Computational identification of anti-cancer compounds targeting the RNA-binding domain of human FOX-1 protein (RBFOX1) by Muhammad Tahir ul Qamar, Pablo Sanz-Jimenez, Shaima Rabeea Banoon, Xi-Tong Zhu, Fahad M. Aldakheel, Nahlah Makki Almansour, Leen A. Aldaiji, Wafa Abdullah I. Al-Megrin, Faisal Ahmad

“…Results shows that control (3S,5aS,6R,8aS,9R,10S,12R,12aS)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol (artenimol) reflecting the binding affinities of −7.9 kcal/mol, Top1 (4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid) shows −8.7 kcal/mol and Top2 (R)-1-carboxy-5-((S)-2-((2R,4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)-2-(2-phenylacetamido)acetamido)pentan-1-aminium indicating −8.2 k cal/mol. Additional, molecular dynamic simulation studies shows significant stability during RMSD and RMSF analyses over a 100 ns timescale. …”
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Clinical outcomes over 2 years following arthroscopic ankle lateral ligament repair with os subfibulare by Shohei Sano, Noriyuki Kanzaki, Kiminari Kataoka, Koji Nukuto, Tetsuya Yamamoto, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

“…Clinical outcomes were assessed using the Japanese Society for Surgery of the Foot (JSSF) scale and the Self-administered Foot Evaluation Questionnaire (SAFE-Q). In addition, the bone-union rate was evaluated by using plain computer tomography in the ossicle group. …”
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Predicting breast cancer prognosis using PR and PIK3CA biomarkers: a comparative analysis of diagnostic groups by Yuting Feng, Qingzhen Song, Lei Yan, Ruoqi Li, Mengqin Yang, Peng Bu, Jing Lian

“…Results Significant differences in age, ER expression, and Ki67, HER2, and PIK3CA mutation status were detected between the groups (P < 0.05). …”
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Quantitative proteomics and targeted metabolomics reveal the role of Cassia siamea L. extract in the response to high-fat diet-induced obesity in Drosophila by Ananya Dechakhamphu, Nattapong Wongchum, Theeraphan Chumroenphat, Alongklod Tanomtong, Sirithon Siriamornpun

“…Additionally, CSE increased survival rates, physical strength, and antioxidant capacity, as evidenced by increased SOD1 activity and resistance to oxidative stress. …”
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Prospects for the use of deep brain stimulation in the treatment of Parkinson's disease in Ukraine by K.R. Kostiuk, A.O. Lisianyi, Yu.M. Medvediev, A.O. Popov, V.V. Cheburakhin, V.M. Buniakin, D.A. Tevzadze

“…Radiofrequency (RF) destruction of the subcortical nuclei was performed on 522 patients: 392 underwent unilateral thalamotomy, 50 underwent bilateral thalamotomy, 36 underwent unilateral pallidotomy, 2 underwent bilateral pallidotomy, 30 under­went thalamotomy combined with contralateral pallidotomy, and 12 underwent thalamotomy combined with contralateral subthalamic nucleus (STN) destruction. Additionally, neurostimulation surgery was performed on 37 patients, and combined surgical interventions (stereotactic RF destruction and deep brain stimulation (DBS) system implantation) were performed on 7 patients. …”
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Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…As more biologics become available and additional trials are published we will provide updated versions of this white paper every few years. …”
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The role of activated partial thrombin time in mediating the impact of poorly glycemic control on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus by Hui Zhang, Minghui Chen, Lijie Sun, Wenwen Zhu, Wenwen Zhu, Tong Niu, Huzaifa Fareeduddin Mohammmed Farooqui, Hongxiao Wang, Bing Song, Jumei Wang, Haoqiang Zhang

“…APTT mediated the relationship between HbA1c and the conduction velocities of sensory fibers in the ulnar nerve or sural nerve by 34.66% or 22.03%, respectively.ConclusionsIn patients with T2DM, uncontrolled HbA1c and shorter APTT emerges as risk factors for DPN. Additionally, the effect of increased HbA1c upon DPN, especially for influenced conduction velocities of sensory fibers in both the ulnar nerve and sural nerve may partly medicated by decreased APTT.…”
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Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

