T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy by Linghua Wang, Siqing Fu, Aung Naing, Funda Meric-Bernstam, Carl Morrison, Joud Hajjar, Mingxuan Xu, Anas Alshawa, Bettzy Stephen, Ying Yuan, Jordi Rodon Ahnert, Abdulrazzak Zarifa, Shrutii Sarda, Timothy Looney, Sapna P Patel, Geoffrey M Lowman, Dzifa Yawa Duose, Jeffrey M Conroy, Evan Kwiatkowski

“…We employed multiplex PCR to create amplicons spanning the three beta chain complementarity-determining regions (CDR) regions to enable detection of polymorphism within the germline-encoded framework and CDR1 and CDR2 regions in addition to CDR3 profiling. Resultant amplicons were sequenced via the Ion Torrent and TRBV allele profiles constructed for each individual was correlated with irAE annotations to identify haplotypes associated with severe irAEs (≥ grade 3).Results Our study included 81 patients who had irAEs when treated with immunotherapy for cancer. …”
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Predictive markers of rapid disease progression and chemotherapy resistance in triple-negative breast cancer patients following postoperative adjuvant therapy by Tao Ma, Xiao-meng Hao, Hong-dan Chen, Min-hui Zheng, Xiao-geng Chen, Shuang-Long Cai, Jin Zhang

“…Of these, 369 were categorized as experiencing rapid relapse, while 1925 did not relapse rapidly. Logistic regression analysis was applied to determine potential markers predictive of rapid relapse post-chemotherapy. …”
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Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep by Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Zhiyun Hao, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

“…Utilizing functional enrichment analysis on the target genes, we successfully identified a number of target genes might be associated with the improvement of wool fineness, such as FOXN1, LIPK, LOC101116068, LOC101106296, KRTAP5.4, KRT71, KRT82, DNASE1L2, which are related to hair follicle development, histidine metabolism, epidermal cell differentiation, oxidative phosphorylation and hair cycle process. Additionally, the interoperability network involving lncRNAs-mRNAs indicated lncRNAs (MSTRG.17445.2, XR_006060725.1, MSTRG.871.1, MSTRG.10907.4) might play a significant role in the wool growth development and fineness improvement process. …”
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Agricultural GDP exposure to drought and its machine learning-based prediction in the Jialing River Basin, China by Xinzhi Wang, Qingxia Lin, Zhiyong Wu, Yuliang Zhang, Changwen Li, Ji Liu, Shinan Zhang, Songyu Li

“…Subsequently, the standardized precipitation evapotranspiration index (SPEI) and standardized soil moisture index (SSMI) were applied to analyze the spatial-temporal patterns of droughts. Additionally, cropland exposure to drought was evaluated using gridded agricultural GDP data derived from pixel interpolation. …”
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Characterization of three novel Helicobacter species infecting stomachs of dogs and cats: Helicobacter gastrocanis sp. nov., Helicobacter gastrofelis sp. nov., and Helicobacter fel... by Emiko Rimbara, Sae Aoki, Masato Suzuki, Hirotaka Kobayashi, Taisuke Nakagawa, Yuko Goto-Koshino, Sachiyo Nomura, Sachiyo Nomura, Wan-Ying Du, Hidenori Matsui, Shigetarou Mori, Keigo Shibayama, Tsuyoshi Kenri, Koichi Ohno

“…Phylogenetic analysis based on ureAB gene sequences obtained from gastric specimens from 47 dogs and 24 cats in Japan revealed that 29.8% of dogs were infected with H. gastrocanis, while H. gastrofelis infected 44.7% of dogs and 12.5% of cats. Additionally, 10.6% of dogs and 20.8% of cats were infected with H. felistomachi. …”
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Association between clinical-biological characteristics of Klebsiella pneumoniae and 28-day mortality in patients with bloodstream infection by Xiaofeng Yu, Yi Zhao, Xiao Sun, Jiahui Luan, Haiyan Wang, Tianyu Sun, Tongtong Lin, Xia Zhou, Wei Yang, Ziguang Deng, Bo Liu, Hongyun Cao

