Assessing and predicting the value of ecosystem services in Sanya City, Hainan Island, China by Peihong Song, Qiu Yang, Wenyin Wu, Tianyan Su, Yamin Jiang, Jingli Lu, Zhongyi Sun, Jie Zhang, Rui Yu, Peng Wang, Lan Wu, Huai Yang, Wenjie Liu

“…In this study, the ESV of Sanya City in 2000, 2010, and 2020 was evaluated using the equivalent coefficient method. Additionally, the Future land-use simulation (FLUS) model was employed to predict land-use changes in 2030 under five different scenarios. …”
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Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure by Jing Liu, Tao Li, Yi Zhou, Yuanyuan Chen, Hai Li, Yan Huang, Jing Li, Yu Shi, Xin Zheng, Yanhang Gao, Xinxin Liu, Weituo Zhang, Shan Yin, Xia Yu, Jifang Sheng, Zhiwei Li, Feng Liu, Guohong Deng, Jinjun Chen, Zhongji Meng, Zhiping Qian, Xiaobo Lu, Wenyi Gu, Qun Cai, Xiaobo Wang, Qun Zhang, Xue Mei, Wenting Tan, Jia Shang, Xinyi Zhou, Chang Jiang, Ruoqi Zhou, Beiling Li, Huadong Yan, Yubao Zheng, Xiaomei Xiang, Yixin Hou, Shue Xiong, Ruochan Chen, Liyuan Long, Xiuhua Jiang, Sen Luo, Jinming Zhao, Liujuan Ji, Rongjiong Zheng

“…In this study, we identified additional predictive parameters and reformed the MELD score to predict ACLF more accurately.Methods A meta-analysis was performed on relevant studies to identify the predictive factors of 28-day/90-day outcomes of ACLF, which were validated in two large prospective cohorts. …”
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Subsequent chemical and foraging ecology preferences of Theocolax elegans (Westwood) (Hymenoptera: Pteromalidae) reared on two alternate stored product host insects by Jacqueline M. Maille, Chloe E. Albin, Rachel R. Harman, Matthew C. Hetherington, Sabita Ranabhat, Jennifer Abshire, Jaye Montgomery, Ian M. Stoll, Madison Lillich, Samantha Gillette, Daniel Brabec, Kun Yan Zhu, Erin D. Scully, Alison R. Gerken, William R. Morrison, III

“…Both host species are cosmopolitan and destructive pests of bulk wheat. In addition, either species could be used when mass rearing T. elegans. …”
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N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility by Yalun He, Jie Ding, Tonglin Bai, Yangshuo Li, Xiaolan Liang, Yiming Chen, Yi Lin, Wen Cheng, Chaoqin Yu

“…Functional enrichment analysis of differentially expressed genes (DEGs) between these clusters, along with immune cell infiltration analysis, was subsequently conducted. In addition, the single-cell dataset GSE214411 was analyzed to explore the role of m6A regulators in various cell types. …”
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Development of an individualized dementia risk prediction model using deep learning survival analysis incorporating genetic and environmental factors by Shiqi Yuan, Qing Liu, Xiaxuan Huang, Shanyuan Tan, Zihong Bai, Juan Yu, Fazhen Lei, Huan Le, Qingqing Ye, Xiaoxue Peng, Juying Yang, Yitong Ling, Jun Lyu

“…The results showed that the average Harrell's C-index for the DeepSurv model was 0.743, for the DeepHit model it was 0.633, for the CoxPH model it was 0.749, and for the Kaplan–Meier estimator model it was 0.500. In addition, the average D-Calibration Survival Measure was 6.014, 4408.086, 32274.743, and 1.508, respectively. …”
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Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma by Teresa Troiani, Fabiana Napolitano, Luigi Formisano, Roberto Bianco, Daniela Russo, Daniela Esposito, Giuseppe Ercolano, Angela Ianaro, Alberto Servetto, Daniela Claudia Maresca, Marcella Scala, Annarita Amato, Stefania Belli, Claudia Maria Ascione, Angela Vallefuoco, Giovanna Attanasio, Fabio Somma, Silvia Varricchio, Massimo Mascolo, Claudia Costa, Alessia Villani, Massimiliano Scalvenzi, Gianfranco Orlandino

“…Finally, IL8 mirrored the tissue results, unlike IL1β, with early (T1) and then sustained (T3) downregulation of its levels in responder patients, while increased in non-responders.Conclusions Taken together, these findings shed light on the significance of early transcriptomic and immune cell modulation in predicting responses to cemiplimab therapy. Additionally, our data suggest that IL8 levels in peripheral blood offer promising avenues for personalized treatment selection and response assessment in patients with cSCC receiving cemiplimab, while PD1+Tregs can be followed longitudinally to monitor response to therapy.…”
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Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity by Markus Engelmann, Markus Engelmann, Juliane Götze, Juliane Götze, Philipp Baumbach, Philipp Baumbach, Charles Neu, Charles Neu, Utz Settmacher, Michael Ardelt, Hermann Kissler, Sina M. Coldewey, Sina M. Coldewey