“…Complementing this, an additional assembly of 35 regulators are considered to be regulators of activity, degradation, and translocation dynamics of enzymes integral to the aforementioned pathway. …”
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Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

“…After a Shapiro-Wilk test, non-parametric repeated measures analyses of variance (Friedman's test) and post-hoc comparisons corrected with the Benjamini-Hochberg approach were performed to compare the effects on primary and secondary cognitive outcomes over experimental intervention and Standard Care.ResultsThe results from the Friedman analysis revealed significant improvements in Word List Immediate Recall, Digit Span Forward and Complex Figure Recall (all p &lt; 0.001) following the HB-CCT, compared to the Baseline. Additionally, Naming performance showed significant improvement after the HB-CCT (p = 0.02). …”
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Larvicidal activity of Bacillus thuringiensis strains against Aedes aegypti and Culex quinquefasciatus mosquitoes by Prakai Rajchanuwong, Sawaporn Peaboon, Ratchadawan Ngoen-Klan, Atsalek Rattanawannee, Atirat Noosidum, Boonhiang Promdonkoy, Jariya Chanpaisaeng, Theeraphap Chareonviriyaphap

“…In this study, we screened Bacillus thuringiensis strains as biological control agents for potential toxins against mosquito larvae as an additional control tool. Preliminary bioassays conducted on 434 strains demonstrated that 41 strains (11.64%) and 14 strains (3.97%) achieved 100% mortality against Ae. aegypti and Cx. quinquefasciatus larvae, respectively. …”
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Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese by Jin Yu, Ichraf Mabrouk, Qiuyuan Liu, Yuxuan Zhou, Yupu Song, Jingyun Ma, Fengshuo Liu, Xiangman Hu, Zhiyi Yang, Yuxia Zeng, Jingtao Hu, Yongfeng Sun

“…The protein-protein interaction network analysis (PPI) indicated that selected DEGs, such as PDIA3, ATCB, PKM, PGAM1, NME2, LDHB, and CALM2, were highly related to the regulation of the reproduction system development. Additionally, the expression trends of 4 identified DEGs were validated by RT-qPCR. …”
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Development and validation of a nomogram for predicting lung cancer based on acoustic–clinical features by Zhou Lu, Zhou Lu, Jiaojiao Sha, Xunxia Zhu, Xiaoyong Shen, Xiaoyu Chen, Xin Tan, Rouyan Pan, Shuyi Zhang, Shi Liu, Tao Jiang, Jiatuo Xu

“…Furthermore, the nomogram model was compared with predictive models that were developed using six additional machine-learning (ML) methods.ResultsOur acoustic–clinical nomogram model demonstrated a strong discriminative ability, with AUCs of 0.774 (95% confidence interval [CI], 0.716–0.832) and 0.714 (95% CI: 0.616–0.811) in the training and test sets, respectively. …”
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Large-scale high purity and brightness structural color generation in layered thin film structures via coupled cavity resonance by Wang Danyan, Ji Chengang, Li Moxin, Xing Zhenyu, Gao Hao, Li Xiaochan, Zhou Huixian, Hu Yuhui, Lin Zhelin, Zhang Cheng

