MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Mechanistic insights were gained through the analysis of the STAT3/HIF-1α/VEGF signaling pathway, tissue dual-fluorescence localization,chromatin immunoprecipitation sequencing (ChIP-seq), and dual-luciferase reporter (DLR) assays. Additionally, the differential expression of miRNAs between DSS-Exo and Exo was explored and validation of key miRNA. …”
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Effect of Traditional Chinese Medicine nursing under the theory of symptom management on the treatment of chemotherapy-induced nausea and vomiting in patients with gynecological tu... by WEI Xiaolin (魏小林), LIU Dan (刘丹), XU Xuewen (徐雪雯), LIU Hui (刘慧)

“…Results After the intervention, there was a significant difference in the score of delayed nausea between the two groups(F=5. 408, P<0. 05), but there was no significant difference in the score of acute nausea(F=2. 467, P＞0. 05). In addition, here were statistically significant differences in the physical field, psychological field and environmental field of WHOQOL-BREF between the two groups(P<0. 05). …”
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Evaluation of Modified Frailty Index-5 as a Predictor of 60-day Perioperative Morbidity and Mortality in Geriatric Patients Presenting for Orthopaedic Surgery: A Prospective Cohort... by Aparna Ashay Nerurkar, Amreen Fatima

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Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experience... by Xiriaili Kadier, Kai Liu, Aierbanjiang Shali, Yimurang Hamiti, Sulong Wang, Xin Yang, Alimu Keremu, Aihemaitijiang Yusufu

“…Following the completion of distraction, the Ilizarov apparatus or monorail fixator was retained for an additional 2.20 ± 0.53 weeks before being exchanged for the external locking compression plate (ELCP). …”
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Responsabilidades civiles, éticas y legales del profesional de enfermería en Caaguazú, Paraguay by Gloria Sebastiana González Vázquez, Guiomar Viveros de Cabello, Julieta Mendez Romero, Cristian Villagra Gonzalez, Deysi Galeano

“…More than half of nursing professionals under 32 years of age have a poor level of knowledge about criminal responsibilities, which highlights the need to implement continuous training programs in these critical areas, in addition to being legal support in the current journal of his profession. …”
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Screening and identification of vascular endothelial cell targeting peptide in gastric cancer through novel integrated in vitro and in vivo strategy by Yan-ting Zhang, Sheng-hui Wang, Li Zhao, Hui-min Wang, Lin Wang, Rong-rong Shi, Si-chao Liang, Bao-feng Li, Bei Chen

“…After four rounds of iterative screening, a targeting peptide specifically targeting gastric cancer vasculature was obtained. In addition, an in vitro co-culture model by culturing HUVEC in tumor conditioned medium (Co-HUVEC) was established to investigate the affinity of these peptides. …”
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<i>Pleurotus ostreatus</i>: Nutritional Enhancement and Antioxidant Activity Improvement Through Cultivation on Spent Mushroom Substrate and Roots of Leafy Vegetables by Eirini-Maria Melanouri, Ilias Diamantis, Marianna Dedousi, Eleni Dalaka, Paraskevi Antonopoulou, Seraphim Papanikolaou, Ioannis Politis, Georgios Theodorou, Panagiota Diamantopoulou

“…Furthermore, the use of RLV reduced the fat content compared to the control substrate, except in the case of the SMS 50%–RLV 40% substrate, where the highest fat content was observed in the produced mushrooms (4.68% <i>w</i>/<i>w</i>). Additionally, the protein content increased with the use of RLV. …”
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Application of Kansei Engineering in Various Train Compartment Designs to Determine the User's Affective Response by Dinda Karina Yohanny, Lu'Lu' Purwaningrum, Ambar Mulyono

“…Kereta api mendapat permintaan yang tinggi bagi perjalanan jauh, jadi terdapat keperluan untuk pembahagian pasaran. …”
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No increase is detected and modeled for the seasonal cycle amplitude of <i>δ</i>¹³C of atmospheric carbon dioxide by F. Joos, F. Joos, S. Lienert, S. Lienert, S. Zaehle

“…We propose applying seasonally resolved <span class="inline-formula"><i>δ</i>¹³</span>C<span class="inline-formula">_a</span> observations as an additional constraint for land biosphere models and underlying processes for improved projections of the anthropogenic carbon sink.…”
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Effect of filling materials on reclaimed soil potassium adsorption and desorption in mining area by Kexin JING, Zhoubin DONG, Huaizhi BO, Zhiliang WANG, Shaohao HU, Xinju LI, Xiangyu MIN

“…The XRD patterns and FTIR curves of the reclaimed minesoils showed weakened diffraction peaks of illite and characteristic peaks of —OH groups caused by illite. Additionally, the surface of the reclaimed mine soils appeared smoother, and the specific surface area and pore volume were smaller than ZC. …”
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Perbandingan Metode Supervised Machine Learning untuk Prediksi Prevalensi Stunting di Provinsi Jawa Timur by M Syauqi Haris, Ahsanun Naseh Khudori, Wahyu Teja Kusuma