“…Antimicrobial susceptibility testing, string testing, and whole-genome sequencing (WGS) were performed on all isolates. Additionally, relevant bioinformatics analyses, such as phylogenetic analysis and assessment of resistance and virulence genes, were carried out. …”
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Dynamic development of gut microbiota and metabolism during and after weaning of kittens by Hong Zhang, Yang Ren, Siyu Wei, Hongli Jin, Yizhen Wang, Mingliang Jin

“…Pathway analysis revealed significant enrichment in eight metabolic pathways, with key changes in arginine metabolism and biosynthesis. Additionally, bacteria such as Bacteroides fragilis, Bacteroides stercoris, Leuconostoc citreum, and Bifidobacterium adolescentis were positively correlated with serum metabolic changes, emphasizing the link between gut microbiota and systemic metabolism (P < 0.05, n = 20). …”
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Association between HALP (hemoglobin, albumin, lymphocyte, and platelet) score and poor outcomes in acute ischemic stroke patients with type 2 diabetes mellitus: a study from the T... by Xu Zhu, Yijun Zhang, Yijun Zhang, Yijun Zhang, Yijun Zhang, Yijun Zhang, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Anxin Wang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Guoyuan Yu, Shifeng Xiang, Yiping Wu, Xia Meng, Xia Meng, Xia Meng, Xia Meng, Xia Meng

“…After adjusting for confounders, it was found that patients in the highest HALP score quartile had lower mRS scores of 2–6 (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.51–0.80) and 3–6 (OR, 0.53; 95% CI, 0.51–0.82) at the 3-month follow-up. …”
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A low-protein soybean-free diet improves carcass traits and meat quality and modulates the colonic microbiota in Daweizi pigs by Haohua Fu, Taoming Yang, Hengjia Ni, Hengjia Ni, Jing Li, Fenfen Liu, Jingbo Liu, Yulong Yin, Yulong Yin

“…Thirty-six healthy Daweizi pigs (average body weight 23.60 ± 1.34 kg) were raised under the same conditions and randomly assigned to two dietary treatments: (1) Con group, corn-soybean base meal; (2) LPNS group. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly expressed in MS brain lesions. …”
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Elevated Kappa Index in the Absence of Cerebrospinal Fluid IgG Oligoclonal Bands: Contribution of Intrathecal IgM and IgA Synthesis by Krzysztof Smolik, Roberta Bedin, Patrizia Natali, Martina Cardi, Diego Franciotta, Anna Maria Simone, Paolo Immovilli, Mario Santangelo, Matteo Gastaldi, Giulia De Napoli, Francesca Vitetta, Diana Ferraro

“…The most frequent diagnosis in the Kappa+OCB- group was MS (27/69), followed by INFECT (16/69). Additional evidence of IS was demonstrated through an elevated IgG/IgM/IgA index or by the presence of IgM OCBs in 59%, and through only IgM/IgA IS in 52% of cases. …”
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Metabolic and molecular Characterization, following dietary exposure to DINCH, Reveals new Implications for its role as a Metabolism-Disrupting chemical by Sontje Krupka, Alix Sarah Aldehoff, Cornelius Goerdeler, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Kristin Schubert, Nora Klöting, Martin von Bergen, Matthias Blüher

“…Plastic materials are ubiquitous, leading to constant human exposure to plastic additives such as plasticizers. There is growing evidence that plasticizers may contribute to obesity due to their disruptive effects on metabolism. …”
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Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study by Anabel Franco-Moreno, Elena Madroñal-Cerezo, Cristina Lucía de Ancos-Aracil, Ana Isabel Farfán-Sedano, Nuria Muñoz-Rivas, José Bascuñana Morejón-Girón, José Manuel Ruiz-Giardín, Federico Álvarez-Rodríguez, Jesús Prada-Alonso, Yvonne Gala-García, Miguel Ángel Casado-Suela, Ana Bustamante-Fermosel, Nuria Alfaro-Fernández, Juan Torres-Macho

“…This study’s limitations include potential information bias from electronic health records and a small cancer sample size. In addition, variability in detection protocols and evolving clinical practices may affect model accuracy. …”
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Hemşirelerin Hemşire Yardımcılarının İş ve Görev Tanımları ile İlgili Görüşleri: Malatya Örneği by Yasin Çetin, Emriye Hilal Yayan

