Insights into mungbean defense response to Cercospora leaf spot based on transcriptome analysis by Sukanya Inthaisong, Pakpoom Boonchuen, Tana Jaichopsanthia, Pongpan Songwattana, Apinya Khairum, Witsarut Chueakhunthod, Akkawat Tharapreuksapong, Panlada Tittabutr, Neung Teaumroong, Piyada Alisha Tantasawat

“…Hypersensitive response (HR) started to appear at 2 days after inoculation (DAI) in SUPER5 but was never observed in CN84-1. …”
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Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types by Jeffrey S Ross, Richard S P Huang, Jake G Maule, Lani K Clinton, Ryon P Graf, Jinpeng Xiao, Geoffrey R Oxnard

“…These findings represent an additional factor for clinical teams to consider when deciding which PD-L1 IHC assay (and in turn which CDx-associated PD-L1 based immunotherapy) is most appropriate for each individual patient.…”
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Optimasi Weight AHP Menggunakan Genetic Algorithm untuk Rekomendasi Platform Media Sosial Sebagai Sarana Promosi Digital by Risqy Siwi Pradini, Mochammad Anshori, M. Syauqi Haris

“…The higher the popsize, the greater the potential fitness value generated, however increasing the popsize itself does not guarantee obtaining a better fitness value so you need to think about other factors as well. In addition, the greater the number of generations, the more frequently the evolutionary process will occur. …”
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Gender Analysis, Milk Value Chain, Kabale Uganda. Kabale: Kabale University. by Tugume, Samuel

“…While comparing the challenges faced by the male and female genders, men have better access to education and training than women(4.2 vs. 2.2) women perform a larger share of unpaid or underpaid labour(4.6 vs. 1.7), women face greater challenges in accessing markets and value-addition opportunities. (4.6 vs. 2.1); women likely have less time to dedicate solely to farm activities (4.2 vs. 2.3); men hold more decision-making authority (3.9 vs. 2.7) while both genders might face challenges in accessing these services, but women are still disadvantaged (4.7 vs. 4.5). …”
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Patient-centred care and quality of life and hope among Japanese patients receiving home medical care: a multicentre, cross-sectional study by Nobuhiro Ikeda, Michiko Hinata, Noriaki Kurita, Tomoka Nakamura, Takashi Fujii, Chihiro Tsuchiya, Yukio Tsugihashi, Hidekazu Iida, Shinu Hayashi, Masakazu Yasunaka, Misaki Hirose, Yutaka Shirahige, Shinsuke Muto, Tatsunobu Natsubori, Wataru Nakagawa, Akihiko Yonenaga, Lina Inagaki, Shioto Itakura, Naoya Miyashita, Takuya Furugen, Takafumi Abo, Sadayuki Okudaira, Kazuhiko Takuma, Masahiro Deguchi, Yoshitaka Harada, Seiji Matsuo, Motomichi Nakagawa, Ken Tanigawa, Yoshio Ochi, Sadanobu Ogasawara, Kazuhiko Hoshino, Momoko Aruga, Yoshinori Nakamura, Nobuhiro Sawa, Yosuke Akashi, Nobuyuki Miyagi, Toyohiro Terasaki, Kunihiro Kinoshita, Masaji Kikukawa, Hisakazu Kato, Masayuki Amano, Kentaro Asakura, Naoto Fukui

“…Similarly, a higher JPCAT-SF total score was associated with a higher HR-Hope score (adjusted mean difference per 10-point increase: 4.8, 95% CI 2.9 to 6.7). Additionally, higher scores in individual JPCAT-SF domains were associated with higher HR-Hope scores: first contact (2.7, 95% CI 1.3 to 4.1), longitudinality (2.5, 95% CI 0.8 to 4.2), coordination (1.2, 95% CI 0.2 to 2.3), comprehensiveness (services available: 1.8, 95% CI 0.5 to 3.2; services provided: 1.3, 95% CI 0.4 to 2.3) and community orientation (1.8, 95% CI 0.5 to 3.1).Conclusions Higher quality patient-centred care is positively associated with enhanced QOL and hope among home medical care patients. …”
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Amoeba plate test with Acanthamoeba castellanii as an innovative tool for Nocardia recovery from sputum samples: a proof-of-concept study by Coralie Espinasse, Ghislaine Descours, Marine Ibranosyan, Laetitia Beraud, Christophe Ginevra, Joelle Chastang, Oana Dumitrescu, Frédéric Laurent, Verónica Rodriguez Nava, Sophie Jarraud, Camille Allam

