Non-small Cell Lung Cancer Cell Line PC-9 Drug-resistant Mutant Cell Line 
Establishment and Validation of Their Sensitivity to EGFR Inhibitors by Tao HU, Yang LOU, Mingbo SU

“…This model, with the EGFRD19/T790M/C797S mutant, was used to investigate the inhibitory effects of EGFR-TKIs on cell proliferation through MTS assay. Additionally, Western blot analysis was conducted to assess the regulation of EGFR protein expression and the phosphorylation levels of downstream signaling molecules, including protein kinase B (AKT) and mitogen-activated protein kinase (MAPK). …”
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Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against Mycobacterium abscessus by Jifang Zheng, Qiang Liu, Haoran Wang, Fengmin Huo, Junnan Jia, Hairong Huang, Suting Chen

“…When CCCP is paired with bedaquiline and clofazimine, it exhibits additive effects. Moreover, high levels of CCCP in combination with other antibiotics were found to rapidly eradicate the bacteria. …”
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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Conclusions Our findings demonstrate that NPT100-18A limits neuronal degeneration in a human in vitro model of PD. In addition, we provide first mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might contribute to the neuroprotective effects of NPT100-18A.…”
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Sensory and Lipid Profile Optimization of Functional Brownies Through Cold-Pressed Nut Oil Substitution for Butter by Elena Martínez, José Emilio Pardo, Manuel Álvarez-Ortí, M. Esther Martínez-Navarro, Adrián Rabadán

“…Linoleic acid (polyunsaturated fatty acid) also increased in all reformulated brownies, with the highest levels found in the walnut oil-based brownies. Additionally, the levels of Vitamin E were higher in the 100% nut oil substitutions, offering potential health benefits. …”
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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…In subgroup analyses, the levels showed a linear relationship with the likelihood of experiencing END and poor prognosis at the 90-day mark after ICH. Additionally, the levels were independently associated with END, ordinal mRS scores, and poor prognosis. …”
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Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity by Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…We validated its performance of deconvolution of tumor regions in an independent cohort. In addition, we showed the significant association of MeHEG-based epigenetic heterogeneity with the genomic heterogeneity in mutation and copy number variation in our in-house and TCGA cohorts. …”
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Meta-analysis on the chronic effects of exercise on depression in older adults by Melanie Mack, Claudia Voelcker-Rehage, Pinelopi S. Stavrinou, Iuliia Pavlova, Yaël Netz, Burcu Kömürcü Akik, Antonia Kaltsatou, Sandra Haider, Christoforos D. Giannaki, Arzu Erden, Andreea Badache, Michel Audiffren

“…Regarding exercise characteristics, effects were particularly strong for interventions that included exergames, had a long duration, and involved high cognitive demand. Additionally, effects increased with advancing age and higher baseline depression severity. …”
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Estimation of livestock greenhouse gas for impact mitigation by D.S.I. Sondakh, F.R. Tulungen, J.K. Kampilong, F.S.J. Rumondor, Y.S. Kawuwung, E.P. Sanggelorang

“…In Kawangkoan District, the greenhouse gas emissions were dominated by methane from enteric fermentation and manure management, which accounted for 15.23 and 20.05 percent (5.63 and 1.43 gigagrams of carbon dioxide equivalent). In addition, the total emission accounted for 11.33 percent at 7.11 gigagrams of carbon dioxide equivalent.CONCLUSION: The study produced an estimate of greenhouse gases from the livestock sector in the Minahasa Regency. …”
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HistoNeXt: dual-mechanism feature pyramid network for cell nuclear segmentation and classification by Junxiao Chen, Ruixue Wang, Wei Dong, Hua He, Shiyong Wang

“…The performance in nuclear segmentation was evaluated using the Dice Similarity Coefficient (DICE), the Aggregated Jaccard Index (AJI) and Panoptic Quality (PQ), and the classification performance was evaluated using F1 scores and category-specific F1 scores. In addition, computational complexity, measured in Giga Floating Point Operations Per Second (GFLOPS), was used as an indicator of resource consumption. …”
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Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies by Di Zhang, Miaoyu Ye, Yao Xu, Luyu Jiang, Yanmei Hu, Qi Zhang, Xiao Han, Qian Dai, Junhui Qian, Jian Luo, Qiang Yuan

“…AMSTAR-2, ROBIS, PRISMA 2020, and GRADE tools were used to evaluate the methodological quality, bias risk, reporting quality, and evidence strength of all SR/MA. Additionally, we applied the corrected covered area (CCA) method to measure overlap in randomized controlled trials (RCTs) cited among the SR/MA.Results3 SRs and 6 MAs were included in the analysis: 3 studies were low quality by AMSTAR-2, and 6 studies were very low quality. …”
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Exploraciones personales sobre las condiciones precedentes de la violencia sexual en el marco del conflicto armado enColombia by Paula Natalia Rincón Chitiva, Juan Felipe Monroy Simbaqueba

