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66781
Penggunaan Internet Dikalangan Siswa SD di Kota Ternate: Suatu Survey, Penerapan Algoritma Clustering dan Validasi DBI
Published 2020-12-01“…Hasil dari penelitian ini dari 933 responden diperoleh 51,45 % siswa SD di kota Ternate aktif di jejaring sosial dengan 53,70% di whatsapp, 40,30% di instagram dan 27,80% di facebook. …”
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66782
Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC
Published 2025-01-01“…The overall percentage of activated MCs in ccRCC tissues did not change significantly but shifted toward a more activated subpopulation (VEGFA+ MCs), with a concomitant decrease in proliferative MCs (TNF+ MCs) and resting MCs. …”
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66783
Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study
Published 2025-01-01“…In both subgroups of mouthwash users, sVCAM-1 was positively correlated with serum nitrate and salivary nitrate. In addition, sVCAM-1 was positively correlated with serum nitrite in participants who used mouthwash frequently (ρ_S = 0.18, p = 0.045).DiscussionRegular use of OTC mouthwash was associated with systemic nitric oxide. …”
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66784
Designing a Conceptual model for Evaluating the Performance of Software Developers in Fintech Organizations
Published 2024-11-01“…The data extracted from these interviews were analyzed using the content analysis method, with the assistance of Maxqda software. In addition, the fuzzy Delphi method, coupled with a two-stage expert survey, was employed to confirm and rank the identified components. …”
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66785
Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions
Published 2024-04-01“…The distribution of HR-HPV in severe squamous lesions is complex, involving many HR-HPV genotypes in addition to HPV16, while the distribution of HR-HPV genotypes in endocervical glandular lesions is mainly limited in HPV18 and HPV16.Large datasets from China have identified the three most common HR-HPV genotypes in this population as stratified by diagnostic category: HPV52, HPV16, HPV58 in histologically negative cases and cervical intraepithelial neoplasia 1 (CIN1); HPV16, HPV52, HPV58 in CIN2/3; HPV16, HPV58, HPV52 or HPV18 in squamous cell carcinoma (SCC); HPV16, HPV18 and HPV52 in endocervical adenocarcinoma in situ (AIS), invasive adenocarcinoma, as well as mixed squamous and glandular lesions. …”
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66786
AVANÇOS E RETROCESSOS NA POLÍTICA DE EDUCAÇÃO DE JOVENS E ADULTOS NO ESTADO DE MATO GROSSO/BRASIL (2008/2017)
Published 2019-06-01“…The research undertaken showed that, in addition to the concentration of these formative spaces in a reduced number of municipalities of the state, the original pedagogical proposal was significantly modified already in its first years of operation. …”
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66787
Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics
Published 2025-01-01“…Using the agonist of HO-1 agonist cobalt protoporphyrin (CoPP) to induce HO-1 overexpression can significantly alleviate the decrease in FAC-induced BRL-3A cell viability (<i>p</i> < 0.01), ROS (<i>p</i> < 0.01), and lipid ROS (<i>p</i> < 0.01). In addition, siLnc286.2 treatment can increase HO-1 expression, alleviate the decline of FAC-induced BRL-3A cell activity, and increase lipid ROS (<i>p</i> < 0.05) content. …”
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66788
Risk barriers and sustainability in payment for ecosystem service implementation in smallholder forestry
Published 2024-07-01“…The findings indicate that financial limitations arise as a noteworthy obstacle, as small-scale farmers encounter considerable economic hardships and discouragingly expensive implementation expenses (ranging from 150 United States dollar per metric ton of carbon dioxide). Additionally, they face a low credit price (approximately 50 United States dollar per metric ton of carbon dioxide equivalent). …”
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66789
Microbial community structure and functional traits involved in the adaptation of culturable bacteria within the gut of amphipods from the deepest ocean
Published 2025-01-01“…The environmental response genes and a specialized KDP transport system allow it to adapt to the challenging conditions of the Hadal Zone. …”
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66790
Cost-Consequence Analysis of Apixaban Versus Rivaroxaban for Managing Patients with Venous Thromboembolism in Saudi Arabia
Published 2025-02-01“…This resulted in an ICER of $6916.07 for the prevention of an additional composite outcome when using apixaban instead of rivaroxaban. …”
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66791
Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats
