Effects of cage size on the natural behavior, serum parameters, production performance and hypothalamic mRNA expression profiles of laying hens by Yi Wan, Ruiyu Ma, Renrong Qi, Dawei Jiang, Helong Guan, Wei Liu, Junying Li, Yan Li, Kai Zhan

“…The serum levels of MDA, CORT, AST and T-CH were significantly lower in the LC and MC groups than in the SC group (P <0.05), whereas the serum activities of SOD and GSH-Px were significantly greater (P <0.05). Additionally, compared to the SC group, the laying rates were increased by 1.61% and 2.20% (P <0.05), and the feed conversion ratio (FCR) were improved by 1.35% and 2.25%, respectively (P <0.05) in the LC and MC groups, respectively. …”
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning by Zuhui Pu, Zuhui Pu, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Lisha Mou, Lisha Mou

“…Correlations between immune cells and key RMITRGs were investigated, and the interactions among these genes were explored through protein-protein interaction (PPI) network analysis. Additionally, we performed a detailed cell-cell communication analysis to identify significant signaling pathways in T2D.ResultsOur analysis identified 1953 DEGs between T2D and ND patients, with the Stepglm[backward] plus GBM model demonstrating high predictive accuracy and identifying 13 hub RMITRGs. …”
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Deep learning captures the effect of epistasis in multifactorial diseases by Vladislav Perelygin, Alexey Kamelin, Alexey Kamelin, Nikita Syzrantsev, Layal Shaheen, Layal Shaheen, Anna Kim, Nikolay Plotnikov, Anna Ilinskaya, Valery Ilinsky, Alexander Rakitko, Alexander Rakitko, Maria Poptsova

“…The aim of the presented study is to explore the power of non-linear machine learning algorithms and deep learning models to predict the risk of multifactorial diseases with epistasis.MethodsSimulated data with 2- and 3-loci interactions and tested three different models of epistasis: additive, multiplicative and threshold, were generated using the GAMETES. …”
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TPDTNet: Two-Phase Distillation Training for Visible-to-Infrared Unsupervised Domain Adaptive Object Detection by Siyu Wang, Xiaogang Yang, Ruitao Lu, Shuang Su, Bin Tang, Tao Zhang, Zhengjie Zhu

“…Specifically, in the first phase, we incorporate a contrastive learning framework to maximize the mutual information between the source and target domains. In addition, we construct a generative model that learns only a unidirectional modality conversion mapping, thereby capturing the associations between their visual contents. …”
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Multi-Isotope Geochemical Baseline Study of the Carbon Management Canada Research Institutes CCS Field Research Station (Alberta, Canada), Prior to CO2 Injection by Rachel E. Utley, Emma Martin-Roberts, Nicholas Utting, Gareth Johnson, Domokos Györe, Marta Zurakowska, Finlay M. Stuart, Adrian J. Boyce, Thomas H. Darrah, Pauline Gulliver, R. Stuart Haszeldine, Don Lawton, Stuart M. V. Gilfillan

“…In contrast, the measured 4He concentrations in shallow groundwaters at the site are much lower and may be explained by gas loss from the system or in situ production generated by radioactive decay of U and Th within the host rocks. Additionally, the injected CO2 is low in He, Ne and Ar concentrations, yet enriched in 84Kr and 132Xe relative to 36Ar, highlighting that inherent noble gas isotopic fingerprints could be effective as a distinct geochemical tracer of injected CO2 at the FRS.…”
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High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents by Marloes I Hofstee, Joanna Kaczorowska, Abigail Postema, Erna Zomer, Maren van Waalwijk, Gustaaf Jonathans, Lia GH de Rond, Gaby Smits, Lotus L van den Hoogen, Gerco den Hartog, Anne-Marie Buisman