“…It became evident that in the armed conflict, sexual violence is possible because it is based on gender inequalities already present in the relationships and the communities, which result in a high social tolerance for it. Additionally, sexual violence is supported by masculinities and femininities that have normalized power relationships in which men dominate and demonstrate their violent actions, and women are taken as available bodies with limited abilities, whose ways of being respond to impositions of a patriarchal culture. …”
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Alternative psychopharmacologic treatments for pediatric catatonia: a retrospective analysis by Joshua R. Smith, Joshua R. Smith, Isaac Baldwin, Tasia York, Carina Anderson, Trey McGonigle, Simon Vandekar, Lee Wachtel, James Luccarelli, James Luccarelli

“…All patients were stabilized on either clonazepam or diazepam, with 21 (68%) requiring treatment with an additional medication of either an anti-epileptic, N-methyl-D-aspartate (NMDA) receptor antagonist, and aripiprazole or clozapine. …”
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A visual walkthrough of robotic partial mesorectal excision using the Versius surgical system by Amro Mureb

“…A recent systematic review on distal mesorectal spread and PME showed that for partial mesorectal excision, substantial overtreatment is present if a distal margin of more than 5 cm is routinely utilized; in addition, PME has good oncological results and leads to the best-fitted functional results possible for the patient's condition.1,2 Regarding the morbidity and oncological outcomes after PME, Kanso et al. showed that PME can be performed safely, with a low risk of definitive stoma and local recurrence and the survival rate that was observed, indicates that the prognosis is not altered compared with TME in the treatment of upper and some middle rectal tumour.3 Another study evaluating the oncological outcomes of PME in patients with upper and middle rectal cancer showed that PME and shorter resection margins do not jeopardize the oncological outcomes.4 Robotic colorectal surgery has gained popularity in the last few years as it overcomes most of the limitations of conventional laparoscopic surgery, especially when working in a confined, narrow pelvis. …”
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Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…The review highlighted the widespread prevalence of ESBL genes, particularly blaTEM and blaCTX-M-15, and the emergence of carbapenemase genes such as blaOXA-48 and blaNDM-1 and blaKPC-2. Additionally, colistin resistance through the mcr-1 gene and mgrB mutations was reported in Saudi Arabia and the UAE, posing a significant public health challenge.ConclusionData from GHC countries shows significant gaps, particularly in community and environmental and molecular epidemiology studies. …”
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Influence of diet nutrient density and a multicarbohydrase containing α-galactosidase on performance, carcass characteristics, breast myopathies, and nutrient utilization of broile... by J.P. Gulizia, J.I. Vargas, S.M. Bonilla, J.R. Hernandez, L.M. Almeida, P. Soster, S. Thuekeaw, B. Hutson, S. Llamas-Moya, T. Duong, W.J. Pacheco

“…The third diet, RE90AA, contained RE with 90% AA density. Additional treatments were prepared by supplementing 0.2 g CAG per kg feed to the basal diets. …”
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Clinical Study of Repetitive Transcranial Magnetic Stimulation Combined with Social Rehabilitation Training on Children with Attention Deficit Hyperactivity Disorder by JING Xinli, ZHU Min, NIU Yujia

“…The observation group received rTMS combined with the program for the education and enrichment of relational skills (PEERS) social rehabilitation training in addition to the routine medication, including 15 minutes rTMS treatment a time, twice a week for 12 weeks. …”
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A unique Helicobacter pylori strain to study gastric cancer development by Jeannette M. Whitmire, Ian H. Windham, Morris O. Makobongo, Mandy D. Westland, Sirena C. Tran, Jaume Piñol, Yvonne Hui, Rasha Raheem Alkarkoushi, Oscar Q. Pich, David J. McGee, M. Blanca Piazuelo, Angela Melton-Celsa, Traci L. Testerman, Timothy L. Cover, D. Scott Merrell

“…The ΔcagA USU101 strain colonized gerbils at levels similar to WT, but did not induce comparable levels of inflammation or disease. …”
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Synthesis of novel titania nanoparticles using corn silky hair fibres and their role in developing a smart restorative material in dentistry by Afsheen Mansoor, Emaan Mansoor, Ezza Mansoor, Efrah Mansoor, Atta Ullah Shah, Uzma Asjid, João Filipe Brochado Martins, Sami Ullah Khan, Paulo J. Palma

“…Conclusion: This study developed eco-friendly and sustainable titanium dioxide nanoparticles from silky corn hair fibres. The addition of titania nanoparticles to conventional glass-ionomer cement resuledt in increased enamel shear bond strength and altered surface texture with higher titanium and fluorine content, making it a promising smart restorative material for dentistry. …”
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Intelligent fault diagnosis method for rolling bearings based on flexible residual neural network by Chuang CHEN, Xianfeng LI, Jiantao SHI, Dongdong YUE

“…Signals obtained from industrial applications often contain unavoidable noise, complicating analysis. Additionally, the intricate working conditions in actual operations can greatly influence bearing signal characteristics. …”
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PhantomAR: gamified mixed reality system for alleviating phantom limb pain in upper limb amputees—design, implementation, and clinical usability evaluation by Cosima Prahm, Korbinian Eckstein, Michael Bressler, Zhixing Wang, Xiaotong Li, Takashige Suzuki, Adrien Daigeler, Jonas Kolbenschlag, Hideaki Kuzuoka

“…The study enrolled 10 able-bodied individuals and 8 individuals with unilateral, transradial amputation. …”
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