 years: a systematic review by Ankita Umrao, Monika Pahuja, Nabendu Sekhar Chatterjee

“…Nrf2 is a regulator of FXN, which is a modulator of oxidative stress in animals and humans. Omaveloxolone (Omav) is an Nrf2 activator and has been reported to have antioxidative potential in various disease conditions. …”
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