Understanding barriers and facilitators to implementation of a patient safety bundle for pregnancy-related severe hypertension in 3 North Carolina outpatient clinics: a qualitative... by Aparna G. Kachoria, Hiba Fatima, Alexandra F. Lightfoot, Linda Tawfik, Joan Healy, Asia Carter, Narges Farahi, E. Nicole Teal, Joumana K. Haidar, Herbert B. Peterson, M. Kathryn Menard

“…The interview guide was created using the Consolidated Framework for Implementation Research domains to identify facilitators and barriers to implementation. Additionally, three focus group discussions with patient participants were conducted to understand lived experiences and perceptions of respectful care. …”
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Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers by Xiufen Zheng, Zikai Chen, Miao Liang, Liting Zhou, Miaoru Wang, Silin Zhang, Shuyun Zhang, Lei Ma, Wei Yi, Xiawen Liu

“…In a PCOS mouse model, we assessed the effects of (R)-NAF and (S)-NAF on serum androgen levels, menstrual cycles, ovarian morphology, and UGT2Bs expression. Additionally, luciferase reporter and ChIP assays were utilized to study UGT2B15 regulation by NR1H4. …”
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Selective expression and significance of ACKR2 in lung aerocytes by Alberto Mantovani, Gianluigi Condorelli, Raffaella Bonecchi, Massimo Locati, Marina Sironi, Roberta Carriero, Francesca Albano, Valeria Mollica Poeta, Lucia Zotti, Alessandra Castagna, Arianna Felicetta, Alessandro Mesaglio, Elisa Zaghen, Arianna Capucetti, Rachele Di Donato, Mattia Laffranchi, Matteo Massara, Silvano Sozzani

“…This protection was associated with an increased presence of activated T lymphocytes infiltrating the lungs compared with WT mice. Additionally, in a model of acute lung injury, mice with selective deletion from the endothelial compartment exhibited heightened extravasation of T lymphocytes compared with both ACKR2 KO and WT mice.Conclusions These results indicate that ACKR2 is selectively expressed by lung vascular capillaries (aerocytes) that are devoted to the regulation of leukocyte extravasation. …”
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Balancing environmental impact: A sustainability index analysis of sorghum production for food and feed by A. Prabowo, R.N. Hayati, S. Minarsih, B. Haryanto, D.D. Ludfiani, A. Supriyo, S. Subiharta, E. Nurwahyuni, Y. Hindarwati, M.N. Setiapermas, S. Sudarto, S. Samijan, B. Utomo, E. Winarn, N.D. Suretno, W. Wibawa, S. Agustini, A. Prasetyo, F.R.P. Hantoro, W. Hariyanto, V.E. Aristya

“…The average productivity at the study site was 6-7 tons per hectare, with a production potency of 300-350 tons per year. Additionally, the potency of sorghum stover production was 471.8 ton per year of dry matter and could be used as feed for 163 animal units per year…”
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Optimizing hip MRI: enhancing image quality and elevating inter-observer consistency using deep learning-powered reconstruction by Yimeng Kang, Wenjing Li, Qingqing Lv, Qiuying Tao, Jieping Sun, Jinghan Dang, Xiaoyu Niu, Zijun Liu, Shujian Li, Zanxia Zhang, Kaiyu Wang, Baohong Wen, Jingliang Cheng, Yong Zhang, Weijian Wang

“…To gauge interobserver agreement for the assessed pathologies across image sets, we employed weighted kappa statistics. Additionally, the Wilcoxon signed rank test was employed to compare image quality and quantitative rSNR and rCNR measurements. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

“…Methods: The antibacterial and anti-biofilm activity of the juglone derivatives were investigated against laboratory strains MRSA using well and disc diffusion method. In addition, we evaluated the anti-biofilm inhibition potential of the juglone derivatives using a crystal violet-based assay in 96-well micro-titer plate. …”
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Associations of arthritis with functional disability and depressive symptoms in general US adults: NHANES 1988–1994 and 1999–2018 by Xiaoting Liu, Yunzhen Huang, Jinjing Fu, Mayila Mohedaner, Danzengzhuoga, Gan Yang, Zhenqing Yang, Xueqin Li, Xinye Ma, Qiqi Zhang, Zuyun Liu, Xifeng Wu, Zhimin Ying