“…Conclusions The booster vaccinations upheld humoral responses of NH residents to WT and Omicron SARS-CoV-2. This, in addition to the less virulent circulating strains, decreased symptom severity and treatment durations for SARS-CoV-2-infected NH residents. …”
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New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis by Aleksandra Lesiak, Aleksandra Lesiak, Karolina Wodz, Justyna Ceryn, Dorota Sobolewska-Sztychny, Dorota Sobolewska-Sztychny, Igor Bednarski, Janusz Piekarski, Marta Pabianek, Dariusz Nejc, Izabela Dróżdż, Joanna Narbutt, Marcin Noweta, Magdalena Ciążyńska, Magdalena Ciążyńska

“…Silencing NLRP1 or NLRP3 via RNA interference in primary human keratinocytes resulted in a significant reduction of cytokine gene expression. Additionally, a notable increase in tumor marker gene expression was observed in cells with functional NLRP1 and NLRP3 following UV radiation, whereas silencing these inflammasome genes altered the expression profiles of these markers.ConclusionThis study provides a pioneering comprehensive assessment of the roles of NLRP1, NLRP3, and IL-33 in the pathogenesis of UV-induced cutaneous carcinogenesis. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Findings were confirmed in two different HEV genotype 3 clones. In addition, we demonstrate that HiBiT-tagged HEV, offering rapid and several-log amplitude detection, can be used for the evaluation of antiviral drugs and neutralizing antibodies. …”
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Exploring urban-rural inequalities of maternal healthcare utilization in Bangladesh by A.T.M. Shariful Alam, Shorful Alam, Kashfia Mobasshira, S.M. Nuruzzaman Anik, Mohammad Nayeem Hasan, Muhammad Abdul Baker Chowdhury, Md Jamal Uddin

“…Rich families had odds ratios of 1.91, 2.42, and 2.5 compared to the ''poor'' group for ANC, FBD, and SBA, respectively. …”
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Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study by Thomas Lee, Sandeep Singh, Phyo Kyaw Myint, Sheila Jones, Ben Carter, Susan Moug, Terry Quinn, Michael Thomas, Emma Bhatti, Angeline Price, Fenella Barlow-Pay, Siobhan Duffy, Lyndsay Pearce, Arturo Vilches-Moraga, Michael Stechman, Philip Braude, Emma Mitchell, Alessia Verduri, Kathryn McCarthy, Jonathan Hewitt, Charlotte Davey, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Dolcie Paxton, Francis Rickard, Mark Holloway, James Hesford, Tarik Jichi, Norman Galbraith, Jenny Edwards, Carly Bisset, Ross Alexander, Abigail Ingham, Roxanna Short, Aine McGovern, Jemima Collins, Eilidh Bruce, Alice Einarsson, Enrico Clini, Giovanni Guaraldi, Madeline Garcia, Shefali Sangani, Thomas Kneen, George Kyriakopoulos, Denise Tan

“…We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. …”
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Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…Serum samples will be taken before and 28 days after the booster, with additional sampling for exploratory endpoints in subgroups. …”
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Clinical Findings in Diabetes Mellitus Patients with COVID-19 by Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Jinhua Li, Wenlong He, Bo Yu, Chenfang Wu, Zhiguo Zhou, Hong Luo, Hong Peng

“…High levels of HbA1c and proteinuria could be potential risk factors for severe COVID-19 in DM patients. In addition to timely systemic therapy, the control of blood glucose and proper diabetic therapy is essential to improve the prognosis of severe DM patients with COVID-19.…”
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Genetic investigations of autosomal recessive inherited ichthyosis impressed by fetal ultrasound: Exome sequencing and haplotype linkage analysis by Ting-Yu Chang, Zhu Wei Lim, Yi-Tzu Chu, Wan-Ju Wu, Mei-Hui Lee, Shun-Ping Chang, Dong-Jay Lee, Wen-Hsiang Lin, Ming Ho, Jin-Chung Shih, Gwo-Chin Ma, Ming Chen