“… Stunting atau kasus balita kerdil/pendek adalah salah satu masalah di bidang kesehatan yang saat ini sedang dihadapi oleh masyarakat Indonesia. …”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…Tumors with elevated αvβ8 expression were particularly responsive to 130H2 treatment. Additionally, favorable pharmacokinetic properties were observed in cynomolgus monkeys. …”
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Estimating and forecasting daily reference crop evapotranspiration in China with temperature-driven deep learning modelsMendeley Data by Jia Zhang, Yimin Ding, Lei Zhu, Yukuai Wan, Mingtang Chai, Pengpeng Ding

“…Specifically, the RMSE values for the ETo forecasts made by GRU model for the 1st, 4th, 7th, and 15th days in the future have decreased from 0.70, 0.87, 1.00 and 1.33 mm d−1 to 0.51, 0.56, 0.61 and 0.67 mm d−1, respectively. Additionally, compared to previous studies, we have successfully extended the lead time of ETo forecasts from 7 days to 15 days. …”
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Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…Furthermore, this study also provided a baseline understanding for future research work in the field of applications of Clitoria ternatea flower extracts for their long-term effects on human health such as a food additive, antioxidant, and cosmetic.…”
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Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability by Ralph Maddison, Rebecca Nourse, Reza Daryabeygikhotbehsara, Teketo Kassaw Tegegne, Paul Jansons, Jonathan Charles Rawstorn, John Atherton, Andrea Driscoll, Brian Oldenburg, Rajesh Vasa, Vassilis Kostakos, Tilman Dingler, Gavin Abbott, Paul Scuffham, Jo-Anne Elizabeth Manski-Nankervis, Dominika Kwasnicka, Finn Kensing, Sheikh Mohammed Shariful Islam, Anthony Maeder, Yuxin Zhang

“… BackgroundHeart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body’s needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. …”
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Dialing the glenosphere eccentricity posteriorly to optimize range of motion in reverse shoulder arthroplasty by Stefan Bauer, MD, Arnaud Meylan, MD, Jaad Mahlouly, MD, Wei Shao, MD, William G. Blakeney, MBBS, MSc, MS, FRACS

“…A 135° stem with a +10° liner (145°) was combined with a 25-mm standard/or +3-mm lateralized baseplate (BP) and a 36-mm +2-mm eccentric glenosphere in 4 ECC positions (50° posterior; 30° posterior; 30° anterior; 50° anterior) from the reference position 0° neutral (10 models). Additionally, a concentric 39-mm glenosphere was tested (+2 models). …”
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Addressing Critical Mistakes in Administering Intravenous Medications at Omdurman Military Hospital, Khartoum, Sudan by Ahmed WAM, Abdelrahman AEHE, Mohamed AA, Mohammed IO, Mustafa AMA, Ahmed ZEE, Mohamed MMT, Alghamdi FAA, Elbashir AEE, Alkubati S, Al-Sowaidi A, Dinar NMAA, Obadi AA, Saleh KA

“…In contrast, five types of administration errors were reported, with the most prevalent being incorrect administration rates (68.7%) and the absence of post-administration side-effect assessments (84.8%). Additionally, 83.3% of nurses did not label the unused portion of a drug intended for the next dose.Conclusion: This study identifies a total of 11 different types of errors in IV drug preparation and administration, some of which are associated with the hospital’s work environment. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…These symptoms included a notable increase in both the number of calcified tissues and osteophytes (p < 0.001), an enlargement of the calcified meniscus and synovial tissue volume (p < 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (p = 0.035). Additionally, we observed elevated histological scores for synovitis (p < 0.001). …”
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Distribution of Vibrio parahaemolyticus in pacific white shrimp Litopenaeus vannamei through immersion as a natural infection model by Sukma Sari Anggraeni, Sukenda, Sri Nuryati, Dinamella Wahjuningrum

“…Infected shrimp exhibited clinical symptoms such as a pale body and hepatopancreas, along with empty gut. Shrimp mortality reached 97.08%, while no mortality occurred in the control grouph. …”
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Patterns and wavelet coherence analysis of tidal dynamics and chlorophyll a concentration by M.N. Hidayat, R. Wafdan, M. Ramli, Z.A. Muchlisin, S. Rizal

“…This study aims to explore the complex relationship between tidal movements and chlorophyll a concentrations in the northern Bay of Bengal, focusing on how tidal rhythms affect chlorophyll a concentrations.METHODS: The analyzed variables include tidal parameters, such as lunar semidiurnal tidal characteristics and Simpson–Hunter parameters, as well as sea level, tidal current, and current magnitude, obtained from the tidal model driver. Additionally, hourly chlorophyll a data for January 2022 were acquired from the geostationary meteorological satellite Himawari-8, and the rate of change of chlorophyll a was determined through chlorophyll a calculations. …”
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