“…In sputa, APT resulted in greater Nocardia growth (63%, 22/35 vs 37%, 13/35; P = 0.008). In addition, the elimination of interfering flora was more frequent using APT (34%, 12/35 vs 11%, 4/35; P = 0.01), and the overall abundance of flora was lower (median [interquartile range, IQR]: 1 [0–2] vs 3 [1-3]; P < 0.0001). …”
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Effect of Chinese herbal tea in the treatment of throat pain and swelling after anterior cervical spine surgery (中药代茶饮治疗颈椎前路术后咽喉部肿痛效果观察) by KANG Jingjing (康京京), DU Jian (杜渐), ZHANG Zhe (张喆), LI Huibin (李会斌), DU Li (杜丽), SUN Feifei (孙飞飞)

“…Both the groups received routine treatment and nursing after surgery, and the observation group was given additional treatment of Chinese herbal tea. The degree of throat pain and swelling was evaluated at 24 h, 3 days and 7 days after surgery. …”
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Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing by Fuling Mao, Zixuan Hu, Ruifeng Shi, Hongbing Zhang, Zihe Zhang, Yongwen Li, Xuanguang Li, Penghu Gao, Jinhui Li, Minghui Liu, Hongyu Liu, Jun Chen

“…Intriguingly, a protective microbial cluster was identified encompassing nine genera associated with delayed disease recurrence, with functional analyses suggested that these microbiota predominantly exerted metabolism‐related functions. Additionally, a harmful microbial cluster (HMC) was identified, including three genera. …”
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A machine learning model to predict neurological deterioration after mild traumatic brain injury in older adults by Daisu Abe, Motoki Inaji, Takeshi Hase, Eiichi Suehiro, Naoto Shiomi, Hiroshi Yatsushige, Shin Hirota, Shu Hasegawa, Hiroshi Karibe, Akihiro Miyata, Kenya Kawakita, Kohei Haji, Hideo Aihara, Shoji Yokobori, Takeshi Maeda, Takahiro Onuki, Kotaro Oshio, Nobukazu Komoribayashi, Michiyasu Suzuki, Taketoshi Maehara

“…Among several machine learning algorithms, eXtreme Gradient Boosting (XGBoost) demonstrated the highest predictive accuracy in cross-validation, with an AUROC of 0.81 (±0.07) and an AUPRC of 0.33 (±0.08). Through SHapley Additive exPlanations (SHAP) analysis, five important features (D-dimer, fibrinogen, acute subdural hematoma thickness, cerebral contusion size, and systolic blood pressure) were identified and used to construct a better performing model (cross-validation AUROC of 0.84 and AUPRC of 0.34; testing data AUROC of 0.77 and AUPRC of 0.19). …”
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miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken by Qingqing Geng, Cai Hu, Ziduo Zhao, Zhe Wang, Fufu Cheng, Jing Chen, Qisheng Zuo, Yani Zhang

“…We found that overexpression of TBX6 promoted SSCs formation. Additionally, we identified Vitamin B6, a key metabolite affecting SSCs formation, as an upstream regulator of miR-1458 expression. …”
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Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer by Riqing Huang, Anqi Hu, Qixiang Rong, Ditian Shu, Meiting Chen, Wei Yang, Yue Zhang, Qiufan Zheng, Xin An, Cong Xue, Haifeng Li, Yanxia Shi

“…Patients with amplifications in cell cycle-related genes showed inferior median progression-free survival (PFS) than those without amplifications (2.07 months vs. 8.40 months; HR = 5.24; 95% CI 2.11–13.01; p < 0.001), particularly in HER2-low patients (2.07 months vs. 8.27 months; HR = 4.23; 95% CI 1.50–11.91; p = 0.004). Additionally, ERBB2/CDK12 co-amplification exhibited a superior median PFS in all patients (19.33 months vs. 5.43 months; HR = 0.13; 95% CI 0.04–0.45; p < 0.001) and in HER2-positive patients (19.33 months vs. 6.87 months; HR = 0.18; 95% CI 0.05–0.72; p = 0.007). …”
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Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity by Hongqiang Zhang, Zhixin Tu, Sihua Liu, Jumei Wang, Jie Shi, Xingyu Li, Rongdongqing Shi, Minghui Chen, Tong Yue, Sihui Luo, Yu Ding, Xueying Zheng