“…Giriş: Sağlık hizmeti sunumunda, eğitimleri lise düzeyinde verilen hemşire yardımcılığı adı altında yeni bir meslek grubu tanımı yapılmıştır. …”
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Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma by Chun-Nan Yeh, Yu-Chan Chang, Yi-Chen Yeh, Yu-Chao Wang, Dennis Shin-Shian Hsu, Meng-Lun Lu, Michael Hsiao, Ming-Huang Chen, Nai-Jung Chiang, Shin-Yi Chung, Chien-Jung Huang, Ming-Hsien Chan, Tzu-Sheng Hsu, Yi-Ping Hung

“…Gene expression analyses identified significant upregulation of B cell-related genes in TLSs. Additionally, TLSs exhibited higher properties of memory B cells and myeloid dendritic cells but lower levels of innate immune cells compared with TILs. …”
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UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…This predicted relationship was then repeatedly validated using different in vivo and in vitro experimental methods. Additionally, multiple experimental approaches were implemented, encompassing western blotting, Co-IP, GST pull-down, flow cytometry, mass spectrometry, immunofluorescence, immunohistochemistry, and qRT-PCR to reveal the molecular mechanism of UBE2T-mediated immune escape and BrM.Results Our results indicate that expressed at elevated levels in breast cancer, UBE2T is negatively linked to patient prognosis, especially in BrM of TNBC. …”
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ANN-based two hidden layers computational procedure for analysis of heat transport dynamics in polymer-based trihybrid Carreau nanofluid flow over needle geometry by Adil Darvesh, Fethi Mohamed Maiz, Basma Souayeh, Luis Jaime Collantes Santisteban, Hakim AL. Garalleh, Afnan Al Agha, Lucerito Katherine Ortiz García, Nicole Anarella Sánchez-Miranda

“…Velocity of fluid is scrutinized through magnetic aspect and transport of heat is inspected through thermal radiation and heat sink source. In addition, implementing advance ANN-based computational procedures such as multi layers neural networks (MLNNs) provide valuable aid in unmatched capability for capturing the high complexity of heat transfer in fluid flow problems. …”
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Turning the Surface Electronic Effect Over Core‐Shell CoS2─FexCo1‐xS2 Nanooctahedra Toward Electrochemical Water Splitting in the Alkaline Medium by Lian‐Ming Lyu, Yu‐Chung Chang, Han‐Jung Li, Pei‐En Wang, Ruei‐Hung Juang, Ming‐Yen Lu, Cheng‐Shiuan Li, Chun‐Hong Kuo

“…Abstract The long‐term challenge in overall water splitting is the conflict in the pH condition of electrolytes for achieving efficient hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) at the same time, in addition to the typical cost issue in catalysts. It hence raises an intense research interest in seeking cost‐efficient non‐noble metal electrocatalysts as well as compromising electrolyte conditions for electrocatalytic HER and OER. …”
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DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment by Jeong Min Lee, Won Hyeok Lee, Seung Hyeon Cho, Jeong Woo Park, Hyuk Nam Kwon, Ji Hye Kim, Sang Hun Lee, Ji Hyung Yoon, Sungchan Park, Seong Cheol Kim

“…In DU145 and LNCaP-FGC (DRG2 low), docetaxel increased sub-G1 but not G2/M arrest and induced apoptosis, whereas olaparib had no additional effect. In LNCaP-LN3 (DRG2 high, p53 wild-type), docetaxel increased sub-G1 and G2/M arrest, furthermore olaparib enhanced cell death. …”
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Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariecto... by Tahsin Zahan, Mirza Alimullah, Ishrat Jahan, Md. Borhan Uddin, Khondker Ayesha Akter, Md. Junaeid Rahman, Shahnaz Siddiqua, Kamrun Nahar Ela, Sakil Amin, Khondoker Shahin Ahmed, Hemayet Hossain, Ferdous Khan, Md Ashraful Alam, Nusrat Subhan

“…All of the rats were sacrificed at the end of the study to examine the physiological parameters and oxidative stress markers, and tissue samples were obtained. In addition, the process of histological staining of liver sections was done for inflammation as well as tissue fibrosis. …”
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