“…In order to ascertain the efficacy of bariatric interventions, it is important to assess not only weight loss, but also changes in body composition. Additionally, the aim of this study was to investigate the association between weight loss and cellular oxygen metabolism, a surrogate for mitochondrial function. …”
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Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Andrzej Kotela, Marta Skoda, Michał Pyzlak, Aleksandra Stangret, Ireneusz Kotela, Dariusz Szukiewicz

“…Tissue specimens including articular cartilage and synovial membrane were similarly collected during surgery and stained immunohistologically using selected antibodies including anti-CX3CR1, anti-CD56, anti-CD68, and anti-CD31. Additionally, the analysis included the assessment of articular cartilage, synovial membrane, and blood vessel morphology. …”
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Fusarium Head Blight in Argentina, a Profile of Produced Mycotoxins and a Biocontrol Strategy in Barley During Micro-Malting Process by María Silvina Alaniz-Zanon, Marianela Bossa, Lorenzo Antonio Rosales Cavaglieri, Juan Manuel Palazzini, Michael Sulyok, Sofía Noemí Chulze, María Laura Chiotta

“…The aims of this study were to determine (a) the incidence of the main species causing FHB in different locations of the barley-growing region of Argentina, (b) their ability to produce mycotoxins, and (c) the levels of deoxynivalenol (DON) and nivalenol (NIV) natural occurrence in grains at the harvest stage. Additionally, a strain of <i>Bacillus velezensis</i> was studied as a biocontrol agent in order to control <i>F. graminearum</i> sensu stricto and mycotoxin accumulation during the malting process, with the final objective being to reduce DON contamination in the beer manufacture chain. …”
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Evaluation of the resistome and gut microbiome composition of hospitalized patients in a health unit of southern Brazil coming from a high animal husbandry production region by Elisa Pires Coltro, Elisa Pires Coltro, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Lucas Cafferati Beltrame, Caroline Ribeiro da Cunha, Caetana Paes Zamparette, Clarissa Feltrin, Vilmar Benetti Filho, Patrícia de Almeida Vanny, Sérgio Beduschi Filho, Taíse Costa Ribeiro Klein, Mara Cristina Scheffer, Jussara Kasuko Palmeiro, Jussara Kasuko Palmeiro, Glauber Wagner, Thaís Cristine Marques Sincero, Thaís Cristine Marques Sincero, Carlos Rodrigo Zárate-Bladés, Carlos Rodrigo Zárate-Bladés

“…Metagenomic sequencing and resistome analysis were employed to identify antimicrobial resistance genes (ARGs) and their associated bacterial taxa. Additionally, the impact of the hospital environment on the resistome and microbiome profiles of these patients was assessed.ResultsA total of 247 genetic elements related to AMR were identified, with 66.4% of these elements present in both admission and discharge samples. …”
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Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review by Ramya Sekar, Selvaraj Jayaraman, Saranya Varadarajan, Thodur Madapusi Balaji, Vishnupriya Veeraraghavan, Prabhu Shankar Dayasankar, Dharshini Devi J

“…Methods: The keywords H19 or lncRNA H19 or long non-coding RNA H19″ AND “oral cancer or oral squamous cell carcinoma or tongue squamous cell carcinoma or OSCC” were used to search databases such as PubMed, Scopus, and Clinical Key on 9th December 2024. In addition, the authors manually scanned the reference lists of the included studies or relevant reviews identified through the search to ensure literature saturation. …”
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First clinical cases of leishmaniosis in meerkats (Suricata suricatta) housed in wildlife parks in Madrid, Spain by Pablo Moraleda-Berral, Rosa Gálvez, Eva Martínez-Nevado, Lino Pérez de Quadros, Juncal García, Manuel de la Riva-Fraga, Juan Pedro Barrera, Efrén Estévez-Sánchez, Lourdes Cano, Rocío Checa, María Ángeles Jiménez-Martínez, Ana Montoya, Guadalupe Miró

“…Serological tests [rK-39 and enzyme-linked immunosorbent assay (ELISA)] and molecular tests [nested polymerase chain reaction (PCR) and real-time PCR] were performed to detect Leishmania DNA. Additionally, an entomological study was carried out in both zoological parks, with molecular tests performed on female Phlebotomus perniciosus sand flies to determine their blood meal source and detect Leishmania DNA. …”
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Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study by Ping Zhou, Jun Chen, Ying Liu, Cheng Chen, Xin Guo, Zhangbin Yu, Jiebo Liu, Yanping Guo, Dan Dan Rao, Shengnan He, Xudong Yan, Wanxiang He, Songzhou Xu, Ruolin Zhang