“…Abstract Objectives This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X‐ray examination) and functional disability. …”
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The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China by Xiaorui Wang, Bo Zhu, Hanping Li, Jingwan Han, Xiaolin Wang, Lei Jia, Bohan Zhang, Jingyun Li, Linding Wang, Yongjian Liu, Hongling Wen, Lin Li

“…We also performed a distance-based molecular network analysis to identify potential relationships among different HIV-positive individuals. In addition, spatiotemporal evolutionary dynamics analysis of the candidate CRF80_0107 sequences was performed via a Bayesian approach. …”
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Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…The novel finding of type I interferon (IFN‐I) pathway activation suggests a regulatory mechanism that may drive this expansion and enhance antibody secretion. Additionally, activation of Toll‐like receptor 2 (TLR2) in myeloid cells was noted, which may connect to tumor necrosis factor‐alpha (TNF‐α) secretion. …”
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Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains by Peter Andrew Meaney, Christine Lynn Joyce, Ambrose Agweyu, Joseph R Mwanga, Marc Berg, Adolfine Hokororo, Hanston Ndosi, Alex Dahlen, Theopista Jacob, Florence Salvatory Kalabamu, Rishi Mediratta, Boris Rozenfeld, Zachary Haines Smith, Neema Chami, Namala Mkopi, Castory Mwanga, Enock Diocles

“…To assess implementation success, we used the Reach, Efficacy, Adoption, Implementation and Maintenance framework and to describe baseline provider knowledge and metacognition we used Howell’s conscious-competence model. Additionally, we explored provider characteristics associated with initial learning completion or persistent activity.Results aESNC reached 85% (195/231) of providers: 75 medical, 53 nursing and 21 clinical officers; 110 (56%) were at the zonal hospital and 85 (44%) at health centres. …”
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Impaired hemodynamic forces assessed by routine CMR and its determinants in different duration T2DM patients with normal LV function and myocardial strain by Guozhu Shao, Guozhu Shao, Guozhu Shao, Yukun Cao, Yukun Cao, Yukun Cao, Yue Cui, Yue Cui, Yue Cui, Hongyan Li, Heshui Shi, Heshui Shi, Heshui Shi

“…Both HDF Strength (RMS) L-S (%) and HDF Strength (RMS) A-B (%) value were independently related to the extent of LGE (β = 0.435, p = 0.001; β = −0.329, p = 0.006, respectively). In addition, HDF Strength (RMS) L-S (%) was also independently correlated with insulin treatment(β = 0.291, p = 0.013).ConclusionsHDF analysis can provide valuable insights into subclinical myocardial dysfunction prior to changes in ejection fraction and myocardial strain, suggesting that HDF analysis may be a potential early marker of subclinical myocardial dysfunction. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…The mean EoE endoscopic reference scoring system scores changed from a baseline of 6.9 (before dupilumab) to 0.3 (after dupilumab). In addition to the improvement in EoE, the use of corticosteroids in EoE and inhaled corticosteroids in asthma was decreased for all patients, suggesting that dupilumab may be effective in patients with multiple concurrent atopic conditions. …”
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Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis by Lin Wang, Xiao-Fei Zhang, Xue Zhang, Dong-Yan Guo, Yu-Wei Duan, Zhi-Chao Wang, Li-Shan Pei, Han Ru, Jiang-Xue Cheng, Ya-Jun Shi, Jun-Bo Zou