“…We employed restricted cubic splines to examine non-linear associations, and Cox models were developed on either side of the inflection point for additional investigation. Meanwhile, the predictive values of five IR surrogates were further assessed. …”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

“…While GuanCEST and amineCEST are highly sensitive for delineating stroke lesions, amideCEST is more suitable for precise pH mapping as it is not influenced by metabolite changes within the stroke lesion. Additionally, at low B1 values, amideCEST and GuanCEST can be used to map protein and creatine concentrations separately, since they are independent of pH changes at these lower B1 values. …”
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Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…The best model would be selected with the predictive performance and interpreted with Shapley Additive exPlanations method. The study is registered in Clinical Trial (ChiCTR2400085338). …”
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Effectiveness of mDiabetes intervention in enhancing diabetes awareness and promoting healthy lifestyle changes among the general population in rural India by Padmaja Kumari Rani, Padmaja Kumari Rani, Padmaja Kumari Rani, Jachin David Williams, Nidhi Jaswal, Venkateswaralu Yandluri, Payal Sangani, Kavya Sanagavarapu, Ramya Natarajan, Sandhya Ramalingam, Nalini Saligram, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna

“…Under this program, 56 diabetes prevention messages (twice a week) in local language) were disseminated among the participants via voice calls for a period of 6 months. Additionally, community health education meetings were facilitated by trained community health workers and educational leaflets were distributed among the community members. …”
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Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study by Shiming He, Shiming He, Shiming He, Chao Wang, Chao Wang, Chao Wang, Xin Huang, Xin Huang, Xin Huang, Guoan Jian, Guoan Jian, Guoan Jian, Zihao Lu, Zihao Lu, Zihao Lu, Kun Jiang, Kun Jiang, Kun Jiang, Guobo Xie, Guotai Sheng, Yang Zou

“…Multivariable Cox regression was employed to explore the relationships between eGDR and mortality rates under varying glycemic states. Additionally, Kaplan-Meier curves were used to compare the cumulative incidence of cardiovascular and all-cause mortality across different metabolic statuses. …”
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Clinical and analytical monitoring of patients with multiple sclerosis on anti-CD20 therapeutics: a real-world safety profile study by André Aires Fernandes, André Aires Fernandes, Ana Lídia Neves, Ana Lídia Neves, Daniela Ferro, Daniela Ferro, Mafalda Seabra, Mafalda Seabra, Teresa Mendonça, Ricardo Soares dos Reis, Ricardo Soares dos Reis, Maria José Sá, Joana Guimarães, Joana Guimarães, Pedro Abreu, Pedro Abreu

“…A positive correlation was found between serious infectious complications and lower IgG levels. Additionally, longer exposure to anti-CD20 therapy in our cohort was associated with an increased risk of IgG deficiency and a higher incidence of serious infections. …”
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Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs by Ziyi Kang, Jie Kong, Qi Li, Juan Sui, Ping Dai, Kun Luo, Xianhong Meng, Baolong Chen, Jiawang Cao, Jian Tan, Qiang Fu, Qun Xing, Sheng Luan

“…Stochastic simulation was employed to evaluate genetic gain and G × E trends in BS for improving the body weight of L. vannamei, considering selective genotyping strategies for test group (TG) at a commercial farm environment (CE), the number individuals of the selection group (SG) genotyped at nucleus breeding center (NE), and varying levels of G × E. …”
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Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry by Jae Myeong Kang, Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, Sarah Tomaszewski Farias, Michael W. Weiner, Rachel L. Nosheny

“…Those who were Self-ECog total (Odds ratio [95% confidence interval] = 1.390 [1.121–1.708]) and SP-ECog consistent (2.417 [1.591–3.655]) had higher probability of being decliners based on PAL FAMS. …”
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Development characteristics and river blocking outburst analysis of Shadong landslide in the upper reaches of Jinsha River by Shunxiang ZHENG, Jun WANG, Yong YAN, Wen LIU, Heng ZHAO, Junxiang YANG, Xiongan FAN, Yi ZHANG, Meng WANG, Tianbin YU

“…Given the high risk of river blockage and the catastrophic potential of the Shadong landslide, continuous monitoring through integrated sky, air, ground, and interior methods is recommended. Additionally, further study is needed to establish early warning thresholds and accurately manage the risk of major geological disasters.…”
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