“…A three-step analysis strategy—discovery, validation and clinical testing—will be used to identify and validate the clinical utility of novel biomarkers. Additionally, a nested case-control study will be conducted, matching participants 1:1 with a control group sharing similar BPD risk factors.Ethics and dissemination Our protocol has been approved by the Medical Ethics Committees of all participating hospitals, including Peking University Shenzhen Hospital, Shenzhen People’s Hospital, Shenzhen Baoan Women’s and Children’s Hospital, Longgang District Maternity and Child Healthcare Hospital, Nanshan Maternity and Child Healthcare Hospital and Shenzhen Luohu People’s Hospital. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Exploratory outcomes include several environmental as well as personality factors associated with OUD and with propensity to demonstrate a placebo effect.Ethics and dissemination Human subjects oversight for this study is provided by the University of Maryland, Baltimore and University of Maryland, College Park Institutional Review Boards. Additionally, the study protocol is reviewed annually by an independent Data and Safety Monitoring Board. …”
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Outcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study by Yan Sun, Xiaoli Zhu, Jaime Lin, John Abisheganaden, Zhiwen Joseph Lo, Lixia Ge, Joseph Molina, Elaine Tan, Huiling Liew, Jeremy Hoe, Gary Ang, Kai Qiang Low, Theophilus Yap, Nur Aberleen Syafirah Binte Azmi, Enming Yong, Tiffany Chew, Hui Yan Koo, Chelsea Law, Dexter Yak Seng Chan, Claris Shi, Julia Choo, Wai Han Hoi, Sadhana Chandraskear, Jo Ann Lim, Jemes Siow, Sabariah Binte Kaspon, Subramaniam Tavintharan, Daniel Chew

“…The incremental cost-effectiveness ratio (ICER) was calculated for the DEFINITE Care program relative to routine care.Results The estimation of average treatment effects based on propensity scores showed that the DEFINITE Care group exhibited a 9% lower mortality, 5% higher lower extremity amputation (LEA)-free survival, yet a 5% higher minor LEA rate compared with the matched historical controls. Additionally, they experienced fewer inpatient admissions (0.98 fewer episodes) and shorter hospital stays (5.5 fewer days) within 1 year (p-value &lt;0.001). …”
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Morphology, phylogeography, phylogeny, and taxonomy of Cyclorhiza (Apiaceae) by Bo-Ni Song, Xueyimu Aou, Rong-Ming Tian, Jing Cai, Wei-Yan Tan, Chang-Kun Liu, Chang-Kun Liu, Xing-Jin He, Song-Dong Zhou

“…However, its morphology, phylogeny, phylogeography, taxonomy, and evolutionary history were not investigated due to insufficient sampling and lack of population sampling and plastome data. Additionally, we found that Seseli purpureovaginatum was not similar to Seseli members but resembled Cyclorhiza species in morphology, indicating that the taxonomic position of S. purpureovaginatum needs to be re-evaluated.MethodsFirst, we observed the morphology of the genus. …”
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Laser Applications in Metal Orthodontic Bracket Debonding: A Systematic Review by Patryk Woś, Sylwia Kiryk, Tomasz Dyl, Jan Kiryk, Tomasz Horodniczy, Magdalena Szablińska, Magdalena Aleksandra Dubowik, Wojciech Dobrzyński, Marcin Mikulewicz, Jacek Matys, Maciej Dobrzyński

“…SBS comparisons revealed no significant differences between the laser-assisted and traditional debonding methods. Additionally, diode lasers demonstrated the potential to minimize enamel damage, particularly when operated at lower power settings. …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…To counteract intracellular ROS overproduction and the oxidized microenvironment, we constructed vinylphosphonic acid-glutathione (VPA-GSH) conjugates synthesized through a thiol-ene click reaction on Ti substrates, endowing them with good biocompatibility, antioxidant capability, and promotion of osteogenesis. In addition, a substantial amount of GSH was controllably released after transferring the VPA-GSH-loaded Ti substrate from a synthetic solution at pH 3.6 to phosphate-buffered saline at pH 7.4. …”
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Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance, Peter White, Trudie Chalder

“…All items from the World Health Organization Trial Registration Data Set for this protocol can be found in Additional file 2 Table S1.…”
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Monitoring poultry social dynamics using colored tags: Avian visual perception, behavioral effects, and artificial intelligence precision by Florencia B. Rossi, Nicola Rossi, Gabriel Orso, Lucas Barberis, Raul H. Marin, Jackelyn M. Kembro

“…Birds wearing white, gray, purple, and green tags pecked significantly more at their own tags than those with black (control) tags. Additionally, fewer aggressive interactions were observed in groups with orange tags compared to groups with other colors, except for red. …”
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