“…The measured spectra exhibit narrow resonant linewidths (full width at half maximum ∼60 nm), high peak efficiencies (>40 %), and well-suppressed sideband intensities (∼0 %). In addition, the generated color can be easily tuned by adjusting the thickness of SiO2 layer, and the associated color gamut coverage shows a wider range than many existing standards. …”
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JWST-TST DREAMS: A Precise Water Abundance for Hot Jupiter WASP-17b from the NIRISS SOSS Transmission Spectrum by Dana R. Louie, Elijah Mullens, Lili Alderson, Ana Glidden, Nikole K. Lewis, Hannah R. Wakeford, Natasha E. Batalha, Knicole D. Colón, Amélie Gressier, Douglas Long, Michael Radica, Néstor Espinoza, Jayesh Goyal, Ryan J. MacDonald, Erin M. May, Sara Seager, Kevin B. Stevenson, Jeff A. Valenti, Natalie H. Allen, Caleb I. Cañas, Ryan C. Challener, David Grant, Jingcheng Huang, Zifan Lin, Daniel Valentine, Mark Clampin, Marshall Perrin, Laurent Pueyo, Roeland P. van der Marel, C. Matt Mountain

“…We verify our POSEIDON results with petitRADTRANS retrievals. Additionally, we constrain the abundance of log(H ^− ), −10.19 ${}_{-0.23}^{+0.30}$ , finding that our model including H ^− is preferred over our model without H ^− to 5.1 σ . …”
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Connotation, research status, and development directions of clean coal geology in China by Yuegang TANG, Shaoqing WANG, Xiaoshuai WANG, Xin GUO, Yafeng WANG, Liping XUE, Harold H. Schobert

“…Furthermore, this study provides a comprehensive overview of the current status of research on the clean assessment, clean processing, conversion, and utilization of coal resources. Additionally, this study reviews the advances in research on China's clean coal geology, categorizing them into five stages: germination, exploration, maturity, establishment, and expansion. …”
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Biorefinery potential of coffee silverskin: Composition and applications by Elena M. Anchugova, Elena V. Udoratina, Elena G. Kazakova, Anastasiia O. Nosova, Mayya V. Uspenskaya, Tatiana N. Shchemelinina

“…Method: The study employed various analytical techniques, including elemental analysis, chromatography methods, and Fourier transform methods, to characterize the CS biomass. Additionally, three formulations for wet granulations of a biofertilizer were prepared to valorize the silverskin. …”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

“…AS includes regular prostate-specific antigen testing, MRI scans and the offer of repeat biopsy (at 3 years, or if imaging suggests progression). Additional MRI scans and/or biopsies will be performed for biochemical or clinical indications. …”
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Application of trichloroisocyanuric acid in controlling kiwifruit bacterial canker disease demonstrates its promising potential as an eco-friendly bactericide by Jianyou Gao, Jiewei Li, Cuixia Liu, Hongjuan Gong, Beibei Qi, Rongxiang Zhu, Liming Xia, Li Li, Shibiao Liu, Qiaosheng Jiang, Kaiyu Ye, Faming Wang

“…Mechanistic investigations revealed that TCCA inhibited bacterial biofilm formation, impaired motility, disrupted cell integrity, and suppressed the expression of virulence-related genes, ultimately leading to bacterial cell death. Additionally, TCCA treatment of both healthy and infected canes induced the activity of key defense-related enzymes, including catalase (CAT), peroxidase (POD), glutathione reductase (GR), and phenylalanine ammonia-lyase (PAL), suggesting that TCCA may activate systemic plant defense responses. …”
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Dielectric Temperature Stability and Enhanced Energy-Storage Performance of Sr_0.4Ba_0.6(Zr_0.2Ti_0.2Sn_0.2Ta_0.2Nb<sub>... by Yingying Zhao, Ziao Li, Shiqiang Yang, Pu Mao, Ruirui Kang

“…The dielectric characteristics demonstrated typical relaxation behavior and outstanding temperature stability, with a capacitance temperature coefficient (TCC) of less than 5% within the temperature range of 111–317 °C. Additionally, the SBN40-H ceramics exhibit slim P–E loops with negligible hysteresis, which is considered to be related to the existence of weakly coupled relaxors. …”
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Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

“…The relationships between methylation status and classical dosage effect, dosage compensation, and inverse dosage effect were also studied. In addition, we demonstrated that RNA m6A methylation may affect dosage-dependent gene regulation through dosage-sensitive modifiers, alternative splicing, the MSL complex, and other processes. …”
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