“…Conclusion: Preimplantation genetic testing using STR linkage analysis can rescue cases with autosomal recessive inheritance when only one mutation is found in the putative gene, while reanalysis of high-coverage WES by optimized updated bioinformatics should always be considered in addition to whole genome sequencing.…”
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Hemşirelik Öğrencilerinin Toplumsal Cinsiyet Rollerine Yönelik Tutumlarının Meslek Seçimine Etkisinin Belirlenmesi by Berna Bayır, Beyza Nur Ay, Hamza Özcihan

“…Mesleki Uygunluk alt boyutunda en yüksek ortalamalar 6,82 ± 1,75 ile 18-25 yaş grubunda olan 7,11 ± 1,61 ile İç Anadolu Bölgesinde yaşayan öğrenciler aldı. Eşitlikçi cinsiyet rolü ile mesleki uygunluk alt boyutları arasında, Geleneksel Cinsiyet Rolü ile Yaşamsal Nedenler alt boyutları arasında anlamlı bir ilişki belirlendi (p = 0,05). …”
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Uptake of HIV pre-exposure prophylaxis and contraception in South African hair salons: a study protocol for a pilot cluster randomised controlled trial by Christina Psaros, Ingrid Bassett, Sabina Medal Govere, Jana Jarolimova, Joyce Yan, Sthabile Shezi, Lungile M Ngcobo, Shruti Sagar, Dani Zionts, Nduduzo Dube, RA Parker

“…We will assess feasibility by collecting process measures and evaluate retention as continued use of PrEP and contraception separately, defined as one additional visit within 6 months with continued use of PrEP and/or contraception.Ethics and dissemination The study has been approved by the University of KwaZulu-Natal Biomedical Research Ethics Committee and the Massachusetts General Brigham Institutional Review Board. …”
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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…Hub genes in IC/BPS patients were identified through the application of three distinct machine-learning algorithms. Additionally, the inflammatory status and immune landscape of IC/BPS patients were evaluated using the ssGSEA algorithm. …”
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Comparison of Magnetic Resonance Imaging and Operation Waiting Times in Patients Having Traumatic Cervical Spinal Cord Injury; with or without Bony Lesions by Jeong Heo, Woo-Kie Min, Chang-Wug Oh, Joon-Woo Kim, Kyeong-hyeon Park, Il Seo, Eung-Kyoo Park

“…Conclusions If fracture or dislocation is detected by CT, cervical SCI can be easily predicted resulting in MRI and surgical treatment being performed more rapidly. Additionally, fracture or dislocation tends to cause more severe neurological damage, so it is assumed that rapid diagnosis and treatment are possible.…”
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Effectiveness of an electronic clinical decision support system in improving the management of childhood illness in primary care in rural Nigeria: an observational study by Marek Kwiatkowski, Rodolfo Rossi, Torsten Schmitz, Fenella Beynon, Capucine Musard, Marco Landi, Daniel Ishaya, Jeremiah Zira, Muazu Muazu, Camille Renner, Edwin Emmanuel, Solomon Gideon Bulus

“…Tablets were donated, but no additional support or incentives were provided. Intervention and control facilities received supportive supervision based on the national supervision protocol.Primary and secondary outcome measures The primary outcome was caregiver-reported recovery at day 7, collected over the phone. …”
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Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy by Yu Z, Zhou Z, Zhao Y

“…The IC50 of BMS-1166 was 28.77 μM in MDA-MB-231 cells. In addition, the BMS-T7 showed a better inhibitory effect on PD-L1 expression in breast cancer cells and exosomes than the naked drug. …”
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Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis by Sergio Bergese, Richard Berkowitz, Paul Rider, Martin Ladouceur, Suzanne Griffith, Alvaro Segura Vasi, Kristina Cochrane, Linda Wase, Mark A. Demitrack, Ashraf S. Habib

“…Data from the ATHENA trial was used for the oliceridine cohort; and additional baseline characteristics were collected from medical charts. …”
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