“…Compared with Western medicine, the total effective rate (TER) of OA treatment in TCM was significantly increased and the recurrence rate (RR) was significantly decreased (P<0.00001). In addition, the experimental group was also superior to the control group in terms of the indicators of joint activity function, inflammatory factor content, and various indicators affecting bone metabolism. …”
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Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…Moreover, significant increases in intra- and inter-network RSFC were observed, particularly within the visual, default mode, dorsal attention, frontoparietal (FPN), and somatosensory (SMN) networks. Additionally, there were significant correlations between the SOT and inter-network FC [between FPN and SMN, r(9) = –0.784, p = 0.012] and between the DGI and intra-network FC [within SMN, r(9) = 0.728, p = 0.026].DiscussionThese findings suggest that TLNS intervention is an effective in increasing somatosensory processing, vestibular-visual interaction, executive control and flexible shifting, and TLNS may be an effective approach to inducing brain network plasticity and may serve as a potential therapy for mmTBI-related gait and balance deficits.…”
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Cognitive impairment at older ages among 8000 men and women living in Mexico City: a cross-sectional analyses of a prospective study by Carlos González-Carballo, Pablo Kuri-Morales, Erwin Chiquete, Mario Rojas-Russell, Rogelio Santacruz-Benitez, Raúl Ramirez-Reyes, Adrián Garcilazo-Ávila, Jaime Berumen, Eirini Trichia, Louisa Gnatiuc Friedrichs, Paulina Orellana, Carolina Ochoa-Rosales, Gary O’Donovan, Jonathan R Emberson, Roberto Tapia-Conyer, Diego Aguilar-Ramirez, Jesus Alegre-Díaz

“…In 2015–2019 about 10,000 survivors were resurveyed with identical information from the original survey and additional assessments including a cognitive assessment. …”
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Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation by Jingju Yin, Jingju Yin, Jingju Yin, Jingju Yin, Yunyang Liao, Yunyang Liao, Yunyang Liao, Yunyang Liao, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Bangwei Che, Hanghang Zhu, Hanghang Zhu, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bin Shi, Bin Shi

“…Notably, the NT40 group exhibited the lowest T-bet expression (P&lt;0.05) along with the highest levels of Rorγt, Gata3, and Foxp3(P&lt;0.05), followed by the NT15 group. Additionally, the NT40 group demonstrated reduced RANKL, TNF-α, and IL-6 (P&lt;0.05) and increased OPG and IL-10 (P&lt;0.05). …”
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Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…However, weaker correlations in Lahore suggest the presence of additional factors influencing SUHII. A distinct spatial relationship between increased vegetation and cooler areas was observed. …”
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Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense by Mohamed Taieb Bouteraa, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Mohammad Y. Alfaifi, Anis Ben Hsouna, Miroslava Kačániová, Stefania Garzoli, Rania Ben Saad

“…Transgenic <i>Arabidopsis</i> lines overexpressing <i>TdGASA1</i> obtained in this study showed higher tolerance to detrimental effects of H₂O₂, MeJA, and ABA treatment. In addition, these lines exhibited resistance to <i>Fusarium graminearum</i> and <i>Aspergillus niger</i>, which was linked to a marked increase in antioxidant activity in the leaves under stress conditions. …”
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Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis by Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin

“…Furthermore, DMD patients are at risk of developing malignant hyperpyrexia with general/inhaled anesthesia, and dantrolene is often used for effective rescue. In addition, general anesthesia and central neuraxial blockade in patients with severe DMD are unsafe because respiratory depression and myocardial complications may occur after the administration of volatile anesthetics and depolarizing muscle relaxants (succinylcholine) during the induction of anesthesia.ConclusionsPatients with DMD are more sensitive to NMBAs with delayed onset times and prolonged recovery times. …”
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Metabolic profiling of Perilla leaves of different colors: insights into metabolite variation and bioactive compound distribution by Senouwa Segla Koffi Dossou, Qianchun Deng, Feng Li, Lei Wang, Nanjun Jiang, Habtamu Kefale, Rong Zhou, Donghua Li, Meilian Tan, Linhai Wang

“…All DAMs, including four potential metabolic discriminative biomarkers, were screened out. In addition, we revealed the accumulation patterns of bioactive compounds in the leaves of different colors. …”
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