Published 2025-02-01“…Then, the diabetic rats were intervened with low, medium, and high doses of whole wheat noodles feed for 8 weeks, respectively. The body weights, dietary intake, and drinking volume of the rats were measured regularly. …”
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66792
Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease
Published 2025-02-01“…However, the cellular and molecular links between ferroptosis, immune inflammation, and the brain-peripheral blood axis in Alzheimer’s disease (AD) remain unclear.Methods: We integrated bulk RNA-seq data from AD brain tissue and peripheral blood and refined the screening of AD candidate genes through differential gene expression analysis, weighted gene co-expression network analysis (WGCNA), and other approaches. Additionally, we analyzed single-cell RNA-seq (scRNA-seq) data from AD patients’ brain tissue and peripheral blood, combined with scRNA-seq data from experimental autoimmune encephalomyelitis (EAE) mouse brain tissue. …”
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66793
Validation of biomarkers and clinical scores for the detection of uterine leiomyosarcoma: a case-control study with an update of pLMS
Published 2025-01-01“…Welch’s t-test and Hedges’ g were used to evaluate blood markers and optimal thresholds and diagnostic odds ratios were calculated. Scoring systems were compared using receiver operating characteristics and proposed diagnostic cut-offs were reviewed. …”
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66794
HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury
Published 2025-01-01“…Notably, pretreatment with HMGB1 small interfering RNA (siRNA) effectively diminished lactate-mediated HMGB1 lactylation and alleviated the severity of AKI. Additionally, lactate accumulation was found to enhance the expression levels of NETs in the bloodstream, with circulating NETs levels positively correlating with HMGB1 lactylation. …”
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66795
Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer
Published 2025-01-01“…TNBC samples from TCGA-TNBC were classified into high and low-risk groups based on the median risk score. Additionally, correlations with clinical characteristics, Gene Set Enrichment Analysis (GSEA), immune analysis, and pseudotime analysis were performed. …”
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66796
Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis
Published 2025-02-01“…Lastly, with respect to DAS28, resveratrol emerged as the optimal choice (74.3%).ConclusionAccording to the network meta-analysis (NMA), curcumin exhibited superior efficacy compared to placebo in decreasing SJC and TJC. Additionally, curcumin demonstrated greater effectiveness in reducing inflammatory markers. …”
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66797
Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity
Published 2025-01-01“…Trial registration Not applicable since this study did not involve clinical intervention.…”
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66798
Capital structure, profitability, and short-term solvency of nascent SMEs in Ghana: An empirical study
Published 2023-01-01“…This critical insight underscores the importance of managing the capital structure of nascent SMEs, as the improper balance between debt and equity may impede the achievement of short-term solvency and, in turn, hinder the long-term success of the firm. Additionally, while nascent SMEs must prioritize maintaining liquidity to safeguard against unforeseen contingencies, this comes at a high cost in terms of missed opportunities that could significantly enhance the company’s long-term return on assets. …”
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66799
Analisis Penerimaan Learning Management System Institut Teknologi Garut Menggunakan Technology Acceptance Model
Published 2023-08-01“…Dikarenakan Learning Management System (LMS) di Institut Teknologi Garut baru digunakan, maka penelitian ini bertujuan menganalisis penerimaan Learning Management System Institut Teknologi Garut menggunakan metode Technology Acceptance Model, untuk mengetahui pengukuran pengaruh antar konstruk sekaligus sebagai barometer adaptasi penerimaan pengguna terhadap sistem LMS yang digunakan. …”
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66800
Exploring dental students' knowledge on oral cancer prevention: a cross-sectional study in Moldova, Armenia, and Belarus
Published 2025-01-01“…However, we observed a significant increase (p-value < 0.001, ANOVA) in the students` knowledge score as they proceed through study years from third (6.07 ± 2.61) to fifth year (7.49 ± 2.48). In addition, we found that Students with current or previous cigarette smoking habits had significantly (p-value < 0.001, student`s t-test) lower mean knowledge score (5.96 ± 2.82) when compared to students who have never been smokers (6.98 ± 2.42). …”
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